Is the Pace of Biomedical Innovation Slowing?

abstract：:After almost 50 years in science, I believe that there is an acceptable, often advantageous chasm between open-ended basic research-free exploration without a practical destination and in which the original ideas may fade into new concepts-and translational research or clinical research. My basic research on crystalli...

journal_title：Perspectives in biology and medicine

authors： Piatigorsky J

更新日期：2010-10-01 00:00:00

abstract：:Ensuring experimental outcomes are of the highest clinical caliber is crucial prior to the introduction of germline genome editing. However, if we are to police scientific progress using probability or the potential to go wrong, then we must account for the specious standards of human reproduction. With 15% of clinica...

journal_title：Perspectives in biology and medicine

authors： O'Neill HC

更新日期：2020-01-01 00:00:00

abstract：:There is a need in our society to raise the national consciousness about aging, health, and the prospects for longevity, so that many more persons take responsibility for their personal health and understand what we will need in an era of health-care reform to promote health across the life course. We address this imp...

journal_title：Perspectives in biology and medicine

authors： Hamerman D,Fried LP

更新日期：2013-04-01 00:00:00

abstract：:Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...

journal_title：Perspectives in biology and medicine

authors： Brody H

更新日期：2018-01-01 00:00:00

abstract：:The health aspects and benefits of conception control as a justification for U.S. government support of family planning are reviewed. The Family Planning Services Act of 1970 set a goal of serving 5 million indigent women by 1975. It is predicted that the program will far surpass that goal. 340 million dollars were...

journal_title：Perspectives in biology and medicine

authors： Hellman LM

更新日期：1973-04-01 00:00:00

abstract：:There is a growing national awareness that the extraordinary extension of life expectancy in our society poses an impending crisis for our health-care system. This is due in large part to the scarcity of primary-care providers, especially geriatricians. To address these concerns, the Obama administration has considere...

journal_title：Perspectives in biology and medicine

authors： Hamerman D

更新日期：2009-07-01 00:00:00

abstract：:The treatment of broken bones has long adhered to principles of tight juxtaposition of fracture ends and of strict rest. Splinting and casting with plaster of Paris helped considerably. Attempts at internal splinting with pegs, bolts, or stabilizing contraptions usually failed. Foreign materials were either not biocom...

journal_title：Perspectives in biology and medicine

authors： Pierach CA

更新日期：2014-07-01 00:00:00

abstract：:The incidence of brain tumors is rising in children and the elderly, but little is known about the mechanisms underlying brain tumor initiation and progression. In the 1940s, Zimmerman and coworkers exploited the tumor-promoting potential of polycyclic hydrocarbons to produce brain tumor models in adult mice that simu...

journal_title：Perspectives in biology and medicine

authors： Seyfried TN

更新日期：2001-04-01 00:00:00

abstract：:As health care has become of great importance to both individual citizens and to society, it has become more important to understand medicine's relationship to the society it serves in order to have a basis for meaningful dialogue. During the past decade, individuals in the medical, legal, social sciences, and health ...

journal_title：Perspectives in biology and medicine

authors： Cruess RL,Cruess SR

更新日期：2008-10-01 00:00:00

abstract：:How will developments in genetic knowledge affect the classification of disease? Leaders in genetics have suggested that knowledge of the role of genes in disease can determine nosology. Diseases might be defined by genotype, thus avoiding the limitations of more empirical approaches to categorization. Other commentat...

journal_title：Perspectives in biology and medicine

authors： Miller FA,Begbie ME,Giacomini M,Ahern C,Harvey EA

更新日期：2006-01-01 00:00:00

abstract：:As a result of the growth of evidence-based practices across the world, health-care providers and policymakers in the United States, United Kingdom, and Europe have established institutes such as the United Kingdom's National Institute for Health and Clinical Excellence (NICE) to produce clinical guidelines that physi...

journal_title：Perspectives in biology and medicine

authors： McGoey L

更新日期：2009-04-01 00:00:00

abstract：:Mary Shelley's Frankenstein is 200 years old and remains relevant to 21st-century scientific experimentation. Molecular biologists today have become especially bold in their attempts to cure diseases while remaining mindful of the real dangers of their research. Scientists presumably share an abiding concern about pro...

journal_title：Perspectives in biology and medicine

authors： Nowlin C

更新日期：2018-01-01 00:00:00

abstract：:Several studies suggest that clinical researchers are prone to overestimating the chance that scientific protocols will succeed, say, by confirming a treatment hypothesis or reaching recruitment targets. In this essay, we address the normative question of whether such "unrealistic optimism" is harmful in clinical rese...

journal_title：Perspectives in biology and medicine

authors： Benjamin D,Kimmelman J

更新日期：2016-01-01 00:00:00

abstract：:Randomized, controlled clinical trials (RCTs) may be possible, permissible, and practical in certain circumstances, but ethical or practical considerations often preclude their utilization. In many such cases, ethical objections will not apply to a similarly oriented, prospective, matched-pair observational study. Add...

journal_title：Perspectives in biology and medicine

authors： Kowalski CJ

更新日期：2013-04-01 00:00:00

abstract：:In this essay we link the rationale for the medical humanities with radical hermeneutics, a move that infuses the medical humanities with incredulity and suspicion. This orientation is particularly important at this historical moment, when the evidence-based and competency blanket is threatening to overpower all aspec...

journal_title：Perspectives in biology and medicine

authors： Wear D,Aultman JM

更新日期：2007-07-01 00:00:00

abstract：:Since the 19th century, we have come to think of disease in terms of specific entities--entities defined and legitimated in terms of characteristic somatic mechanisms. Since the last third of that century, we have expanded would-be disease categories to include an ever-broader variety of emotional pain, idiosyncrasy, ...

journal_title：Perspectives in biology and medicine

authors： Rosenberg CE

更新日期：2006-07-01 00:00:00

abstract：:Over recent years there has been a gratifying decrease in the incidence of recorded deaths from coronary artery disease in the Western world. The common view is that coronary artery disease is a recent phenomenon, that we have been subject to an epidemic in the mid-20th century that is now tailing off, and that with a...

journal_title：Perspectives in biology and medicine

authors： John LC

更新日期：2012-01-01 00:00:00

abstract：:The impact of chronic illness on patients has been discussed extensively, but little attention has been paid to the reverse situation: the need for patients who have been chronically ill since childhood to adjust to health and normality in adulthood. Drawing upon the narratives of two adults with childhood onset disea...

journal_title：Perspectives in biology and medicine

authors： Orfali K,Anderson-Shaw L

更新日期：2005-04-01 00:00:00

abstract：:This article outlines a Darwinian approach to sports that takes into account its profoundly cultural character and thereby overcomes the traditional nature-culture dichotomies in the sociology of sport. We argue that there are good reasons to view sports as culturally evolved signaling systems that serve a function si...

journal_title：Perspectives in biology and medicine

authors： De Block A,Dewitte S

更新日期：2009-01-01 00:00:00

abstract：:This is a daunting time, not only in terms of our public health and our economic health but also in terms of the health of the republic. It is an old theme that any form of popular government needs virtuous citizens if it is to survive. It also needs citizens to agree on what counts as a virtue. I fear that the pandem...

journal_title：Perspectives in biology and medicine

authors： Brudney D

更新日期：2020-01-01 00:00:00

abstract：:The idea of being "haunted" appears often in accounts of the experience of health-care professionals and trainees who suffer from unresolved sorrow or regret about past clinical events, in particular the deaths of patients. The trope of haunting draws a direct line between past professional trauma and the dread of fut...

journal_title：Perspectives in biology and medicine

authors： Belling C

更新日期：2020-01-01 00:00:00

abstract：:Since the beginning of the 21st century, the living conditions of undocumented migrant workers in Belgium have deteriorated drastically. In Brussels, after various social actions, undocumented people began squatting and occupying public buildings to make their struggle visible to society. Desperate, some seized the po...

journal_title：Perspectives in biology and medicine

authors： Vanobberghen R,Louckx F,Depoorter AM,Devroey D,Vandevoorde J

更新日期：2019-01-01 00:00:00

abstract：:Social media use in modern medicine is fraught with ethical dilemmas and risks of unprofessional behavior. This essay surveys the existing literature on the possibilities and pitfalls of social media use by health-care professionals and concludes that non-engagement with social media is not an option. A mindful approa...

journal_title：Perspectives in biology and medicine

authors： Frischtak H,Sinha P

更新日期：2013-10-01 00:00:00

abstract：:The traditional forms of public health law were directed largely toward communicable diseases and other externalities, such as pollution, with negative health impacts. The more modern view treats any health issue that affects large numbers of individuals as one of public health, which would include such problems as ob...

journal_title：Perspectives in biology and medicine

authors： Epstein RA

更新日期：2003-07-01 00:00:00

abstract：:In the period of "classical genetics" (roughly 1915-950), the common view of the gene was mechanistic--hat is, genes were seen as individual, atomistic units, as material components of the chromosomes. Although it was recognized early on that genes could interact and influence each other's expression, they were still ...

journal_title：Perspectives in biology and medicine

authors： Allen GE

更新日期：2014-01-01 00:00:00

abstract：:During the 1970s, something deeply consequential happened in the cultural, economic, and social relationships between science and technology. Paul Forman has proposed that the abrupt reversal of the culturally ascribed primacy in the science-technology relationship circa 1980 be taken as a demarcation of postmodernity...

journal_title：Perspectives in biology and medicine

authors： Schweber SS

更新日期：2009-01-01 00:00:00

abstract：:How can we provide the best care for growing numbers of very frail, very sick, or very old people? The disciplines of geriatrics, palliative care, and clinical ethics each have a good deal to offer to improve care for elders, yet each field is saddled with heavy historical baggage. Using a case as a springboard, we ad...

journal_title：Perspectives in biology and medicine

authors： Smith AK,Micco G

更新日期：2017-01-01 00:00:00

abstract：:The organism, like the molecule, the cell, and the species, is one of the fundamental levels in our hierarchical classification of life and its components. The units ranked at these levels, being concrete, particular things, are individuals in the broadest philosophical sense. But in a much narrower and more familiar ...

journal_title：Perspectives in biology and medicine

authors： Ghiselin MT

更新日期：2011-04-01 00:00:00

abstract：:Popular fiction responds to, and may exacerbate, public anxieties in ways that more highbrow literary texts may not. Robin Cook's 1977 novel Coma exemplifies the ways in which medical thrillers participate in the public discourse about health care. Written shortly after the medical establishment promoted "irreversible...

journal_title：Perspectives in biology and medicine

authors： Belling C

更新日期：2010-07-01 00:00:00

abstract：:Fifty years after Beecher's landmark article, an old question is being debated anew: is it ethical to conduct clinical research without consent? This paper provides a systematic analysis of this question. First, it describes five clinical trials that have either been conducted (or proposed) without the subjects provid...

journal_title：Perspectives in biology and medicine

authors： Kim SY

更新日期：2016-01-01 00:00:00