Give me a break: Gerhard Küntscher and his nail.

abstract：:This paper constructs a brief history of the biochemical term agonist by exploring the multiple meanings of the root agôn in ancient Greek literature and describing how agonist first appeared in the scientific literature of the 20th century in the context of neurophysiologists' debates about the existence and properti...

journal_title：Perspectives in biology and medicine

authors： Russo R

更新日期：2002-07-01 00:00:00

abstract：:Ensuring experimental outcomes are of the highest clinical caliber is crucial prior to the introduction of germline genome editing. However, if we are to police scientific progress using probability or the potential to go wrong, then we must account for the specious standards of human reproduction. With 15% of clinica...

journal_title：Perspectives in biology and medicine

authors： O'Neill HC

更新日期：2020-01-01 00:00:00

abstract：:This article reviews the cultural history of man's relationship with tobacco and the steps in the discovery of tobacco addiction. Nicotine dependence (ND) or nicotine addiction (NA), among other forms of drug addiction, continues to be a significant public health problem in the world, as it is associated with major se...

journal_title：Perspectives in biology and medicine

authors： Russo P,Nastrucci C,Alzetta G,Szalai C

更新日期：2011-10-01 00:00:00

abstract：:The term innovation is frequently used as a justification for allowing clinicians to offer unproven autologous stem cell-based interventions (SCBIs) to their patients. Proponents of this kind of innovation (which we refer to as "clinical innovation") argue that physicians should be free to administer whatever interven...

journal_title：Perspectives in biology and medicine

authors： Lipworth W,Stewart C,Kerridge I

更新日期：2018-01-01 00:00:00

abstract：:This is a daunting time, not only in terms of our public health and our economic health but also in terms of the health of the republic. It is an old theme that any form of popular government needs virtuous citizens if it is to survive. It also needs citizens to agree on what counts as a virtue. I fear that the pandem...

journal_title：Perspectives in biology and medicine

authors： Brudney D

更新日期：2020-01-01 00:00:00

abstract：:Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...

journal_title：Perspectives in biology and medicine

authors： Brody H

更新日期：2018-01-01 00:00:00

abstract：:The general population is experiencing lifelong exposure to old and new hazardous substances. By using data collected from a subject's own teeth, accuracy in determining the effects of exposure is assured since extrapolation is excluded. The establishment of a common tooth bank can provide means to integrate data from...

journal_title：Perspectives in biology and medicine

authors： Sharon IM

更新日期：1988-10-01 00:00:00

abstract：:Biologists use models in two distinct ways that have not been clearly articulated. A model may be used either as an exemplar of a larger group, or as a surrogate for a specific target. Zebrafish serve as an exemplary model of vertebrates in developmental biology; rodents are both exemplary vertebrates and specific sur...

journal_title：Perspectives in biology and medicine

authors： Bolker JA

更新日期：2009-10-01 00:00:00

abstract：:There is a need in our society to raise the national consciousness about aging, health, and the prospects for longevity, so that many more persons take responsibility for their personal health and understand what we will need in an era of health-care reform to promote health across the life course. We address this imp...

journal_title：Perspectives in biology and medicine

authors： Hamerman D,Fried LP

更新日期：2013-04-01 00:00:00

abstract：:There is a growing national awareness that the extraordinary extension of life expectancy in our society poses an impending crisis for our health-care system. This is due in large part to the scarcity of primary-care providers, especially geriatricians. To address these concerns, the Obama administration has considere...

journal_title：Perspectives in biology and medicine

authors： Hamerman D

更新日期：2009-07-01 00:00:00

abstract：:Popular fiction responds to, and may exacerbate, public anxieties in ways that more highbrow literary texts may not. Robin Cook's 1977 novel Coma exemplifies the ways in which medical thrillers participate in the public discourse about health care. Written shortly after the medical establishment promoted "irreversible...

journal_title：Perspectives in biology and medicine

authors： Belling C

更新日期：2010-07-01 00:00:00

abstract：:The advent of electronic health records (EHRs) to improve access and enable research in the everyday clinical world has simultaneously made medical information much more vulnerable to illicit, non-beneficent uses. This wealth of identified, aggregated data has and will attract attacks by domestic governments for surve...

journal_title：Perspectives in biology and medicine

authors： Graves S

更新日期：2013-01-01 00:00:00

abstract：:This article describes the origins and drafting of the Belmont Report by members of the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. ...

journal_title：Perspectives in biology and medicine

authors： Beauchamp TL

更新日期：2020-01-01 00:00:00

abstract：:Charles Dickens's adult life parallels the period when the movement for sanitary reform took root in England. Although he was not one of its leaders, he became in time one of its most outspoken advocates. This essay describes Dickens's growing involvement in the sanitary movement and looks at one of the most important...

journal_title：Perspectives in biology and medicine

authors： Litsios S

更新日期：2003-04-01 00:00:00

abstract：:In 1900 William Osler established a friendship with Harvey Cushing that encompassed the personal and professional aspects of their lives for over two decades. Their shared participation in the covenant of medicine shaped an intense friendship and mentoring relationship that profited both individuals immeasurably. The ...

journal_title：Perspectives in biology and medicine

authors： Duffy TP

更新日期：2005-10-01 00:00:00

abstract：:Over recent years there has been a gratifying decrease in the incidence of recorded deaths from coronary artery disease in the Western world. The common view is that coronary artery disease is a recent phenomenon, that we have been subject to an epidemic in the mid-20th century that is now tailing off, and that with a...

journal_title：Perspectives in biology and medicine

authors： John LC

更新日期：2012-01-01 00:00:00

abstract：:In retrospect, mortality from coronary heart disease (CHD) in the 20th century followed an epidemic pattern: mortality rates increased dramatically from 1920 until about 1960, remained roughly constant for almost a decade, and have been decreasing since the late 1960s. CHD has traditionally been conceived of as a sing...

journal_title：Perspectives in biology and medicine

authors： Azambuja MI,Levins R

更新日期：2007-04-01 00:00:00

abstract：:Since the beginning of the 21st century, the living conditions of undocumented migrant workers in Belgium have deteriorated drastically. In Brussels, after various social actions, undocumented people began squatting and occupying public buildings to make their struggle visible to society. Desperate, some seized the po...

journal_title：Perspectives in biology and medicine

authors： Vanobberghen R,Louckx F,Depoorter AM,Devroey D,Vandevoorde J

更新日期：2019-01-01 00:00:00

abstract：:An intersex condition is one in which an individual is born with atypical male or female external genitalia, gonads, hormones, or chromosomes. Older terms, such as pseudohermaphroditism and hermaphroditism, are controversial, leading the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for P...

journal_title：Perspectives in biology and medicine

authors： Reis E,McCarthy MW

更新日期：2016-01-01 00:00:00

abstract：:Concerns about nature are playing increasingly prominent roles in a variety of social debates, including medical biotechnology, environmental protection, and agricultural biotechnology. These concerns are often simply rejected as incoherent: critics argue that there is no good account for how natural states of affairs...

journal_title：Perspectives in biology and medicine

authors： Kaebnick GE

更新日期：2007-10-01 00:00:00

abstract：:The health aspects and benefits of conception control as a justification for U.S. government support of family planning are reviewed. The Family Planning Services Act of 1970 set a goal of serving 5 million indigent women by 1975. It is predicted that the program will far surpass that goal. 340 million dollars were...

journal_title：Perspectives in biology and medicine

authors： Hellman LM

更新日期：1973-04-01 00:00:00

abstract：:Kelly, Kelly, and Russo (2014) recently proposed to integrate biological, behavioral, and social mechanisms into "mixed mechanisms" situated in the individual's "lifeworld" when considering illness causation. This article suggests considering terminological discrepancies, replacing the pathogenetic with an etiological...

journal_title：Perspectives in biology and medicine

authors： Dammann O

更新日期：2017-01-01 00:00:00

abstract：:The impact of chronic illness on patients has been discussed extensively, but little attention has been paid to the reverse situation: the need for patients who have been chronically ill since childhood to adjust to health and normality in adulthood. Drawing upon the narratives of two adults with childhood onset disea...

journal_title：Perspectives in biology and medicine

authors： Orfali K,Anderson-Shaw L

更新日期：2005-04-01 00:00:00

abstract：:As a result of the growth of evidence-based practices across the world, health-care providers and policymakers in the United States, United Kingdom, and Europe have established institutes such as the United Kingdom's National Institute for Health and Clinical Excellence (NICE) to produce clinical guidelines that physi...

journal_title：Perspectives in biology and medicine

authors： McGoey L

更新日期：2009-04-01 00:00:00

abstract：:Fifty years after Beecher's landmark article, an old question is being debated anew: is it ethical to conduct clinical research without consent? This paper provides a systematic analysis of this question. First, it describes five clinical trials that have either been conducted (or proposed) without the subjects provid...

journal_title：Perspectives in biology and medicine

authors： Kim SY

更新日期：2016-01-01 00:00:00

abstract：:This article is concerned with the practice of bioethics outside of the Euro-American and Anglophone settings in which it was first formulated. In theoretical terms, the article considers the frictions that arise when global-scale projects such as bioethics are introduced into diverse social and cultural settings. Met...

journal_title：Perspectives in biology and medicine

authors： Simpson B

更新日期：2018-01-01 00:00:00

abstract：:How can we provide the best care for growing numbers of very frail, very sick, or very old people? The disciplines of geriatrics, palliative care, and clinical ethics each have a good deal to offer to improve care for elders, yet each field is saddled with heavy historical baggage. Using a case as a springboard, we ad...

journal_title：Perspectives in biology and medicine

authors： Smith AK,Micco G

更新日期：2017-01-01 00:00:00

abstract：:After almost 50 years in science, I believe that there is an acceptable, often advantageous chasm between open-ended basic research-free exploration without a practical destination and in which the original ideas may fade into new concepts-and translational research or clinical research. My basic research on crystalli...

journal_title：Perspectives in biology and medicine

authors： Piatigorsky J

更新日期：2010-10-01 00:00:00

abstract：:A detailed review of hospital records, physician's notes, diaries, letters, and autopsy reports offers sufficient clinical grounds to establish that Eugene O'Neill developed adrenal insufficiency, secondary to tuberculosis, in later life--a fact hitherto unknown--the condition not becoming manifest until after he had ...

journal_title：Perspectives in biology and medicine

authors： Hamilton JW

更新日期：1987-01-01 00:00:00

abstract：:While the necessity of normalizing surgery on intersexed individuals is a topic of ongoing debate in the 21st century, the origins of surgery as a therapeutic practice for ambiguous or unusual genitalia lie in the 19th century. The first report of corrective surgery published in the United States appeared in the Ameri...

journal_title：Perspectives in biology and medicine

authors： Matta C

更新日期：2005-01-01 00:00:00