Interpreting the implications of DNA ancestry tests.

Abstract:

:Shopping for genetic information has become popular, but consumers may not understand what exactly they are buying. The retail DNA industry is forcing laypersons, academics, and medical and legal professionals alike to face the crossroads of genetics, law, and society. How will we decipher the meanings of the tests, determine the value of the information provided, or appropriately encourage or discourage various applications of that genetic information? When it comes to understanding the signs at the crossroads of disciplines, something is always potentially lost in translation. This article provides an overview of the retail DNA industry, addressing a few questions ripe for misinterpretation and confusion. It argues that the challenges posed by the retail DNA industry are both intelligible and manageable; optimally, multidisciplinary individuals would guide the way, steering the courts, legislature, laboratories, and clinics toward an adequate balance of consumer protection, autonomy, and understanding.

journal_name

Perspect Biol Med

authors

Wagner JK

doi

10.1353/pbm.0.0158

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

231-48

issue

2

eissn

0031-5982

issn

1529-8795

pii

S1529879510200054

journal_volume

53

pub_type

杂志文章
  • Toward a broader notion of community.

    abstract::Both leading scientific journals and the popular press now regularly report the convincing evidence of massive environmental degradation and decline. Yet despite the seriousness of the problems, despite their anthropogenic nature, and despite their profound implications for present and future population health, such t...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2007.0008

    authors: Levine BR

    更新日期:2007-01-01 00:00:00

  • Flexner at 100: a brief view from Oxford.

    abstract::Of all the principles set out by Flexner in 1910, the most fundamental, that of academic and scientific excellence, is more relevant to medical education in the United Kingdom today than ever before. To realize this, undergraduate medical education (UGME) at Oxford has evolved to incorporate the tutorial method of tea...

    journal_title:Perspectives in biology and medicine

    pub_type: 传,历史文章,杂志文章

    doi:10.1353/pbm.2011.0013

    authors: Fleming KA

    更新日期:2011-01-01 00:00:00

  • Darwinism and the cultural evolution of sports.

    abstract::This article outlines a Darwinian approach to sports that takes into account its profoundly cultural character and thereby overcomes the traditional nature-culture dichotomies in the sociology of sport. We argue that there are good reasons to view sports as culturally evolved signaling systems that serve a function si...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.0.0063

    authors: De Block A,Dewitte S

    更新日期:2009-01-01 00:00:00

  • Eugene O'Neill and Addison's disease.

    abstract::A detailed review of hospital records, physician's notes, diaries, letters, and autopsy reports offers sufficient clinical grounds to establish that Eugene O'Neill developed adrenal insufficiency, secondary to tuberculosis, in later life--a fact hitherto unknown--the condition not becoming manifest until after he had ...

    journal_title:Perspectives in biology and medicine

    pub_type: 传,历史文章,杂志文章

    doi:10.1353/pbm.1987.0051

    authors: Hamilton JW

    更新日期:1987-01-01 00:00:00

  • The significance of teeth in pollution detection.

    abstract::The general population is experiencing lifelong exposure to old and new hazardous substances. By using data collected from a subject's own teeth, accuracy in determining the effects of exposure is assured since extrapolation is excluded. The establishment of a common tooth bank can provide means to integrate data from...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.1988.0031

    authors: Sharon IM

    更新日期:1988-10-01 00:00:00

  • The foundation of physicianship.

    abstract::Although the practice of medicine continually changes in response to new biomedical understanding, novel technologies, and evolving cultural contexts, the ethical foundations of the clinical relationship between patient and physician paradoxically remain constant. There are fundamental characteristics with respect to ...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2012.0002

    authors: Fuks A,Brawer J,Boudreau JD

    更新日期:2012-01-01 00:00:00

  • The Role of Physicians During Hunger Strikes of Undocumented Migrant Workers in a Non-Custodial Setting.

    abstract::Since the beginning of the 21st century, the living conditions of undocumented migrant workers in Belgium have deteriorated drastically. In Brussels, after various social actions, undocumented people began squatting and occupying public buildings to make their struggle visible to society. Desperate, some seized the po...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2019.0006

    authors: Vanobberghen R,Louckx F,Depoorter AM,Devroey D,Vandevoorde J

    更新日期:2019-01-01 00:00:00

  • "He knows that machine is his mortality": old and new social and cultural patterns in the clinical trial of the AbioCor artificial heart.

    abstract::The clinical trial of the AbioCor artificial heart, initiated in July 2001 and still in process, has taken place within a matrix of social and cultural patterns that are both "old" and new. The old patterns--those that have accompanied previous clinical trials of other vital artificial organs and transplantation in th...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2004.0006

    authors: Fox RC,Swazey JP

    更新日期:2004-01-01 00:00:00

  • Global Bioethics: A Story of Dreams and Doubts from Bengal.

    abstract::This article is concerned with the practice of bioethics outside of the Euro-American and Anglophone settings in which it was first formulated. In theoretical terms, the article considers the frictions that arise when global-scale projects such as bioethics are introduced into diverse social and cultural settings. Met...

    journal_title:Perspectives in biology and medicine

    pub_type: 传,历史文章,杂志文章

    doi:10.1353/pbm.2018.0038

    authors: Simpson B

    更新日期:2018-01-01 00:00:00

  • Conception control as a health practice: an emerging concept in government and medicine.

    abstract::The health aspects and benefits of conception control as a justification for U.S. government support of family planning are reviewed. The Family Planning Services Act of 1970 set a goal of serving 5 million indigent women by 1975. It is predicted that the program will far surpass that goal. 340 million dollars were...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.1973.0050

    authors: Hellman LM

    更新日期:1973-04-01 00:00:00

  • A consumer's guide to superorganisms.

    abstract::The organism, like the molecule, the cell, and the species, is one of the fundamental levels in our hierarchical classification of life and its components. The units ranked at these levels, being concrete, particular things, are individuals in the broadest philosophical sense. But in a much narrower and more familiar ...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2011.0022

    authors: Ghiselin MT

    更新日期:2011-04-01 00:00:00

  • The body, its emotions, the self, and consciousness.

    abstract::This article proposes a means for better understanding the self and consciousness. Data indicate that the basic "emotional brain" continually computes potential survival risk against reward to rank consequent "emotion scores" for all sensory inputs. These scores compete to yield winner-takes-all outcomes that determin...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2012.0031

    authors: Boyd GW

    更新日期:2012-07-01 00:00:00

  • Let the shoemaker stick to his last: a defense of the "old" public health.

    abstract::The traditional forms of public health law were directed largely toward communicable diseases and other externalities, such as pollution, with negative health impacts. The more modern view treats any health issue that affects large numbers of individuals as one of public health, which would include such problems as ob...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Epstein RA

    更新日期:2003-07-01 00:00:00

  • Confidentiality, electronic health records, and the clinician.

    abstract::The advent of electronic health records (EHRs) to improve access and enable research in the everyday clinical world has simultaneously made medical information much more vulnerable to illicit, non-beneficent uses. This wealth of identified, aggregated data has and will attract attacks by domestic governments for surve...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2013.0003

    authors: Graves S

    更新日期:2013-01-01 00:00:00

  • Conceiving wholeness: women, motherhood, and ovarian transplantation, 1902 and 2004.

    abstract::Scholars have shown that organ transplantation may transform ideas about one's body, with recipients feeling that they are receiving not just a body part but also a part of the donor's identity. This article focuses on a different way in which organ transplantation shapes recipient identity: the idea of becoming whole...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2011.0036

    authors: Rodriguez SB,Campo-Engelstein L

    更新日期:2011-07-01 00:00:00

  • Head-counting vs. heart-counting: an examination of the recent case of the conjoined twins from Malta.

    abstract::This paper reexamines the recent case of the conjoined twins from Malta. Survival was said to be possible only through separation, which would actually leave only one twin alive. The parents refused to allow the killing of one to save the other, but the court ruled that this would amount to the neglect of innocent lif...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2002.0063

    authors: Barilan YM

    更新日期:2002-10-01 00:00:00

  • Haunted Doctors.

    abstract::The idea of being "haunted" appears often in accounts of the experience of health-care professionals and trainees who suffer from unresolved sorrow or regret about past clinical events, in particular the deaths of patients. The trope of haunting draws a direct line between past professional trauma and the dread of fut...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2020.0034

    authors: Belling C

    更新日期:2020-01-01 00:00:00

  • Marino Ortolani: "Does That Baby's Hip Go Click?".

    abstract::Marino Ortolani (1904-1983), a pediatrician from Ferrara, in northeastern Italy, was an outstanding pioneer in the early diagnosis and treatment of hip dysplasia. In 1935, while examining hip abduction-adduction in a six-month-old baby, Ortolani noted that a clearly audible and palpable "click" was sufficient to revea...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2014.0035

    authors: Stecco C,Porzionato A,Macchi V,Fantoni I,Ortolani L,De Caro R

    更新日期:2014-10-01 00:00:00

  • Origins of the classical gene concept, 1900-1950: genetics, mechanistic, philosophy, and the capitalization of agriculture.

    abstract::In the period of "classical genetics" (roughly 1915-950), the common view of the gene was mechanistic--hat is, genes were seen as individual, atomistic units, as material components of the chromosomes. Although it was recognized early on that genes could interact and influence each other's expression, they were still ...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2014.0003

    authors: Allen GE

    更新日期:2014-01-01 00:00:00

  • A natural history of "agonist".

    abstract::This paper constructs a brief history of the biochemical term agonist by exploring the multiple meanings of the root agôn in ancient Greek literature and describing how agonist first appeared in the scientific literature of the 20th century in the context of neurophysiologists' debates about the existence and properti...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2002.0056

    authors: Russo R

    更新日期:2002-07-01 00:00:00

  • The Belmont Report and Innovative Clinical Research.

    abstract::A central pillar of the Belmont Report is that a bright line must be drawn between medical practice and biomedical research. That line may have been brighter 50 years ago. Today, the typical physician is likely to work for a corporation or health system that styles itself as a learning health system. Such systems incr...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2020.0026

    authors: Lantos JD

    更新日期:2020-01-01 00:00:00

  • Telling stories about illness and disability: the limits and lessons of narrative.

    abstract::Autobiographical narratives of illness and disability are influential in popular and medical discourses of illness and disability, in part because these narratives represent illness and disability within a sociocultural context, intersecting with other categories of difference. Clinicians can benefit patients through ...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.0.0135

    authors: Garden R

    更新日期:2010-01-01 00:00:00

  • When ethics precludes randomization: put prospective, matched-pair observational studies to work.

    abstract::Randomized, controlled clinical trials (RCTs) may be possible, permissible, and practical in certain circumstances, but ethical or practical considerations often preclude their utilization. In many such cases, ethical objections will not apply to a similarly oriented, prospective, matched-pair observational study. Add...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2013.0014

    authors: Kowalski CJ

    更新日期:2013-04-01 00:00:00

  • Creating difficulties everywhere.

    abstract::In this essay we link the rationale for the medical humanities with radical hermeneutics, a move that infuses the medical humanities with incredulity and suspicion. This orientation is particularly important at this historical moment, when the evidence-based and competency blanket is threatening to overpower all aspec...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2007.0040

    authors: Wear D,Aultman JM

    更新日期:2007-07-01 00:00:00

  • Birth Narratives, Babies, and the Catholic Moral Imagination: Informing Influences on the Pope's Address.

    abstract::This commentary considers two informing influences on Pope Francis's support of perinatal hospice care for families facing diagnoses of serious fetal anomalies. Reflecting on the morally formative scriptural narrative of Mary's pregnancy and Jesus's birth and drawing upon an often-repeated idea of Pope Francis's papac...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2020.0044

    authors: Hardt J

    更新日期:2020-01-01 00:00:00

  • Parasites and progress: ethical decision-making and the Santee-Cooper Malaria study, 1944-1949.

    abstract::As part of a mid-1940s malaria research program, U.S. Public Health Service researchers working in South Carolina chose to withhold treatment from a group of subjects while testing the efficacy of a new insecticide. Research during World War II had generated new tools to fight malaria, including the insecticide DDT an...

    journal_title:Perspectives in biology and medicine

    pub_type: 历史文章,杂志文章

    doi:10.1353/pbm.2008.0011

    authors: Slater L,Humphreys M

    更新日期:2008-01-01 00:00:00

  • Torture in Abu Ghraib.

    abstract::Iraqi detainees subjected to torture and mistreatment at Abu Ghraib prison may continue to suffer from significant physical and psychological consequences of their abuse. This article reports two cases of Iraqi individuals allegedly tortured at Abu Ghraib. Detailed forensic evaluations were conducted approximately one...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2006.0059

    authors: Keller AS

    更新日期:2006-10-01 00:00:00

  • Heuristics and Explanation in Translational Medicine.

    abstract::The reigning paradigm of rational drug discovery in translational medicine attempts to exploit biological theories and pathophysiological explanations to identify novel drug targets and therapeutic strategies. Yet because many theories in medicine are either incomplete (at best) or false (at worst), relying on theoret...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章

    doi:10.1353/pbm.2019.0039

    authors: Hey SP

    更新日期:2019-01-01 00:00:00

  • "Meaning-making" in language and biology.

    abstract::The linguistic metaphor in biology adheres to a representational theory that seeks similarities between pre-given domains. The point of departure of this paper is the generative and nonrepresentational conception of metaphor. This paper argues that by adopting the nonrepresentational conception of metaphor, meaning-ma...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章,评审

    doi:10.1353/pbm.2005.0076

    authors: Neuman Y

    更新日期:2005-07-01 00:00:00

  • Expectations and obligations: professionalism and medicine's social contract with society.

    abstract::As health care has become of great importance to both individual citizens and to society, it has become more important to understand medicine's relationship to the society it serves in order to have a basis for meaningful dialogue. During the past decade, individuals in the medical, legal, social sciences, and health ...

    journal_title:Perspectives in biology and medicine

    pub_type: 杂志文章,评审

    doi:10.1353/pbm.0.0045

    authors: Cruess RL,Cruess SR

    更新日期:2008-10-01 00:00:00