Abstract:
:Diverse and non-coherent sets of epistemological principles currently inform research in the general area of functional genomics. Here, from the personal point of view of a scientist with over half a century of immersion in hypothesis driven scientific discovery, I compare and deconstruct the ideological bases of prominent recent alternatives, such as "discovery science," some productions of the ENCODE project, and aspects of large data set systems biology. The outputs of these types of scientific enterprise qualitatively reflect their radical definitions of scientific knowledge, and of its logical requirements. Their properties emerge in high relief when contrasted (as an example) to a recent, system-wide, predictive analysis of a developmental regulatory apparatus that was instead based directly on hypothesis-driven experimental tests of mechanism.
journal_name
Perspect Biol Medjournal_title
Perspectives in biology and medicineauthors
Davidson EHdoi
10.1353/pbm.2015.0025subject
Has Abstractpub_date
2015-04-01 00:00:00pages
165-81issue
2eissn
0031-5982issn
1529-8795pii
S1529879515200038journal_volume
58pub_type
杂志文章abstract::This is a daunting time, not only in terms of our public health and our economic health but also in terms of the health of the republic. It is an old theme that any form of popular government needs virtuous citizens if it is to survive. It also needs citizens to agree on what counts as a virtue. I fear that the pandem...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2020.0050
更新日期:2020-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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更新日期:2018-01-01 00:00:00
abstract::In 1900 William Osler established a friendship with Harvey Cushing that encompassed the personal and professional aspects of their lives for over two decades. Their shared participation in the covenant of medicine shaped an intense friendship and mentoring relationship that profited both individuals immeasurably. The ...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
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abstract::When we figure medical practice as warfare, an individual clinician may be either a dutiful combatant or a conscientious objector. The rhetorical structure of this choice means that clinicians may exercise their consciences by loyally joining or disloyally exiting the medical ranks' battle against disease. But there a...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
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abstract::We argue that medical decisions on behalf of children should be made with the welfare of the child as the primary interest, that parents should generally be allowed to determine which options optimize the interests of their child, and that those decisions should be formally challenged only when the parental decision p...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2016.0007
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abstract::The idea of being "haunted" appears often in accounts of the experience of health-care professionals and trainees who suffer from unresolved sorrow or regret about past clinical events, in particular the deaths of patients. The trope of haunting draws a direct line between past professional trauma and the dread of fut...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2020.0034
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abstract::This article outlines a Darwinian approach to sports that takes into account its profoundly cultural character and thereby overcomes the traditional nature-culture dichotomies in the sociology of sport. We argue that there are good reasons to view sports as culturally evolved signaling systems that serve a function si...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0063
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0012
更新日期:2019-01-01 00:00:00
abstract::Charles Dickens's adult life parallels the period when the movement for sanitary reform took root in England. Although he was not one of its leaders, he became in time one of its most outspoken advocates. This essay describes Dickens's growing involvement in the sanitary movement and looks at one of the most important...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2003.0025
更新日期:2003-04-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2020.0026
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2016.0033
更新日期:2016-01-01 00:00:00
abstract::Randomized, controlled clinical trials (RCTs) may be possible, permissible, and practical in certain circumstances, but ethical or practical considerations often preclude their utilization. In many such cases, ethical objections will not apply to a similarly oriented, prospective, matched-pair observational study. Add...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0014
更新日期:2013-04-01 00:00:00
abstract::Milton Winternitz led Yale Medical School as its Dean from 1920 to 1935. An innovative, even maverick leader, he not only kept the school from going under, but turned it into a first-class research institution. Dedicated to the new scientific medicine established in Germany, he was equally fervent about "social medici...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2003.0046
更新日期:2003-07-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2001.0058
更新日期:2001-07-01 00:00:00
abstract::The clinical trial of the AbioCor artificial heart, initiated in July 2001 and still in process, has taken place within a matrix of social and cultural patterns that are both "old" and new. The old patterns--those that have accompanied previous clinical trials of other vital artificial organs and transplantation in th...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2004.0006
更新日期:2004-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0084
更新日期:2009-04-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2017.0039
更新日期:2017-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2015.0036
更新日期:2015-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 评论,杂志文章
doi:10.1353/pbm.2018.0014
更新日期:2018-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0006
更新日期:2019-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2014.0021
更新日期:2014-07-01 00:00:00
abstract::Iraqi detainees subjected to torture and mistreatment at Abu Ghraib prison may continue to suffer from significant physical and psychological consequences of their abuse. This article reports two cases of Iraqi individuals allegedly tortured at Abu Ghraib. Detailed forensic evaluations were conducted approximately one...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2006.0059
更新日期:2006-10-01 00:00:00
abstract::Both leading scientific journals and the popular press now regularly report the convincing evidence of massive environmental degradation and decline. Yet despite the seriousness of the problems, despite their anthropogenic nature, and despite their profound implications for present and future population health, such t...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2007.0008
更新日期:2007-01-01 00:00:00
abstract::Social media use in modern medicine is fraught with ethical dilemmas and risks of unprofessional behavior. This essay surveys the existing literature on the possibilities and pitfalls of social media use by health-care professionals and concludes that non-engagement with social media is not an option. A mindful approa...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0039
更新日期:2013-10-01 00:00:00
abstract::The recent death of a normal healthy volunteer, as well as the increased use of normal volunteers as research subjects, has heightened the attention given to the participation of normal volunteers in clinical research. An overlooked sub-population of normal healthy volunteers are repeat, veteran volunteers. This essay...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2003.0094
更新日期:2003-10-01 00:00:00
abstract::Antibody-dependent enhancement is a general in vitro property of enveloped viruses. In certain circumstances, antibody-dependent enhancement is a bona fide pathophysiologic mechanism in vivo. There are several examples of virus disease of humans and animals in which incomplete or partial immunity can lead to enhanced ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.1992.0048
更新日期:1992-07-01 00:00:00
abstract::As part of a mid-1940s malaria research program, U.S. Public Health Service researchers working in South Carolina chose to withhold treatment from a group of subjects while testing the efficacy of a new insecticide. Research during World War II had generated new tools to fight malaria, including the insecticide DDT an...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2008.0011
更新日期:2008-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2018.0029
更新日期:2018-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.2012.0042
更新日期:2012-01-01 00:00:00
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journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0168
更新日期:2010-07-01 00:00:00