Dopamine modulates female sexual receptivity in Drosophila melanogaster.

abstract：:One of the most fascinating questions in evolutionary biology is how traits unique to humans, such as their high cognitive abilities, erect bipedalism, and hairless skin, are encoded in the genome. Recent advances in genomics have begun to reveal differences between the genomes of the great apes. It has become evident...

journal_title：Journal of neurogenetics

authors： Sassa T

更新日期：2013-09-01 00:00:00

abstract：:Intrahippocampal microinjections with anti-Met-enkephalin antiserum enhanced novelty-induced vertically oriented exploratory acts and horizontal locomotor activity in inbred mouse strain DBA/2 and reduced these behaviors in C57BL/6 so that strain differences originally present between the normal serum controls were el...

journal_title：Journal of neurogenetics

authors： van Abeelen JH,Gerads HJ

更新日期：1986-05-01 00:00:00

abstract：:Signaling from the postsynaptic compartment regulates multiple aspects of synaptic development and function. Syntaxin 4 (Syx4) is a plasma membrane t-SNARE that promotes the growth and plasticity of Drosophila neuromuscular junctions (NMJs) by regulating the localization of key synaptic proteins in the postsynaptic co...

journal_title：Journal of neurogenetics

authors： Harris KP,Littleton JT,Stewart BA

更新日期：2018-09-01 00:00:00

abstract：:Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...

journal_title：Journal of neurogenetics

authors： Nicita F,Garone G,Papetti L,Consoli F,Magliozzi M,De Luca A,Spalice A

更新日期：2015-01-01 00:00:00

abstract：:Inbred mice of the DBA/2J and C57BL/6J strains are known to differ in physiological and behavioral characteristics that are partially controlled by nuclei in the preoptic area/anterior hypothalamus. We describe a distinguishing nucleus of darkly staining, densely packed cells, which we term the medioventral pars compa...

journal_title：Journal of neurogenetics

authors： Robinson SM,Fox TO,Sidman RL

更新日期：1985-12-01 00:00:00

abstract：:Predictions from the theory of transfection, Karl-Friedrich Fischbach's first paper, were confirmed 20 years later. Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functio...

journal_title：Journal of neurogenetics

authors： Spatz HC

更新日期：2014-09-01 00:00:00

abstract：:Autosomal recessive cerebellar ataxias are a group of clinically and genetically heterogeneous neurodegenerative disorders. Growing data have shown that there is difficulty with genetic counseling in a deeply consanguineous population because of the presence of genetic heterogeneity in patients sharing similar phenoty...

journal_title：Journal of neurogenetics

authors： Bouhlal Y,Zouari M,Kefi M,Ben Hamida C,Hentati F,Amouri R

更新日期：2008-01-01 00:00:00

abstract：:Altered synaptic strength underlies information storage in neural circuits. Neuromodulatory transmitters such as norepinephrine (NE) facilitate long-lasting synaptic plasticity by recruiting and modifying multiple molecular elements of synaptic signaling, including specific transmitter receptors, intracellular protein...

journal_title：Journal of neurogenetics

authors： Nguyen PV,Gelinas JN

更新日期：2018-09-01 00:00:00

abstract：:The horizontal system and vertical system cells of the dipteran optic lobes are well understood regarding their physiology and role in visually guided behavior. Little is known, however, about their development. Drosophila optomotor-blind (omb) is required for the development of the HS/VS cells which are lacking in th...

journal_title：Journal of neurogenetics

authors： Sen A,Grimm S,Hofmeyer K,Pflugfelder GO

更新日期：2014-09-01 00:00:00

abstract：:Most insertional mutagenesis screens of Drosophila performed to date have not used target chromosomes that have been checked for their suitability for phenotypic screens for viable phenotypes. To address this, we have generated a selection of stocks carrying either isogenized second chromosomes or isogenized third chr...

journal_title：Journal of neurogenetics

authors： Sharma P,Asztalos Z,Ayyub C,de Bruyne M,Dornan AJ,Gomez-Hernandez A,Keane J,Killeen J,Kramer S,Madhavan M,Roe H,Sherkhane PD,Siddiqi K,Silva E,Carlson JR,Goodwin SF,Heisenberg M,Krishnan K,Kyriacou CP,Partridge L,

更新日期：2005-04-01 00:00:00

abstract：:Based on unbeatable genetic accessibility and relative simplicity, the Drosophila larval neuromuscular junction has become a widely used model system for studying functional and structural aspects of excitatory glutamatergic synapses. Membrane-associated guanylate kinase-like proteins (MAGUKs) are first-order scaffold...

journal_title：Journal of neurogenetics

authors： Thomas U,Kobler O,Gundelfinger ED

更新日期：2010-09-01 00:00:00

abstract：:This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...

journal_title：Journal of neurogenetics

authors： Leung HT,Shino S,Kim E

更新日期：2012-06-01 00:00:00

abstract：:To date, less than 10 pedigrees have been reported with ZNF335 mutations since it was discovered in 2012 and little is known about ZNF335-related clinical spectrum. We describe a 12 years old male patient who is only child of nonconsanguineous Turkish parents. Trio whole genome sequencing identified previously unrepor...

journal_title：Journal of neurogenetics

authors： Caglayan AO,Yaghouti K,Kockaya T,Kemer D,Cankaya T,Ameziane N,Cogulu O,Coker M,Yalcinkaya C

更新日期：2020-11-20 00:00:00

abstract：:Courtship suppression is an associative conditioning procedure in Drosophila melanogaster that is ethologically based and capable of being tested on individual flies. We have expanded the range of the courtship conditioning by developing an excitatory procedure in which male flies learn to associate a novel odor with ...

journal_title：Journal of neurogenetics

authors： Broughton SJ,Tully T,Greenspan RJ

更新日期：2003-01-01 00:00:00

abstract：:The cell-surface-signaling protein Notch, is required for numerous developmental processes and typically specifies which of two adjacent cells will adopt a non-neuronal developmental fate. It has recently been implicated in long-term memory formation in mammals and Drosophila. Here, we investigated whether activity-de...

journal_title：Journal of neurogenetics

authors： de Bivort BL,Guo HF,Zhong Y

更新日期：2009-01-01 00:00:00

abstract：:Single-gene mutants of Drosophila have not only increased our understanding of the biochemical processes underlying learning and memory processes, but also established structure-function relationships. The first relevant mutants were identified by Martin Heisenberg nearly 30 years ago in a screen for altered adult bra...

journal_title：Journal of neurogenetics

authors： Hovhanyan A,Raabe T

更新日期：2009-01-01 00:00:00

abstract：:When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of...

journal_title：Journal of neurogenetics

authors： Qiu X,Martin GB,Blache D

更新日期：2017-01-01 00:00:00

abstract：:A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have gues...

journal_title：Journal of neurogenetics

authors： Chalfie M

更新日期：2020-09-01 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, T...

journal_title：Journal of neurogenetics

authors： Tajouri L,Ovcaric M,Curtain R,Johnson MP,Griffiths LR,Csurhes P,Pender MP,Lea RA

更新日期：2005-01-01 00:00:00

abstract：:A new autosomal recessive mutation, characterized by an early defect in righting reflex and stiffened gait, progression to severe spasticity, tremor and rigidity, and death before weaning, appeared spontaneously on the C57BL/6 background. It was shown to be an allele of the mutant spastic spa, and shall be known as sp...

journal_title：Journal of neurogenetics

authors： White WF,Regan LJ,Roe AW,Messer A

更新日期：1987-08-01 00:00:00

abstract：:Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...

journal_title：Journal of neurogenetics

authors： Agi E,Langen M,Altschuler SJ,Wu LF,Zimmermann T,Hiesinger PR

更新日期：2014-09-01 00:00:00

abstract：:Learnt predictive behavior faces a dilemma: predictive stimuli will never 'replay' exactly as during the learning event, requiring generalization. In turn, minute differences can become meaningful, prompting discrimination. To provide a study case for an adaptive adjustment of this generalization-discrimination balanc...

journal_title：Journal of neurogenetics

authors： Mishra D,Louis M,Gerber B

更新日期：2010-09-01 00:00:00

abstract：:Kinase-mediated signaling cascades regulate a number of different molecular mechanisms involved in cellular homeostasis, and are viewed as one of the most common intracellular processes that are robustly dysregulated in the pathophysiology of mood disorders such as depression. Newly emerged, rapid acting antidepressan...

journal_title：Journal of neurogenetics

authors： Yuan LL,Wauson E,Duric V

更新日期：2016-01-01 00:00:00

abstract：:The development of the olfactory sense organs on the antenna of the fruit fly Drosophila utilises mechanisms distinct from those used in the rest of the adult peripheral nervous system. Lozenge (lz) is the only locus hither-to identified as required for the development of antennal sense organs. In addition to effects ...

journal_title：Journal of neurogenetics

authors： Gupta BP,Rodrigues V

更新日期：1995-12-01 00:00:00

abstract：:The metabolism of leucine was studied in cultured human fibroblasts derived from patients with defects in each of the major steps in the catabolism of the amino acid. Intact fibroblasts were incubated with [U-14C]leucine and the organic acid products were isolated by liquid partition chromatography. In control fibrobl...

journal_title：Journal of neurogenetics

authors： Yoshida I,Søvik O,Sweetman L,Nyhan WL

更新日期：1985-12-01 00:00:00

abstract：:A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA...

journal_title：Journal of neurogenetics

authors： Breakefield XO,Bressman SB,Kramer PL,Ozelius L,Moskowitz C,Tanzi R,Brin MF,Hobbs W,Kaufman D,Tobin A

更新日期：1986-05-01 00:00:00

abstract：:A telomere is a repetitive DNA structure at chromosomal ends that stabilizes the chromosome structure and prevents harmful end-to-end recombinations. The telomere length of somatic cells becomes shorter with aging because of the "end replication problem." This telomere shortening is accelerated by pathophysiological c...

journal_title：Journal of neurogenetics

authors： Maeda T,Guan JZ,Koyanagi M,Higuchi Y,Makino N

更新日期：2012-06-01 00:00:00

abstract：:Based on the staining of Drosophila embryos with neuron-specific monoclonal antibodies we describe the differentiation of the earliest neurons in the central nervous system. The metameric array undergoes a number of changes during development that distinguish several morphological units: metameres, neuromeres and gang...

journal_title：Journal of neurogenetics

authors： Canal I,Ferrús A

更新日期：1986-09-01 00:00:00

abstract：:SPG3A/atlastin-1 gene mutations cause an autosomal dominant form of hereditary spastic paraplegia (SPG3A-HSP). We used positron emission tomography with [(11)C]DTBZ to assess nigrostriatal dopaminergic integrity in two unrelated adults with SPG3A-HSP due to the common SPG3A/atlastin-1 mutation, R239C. Nigrostriatal do...

journal_title：Journal of neurogenetics

authors： Albin RL,Koeppe RA,Rainier S,Fink JK

更新日期：2008-01-01 00:00:00

abstract：:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...

journal_title：Journal of neurogenetics

authors： Zeuner KE,Acewicz A,Knutzen A,Dressler D,Lohmann K,Witt K

更新日期：2016-01-01 00:00:00