Abstract:
:An intersex condition is one in which an individual is born with atypical male or female external genitalia, gonads, hormones, or chromosomes. Older terms, such as pseudohermaphroditism and hermaphroditism, are controversial, leading the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for Paediatric Endocrinology (ESPE) to propose in 2006 the expression "disorders of sex development" (DSD), a contentious term in its own right, to define congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. The birth of a child with DSD often prompts a long-term, multidisciplinary strategy, involving an array of health-care professionals. While much has been written about these potentially challenging management decisions, particularly those regarding infant genital surgery, very little has been written on the health management of intersex adults, and no literature exists regarding the role of the hospitalists-specialists in inpatient medicine-in the care of patients with DSD. With more than 50,000 members, Hospital Medicine represents the fast-growing subspecialty in the history of medicine. We believe hospitalists are uniquely positioned to provide high-quality care while educating trainees about issues pertinent to this often marginalized patient population. This essay poses a case study to explore some of the medical issues that intersex patients face as adults and that hospitalists will likely encounter.
journal_name
Perspect Biol Medjournal_title
Perspectives in biology and medicineauthors
Reis E,McCarthy MWdoi
10.1353/pbm.2016.0033subject
Has Abstractpub_date
2016-01-01 00:00:00pages
391-398issue
3eissn
0031-5982issn
1529-8795pii
S1529879516300229journal_volume
59pub_type
杂志文章abstract::The idea of being "haunted" appears often in accounts of the experience of health-care professionals and trainees who suffer from unresolved sorrow or regret about past clinical events, in particular the deaths of patients. The trope of haunting draws a direct line between past professional trauma and the dread of fut...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2020.0034
更新日期:2020-01-01 00:00:00
abstract::While the necessity of normalizing surgery on intersexed individuals is a topic of ongoing debate in the 21st century, the origins of surgery as a therapeutic practice for ambiguous or unusual genitalia lie in the 19th century. The first report of corrective surgery published in the United States appeared in the Ameri...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2005.0012
更新日期:2005-01-01 00:00:00
abstract::The general population is experiencing lifelong exposure to old and new hazardous substances. By using data collected from a subject's own teeth, accuracy in determining the effects of exposure is assured since extrapolation is excluded. The establishment of a common tooth bank can provide means to integrate data from...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.1988.0031
更新日期:1988-10-01 00:00:00
abstract::Autobiographical narratives of illness and disability are influential in popular and medical discourses of illness and disability, in part because these narratives represent illness and disability within a sociocultural context, intersecting with other categories of difference. Clinicians can benefit patients through ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0135
更新日期:2010-01-01 00:00:00
abstract::Kelly, Kelly, and Russo (2014) recently proposed to integrate biological, behavioral, and social mechanisms into "mixed mechanisms" situated in the individual's "lifeworld" when considering illness causation. This article suggests considering terminological discrepancies, replacing the pathogenetic with an etiological...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2017.0025
更新日期:2017-01-01 00:00:00
abstract::In 1900 William Osler established a friendship with Harvey Cushing that encompassed the personal and professional aspects of their lives for over two decades. Their shared participation in the covenant of medicine shaped an intense friendship and mentoring relationship that profited both individuals immeasurably. The ...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2005.0087
更新日期:2005-10-01 00:00:00
abstract::This paper reexamines the recent case of the conjoined twins from Malta. Survival was said to be possible only through separation, which would actually leave only one twin alive. The parents refused to allow the killing of one to save the other, but the court ruled that this would amount to the neglect of innocent lif...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2002.0063
更新日期:2002-10-01 00:00:00
abstract::Antibody-dependent enhancement is a general in vitro property of enveloped viruses. In certain circumstances, antibody-dependent enhancement is a bona fide pathophysiologic mechanism in vivo. There are several examples of virus disease of humans and animals in which incomplete or partial immunity can lead to enhanced ...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.1992.0048
更新日期:1992-07-01 00:00:00
abstract::The traditional forms of public health law were directed largely toward communicable diseases and other externalities, such as pollution, with negative health impacts. The more modern view treats any health issue that affects large numbers of individuals as one of public health, which would include such problems as ob...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
abstract::Medical leadership and leadership education have recently emerged as subjects of an expanding though as yet uncritical literature. Considerable attention is being given to the development of courses and electives, together with some proposals for generalizing these offerings to all medical students and doctors. This a...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0027
更新日期:2013-07-01 00:00:00
abstract::Charles Dickens's adult life parallels the period when the movement for sanitary reform took root in England. Although he was not one of its leaders, he became in time one of its most outspoken advocates. This essay describes Dickens's growing involvement in the sanitary movement and looks at one of the most important...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2003.0025
更新日期:2003-04-01 00:00:00
abstract::This paper constructs a brief history of the biochemical term agonist by exploring the multiple meanings of the root agôn in ancient Greek literature and describing how agonist first appeared in the scientific literature of the 20th century in the context of neurophysiologists' debates about the existence and properti...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2002.0056
更新日期:2002-07-01 00:00:00
abstract::In retrospect, mortality from coronary heart disease (CHD) in the 20th century followed an epidemic pattern: mortality rates increased dramatically from 1920 until about 1960, remained roughly constant for almost a decade, and have been decreasing since the late 1960s. CHD has traditionally been conceived of as a sing...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2007.0013
更新日期:2007-04-01 00:00:00
abstract::A central pillar of the Belmont Report is that a bright line must be drawn between medical practice and biomedical research. That line may have been brighter 50 years ago. Today, the typical physician is likely to work for a corporation or health system that styles itself as a learning health system. Such systems incr...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2020.0026
更新日期:2020-01-01 00:00:00
abstract::Since the beginning of the 21st century, the living conditions of undocumented migrant workers in Belgium have deteriorated drastically. In Brussels, after various social actions, undocumented people began squatting and occupying public buildings to make their struggle visible to society. Desperate, some seized the po...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0006
更新日期:2019-01-01 00:00:00
abstract::This article examines five letters from the correspondence of American zoologist Edwin Grant Conklin that highlight his theories of genetic and social inheritance, in order to suggest that Conklin's eugenic beliefs--like those of many American authorities during this time--were complex and sometimes contradictory. The...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2001.0058
更新日期:2001-07-01 00:00:00
abstract::The pace of biomedical innovation is important because it determines the rate of progress in medicine and allied disciplines. A review of the history of medical advances reveals that the three decades from 1950 to 1980 were a particularly innovative time. Subsequent decades have seen fewer seminal advances, despite co...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2018.0067
更新日期:2018-01-01 00:00:00
abstract::During the 1970s, something deeply consequential happened in the cultural, economic, and social relationships between science and technology. Paul Forman has proposed that the abrupt reversal of the culturally ascribed primacy in the science-technology relationship circa 1980 be taken as a demarcation of postmodernity...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0074
更新日期:2009-01-01 00:00:00
abstract::Of all the principles set out by Flexner in 1910, the most fundamental, that of academic and scientific excellence, is more relevant to medical education in the United Kingdom today than ever before. To realize this, undergraduate medical education (UGME) at Oxford has evolved to incorporate the tutorial method of tea...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2011.0013
更新日期:2011-01-01 00:00:00
abstract::The rise of big data and artificial intelligence (AI) in health care has engendered considerable excitement, claiming to improve approaches to diagnosis, prognosis, and treatment. Amidst the enthusiasm, the philosophical assumptions that underlie the big data and AI movement in medicine are rarely examined. This essay...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0012
更新日期:2019-01-01 00:00:00
abstract::The reigning paradigm of rational drug discovery in translational medicine attempts to exploit biological theories and pathophysiological explanations to identify novel drug targets and therapeutic strategies. Yet because many theories in medicine are either incomplete (at best) or false (at worst), relying on theoret...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2019.0039
更新日期:2019-01-01 00:00:00
abstract::After almost 50 years in science, I believe that there is an acceptable, often advantageous chasm between open-ended basic research-free exploration without a practical destination and in which the original ideas may fade into new concepts-and translational research or clinical research. My basic research on crystalli...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2010.0000
更新日期:2010-10-01 00:00:00
abstract::The linguistic metaphor in biology adheres to a representational theory that seeks similarities between pre-given domains. The point of departure of this paper is the generative and nonrepresentational conception of metaphor. This paper argues that by adopting the nonrepresentational conception of metaphor, meaning-ma...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章,评审
doi:10.1353/pbm.2005.0076
更新日期:2005-07-01 00:00:00
abstract::There is a growing national awareness that the extraordinary extension of life expectancy in our society poses an impending crisis for our health-care system. This is due in large part to the scarcity of primary-care providers, especially geriatricians. To address these concerns, the Obama administration has considere...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.0.0092
更新日期:2009-07-01 00:00:00
abstract::Social media use in modern medicine is fraught with ethical dilemmas and risks of unprofessional behavior. This essay surveys the existing literature on the possibilities and pitfalls of social media use by health-care professionals and concludes that non-engagement with social media is not an option. A mindful approa...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2013.0039
更新日期:2013-10-01 00:00:00
abstract::The term innovation is frequently used as a justification for allowing clinicians to offer unproven autologous stem cell-based interventions (SCBIs) to their patients. Proponents of this kind of innovation (which we refer to as "clinical innovation") argue that physicians should be free to administer whatever interven...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2018.0029
更新日期:2018-01-01 00:00:00
abstract::This article is concerned with the practice of bioethics outside of the Euro-American and Anglophone settings in which it was first formulated. In theoretical terms, the article considers the frictions that arise when global-scale projects such as bioethics are introduced into diverse social and cultural settings. Met...
journal_title:Perspectives in biology and medicine
pub_type: 传,历史文章,杂志文章
doi:10.1353/pbm.2018.0038
更新日期:2018-01-01 00:00:00
abstract::Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...
journal_title:Perspectives in biology and medicine
pub_type: 评论,杂志文章
doi:10.1353/pbm.2018.0004
更新日期:2018-01-01 00:00:00
abstract::Scholars have shown that organ transplantation may transform ideas about one's body, with recipients feeling that they are receiving not just a body part but also a part of the donor's identity. This article focuses on a different way in which organ transplantation shapes recipient identity: the idea of becoming whole...
journal_title:Perspectives in biology and medicine
pub_type: 历史文章,杂志文章
doi:10.1353/pbm.2011.0036
更新日期:2011-07-01 00:00:00
abstract::Fifty years after Beecher's landmark article, an old question is being debated anew: is it ethical to conduct clinical research without consent? This paper provides a systematic analysis of this question. First, it describes five clinical trials that have either been conducted (or proposed) without the subjects provid...
journal_title:Perspectives in biology and medicine
pub_type: 杂志文章
doi:10.1353/pbm.2016.0023
更新日期:2016-01-01 00:00:00