Abstract:
:Cacna1f gene mutation could lead to incomplete congenital stationary night blindness (iCSNB) disease. The CSNB-like phenotype rat is a spontaneous rat model caused by Cacna1f gene mutation. The present study explored the phenotypic properties of behavior performance in CSNB rats further. The vision-related behaviors of CSNB rats were assessed with a Morris water maze (MWM), passive avoidance tests, and open-field test. Motor ability was evaluated with a rotarod test and a wire hang test, and mechanical pain and thermalgia were used to evaluate sensory system function. Electroretinograms (ERGs) were recorded to evaluate the function of the retina. The vision-related results showed that longer latencies of escape and reduced probe trial in MWM for CSNB rats. There were more errors in avoidance test; CSNB rats were more active in the open field and presented a different pattern of exploration. The locomotor-related behaviors showed shorter falling latencies in the rotarod test and shorter gripping time in CSNB rats. And mechanical thresholds of pain increased in CSNB rats. The ERGs indicated that both the amplitude and latency of rod and cone systems were impaired in the CSNB rats. In summary, Cacna1f gene mutation changed the performance of various behaviors in the CSNB rat aside from vision-related phenotype. Cacna1f gene might play a role in a wide range of responses in the organism. These results confirm the importance of a comprehensive profile for understanding the behavior phenotype of Cacna1f gene mutation in CSNB rat.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
An J,Wang L,Guo Q,Li L,Xia F,Zhang Zdoi
10.3109/01677063.2012.684416subject
Has Abstractpub_date
2012-09-01 00:00:00pages
363-73issue
3-4eissn
0167-7063issn
1563-5260journal_volume
26pub_type
杂志文章abstract::Caenorhabditis elegans has a simple nervous system of 302 neurons. It however senses environmental cues incredibly precisely and produces various behaviors by processing information in the neural circuit. In addition to classical genetic analysis, fluorescent proteins and calcium indicators enable in vivo monitoring o...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2020.1734001
更新日期:2020-09-01 00:00:00
abstract::A new autosomal recessive mutation, characterized by an early defect in righting reflex and stiffened gait, progression to severe spasticity, tremor and rigidity, and death before weaning, appeared spontaneously on the C57BL/6 background. It was shown to be an allele of the mutant spastic spa, and shall be known as sp...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract::The Drosophila receptor oscillation A (rosA) mutations, which cause electroretinogram (ERG) defects, including oscillations, were localized to the 24F4-25A2 region of chromosome 2L. Genomic fragments from this region, isolated from bacteriophage P1 clones, included those that detect transcriptional defects in rosA mut...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069609107063
更新日期:1996-12-01 00:00:00
abstract::Sarcoglycanopathies (SGPs) constitute a subgroup of autosomal recessive limb girdle muscular dystrophies (LGMDs) which are caused by mutations in sarcoglycan (SGs) genes. SG proteins form a core complex consisting of α, β, γ and δ sarcoglycans which are encoded by SGCA, SGCB, SGCG and SGCD genes, respectively. Genetic...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2016.1141208
更新日期:2016-03-01 00:00:00
abstract::Based on the staining of Drosophila embryos with neuron-specific monoclonal antibodies we describe the differentiation of the earliest neurons in the central nervous system. The metameric array undergoes a number of changes during development that distinguish several morphological units: metameres, neuromeres and gang...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106856
更新日期:1986-09-01 00:00:00
abstract::The metabolism of leucine was studied in cultured human fibroblasts derived from patients with defects in each of the major steps in the catabolism of the amino acid. Intact fibroblasts were incubated with [U-14C]leucine and the organic acid products were isolated by liquid partition chromatography. In control fibrobl...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068509101427
更新日期:1985-12-01 00:00:00
abstract::Altered synaptic strength underlies information storage in neural circuits. Neuromodulatory transmitters such as norepinephrine (NE) facilitate long-lasting synaptic plasticity by recruiting and modifying multiple molecular elements of synaptic signaling, including specific transmitter receptors, intracellular protein...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.1080/01677063.2018.1497630
更新日期:2018-09-01 00:00:00
abstract::Mutations at two fragile sites, FRAXA and FRAXE, loci are caused by an expansion of a CGG/GCC trinucleotide repeat and are characterized by mental retardation. Here we report molecular screening survey of 97 unrelated individuals diagnosed with non-specific mental retardation (MR), which produced positive test for FRA...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/neg.17.2-3.223.230
更新日期:2003-04-01 00:00:00
abstract::Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2016.1238916
更新日期:2016-01-01 00:00:00
abstract::A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106846
更新日期:1986-05-01 00:00:00
abstract::Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.3109/01677063.2014.922557
更新日期:2014-09-01 00:00:00
abstract::We have identified helmsman (hlm), which is expressed in the fruit fly photoreceptor cells during neural network development. Hlm is also expressed in the elongating cells of the embryonic trachea. Both photoreceptor neurons and embryonic trachea cells elongate in precise, targeted growth for cell-to-cell specific rec...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677060801893276
更新日期:2008-01-01 00:00:00
abstract::C. elegans animals mutant for the unc-119 gene exhibit movement, sensory and behavioral abnormalities. Consistent with a nervous system role, unc-119 reporter genes are expressed throughout the C. elegans nervous system. The UNC-119 protein has strong sequence similarity to the predicted protein from a human gene, HRG...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677060009084494
更新日期:2000-01-01 00:00:00
abstract::Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2015.1091452
更新日期:2015-01-01 00:00:00
abstract::Intrahippocampal microinjections with anti-Met-enkephalin antiserum enhanced novelty-induced vertically oriented exploratory acts and horizontal locomotor activity in inbred mouse strain DBA/2 and reduced these behaviors in C57BL/6 so that strain differences originally present between the normal serum controls were el...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106848
更新日期:1986-05-01 00:00:00
abstract::Some cases of Alzheimer's disease are inherited as a dominant trait in humans. To date, mutations in three genes account for some of them: the amyloid precursor protein (APP) and presenilins 1 and 2 (PS-1 and PS-2, respectively). The function of the presenilins is still unclear, although they belong to a transmembrane...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069809108554
更新日期:1998-01-01 00:00:00
abstract::To date, less than 10 pedigrees have been reported with ZNF335 mutations since it was discovered in 2012 and little is known about ZNF335-related clinical spectrum. We describe a 12 years old male patient who is only child of nonconsanguineous Turkish parents. Trio whole genome sequencing identified previously unrepor...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2020.1833006
更新日期:2020-11-20 00:00:00
abstract::Animals make decisions on behavioral choice by evaluating internal and external signals. Individuals often make decisions in different ways, but the underlying neural mechanisms are not well understood. Here, we describe a system for observing the behavior of individual Drosophila melanogaster larvae simultaneously pr...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2016.1202949
更新日期:2016-01-01 00:00:00
abstract::Some of the very first chemosensory mutants in Drosophila were generated in screens done in the 1970s at Obaid Siddiqi's lab in Tata Institute of Fundamental Research (TIFR), Mumbai. This is a personal account of some of the early work with these mutants, which led to their physiological and molecular characterization...
journal_title:Journal of neurogenetics
pub_type: 历史文章,杂志文章
doi:10.3109/01677063.2012.677880
更新日期:2012-09-01 00:00:00
abstract::This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.3109/01677063.2011.650253
更新日期:2012-06-01 00:00:00
abstract::Predictions from the theory of transfection, Karl-Friedrich Fischbach's first paper, were confirmed 20 years later. Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functio...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2013.873430
更新日期:2014-09-01 00:00:00
abstract::Messenger RNA editing of transcripts encoding voltage-sensitive ion channels has not been extensively analyzed--least of all in Drosophila, for which several channel-encoding genes are known. Previous sequence studies of D. melanogaster's cacophony gene, which encodes an alpha 1 calcium-channel subunit called Dmca1A, ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069809108560
更新日期:1998-11-01 00:00:00
abstract::Mutants displaying generalized behavioral defects and one mutant having an enzyme deficiency were examined for electroretinogram (ERG) defects. Mutations in nine genes were examined that cause ERG defects. Two, parats4 and slrpD, cause reversibly temperature dependent loss of the off-transients in the ERG. stnC and Ty...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068909167263
更新日期:1989-01-01 00:00:00
abstract::The development of the olfactory sense organs on the antenna of the fruit fly Drosophila utilises mechanisms distinct from those used in the rest of the adult peripheral nervous system. Lozenge (lz) is the only locus hither-to identified as required for the development of antennal sense organs. In addition to effects ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069509083460
更新日期:1995-12-01 00:00:00
abstract::This report contains additional observations on the cell lineage relationships of the motor neurons of the facial nucleus and of the cerebellar Purkinje cells of the mouse. These cell populations were quantitatively analyzed in the mosaic brains of experimental aggregation chimeras. The cell markers used to perform th...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068409107092
更新日期:1984-12-01 00:00:00
abstract::Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2011.642910
更新日期:2012-03-01 00:00:00
abstract::Neural tube defects (NTD) are a common birth defect, with both genetic and environmental contributions to their etiology. In mouse, null mutations in Noggin result in fully-penetrant NTDs. We investigated Noggin for mutations that may predispose to human NTDs in 202 NTD cases. One variant allele was identified in a ma...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward lo...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.1080/01677060802298509
更新日期:2008-01-01 00:00:00
abstract::Immature D. melanogaster males, like virgin females, often elicit vigorous courtship from mature males. Since males perform the same behaviors in response to attractive males and females, the question arises as to whether the foci--cells in the courting male's nervous system that must be haplo-X for the fly to perform...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068909107103
更新日期:1989-11-01 00:00:00
abstract::Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, T...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677060590949692
更新日期:2005-01-01 00:00:00