Diagnosis and Metaphor.

abstract：:When we figure medical practice as warfare, an individual clinician may be either a dutiful combatant or a conscientious objector. The rhetorical structure of this choice means that clinicians may exercise their consciences by loyally joining or disloyally exiting the medical ranks' battle against disease. But there a...

journal_title：Perspectives in biology and medicine

authors： Nussbaum AM

更新日期：2019-01-01 00:00:00

abstract：:Fifty years after Beecher's landmark article, an old question is being debated anew: is it ethical to conduct clinical research without consent? This paper provides a systematic analysis of this question. First, it describes five clinical trials that have either been conducted (or proposed) without the subjects provid...

journal_title：Perspectives in biology and medicine

authors： Kim SY

更新日期：2016-01-01 00:00:00

abstract：:The pace of biomedical innovation is important because it determines the rate of progress in medicine and allied disciplines. A review of the history of medical advances reveals that the three decades from 1950 to 1980 were a particularly innovative time. Subsequent decades have seen fewer seminal advances, despite co...

journal_title：Perspectives in biology and medicine

authors： Casadevall A

更新日期：2018-01-01 00:00:00

abstract：:The incidence of brain tumors is rising in children and the elderly, but little is known about the mechanisms underlying brain tumor initiation and progression. In the 1940s, Zimmerman and coworkers exploited the tumor-promoting potential of polycyclic hydrocarbons to produce brain tumor models in adult mice that simu...

journal_title：Perspectives in biology and medicine

authors： Seyfried TN

更新日期：2001-04-01 00:00:00

abstract：:Diverse and non-coherent sets of epistemological principles currently inform research in the general area of functional genomics. Here, from the personal point of view of a scientist with over half a century of immersion in hypothesis driven scientific discovery, I compare and deconstruct the ideological bases of prom...

journal_title：Perspectives in biology and medicine

authors： Davidson EH

更新日期：2015-04-01 00:00:00

abstract：:Over time, contemporary writing becomes part of the historical record. In medicine, it is an important learning tool, particularly for understanding the experience and context of disease and illness. Although a century has elapsed since the fictional events on a single day described in James Joyce's Ulysses, the work ...

journal_title：Perspectives in biology and medicine

authors： Shanahan F,Quigley EM

更新日期：2006-04-01 00:00:00

abstract：:Scholars have shown that organ transplantation may transform ideas about one's body, with recipients feeling that they are receiving not just a body part but also a part of the donor's identity. This article focuses on a different way in which organ transplantation shapes recipient identity: the idea of becoming whole...

journal_title：Perspectives in biology and medicine

authors： Rodriguez SB,Campo-Engelstein L

更新日期：2011-07-01 00:00:00

abstract：:The linguistic metaphor in biology adheres to a representational theory that seeks similarities between pre-given domains. The point of departure of this paper is the generative and nonrepresentational conception of metaphor. This paper argues that by adopting the nonrepresentational conception of metaphor, meaning-ma...

journal_title：Perspectives in biology and medicine

authors： Neuman Y

更新日期：2005-07-01 00:00:00

abstract：:Antibody-dependent enhancement is a general in vitro property of enveloped viruses. In certain circumstances, antibody-dependent enhancement is a bona fide pathophysiologic mechanism in vivo. There are several examples of virus disease of humans and animals in which incomplete or partial immunity can lead to enhanced ...

journal_title：Perspectives in biology and medicine

authors： Burke DS

更新日期：1992-07-01 00:00:00

abstract：:Marino Ortolani (1904-1983), a pediatrician from Ferrara, in northeastern Italy, was an outstanding pioneer in the early diagnosis and treatment of hip dysplasia. In 1935, while examining hip abduction-adduction in a six-month-old baby, Ortolani noted that a clearly audible and palpable "click" was sufficient to revea...

journal_title：Perspectives in biology and medicine

authors： Stecco C,Porzionato A,Macchi V,Fantoni I,Ortolani L,De Caro R

更新日期：2014-10-01 00:00:00

abstract：:How we discovered that sea birds on the Great Barrier Reef are riddled with influenza viruses, and how one of these led to a new drug now being used in the battle against the flu. ...

journal_title：Perspectives in biology and medicine

authors： Laver WG

更新日期：2004-10-01 00:00:00

abstract：:The term innovation is frequently used as a justification for allowing clinicians to offer unproven autologous stem cell-based interventions (SCBIs) to their patients. Proponents of this kind of innovation (which we refer to as "clinical innovation") argue that physicians should be free to administer whatever interven...

journal_title：Perspectives in biology and medicine

authors： Lipworth W,Stewart C,Kerridge I

更新日期：2018-01-01 00:00:00

abstract：:Since the beginning of the 21st century, the living conditions of undocumented migrant workers in Belgium have deteriorated drastically. In Brussels, after various social actions, undocumented people began squatting and occupying public buildings to make their struggle visible to society. Desperate, some seized the po...

journal_title：Perspectives in biology and medicine

authors： Vanobberghen R,Louckx F,Depoorter AM,Devroey D,Vandevoorde J

更新日期：2019-01-01 00:00:00

abstract：:Since the 19th century, we have come to think of disease in terms of specific entities--entities defined and legitimated in terms of characteristic somatic mechanisms. Since the last third of that century, we have expanded would-be disease categories to include an ever-broader variety of emotional pain, idiosyncrasy, ...

journal_title：Perspectives in biology and medicine

authors： Rosenberg CE

更新日期：2006-07-01 00:00:00

abstract：:Kelly, Kelly, and Russo (2014) recently proposed to integrate biological, behavioral, and social mechanisms into "mixed mechanisms" situated in the individual's "lifeworld" when considering illness causation. This article suggests considering terminological discrepancies, replacing the pathogenetic with an etiological...

journal_title：Perspectives in biology and medicine

authors： Dammann O

更新日期：2017-01-01 00:00:00

abstract：:An intersex condition is one in which an individual is born with atypical male or female external genitalia, gonads, hormones, or chromosomes. Older terms, such as pseudohermaphroditism and hermaphroditism, are controversial, leading the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for P...

journal_title：Perspectives in biology and medicine

authors： Reis E,McCarthy MW

更新日期：2016-01-01 00:00:00

abstract：:Concerns about nature are playing increasingly prominent roles in a variety of social debates, including medical biotechnology, environmental protection, and agricultural biotechnology. These concerns are often simply rejected as incoherent: critics argue that there is no good account for how natural states of affairs...

journal_title：Perspectives in biology and medicine

authors： Kaebnick GE

更新日期：2007-10-01 00:00:00

abstract：:Although the practice of medicine continually changes in response to new biomedical understanding, novel technologies, and evolving cultural contexts, the ethical foundations of the clinical relationship between patient and physician paradoxically remain constant. There are fundamental characteristics with respect to ...

journal_title：Perspectives in biology and medicine

authors： Fuks A,Brawer J,Boudreau JD

更新日期：2012-01-01 00:00:00

abstract：:This is a daunting time, not only in terms of our public health and our economic health but also in terms of the health of the republic. It is an old theme that any form of popular government needs virtuous citizens if it is to survive. It also needs citizens to agree on what counts as a virtue. I fear that the pandem...

journal_title：Perspectives in biology and medicine

authors： Brudney D

更新日期：2020-01-01 00:00:00

abstract：:In retrospect, mortality from coronary heart disease (CHD) in the 20th century followed an epidemic pattern: mortality rates increased dramatically from 1920 until about 1960, remained roughly constant for almost a decade, and have been decreasing since the late 1960s. CHD has traditionally been conceived of as a sing...

journal_title：Perspectives in biology and medicine

authors： Azambuja MI,Levins R

更新日期：2007-04-01 00:00:00

abstract：:Randomized, controlled clinical trials (RCTs) may be possible, permissible, and practical in certain circumstances, but ethical or practical considerations often preclude their utilization. In many such cases, ethical objections will not apply to a similarly oriented, prospective, matched-pair observational study. Add...

journal_title：Perspectives in biology and medicine

authors： Kowalski CJ

更新日期：2013-04-01 00:00:00

abstract：:This article outlines a Darwinian approach to sports that takes into account its profoundly cultural character and thereby overcomes the traditional nature-culture dichotomies in the sociology of sport. We argue that there are good reasons to view sports as culturally evolved signaling systems that serve a function si...

journal_title：Perspectives in biology and medicine

authors： De Block A,Dewitte S

更新日期：2009-01-01 00:00:00

abstract：:The rise of big data and artificial intelligence (AI) in health care has engendered considerable excitement, claiming to improve approaches to diagnosis, prognosis, and treatment. Amidst the enthusiasm, the philosophical assumptions that underlie the big data and AI movement in medicine are rarely examined. This essay...

journal_title：Perspectives in biology and medicine

authors： Chin-Yee B,Upshur R

更新日期：2019-01-01 00:00:00

abstract：:Both leading scientific journals and the popular press now regularly report the convincing evidence of massive environmental degradation and decline. Yet despite the seriousness of the problems, despite their anthropogenic nature, and despite their profound implications for present and future population health, such t...

journal_title：Perspectives in biology and medicine

authors： Levine BR

更新日期：2007-01-01 00:00:00

abstract：:The clinical trial of the AbioCor artificial heart, initiated in July 2001 and still in process, has taken place within a matrix of social and cultural patterns that are both "old" and new. The old patterns--those that have accompanied previous clinical trials of other vital artificial organs and transplantation in th...

journal_title：Perspectives in biology and medicine

authors： Fox RC,Swazey JP

更新日期：2004-01-01 00:00:00

abstract：:The advent of electronic health records (EHRs) to improve access and enable research in the everyday clinical world has simultaneously made medical information much more vulnerable to illicit, non-beneficent uses. This wealth of identified, aggregated data has and will attract attacks by domestic governments for surve...

journal_title：Perspectives in biology and medicine

authors： Graves S

更新日期：2013-01-01 00:00:00

abstract：:Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...

journal_title：Perspectives in biology and medicine

authors： Brody H

更新日期：2018-01-01 00:00:00

abstract：:While the necessity of normalizing surgery on intersexed individuals is a topic of ongoing debate in the 21st century, the origins of surgery as a therapeutic practice for ambiguous or unusual genitalia lie in the 19th century. The first report of corrective surgery published in the United States appeared in the Ameri...

journal_title：Perspectives in biology and medicine

authors： Matta C

更新日期：2005-01-01 00:00:00

abstract：:The general population is experiencing lifelong exposure to old and new hazardous substances. By using data collected from a subject's own teeth, accuracy in determining the effects of exposure is assured since extrapolation is excluded. The establishment of a common tooth bank can provide means to integrate data from...

journal_title：Perspectives in biology and medicine

authors： Sharon IM

更新日期：1988-10-01 00:00:00

abstract：:This article reviews some of the technological devices and ideas which have been used over the years to answer the question, how does the brain work? It describes some of the early technology-based analogies and models of nerve fibers, and then discusses other analogies and models of the brain based on mechanical and ...

journal_title：Perspectives in biology and medicine

authors： Kirkland KL

更新日期：2002-04-01 00:00:00