Abstract:
:Marino Ortolani (1904-1983), a pediatrician from Ferrara, in northeastern Italy, was an outstanding pioneer in the early diagnosis and treatment of hip dysplasia. In 1935, while examining hip abduction-adduction in a six-month-old baby, Ortolani noted that a clearly audible and palpable "click" was sufficient to reveal congenital pre-dislocation of the hip, a condition he confirmed by an X-ray of the pelvis. This discovery suggested that the sound alone could be used for early diagnosis and treatment of the condition. Ortolani's test is now a widespread diagnostic technique, described in all pediatric and orthopedic textbooks. To confirm his conjecture, Ortolani dissected many hip specimens in very young babies who had died of unrelated causes. He also collected excellent specimens of congenital hip pathology in fetuses at all stages of intrauterine development, proving that hip dysplasia may already occur in utero. After his death, his entire collection was donated to the Institute of Anatomy of the University of Padua, where it is now exhibited in a special showcase. This collection, very impressive for both the number and high anatomical quality of its specimens, is famous worldwide because it demonstrates the etiopathology of hip dysplasia so clearly.
journal_name
Perspect Biol Medjournal_title
Perspectives in biology and medicineauthors
Stecco C,Porzionato A,Macchi V,Fantoni I,Ortolani L,De Caro Rdoi
10.1353/pbm.2014.0035subject
Has Abstractpub_date
2014-10-01 00:00:00pages
538-46issue
4eissn
0031-5982issn
1529-8795pii
S1529879514400073journal_volume
57pub_type
历史文章,杂志文章abstract::Since the 19th century, we have come to think of disease in terms of specific entities--entities defined and legitimated in terms of characteristic somatic mechanisms. Since the last third of that century, we have expanded would-be disease categories to include an ever-broader variety of emotional pain, idiosyncrasy, ...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2006.0046
更新日期:2006-07-01 00:00:00
abstract::In this essay we link the rationale for the medical humanities with radical hermeneutics, a move that infuses the medical humanities with incredulity and suspicion. This orientation is particularly important at this historical moment, when the evidence-based and competency blanket is threatening to overpower all aspec...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2007.0040
更新日期:2007-07-01 00:00:00
abstract::Shopping for genetic information has become popular, but consumers may not understand what exactly they are buying. The retail DNA industry is forcing laypersons, academics, and medical and legal professionals alike to face the crossroads of genetics, law, and society. How will we decipher the meanings of the tests, d...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0158
更新日期:2010-04-01 00:00:00
abstract::Iraqi detainees subjected to torture and mistreatment at Abu Ghraib prison may continue to suffer from significant physical and psychological consequences of their abuse. This article reports two cases of Iraqi individuals allegedly tortured at Abu Ghraib. Detailed forensic evaluations were conducted approximately one...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2006.0059
更新日期:2006-10-01 00:00:00
abstract::In retrospect, mortality from coronary heart disease (CHD) in the 20th century followed an epidemic pattern: mortality rates increased dramatically from 1920 until about 1960, remained roughly constant for almost a decade, and have been decreasing since the late 1960s. CHD has traditionally been conceived of as a sing...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2007.0013
更新日期:2007-04-01 00:00:00
abstract::The organism, like the molecule, the cell, and the species, is one of the fundamental levels in our hierarchical classification of life and its components. The units ranked at these levels, being concrete, particular things, are individuals in the broadest philosophical sense. But in a much narrower and more familiar ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2011.0022
更新日期:2011-04-01 00:00:00
abstract::We argue that medical decisions on behalf of children should be made with the welfare of the child as the primary interest, that parents should generally be allowed to determine which options optimize the interests of their child, and that those decisions should be formally challenged only when the parental decision p...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2016.0007
更新日期:2016-01-01 00:00:00
abstract::Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...
journal_title:Perspectives in biology and medicine
pub_type: 评论,杂志文章
doi:10.1353/pbm.2018.0004
更新日期:2018-01-01 00:00:00
abstract::An intersex condition is one in which an individual is born with atypical male or female external genitalia, gonads, hormones, or chromosomes. Older terms, such as pseudohermaphroditism and hermaphroditism, are controversial, leading the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for P...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2016.0033
更新日期:2016-01-01 00:00:00
abstract::How will developments in genetic knowledge affect the classification of disease? Leaders in genetics have suggested that knowledge of the role of genes in disease can determine nosology. Diseases might be defined by genotype, thus avoiding the limitations of more empirical approaches to categorization. Other commentat...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2006.0012
更新日期:2006-01-01 00:00:00
abstract::Since the beginning of the 21st century, the living conditions of undocumented migrant workers in Belgium have deteriorated drastically. In Brussels, after various social actions, undocumented people began squatting and occupying public buildings to make their struggle visible to society. Desperate, some seized the po...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0006
更新日期:2019-01-01 00:00:00
abstract::Medical leadership and leadership education have recently emerged as subjects of an expanding though as yet uncritical literature. Considerable attention is being given to the development of courses and electives, together with some proposals for generalizing these offerings to all medical students and doctors. This a...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0027
更新日期:2013-07-01 00:00:00
abstract::After almost 50 years in science, I believe that there is an acceptable, often advantageous chasm between open-ended basic research-free exploration without a practical destination and in which the original ideas may fade into new concepts-and translational research or clinical research. My basic research on crystalli...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2010.0000
更新日期:2010-10-01 00:00:00
abstract::Judgments of futility are always relative to some goal. In light of that proposition, continued treatment for those diagnosed as "brain dead" is not necessarily futile. ...
journal_title:Perspectives in biology and medicine
pub_type: 评论,杂志文章
doi:10.1353/pbm.2018.0014
更新日期:2018-01-01 00:00:00
abstract::The concept and determination of death by neurological or cardio-circulatory criteria play a crucial role for medical practice, society, and the law. Academic debates on death determination have regained momentum, and recent cases involving the neurological determination of death ("brain death") in the United States h...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2015.0036
更新日期:2015-01-01 00:00:00
abstract::The pace of biomedical innovation is important because it determines the rate of progress in medicine and allied disciplines. A review of the history of medical advances reveals that the three decades from 1950 to 1980 were a particularly innovative time. Subsequent decades have seen fewer seminal advances, despite co...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2018.0067
更新日期:2018-01-01 00:00:00
abstract::Diverse and non-coherent sets of epistemological principles currently inform research in the general area of functional genomics. Here, from the personal point of view of a scientist with over half a century of immersion in hypothesis driven scientific discovery, I compare and deconstruct the ideological bases of prom...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2015.0025
更新日期:2015-04-01 00:00:00
abstract::The rise of big data and artificial intelligence (AI) in health care has engendered considerable excitement, claiming to improve approaches to diagnosis, prognosis, and treatment. Amidst the enthusiasm, the philosophical assumptions that underlie the big data and AI movement in medicine are rarely examined. This essay...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0012
更新日期:2019-01-01 00:00:00
abstract::Kelly, Kelly, and Russo (2014) recently proposed to integrate biological, behavioral, and social mechanisms into "mixed mechanisms" situated in the individual's "lifeworld" when considering illness causation. This article suggests considering terminological discrepancies, replacing the pathogenetic with an etiological...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2017.0025
更新日期:2017-01-01 00:00:00
abstract::This article reviews some of the technological devices and ideas which have been used over the years to answer the question, how does the brain work? It describes some of the early technology-based analogies and models of nerve fibers, and then discusses other analogies and models of the brain based on mechanical and ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.2002.0033
更新日期:2002-04-01 00:00:00
abstract::The clinical trial of the AbioCor artificial heart, initiated in July 2001 and still in process, has taken place within a matrix of social and cultural patterns that are both "old" and new. The old patterns--those that have accompanied previous clinical trials of other vital artificial organs and transplantation in th...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2004.0006
更新日期:2004-01-01 00:00:00
abstract::The treatment of broken bones has long adhered to principles of tight juxtaposition of fracture ends and of strict rest. Splinting and casting with plaster of Paris helped considerably. Attempts at internal splinting with pegs, bolts, or stabilizing contraptions usually failed. Foreign materials were either not biocom...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2014.0021
更新日期:2014-07-01 00:00:00
abstract::As part of a mid-1940s malaria research program, U.S. Public Health Service researchers working in South Carolina chose to withhold treatment from a group of subjects while testing the efficacy of a new insecticide. Research during World War II had generated new tools to fight malaria, including the insecticide DDT an...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2008.0011
更新日期:2008-01-01 00:00:00
abstract::In 1900 William Osler established a friendship with Harvey Cushing that encompassed the personal and professional aspects of their lives for over two decades. Their shared participation in the covenant of medicine shaped an intense friendship and mentoring relationship that profited both individuals immeasurably. The ...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2005.0087
更新日期:2005-10-01 00:00:00
abstract::Although the practice of medicine continually changes in response to new biomedical understanding, novel technologies, and evolving cultural contexts, the ethical foundations of the clinical relationship between patient and physician paradoxically remain constant. There are fundamental characteristics with respect to ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2012.0002
更新日期:2012-01-01 00:00:00
abstract::Autobiographical narratives of illness and disability are influential in popular and medical discourses of illness and disability, in part because these narratives represent illness and disability within a sociocultural context, intersecting with other categories of difference. Clinicians can benefit patients through ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0135
更新日期:2010-01-01 00:00:00
abstract::The traditional forms of public health law were directed largely toward communicable diseases and other externalities, such as pollution, with negative health impacts. The more modern view treats any health issue that affects large numbers of individuals as one of public health, which would include such problems as ob...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
abstract::Scholars have shown that organ transplantation may transform ideas about one's body, with recipients feeling that they are receiving not just a body part but also a part of the donor's identity. This article focuses on a different way in which organ transplantation shapes recipient identity: the idea of becoming whole...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2011.0036
更新日期:2011-07-01 00:00:00
abstract::Biologists use models in two distinct ways that have not been clearly articulated. A model may be used either as an exemplar of a larger group, or as a surrogate for a specific target. Zebrafish serve as an exemplary model of vertebrates in developmental biology; rodents are both exemplary vertebrates and specific sur...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0125
更新日期:2009-10-01 00:00:00
abstract::The advent of electronic health records (EHRs) to improve access and enable research in the everyday clinical world has simultaneously made medical information much more vulnerable to illicit, non-beneficent uses. This wealth of identified, aggregated data has and will attract attacks by domestic governments for surve...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0003
更新日期:2013-01-01 00:00:00