Heuristics and Explanation in Translational Medicine.

abstract：:Mary Shelley's Frankenstein is 200 years old and remains relevant to 21st-century scientific experimentation. Molecular biologists today have become especially bold in their attempts to cure diseases while remaining mindful of the real dangers of their research. Scientists presumably share an abiding concern about pro...

journal_title：Perspectives in biology and medicine

authors： Nowlin C

更新日期：2018-01-01 00:00:00

abstract：:This article is concerned with the practice of bioethics outside of the Euro-American and Anglophone settings in which it was first formulated. In theoretical terms, the article considers the frictions that arise when global-scale projects such as bioethics are introduced into diverse social and cultural settings. Met...

journal_title：Perspectives in biology and medicine

authors： Simpson B

更新日期：2018-01-01 00:00:00

abstract：:Although the practice of medicine continually changes in response to new biomedical understanding, novel technologies, and evolving cultural contexts, the ethical foundations of the clinical relationship between patient and physician paradoxically remain constant. There are fundamental characteristics with respect to ...

journal_title：Perspectives in biology and medicine

authors： Fuks A,Brawer J,Boudreau JD

更新日期：2012-01-01 00:00:00

abstract：:Over time, contemporary writing becomes part of the historical record. In medicine, it is an important learning tool, particularly for understanding the experience and context of disease and illness. Although a century has elapsed since the fictional events on a single day described in James Joyce's Ulysses, the work ...

journal_title：Perspectives in biology and medicine

authors： Shanahan F,Quigley EM

更新日期：2006-04-01 00:00:00

abstract：:Several studies suggest that clinical researchers are prone to overestimating the chance that scientific protocols will succeed, say, by confirming a treatment hypothesis or reaching recruitment targets. In this essay, we address the normative question of whether such "unrealistic optimism" is harmful in clinical rese...

journal_title：Perspectives in biology and medicine

authors： Benjamin D,Kimmelman J

更新日期：2016-01-01 00:00:00

abstract：:The rise of big data and artificial intelligence (AI) in health care has engendered considerable excitement, claiming to improve approaches to diagnosis, prognosis, and treatment. Amidst the enthusiasm, the philosophical assumptions that underlie the big data and AI movement in medicine are rarely examined. This essay...

journal_title：Perspectives in biology and medicine

authors： Chin-Yee B,Upshur R

更新日期：2019-01-01 00:00:00

abstract：:The concept of placebo has evolved over time. Generally believed to be the basis of the premodern pharmacopoeia, the placebo has been adopted in practice as a harmless but unscientific approach towards alleviating symptoms. Currently, many medical scientists view placebos pejoratively as confounding elements in the an...

journal_title：Perspectives in biology and medicine

authors： Kradin RL

更新日期：2004-07-01 00:00:00

abstract：:The term innovation is frequently used as a justification for allowing clinicians to offer unproven autologous stem cell-based interventions (SCBIs) to their patients. Proponents of this kind of innovation (which we refer to as "clinical innovation") argue that physicians should be free to administer whatever interven...

journal_title：Perspectives in biology and medicine

authors： Lipworth W,Stewart C,Kerridge I

更新日期：2018-01-01 00:00:00

abstract：:This article examines five letters from the correspondence of American zoologist Edwin Grant Conklin that highlight his theories of genetic and social inheritance, in order to suggest that Conklin's eugenic beliefs--like those of many American authorities during this time--were complex and sometimes contradictory. The...

journal_title：Perspectives in biology and medicine

authors： Reumann M,Fausto-Sterling A

更新日期：2001-07-01 00:00:00

abstract：:This article reviews the cultural history of man's relationship with tobacco and the steps in the discovery of tobacco addiction. Nicotine dependence (ND) or nicotine addiction (NA), among other forms of drug addiction, continues to be a significant public health problem in the world, as it is associated with major se...

journal_title：Perspectives in biology and medicine

authors： Russo P,Nastrucci C,Alzetta G,Szalai C

更新日期：2011-10-01 00:00:00

abstract：:Marino Ortolani (1904-1983), a pediatrician from Ferrara, in northeastern Italy, was an outstanding pioneer in the early diagnosis and treatment of hip dysplasia. In 1935, while examining hip abduction-adduction in a six-month-old baby, Ortolani noted that a clearly audible and palpable "click" was sufficient to revea...

journal_title：Perspectives in biology and medicine

authors： Stecco C,Porzionato A,Macchi V,Fantoni I,Ortolani L,De Caro R

更新日期：2014-10-01 00:00:00

abstract：:Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...

journal_title：Perspectives in biology and medicine

authors： Brody H

更新日期：2018-01-01 00:00:00

abstract：:The recent death of a normal healthy volunteer, as well as the increased use of normal volunteers as research subjects, has heightened the attention given to the participation of normal volunteers in clinical research. An overlooked sub-population of normal healthy volunteers are repeat, veteran volunteers. This essay...

journal_title：Perspectives in biology and medicine

authors： Tishler CL,Bartholomae S

更新日期：2003-10-01 00:00:00

abstract：:The treatment of broken bones has long adhered to principles of tight juxtaposition of fracture ends and of strict rest. Splinting and casting with plaster of Paris helped considerably. Attempts at internal splinting with pegs, bolts, or stabilizing contraptions usually failed. Foreign materials were either not biocom...

journal_title：Perspectives in biology and medicine

authors： Pierach CA

更新日期：2014-07-01 00:00:00

abstract：:Shopping for genetic information has become popular, but consumers may not understand what exactly they are buying. The retail DNA industry is forcing laypersons, academics, and medical and legal professionals alike to face the crossroads of genetics, law, and society. How will we decipher the meanings of the tests, d...

journal_title：Perspectives in biology and medicine

authors： Wagner JK

更新日期：2010-04-01 00:00:00

abstract：:Concerns about nature are playing increasingly prominent roles in a variety of social debates, including medical biotechnology, environmental protection, and agricultural biotechnology. These concerns are often simply rejected as incoherent: critics argue that there is no good account for how natural states of affairs...

journal_title：Perspectives in biology and medicine

authors： Kaebnick GE

更新日期：2007-10-01 00:00:00

abstract：:In retrospect, mortality from coronary heart disease (CHD) in the 20th century followed an epidemic pattern: mortality rates increased dramatically from 1920 until about 1960, remained roughly constant for almost a decade, and have been decreasing since the late 1960s. CHD has traditionally been conceived of as a sing...

journal_title：Perspectives in biology and medicine

authors： Azambuja MI,Levins R

更新日期：2007-04-01 00:00:00

abstract：:The impact of chronic illness on patients has been discussed extensively, but little attention has been paid to the reverse situation: the need for patients who have been chronically ill since childhood to adjust to health and normality in adulthood. Drawing upon the narratives of two adults with childhood onset disea...

journal_title：Perspectives in biology and medicine

authors： Orfali K,Anderson-Shaw L

更新日期：2005-04-01 00:00:00

abstract：:During the 1970s, something deeply consequential happened in the cultural, economic, and social relationships between science and technology. Paul Forman has proposed that the abrupt reversal of the culturally ascribed primacy in the science-technology relationship circa 1980 be taken as a demarcation of postmodernity...

journal_title：Perspectives in biology and medicine

authors： Schweber SS

更新日期：2009-01-01 00:00:00

abstract：:While the necessity of normalizing surgery on intersexed individuals is a topic of ongoing debate in the 21st century, the origins of surgery as a therapeutic practice for ambiguous or unusual genitalia lie in the 19th century. The first report of corrective surgery published in the United States appeared in the Ameri...

journal_title：Perspectives in biology and medicine

authors： Matta C

更新日期：2005-01-01 00:00:00

abstract：:The idea of being "haunted" appears often in accounts of the experience of health-care professionals and trainees who suffer from unresolved sorrow or regret about past clinical events, in particular the deaths of patients. The trope of haunting draws a direct line between past professional trauma and the dread of fut...

journal_title：Perspectives in biology and medicine

authors： Belling C

更新日期：2020-01-01 00:00:00

abstract：:As a result of the growth of evidence-based practices across the world, health-care providers and policymakers in the United States, United Kingdom, and Europe have established institutes such as the United Kingdom's National Institute for Health and Clinical Excellence (NICE) to produce clinical guidelines that physi...

journal_title：Perspectives in biology and medicine

authors： McGoey L

更新日期：2009-04-01 00:00:00

abstract：:This commentary considers two informing influences on Pope Francis's support of perinatal hospice care for families facing diagnoses of serious fetal anomalies. Reflecting on the morally formative scriptural narrative of Mary's pregnancy and Jesus's birth and drawing upon an often-repeated idea of Pope Francis's papac...

journal_title：Perspectives in biology and medicine

authors： Hardt J

更新日期：2020-01-01 00:00:00

abstract：:Over recent years there has been a gratifying decrease in the incidence of recorded deaths from coronary artery disease in the Western world. The common view is that coronary artery disease is a recent phenomenon, that we have been subject to an epidemic in the mid-20th century that is now tailing off, and that with a...

journal_title：Perspectives in biology and medicine

authors： John LC

更新日期：2012-01-01 00:00:00

abstract：:Scholars have shown that organ transplantation may transform ideas about one's body, with recipients feeling that they are receiving not just a body part but also a part of the donor's identity. This article focuses on a different way in which organ transplantation shapes recipient identity: the idea of becoming whole...

journal_title：Perspectives in biology and medicine

authors： Rodriguez SB,Campo-Engelstein L

更新日期：2011-07-01 00:00:00

abstract：:The linguistic metaphor in biology adheres to a representational theory that seeks similarities between pre-given domains. The point of departure of this paper is the generative and nonrepresentational conception of metaphor. This paper argues that by adopting the nonrepresentational conception of metaphor, meaning-ma...

journal_title：Perspectives in biology and medicine

authors： Neuman Y

更新日期：2005-07-01 00:00:00

abstract：:This article outlines a Darwinian approach to sports that takes into account its profoundly cultural character and thereby overcomes the traditional nature-culture dichotomies in the sociology of sport. We argue that there are good reasons to view sports as culturally evolved signaling systems that serve a function si...

journal_title：Perspectives in biology and medicine

authors： De Block A,Dewitte S

更新日期：2009-01-01 00:00:00

abstract：:How can we provide the best care for growing numbers of very frail, very sick, or very old people? The disciplines of geriatrics, palliative care, and clinical ethics each have a good deal to offer to improve care for elders, yet each field is saddled with heavy historical baggage. Using a case as a springboard, we ad...

journal_title：Perspectives in biology and medicine

authors： Smith AK,Micco G

更新日期：2017-01-01 00:00:00

abstract：:The health aspects and benefits of conception control as a justification for U.S. government support of family planning are reviewed. The Family Planning Services Act of 1970 set a goal of serving 5 million indigent women by 1975. It is predicted that the program will far surpass that goal. 340 million dollars were...

journal_title：Perspectives in biology and medicine

authors： Hellman LM

更新日期：1973-04-01 00:00:00

abstract：:We argue that medical decisions on behalf of children should be made with the welfare of the child as the primary interest, that parents should generally be allowed to determine which options optimize the interests of their child, and that those decisions should be formally challenged only when the parental decision p...

journal_title：Perspectives in biology and medicine

authors： Diekema DS,Wilfond BS

更新日期：2016-01-01 00:00:00