Abstract:
:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A polymorphism (rs1800497). This study addresses the question of whether the DRD2/ANKK1-Taq1A polymorphism is a risk factor for writer's cramp. We determined the DRD2/ANKK1-Taq1A polymorphism 34 patients with writer's cramp compared to 67 age matched controls. 35.3% of the patients and 31.3% of our controls were assigned to the A1 genotype status (p = .7). Therefore DRD2/ANKK1-Taq1A gene is not a significant risk factor in the evolution of writer's cramp.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Zeuner KE,Acewicz A,Knutzen A,Dressler D,Lohmann K,Witt Kdoi
10.1080/01677063.2016.1238916subject
Has Abstractpub_date
2016-01-01 00:00:00pages
276-279issue
3-4eissn
0167-7063issn
1563-5260journal_volume
30pub_type
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