Abstract：
:We have identified helmsman (hlm), which is expressed in the fruit fly photoreceptor cells during neural network development. Hlm is also expressed in the elongating cells of the embryonic trachea. Both photoreceptor neurons and embryonic trachea cells elongate in precise, targeted growth for cell-to-cell specific recognition. Expression of antisense hlm-interfering RNA during embryogenesis arrests elongation of the developing tracheal cells and blocks maturation. Expression of hlm-interfering RNA during visual system formation results in reduced visual acuity and poor performance in optomotor response, indicative of abnormal neural network development. Hlm is a unique cell surface protein with complement-like protein interaction motifs. We have also cloned hlm from Lucilia cuprina (Australian blowfly), which is approximately 100 million years divergent from Drosophila, and find a remarkable 90% protein identity over the entire 558 amino acid protein. Analysis of the hlm sequence found in other species indicates a significant evolutionary pressure to maintain the hlm protein sequence. Our interpretation is that hlm is involved in cell maturation in both the elongating trachea and elongating photoreceptor cells. Cell adhesion and cell signaling, which are known to use immunoglobulin-like cell adhesion molecules, may use molecular systems analogous to complement to create protein complexes to regulate growth.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
McKay JP,Nightingale B,Pollock JAdoi
10.1080/01677060801893276subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1issue
2eissn
0167-7063issn
1563-5260pii
792344799journal_volume
22pub_type
杂志文章abstract：:Some of the very first chemosensory mutants in Drosophila were generated in screens done in the 1970s at Obaid Siddiqi's lab in Tata Institute of Fundamental Research (TIFR), Mumbai. This is a personal account of some of the early work with these mutants, which led to their physiological and molecular characterization...
journal_title：Journal of neurogenetics
pub_type： 历史文章,杂志文章
doi：10.3109/01677063.2012.677880
更新日期：2012-09-01 00:00:00
abstract：:Most insertional mutagenesis screens of Drosophila performed to date have not used target chromosomes that have been checked for their suitability for phenotypic screens for viable phenotypes. To address this, we have generated a selection of stocks carrying either isogenized second chromosomes or isogenized third chr...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060591007155
更新日期：2005-04-01 00:00:00
abstract：:One of the most fascinating questions in evolutionary biology is how traits unique to humans, such as their high cognitive abilities, erect bipedalism, and hairless skin, are encoded in the genome. Recent advances in genomics have begun to reveal differences between the genomes of the great apes. It has become evident...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2013.789512
更新日期：2013-09-01 00:00:00
abstract：:Altered synaptic strength underlies information storage in neural circuits. Neuromodulatory transmitters such as norepinephrine (NE) facilitate long-lasting synaptic plasticity by recruiting and modifying multiple molecular elements of synaptic signaling, including specific transmitter receptors, intracellular protein...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677063.2018.1497630
更新日期：2018-09-01 00:00:00
abstract：:Animals make decisions on behavioral choice by evaluating internal and external signals. Individuals often make decisions in different ways, but the underlying neural mechanisms are not well understood. Here, we describe a system for observing the behavior of individual Drosophila melanogaster larvae simultaneously pr...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2016.1202949
更新日期：2016-01-01 00:00:00
abstract：:Many declared aims of the genome projects have been achieved. The total genomic sequences of several relatively noncomplex/complex organisms (such as E. coli, yeast, Caenorhabditis, Drosophila) are being determined, and the nucleotide sequencing of the entire human genome will be complete in the near future. However, ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677060109167373
更新日期：2001-01-01 00:00:00
abstract：:The molecular analysis of the Notch locus of Drosophila melanogaster demonstrated that it codes for a protein which shows homology to the epidermal growth factor as well as to the products of certain yeast genes involved in the control of the cell cycle (Wharton et al., 1985a; Breeden and Nasmyth, 1987). The structure...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068909107097
更新日期：1989-09-01 00:00:00
abstract：:Each neuropil module, or cartridge, in the fly's lamina has a fixed complement of cells. Of five types of monopolar cell interneurons, only L4 has collaterals that invade neighboring cartridges. In the proximal lamina, these collaterals form reciprocal synapses with both the L2 of their own cartridge and the L4 collat...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2014.883390
更新日期：2014-09-01 00:00:00
abstract：:SPG3A/atlastin-1 gene mutations cause an autosomal dominant form of hereditary spastic paraplegia (SPG3A-HSP). We used positron emission tomography with [(11)C]DTBZ to assess nigrostriatal dopaminergic integrity in two unrelated adults with SPG3A-HSP due to the common SPG3A/atlastin-1 mutation, R239C. Nigrostriatal do...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060802337307
更新日期：2008-01-01 00:00:00
abstract：:Trembler-J, TrJ, is a peripheral hypomyelinating murine mutant. In intercrosses (TrJ/ + X TrJ/ +) there are severely affected (behaviorally and pathologically), mildly affected, and normal offspring, while backcrosses (TrJ/ + X + / +) produce only mildly affected and normal offspring. We used the closely linked marker...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068309107071
更新日期：1983-09-01 00:00:00
abstract：:A new autosomal recessive mutation, characterized by an early defect in righting reflex and stiffened gait, progression to severe spasticity, tremor and rigidity, and death before weaning, appeared spontaneously on the C57BL/6 background. It was shown to be an allele of the mutant spastic spa, and shall be known as sp...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:C. elegans animals mutant for the unc-119 gene exhibit movement, sensory and behavioral abnormalities. Consistent with a nervous system role, unc-119 reporter genes are expressed throughout the C. elegans nervous system. The UNC-119 protein has strong sequence similarity to the predicted protein from a human gene, HRG...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677060009084494
更新日期：2000-01-01 00:00:00
abstract：:A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have gues...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2020.1833879
更新日期：2020-09-01 00:00:00
abstract：:Inbred mice of the DBA/2J and C57BL/6J strains are known to differ in physiological and behavioral characteristics that are partially controlled by nuclei in the preoptic area/anterior hypothalamus. We describe a distinguishing nucleus of darkly staining, densely packed cells, which we term the medioventral pars compa...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068509101424
更新日期：1985-12-01 00:00:00
abstract：:When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677063.2017.1324857
更新日期：2017-01-01 00:00:00
abstract：:Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.642910
更新日期：2012-03-01 00:00:00
abstract：:The horizontal system and vertical system cells of the dipteran optic lobes are well understood regarding their physiology and role in visually guided behavior. Little is known, however, about their development. Drosophila optomotor-blind (omb) is required for the development of the HS/VS cells which are lacking in th...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2014.917645
更新日期：2014-09-01 00:00:00
abstract：:Newly eclosed Drosophila melanogaster flies were systemically depleted of dopamine by feeding an inhibitor of the biosynthetic enzyme, tyrosine hydroxylase, and analyzed for abnormalities in courtship behavior. Dopamine-depleted females were significantly less receptive to males than were control females, although mal...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677069809167259
更新日期：1998-03-01 00:00:00
abstract：:Intrahippocampal microinjections with anti-Met-enkephalin antiserum enhanced novelty-induced vertically oriented exploratory acts and horizontal locomotor activity in inbred mouse strain DBA/2 and reduced these behaviors in C57BL/6 so that strain differences originally present between the normal serum controls were el...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068609106848
更新日期：1986-05-01 00:00:00
abstract：:Courtship suppression is an associative conditioning procedure in Drosophila melanogaster that is ethologically based and capable of being tested on individual flies. We have expanded the range of the courtship conditioning by developing an excitatory procedure in which male flies learn to associate a novel odor with ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:A telomere is a repetitive DNA structure at chromosomal ends that stabilizes the chromosome structure and prevents harmful end-to-end recombinations. The telomere length of somatic cells becomes shorter with aging because of the "end replication problem." This telomere shortening is accelerated by pathophysiological c...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.651665
更新日期：2012-06-01 00:00:00
abstract：:The slo gene encodes the BK-type Ca(2+)-activated K(+) channels. In Drosophila, expression of slo is induced by organic solvent sedation (benzyl alcohol and ethanol), and this increase in neural slo expression contributes to the production of functional behavioral tolerance (inducible resistance) to these drugs. Withi...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2015.1050097
更新日期：2015-01-01 00:00:00
abstract：:Caenorhabditis elegans has a simple nervous system of 302 neurons. It however senses environmental cues incredibly precisely and produces various behaviors by processing information in the neural circuit. In addition to classical genetic analysis, fluorescent proteins and calcium indicators enable in vivo monitoring o...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2020.1734001
更新日期：2020-09-01 00:00:00
abstract：:This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward lo...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677060802298509
更新日期：2008-01-01 00:00:00
abstract：:Some cases of Alzheimer's disease are inherited as a dominant trait in humans. To date, mutations in three genes account for some of them: the amyloid precursor protein (APP) and presenilins 1 and 2 (PS-1 and PS-2, respectively). The function of the presenilins is still unclear, although they belong to a transmembrane...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677069809108554
更新日期：1998-01-01 00:00:00
abstract：:Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2015.1091452
更新日期：2015-01-01 00:00:00
abstract：:Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2018.1497629
更新日期：2018-09-01 00:00:00
abstract：:The aim of this review is to summarize the history of Dr. Yoshiki Hotta and his collaborators' contributions to the research field of Drosophila phototransduction. The electroretinogram-defective mutants reported in 1970 by Dr. Hotta and Dr. Seymour Benzer in the article entitled "Genetic dissection of the Drosophila ...
journal_title：Journal of neurogenetics
pub_type： 传,历史文章,杂志文章
doi：10.3109/01677063.2011.647144
更新日期：2012-03-01 00:00:00
abstract：:This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2011.650253
更新日期：2012-06-01 00:00:00
abstract：:A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068609106846
更新日期：1986-05-01 00:00:00
