Abstract:
:The Drosophila receptor oscillation A (rosA) mutations, which cause electroretinogram (ERG) defects, including oscillations, were localized to the 24F4-25A2 region of chromosome 2L. Genomic fragments from this region, isolated from bacteriophage P1 clones, included those that detect transcriptional defects in rosA mutants in RNA blot experiments. One of these genomic fragments was used to screen a head cDNA library. The largest cDNA clone (3.6 kb) isolated was shown to rescue a rosA mutant in P element-germline transformation experiments. The ROSA protein deduced from the open reading frame in the 3.6 kb rosA cDNA is 943 amino acids long and is 36-41% identical to members of the superfamily of Na+/Cl(-)-dependent neurotransmitter transporters, with no indication of higher sequence identity to any one subgroup within the superfamily. RNA blot experiments revealed multiple transcripts in various developmental stages, the most abundant one being a 3.7 kb transcript, particularly in the adult head. Tissue in situ experiments identified the rosA transcript to be localized to many tissues, with higher levels of hybridization in the nervous system and digestive tract. The results demonstrate that the rosA gene encodes a novel Na+/Cl(-)-dependent transporter important for normal response properties of the photoreceptor.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Burg MG,Geng C,Guan Y,Koliantz G,Pak WLdoi
10.3109/01677069609107063subject
Has Abstractpub_date
1996-12-01 00:00:00pages
59-79issue
1-2eissn
0167-7063issn
1563-5260journal_volume
11pub_type
杂志文章abstract::The horizontal system and vertical system cells of the dipteran optic lobes are well understood regarding their physiology and role in visually guided behavior. Little is known, however, about their development. Drosophila optomotor-blind (omb) is required for the development of the HS/VS cells which are lacking in th...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2014.917645
更新日期:2014-09-01 00:00:00
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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doi:10.3109/01677063.2015.1050097
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journal_title:Journal of neurogenetics
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doi:
更新日期:2002-01-01 00:00:00
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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