The expression of the neurogenic locus Notch during the postembryonic development of Drosophila melanogaster and its relationship to mitotic activity.

abstract：:From Sydney Brenner's backyard to hundreds of labs across the globe, inspiring six Nobel Prize winners along the way, Caenorhabditis elegans research has come far in the past half century. The journey is not over. The virtues of C. elegans research are numerous and have been recounted extensively. Here, we focus on th...

journal_title：Journal of neurogenetics

authors： Iliff AJ,Xu XZS

更新日期：2020-09-01 00:00:00

abstract：:Based on unbeatable genetic accessibility and relative simplicity, the Drosophila larval neuromuscular junction has become a widely used model system for studying functional and structural aspects of excitatory glutamatergic synapses. Membrane-associated guanylate kinase-like proteins (MAGUKs) are first-order scaffold...

journal_title：Journal of neurogenetics

authors： Thomas U,Kobler O,Gundelfinger ED

更新日期：2010-09-01 00:00:00

abstract：:Learnt predictive behavior faces a dilemma: predictive stimuli will never 'replay' exactly as during the learning event, requiring generalization. In turn, minute differences can become meaningful, prompting discrimination. To provide a study case for an adaptive adjustment of this generalization-discrimination balanc...

journal_title：Journal of neurogenetics

authors： Mishra D,Louis M,Gerber B

更新日期：2010-09-01 00:00:00

abstract：:Each neuropil module, or cartridge, in the fly's lamina has a fixed complement of cells. Of five types of monopolar cell interneurons, only L4 has collaterals that invade neighboring cartridges. In the proximal lamina, these collaterals form reciprocal synapses with both the L2 of their own cartridge and the L4 collat...

journal_title：Journal of neurogenetics

authors： Lüthy K,Ahrens B,Rawal S,Lu Z,Tarnogorska D,Meinertzhagen IA,Fischbach KF

更新日期：2014-09-01 00:00:00

abstract：:Single-gene mutants of Drosophila have not only increased our understanding of the biochemical processes underlying learning and memory processes, but also established structure-function relationships. The first relevant mutants were identified by Martin Heisenberg nearly 30 years ago in a screen for altered adult bra...

journal_title：Journal of neurogenetics

authors： Hovhanyan A,Raabe T

更新日期：2009-01-01 00:00:00

abstract：:The serotonin transporter is an important regulator of serotonergic signaling. In order to analyze where the Drosophila melanogaster ortholog of the mammalian serotonin transporter (dSERT) is expressed in the nervous system, a dSERT antibody serum was used. Ectopic expression studies and loss of function analysis reve...

journal_title：Journal of neurogenetics

authors： Giang T,Ritze Y,Rauchfuss S,Ogueta M,Scholz H

更新日期：2011-03-01 00:00:00

abstract：:A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have gues...

journal_title：Journal of neurogenetics

authors： Chalfie M

更新日期：2020-09-01 00:00:00

abstract：:The aim of this review is to summarize the history of Dr. Yoshiki Hotta and his collaborators' contributions to the research field of Drosophila phototransduction. The electroretinogram-defective mutants reported in 1970 by Dr. Hotta and Dr. Seymour Benzer in the article entitled "Genetic dissection of the Drosophila ...

journal_title：Journal of neurogenetics

authors： Suzuki E,Masai I,Inoue H

更新日期：2012-03-01 00:00:00

abstract：:The shape of a neuron, its morphological signature, dictates the neuron's function by establishing its synaptic partnerships. Here, we review various anatomical methods used to reveal neuron shape and the contributions these have made to our current understanding of neural function in the Drosophila brain, especially ...

journal_title：Journal of neurogenetics

authors： Meinertzhagen IA,Takemura SY,Lu Z,Huang S,Gao S,Ting CY,Lee CH

更新日期：2009-01-01 00:00:00

abstract：:Predictions from the theory of transfection, Karl-Friedrich Fischbach's first paper, were confirmed 20 years later. Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functio...

journal_title：Journal of neurogenetics

authors： Spatz HC

更新日期：2014-09-01 00:00:00

abstract：:Autosomal recessive cerebellar ataxias are a group of clinically and genetically heterogeneous neurodegenerative disorders. Growing data have shown that there is difficulty with genetic counseling in a deeply consanguineous population because of the presence of genetic heterogeneity in patients sharing similar phenoty...

journal_title：Journal of neurogenetics

authors： Bouhlal Y,Zouari M,Kefi M,Ben Hamida C,Hentati F,Amouri R

更新日期：2008-01-01 00:00:00

abstract：:This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...

journal_title：Journal of neurogenetics

authors： Leung HT,Shino S,Kim E

更新日期：2012-06-01 00:00:00

abstract：:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...

journal_title：Journal of neurogenetics

authors： Zeuner KE,Acewicz A,Knutzen A,Dressler D,Lohmann K,Witt K

更新日期：2016-01-01 00:00:00

abstract：:Disturbances in sleep are encountered in the majority of patients with depressive disorder. To elucidate the molecular mechanisms behind this relationship, we examined gene expression changes in a rodent model for disturbed sleep and depression. The animals were treated with daily injections of clomipramine to affect ...

journal_title：Journal of neurogenetics

authors： Lagus M,Gass N,Saharinen J,Savelyev S,Porkka-Heiskanen T,Paunio T

更新日期：2012-09-01 00:00:00

abstract：:Messenger RNA editing of transcripts encoding voltage-sensitive ion channels has not been extensively analyzed--least of all in Drosophila, for which several channel-encoding genes are known. Previous sequence studies of D. melanogaster's cacophony gene, which encodes an alpha 1 calcium-channel subunit called Dmca1A, ...

journal_title：Journal of neurogenetics

authors： Smith LA,Peixoto AA,Hall JC

更新日期：1998-11-01 00:00:00

abstract：:Membrane fusion is essential for the communication of membrane-defined compartments, development of multicellular organisms and tissue homeostasis. Although membrane fusion has been studied extensively, still little is known about the molecular mechanisms. Especially the intercellular fusion of cells during developmen...

journal_title：Journal of neurogenetics

authors： Önel SF,Rust MB,Jacob R,Renkawitz-Pohl R

更新日期：2014-09-01 00:00:00

abstract：:The metabolism of leucine was studied in cultured human fibroblasts derived from patients with defects in each of the major steps in the catabolism of the amino acid. Intact fibroblasts were incubated with [U-14C]leucine and the organic acid products were isolated by liquid partition chromatography. In control fibrobl...

journal_title：Journal of neurogenetics

authors： Yoshida I,Søvik O,Sweetman L,Nyhan WL

更新日期：1985-12-01 00:00:00

abstract：:Abstract: This essay is dedicated to Obaid on the occasion of his 80th birthday. We both worked on the behavior of Drosophila and on what underlies behavior in the fly brain. Is that the fly's mind? The essay is about some limitations of brain science. It is just a little piece of writing. It is meant to honor Obaid f...

journal_title：Journal of neurogenetics

authors： Heisenberg M

更新日期：2012-09-01 00:00:00

abstract：:One of the most fascinating questions in evolutionary biology is how traits unique to humans, such as their high cognitive abilities, erect bipedalism, and hairless skin, are encoded in the genome. Recent advances in genomics have begun to reveal differences between the genomes of the great apes. It has become evident...

journal_title：Journal of neurogenetics

authors： Sassa T

更新日期：2013-09-01 00:00:00

abstract：:When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of...

journal_title：Journal of neurogenetics

authors： Qiu X,Martin GB,Blache D

更新日期：2017-01-01 00:00:00

abstract：:C. elegans animals mutant for the unc-119 gene exhibit movement, sensory and behavioral abnormalities. Consistent with a nervous system role, unc-119 reporter genes are expressed throughout the C. elegans nervous system. The UNC-119 protein has strong sequence similarity to the predicted protein from a human gene, HRG...

journal_title：Journal of neurogenetics

authors： Maduro MF,Gordon M,Jacobs R,Pilgrim DB

更新日期：2000-01-01 00:00:00

abstract：:Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neuro...

journal_title：Journal of neurogenetics

authors： Wei JY,Chung PC,Chu SY,Yu HH

更新日期：2019-03-01 00:00:00

abstract：:Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...

journal_title：Journal of neurogenetics

authors： Nicita F,Garone G,Papetti L,Consoli F,Magliozzi M,De Luca A,Spalice A

更新日期：2015-01-01 00:00:00

abstract：:Glioblastoma multiform (GBM; World Health Organization (WHO) grade IV) and anaplastic astrocytomas (AA; WHO grade III) are highly aggressive and lethal astrocytic brain tumors. To detect cancer-specific somatic mutations in two hot-spot regions of PIK3CA gene, the helical and kinase domains (encoded by exons 9 and 20,...

journal_title：Journal of neurogenetics

authors： Derakhshandeh-Peykar P,Alivi J,Hossein-nezhad A,Rautenstrauss B,Vesal RE,Doriani A

更新日期：2011-12-01 00:00:00

abstract：:otal (ota=olfactory trap abnormal), an X-linked mutation of Drosophila isolated by virtue of abnormal olfactory behavior, is shown to be an allele of rdgB (retinal degeneration B), a gene required for normal visual system physiology. rdgB function is shown to be necessary for olfactory response of both adult files and...

journal_title：Journal of neurogenetics

authors： Woodard C,Alcorta E,Carlson J

更新日期：2007-10-01 00:00:00

abstract：:SPG3A/atlastin-1 gene mutations cause an autosomal dominant form of hereditary spastic paraplegia (SPG3A-HSP). We used positron emission tomography with [(11)C]DTBZ to assess nigrostriatal dopaminergic integrity in two unrelated adults with SPG3A-HSP due to the common SPG3A/atlastin-1 mutation, R239C. Nigrostriatal do...

journal_title：Journal of neurogenetics

authors： Albin RL,Koeppe RA,Rainier S,Fink JK

更新日期：2008-01-01 00:00:00

abstract：:Based on the staining of Drosophila embryos with neuron-specific monoclonal antibodies we describe the differentiation of the earliest neurons in the central nervous system. The metameric array undergoes a number of changes during development that distinguish several morphological units: metameres, neuromeres and gang...

journal_title：Journal of neurogenetics

authors： Canal I,Ferrús A

更新日期：1986-09-01 00:00:00

abstract：:Some of the very first chemosensory mutants in Drosophila were generated in screens done in the 1970s at Obaid Siddiqi's lab in Tata Institute of Fundamental Research (TIFR), Mumbai. This is a personal account of some of the early work with these mutants, which led to their physiological and molecular characterization...

journal_title：Journal of neurogenetics

authors： Hasan G

更新日期：2012-09-01 00:00:00

abstract：:Cacna1f gene mutation could lead to incomplete congenital stationary night blindness (iCSNB) disease. The CSNB-like phenotype rat is a spontaneous rat model caused by Cacna1f gene mutation. The present study explored the phenotypic properties of behavior performance in CSNB rats further. The vision-related behaviors o...

journal_title：Journal of neurogenetics

authors： An J,Wang L,Guo Q,Li L,Xia F,Zhang Z

更新日期：2012-09-01 00:00:00

abstract：:We used the hippocampal slice to examine extracellular electrophysiological responses to nicotine and the difference in sensitivity to nicotine-induced electrophysiological effects between the DBA and C3H mouse strains. Nicotine enhanced CA1 population spikes (PS) evoked by Schaffer collateral stimulation in a concent...

journal_title：Journal of neurogenetics

authors： Freund RK,Wehner JM

更新日期：1987-04-01 00:00:00