Abstract：
:Trembler-J, TrJ, is a peripheral hypomyelinating murine mutant. In intercrosses (TrJ/ + X TrJ/ +) there are severely affected (behaviorally and pathologically), mildly affected, and normal offspring, while backcrosses (TrJ/ + X + / +) produce only mildly affected and normal offspring. We used the closely linked marker vestigial tail, vt, to test whether severely affected offspring of intercrosses (TrJvt/ + + X TrJvt/ + +) were TrJ/TrJ. In 5/6 intercrosses all severely affected animals were short-tailed and vice versa, while all mildly affected animals had long tails and vice versa. It is highly probable that the severely affected, mildly affected, and normal classes of intercross offspring were of TrJ/TrJ, TrJ/+, and +/+ genotypes, respectively.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Henry EW,Sidman RLdoi
10.3109/01677068309107071subject
Has Abstractpub_date
1983-09-01 00:00:00pages
39-52issue
1eissn
0167-7063issn
1563-5260journal_volume
1pub_type
杂志文章abstract：:Messenger RNA editing of transcripts encoding voltage-sensitive ion channels has not been extensively analyzed--least of all in Drosophila, for which several channel-encoding genes are known. Previous sequence studies of D. melanogaster's cacophony gene, which encodes an alpha 1 calcium-channel subunit called Dmca1A, ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677069809108560
更新日期：1998-11-01 00:00:00
abstract：:Intrahippocampal microinjections with anti-Met-enkephalin antiserum enhanced novelty-induced vertically oriented exploratory acts and horizontal locomotor activity in inbred mouse strain DBA/2 and reduced these behaviors in C57BL/6 so that strain differences originally present between the normal serum controls were el...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068609106848
更新日期：1986-05-01 00:00:00
abstract：:Mutants displaying generalized behavioral defects and one mutant having an enzyme deficiency were examined for electroretinogram (ERG) defects. Mutations in nine genes were examined that cause ERG defects. Two, parats4 and slrpD, cause reversibly temperature dependent loss of the off-transients in the ERG. stnC and Ty...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068909167263
更新日期：1989-01-01 00:00:00
abstract：:Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.642910
更新日期：2012-03-01 00:00:00
abstract：:The molecular analysis of the Notch locus of Drosophila melanogaster demonstrated that it codes for a protein which shows homology to the epidermal growth factor as well as to the products of certain yeast genes involved in the control of the cell cycle (Wharton et al., 1985a; Breeden and Nasmyth, 1987). The structure...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068909107097
更新日期：1989-09-01 00:00:00
abstract：:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2016.1238916
更新日期：2016-01-01 00:00:00
abstract：:Single-gene mutants of Drosophila have not only increased our understanding of the biochemical processes underlying learning and memory processes, but also established structure-function relationships. The first relevant mutants were identified by Martin Heisenberg nearly 30 years ago in a screen for altered adult bra...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677060802471700
更新日期：2009-01-01 00:00:00
abstract：:This report contains additional observations on the cell lineage relationships of the motor neurons of the facial nucleus and of the cerebellar Purkinje cells of the mouse. These cell populations were quantitatively analyzed in the mosaic brains of experimental aggregation chimeras. The cell markers used to perform th...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068409107092
更新日期：1984-12-01 00:00:00
abstract：:The aim of this review is to summarize the history of Dr. Yoshiki Hotta and his collaborators' contributions to the research field of Drosophila phototransduction. The electroretinogram-defective mutants reported in 1970 by Dr. Hotta and Dr. Seymour Benzer in the article entitled "Genetic dissection of the Drosophila ...
journal_title：Journal of neurogenetics
pub_type： 传,历史文章,杂志文章
doi：10.3109/01677063.2011.647144
更新日期：2012-03-01 00:00:00
abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, T...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060590949692
更新日期：2005-01-01 00:00:00
abstract：:This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward lo...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677060802298509
更新日期：2008-01-01 00:00:00
abstract：:Altered synaptic strength underlies information storage in neural circuits. Neuromodulatory transmitters such as norepinephrine (NE) facilitate long-lasting synaptic plasticity by recruiting and modifying multiple molecular elements of synaptic signaling, including specific transmitter receptors, intracellular protein...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677063.2018.1497630
更新日期：2018-09-01 00:00:00
abstract：:The cell-surface-signaling protein Notch, is required for numerous developmental processes and typically specifies which of two adjacent cells will adopt a non-neuronal developmental fate. It has recently been implicated in long-term memory formation in mammals and Drosophila. Here, we investigated whether activity-de...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677060902878481
更新日期：2009-01-01 00:00:00
abstract：:This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2011.650253
更新日期：2012-06-01 00:00:00
abstract：:The serotonin transporter is an important regulator of serotonergic signaling. In order to analyze where the Drosophila melanogaster ortholog of the mammalian serotonin transporter (dSERT) is expressed in the nervous system, a dSERT antibody serum was used. Ectopic expression studies and loss of function analysis reve...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.553002
更新日期：2011-03-01 00:00:00
abstract：:Signaling from the postsynaptic compartment regulates multiple aspects of synaptic development and function. Syntaxin 4 (Syx4) is a plasma membrane t-SNARE that promotes the growth and plasticity of Drosophila neuromuscular junctions (NMJs) by regulating the localization of key synaptic proteins in the postsynaptic co...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2018.1501372
更新日期：2018-09-01 00:00:00
abstract：:We have identified helmsman (hlm), which is expressed in the fruit fly photoreceptor cells during neural network development. Hlm is also expressed in the elongating cells of the embryonic trachea. Both photoreceptor neurons and embryonic trachea cells elongate in precise, targeted growth for cell-to-cell specific rec...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060801893276
更新日期：2008-01-01 00:00:00
abstract：:From Sydney Brenner's backyard to hundreds of labs across the globe, inspiring six Nobel Prize winners along the way, Caenorhabditis elegans research has come far in the past half century. The journey is not over. The virtues of C. elegans research are numerous and have been recounted extensively. Here, we focus on th...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2020.1823386
更新日期：2020-09-01 00:00:00
abstract：:Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2018.1497629
更新日期：2018-09-01 00:00:00
abstract：:Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2014.922557
更新日期：2014-09-01 00:00:00
abstract：:Courtship suppression is an associative conditioning procedure in Drosophila melanogaster that is ethologically based and capable of being tested on individual flies. We have expanded the range of the courtship conditioning by developing an excitatory procedure in which male flies learn to associate a novel odor with ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Neural tube defects (NTD) are a common birth defect, with both genetic and environmental contributions to their etiology. In mouse, null mutations in Noggin result in fully-penetrant NTDs. We investigated Noggin for mutations that may predispose to human NTDs in 202 NTD cases. One variant allele was identified in a ma...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068609106846
更新日期：1986-05-01 00:00:00
abstract：:Most insertional mutagenesis screens of Drosophila performed to date have not used target chromosomes that have been checked for their suitability for phenotypic screens for viable phenotypes. To address this, we have generated a selection of stocks carrying either isogenized second chromosomes or isogenized third chr...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060591007155
更新日期：2005-04-01 00:00:00
abstract：:Many declared aims of the genome projects have been achieved. The total genomic sequences of several relatively noncomplex/complex organisms (such as E. coli, yeast, Caenorhabditis, Drosophila) are being determined, and the nucleotide sequencing of the entire human genome will be complete in the near future. However, ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677060109167373
更新日期：2001-01-01 00:00:00
abstract：:Inbred mice of the DBA/2J and C57BL/6J strains are known to differ in physiological and behavioral characteristics that are partially controlled by nuclei in the preoptic area/anterior hypothalamus. We describe a distinguishing nucleus of darkly staining, densely packed cells, which we term the medioventral pars compa...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068509101424
更新日期：1985-12-01 00:00:00
abstract：:SPG3A/atlastin-1 gene mutations cause an autosomal dominant form of hereditary spastic paraplegia (SPG3A-HSP). We used positron emission tomography with [(11)C]DTBZ to assess nigrostriatal dopaminergic integrity in two unrelated adults with SPG3A-HSP due to the common SPG3A/atlastin-1 mutation, R239C. Nigrostriatal do...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060802337307
更新日期：2008-01-01 00:00:00
abstract：:A telomere is a repetitive DNA structure at chromosomal ends that stabilizes the chromosome structure and prevents harmful end-to-end recombinations. The telomere length of somatic cells becomes shorter with aging because of the "end replication problem." This telomere shortening is accelerated by pathophysiological c...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.651665
更新日期：2012-06-01 00:00:00
abstract：:Based on unbeatable genetic accessibility and relative simplicity, the Drosophila larval neuromuscular junction has become a widely used model system for studying functional and structural aspects of excitatory glutamatergic synapses. Membrane-associated guanylate kinase-like proteins (MAGUKs) are first-order scaffold...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2010.493589
更新日期：2010-09-01 00:00:00
abstract：:Cacna1f gene mutation could lead to incomplete congenital stationary night blindness (iCSNB) disease. The CSNB-like phenotype rat is a spontaneous rat model caused by Cacna1f gene mutation. The present study explored the phenotypic properties of behavior performance in CSNB rats further. The vision-related behaviors o...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2012.684416
更新日期：2012-09-01 00:00:00
