Abstract:
:Signaling from the postsynaptic compartment regulates multiple aspects of synaptic development and function. Syntaxin 4 (Syx4) is a plasma membrane t-SNARE that promotes the growth and plasticity of Drosophila neuromuscular junctions (NMJs) by regulating the localization of key synaptic proteins in the postsynaptic compartment. Here, we describe electrophysiological analyses and report that loss of Syx4 leads to enhanced neurotransmitter release, despite a decrease in the number of active zones. We describe a requirement for postsynaptic Syx4 in regulating several presynaptic parameters, including Ca2+ cooperativity and the abundance of the presynaptic calcium channel Cacophony (Cac) at active zones. These findings indicate Syx4 negatively regulates presynaptic neurotransmitter release through a retrograde signaling mechanism from the postsynaptic compartment.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Harris KP,Littleton JT,Stewart BAdoi
10.1080/01677063.2018.1501372subject
Has Abstractpub_date
2018-09-01 00:00:00pages
221-229issue
3eissn
0167-7063issn
1563-5260journal_volume
32pub_type
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