Abstract:
:Mutations at two fragile sites, FRAXA and FRAXE, loci are caused by an expansion of a CGG/GCC trinucleotide repeat and are characterized by mental retardation. Here we report molecular screening survey of 97 unrelated individuals diagnosed with non-specific mental retardation (MR), which produced positive test for FRAXA in two boys and none positive for the FRAXE mutation. In addition, we studied allelic frequency distribution for the FRAXA locus in this group of mentally retarded patients, as well as in the 99 healthy subjects of Yugoslav population. The distribution of FMR1 CGG repeat size in both groups was similar: the most common allele contained 29 repeats (32.86% in the healthy population and 54.54% in MR population), followed by the allele with 28 CGG repeats (21.43% in the healthy and 12.2% in MR population). Premutation alleles with more than 45 repeats were not found in control nor in the MR group.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Major T,Culjkovic B,Stojkovic O,Gucscekic M,Lakic A,Romac Sdoi
10.1080/neg.17.2-3.223.230subject
Has Abstractpub_date
2003-04-01 00:00:00pages
223-30issue
2-3eissn
0167-7063issn
1563-5260pii
M6HKRR3HGH92YAAXjournal_volume
17pub_type
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