Role of hippocampal Met-enkephalin in the genotype-dependent regulation of exploratory behavior in mice.

abstract：:Based on the staining of Drosophila embryos with neuron-specific monoclonal antibodies we describe the differentiation of the earliest neurons in the central nervous system. The metameric array undergoes a number of changes during development that distinguish several morphological units: metameres, neuromeres and gang...

journal_title：Journal of neurogenetics

authors： Canal I,Ferrús A

更新日期：1986-09-01 00:00:00

abstract：:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...

journal_title：Journal of neurogenetics

authors： Zeuner KE,Acewicz A,Knutzen A,Dressler D,Lohmann K,Witt K

更新日期：2016-01-01 00:00:00

abstract：:Autosomal recessive cerebellar ataxias are a group of clinically and genetically heterogeneous neurodegenerative disorders. Growing data have shown that there is difficulty with genetic counseling in a deeply consanguineous population because of the presence of genetic heterogeneity in patients sharing similar phenoty...

journal_title：Journal of neurogenetics

authors： Bouhlal Y,Zouari M,Kefi M,Ben Hamida C,Hentati F,Amouri R

更新日期：2008-01-01 00:00:00

abstract：:A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA...

journal_title：Journal of neurogenetics

authors： Breakefield XO,Bressman SB,Kramer PL,Ozelius L,Moskowitz C,Tanzi R,Brin MF,Hobbs W,Kaufman D,Tobin A

更新日期：1986-05-01 00:00:00

abstract：:Learnt predictive behavior faces a dilemma: predictive stimuli will never 'replay' exactly as during the learning event, requiring generalization. In turn, minute differences can become meaningful, prompting discrimination. To provide a study case for an adaptive adjustment of this generalization-discrimination balanc...

journal_title：Journal of neurogenetics

authors： Mishra D,Louis M,Gerber B

更新日期：2010-09-01 00:00:00

abstract：:We have identified helmsman (hlm), which is expressed in the fruit fly photoreceptor cells during neural network development. Hlm is also expressed in the elongating cells of the embryonic trachea. Both photoreceptor neurons and embryonic trachea cells elongate in precise, targeted growth for cell-to-cell specific rec...

journal_title：Journal of neurogenetics

authors： McKay JP,Nightingale B,Pollock JA

更新日期：2008-01-01 00:00:00

abstract：:Kinase-mediated signaling cascades regulate a number of different molecular mechanisms involved in cellular homeostasis, and are viewed as one of the most common intracellular processes that are robustly dysregulated in the pathophysiology of mood disorders such as depression. Newly emerged, rapid acting antidepressan...

journal_title：Journal of neurogenetics

authors： Yuan LL,Wauson E,Duric V

更新日期：2016-01-01 00:00:00

abstract：:A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have gues...

journal_title：Journal of neurogenetics

authors： Chalfie M

更新日期：2020-09-01 00:00:00

abstract：:Altered synaptic strength underlies information storage in neural circuits. Neuromodulatory transmitters such as norepinephrine (NE) facilitate long-lasting synaptic plasticity by recruiting and modifying multiple molecular elements of synaptic signaling, including specific transmitter receptors, intracellular protein...

journal_title：Journal of neurogenetics

authors： Nguyen PV,Gelinas JN

更新日期：2018-09-01 00:00:00

abstract：:Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2...

journal_title：Journal of neurogenetics

authors： Tse A,Lee AK,Takahashi N,Gong A,Kasai H,Tse FW

更新日期：2018-09-01 00:00:00

abstract：:Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...

journal_title：Journal of neurogenetics

authors： Agi E,Langen M,Altschuler SJ,Wu LF,Zimmermann T,Hiesinger PR

更新日期：2014-09-01 00:00:00

abstract：:The metabolism of leucine was studied in cultured human fibroblasts derived from patients with defects in each of the major steps in the catabolism of the amino acid. Intact fibroblasts were incubated with [U-14C]leucine and the organic acid products were isolated by liquid partition chromatography. In control fibrobl...

journal_title：Journal of neurogenetics

authors： Yoshida I,Søvik O,Sweetman L,Nyhan WL

更新日期：1985-12-01 00:00:00

abstract：:Disturbances in sleep are encountered in the majority of patients with depressive disorder. To elucidate the molecular mechanisms behind this relationship, we examined gene expression changes in a rodent model for disturbed sleep and depression. The animals were treated with daily injections of clomipramine to affect ...

journal_title：Journal of neurogenetics

authors： Lagus M,Gass N,Saharinen J,Savelyev S,Porkka-Heiskanen T,Paunio T

更新日期：2012-09-01 00:00:00

abstract：:Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neuro...

journal_title：Journal of neurogenetics

authors： Wei JY,Chung PC,Chu SY,Yu HH

更新日期：2019-03-01 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, T...

journal_title：Journal of neurogenetics

authors： Tajouri L,Ovcaric M,Curtain R,Johnson MP,Griffiths LR,Csurhes P,Pender MP,Lea RA

更新日期：2005-01-01 00:00:00

abstract：:Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...

journal_title：Journal of neurogenetics

authors： Nicita F,Garone G,Papetti L,Consoli F,Magliozzi M,De Luca A,Spalice A

更新日期：2015-01-01 00:00:00

abstract：:In the homozygous staggerer (sg/sg) mutant mouse, most of the Purkinje cells (the primary targets for olivocerebellar climbing fibers) are missing or ectopic. In this study, the organization and cell number of the inferior olivary complex in sg/sg were determined and compared to the inferior olive of the wildtype (+/+...

journal_title：Journal of neurogenetics

authors： Blatt GJ,Eisenman LM

更新日期：1985-02-01 00:00:00

abstract：:Mutants displaying generalized behavioral defects and one mutant having an enzyme deficiency were examined for electroretinogram (ERG) defects. Mutations in nine genes were examined that cause ERG defects. Two, parats4 and slrpD, cause reversibly temperature dependent loss of the off-transients in the ERG. stnC and Ty...

journal_title：Journal of neurogenetics

authors： Homyk T Jr,Pye Q

更新日期：1989-01-01 00:00:00

abstract：:This report contains additional observations on the cell lineage relationships of the motor neurons of the facial nucleus and of the cerebellar Purkinje cells of the mouse. These cell populations were quantitatively analyzed in the mosaic brains of experimental aggregation chimeras. The cell markers used to perform th...

journal_title：Journal of neurogenetics

authors： Herrup K,Wetts R,Diglio TJ

更新日期：1984-12-01 00:00:00

abstract：:When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of...

journal_title：Journal of neurogenetics

authors： Qiu X,Martin GB,Blache D

更新日期：2017-01-01 00:00:00

abstract：:Predictions from the theory of transfection, Karl-Friedrich Fischbach's first paper, were confirmed 20 years later. Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functio...

journal_title：Journal of neurogenetics

authors： Spatz HC

更新日期：2014-09-01 00:00:00

abstract：:The slo gene encodes the BK-type Ca(2+)-activated K(+) channels. In Drosophila, expression of slo is induced by organic solvent sedation (benzyl alcohol and ethanol), and this increase in neural slo expression contributes to the production of functional behavioral tolerance (inducible resistance) to these drugs. Withi...

journal_title：Journal of neurogenetics

authors： Li X,Ghezzi A,Krishnan HR,Pohl JB,Bohm AY,Atkinson NS

更新日期：2015-01-01 00:00:00

abstract：:Cacna1f gene mutation could lead to incomplete congenital stationary night blindness (iCSNB) disease. The CSNB-like phenotype rat is a spontaneous rat model caused by Cacna1f gene mutation. The present study explored the phenotypic properties of behavior performance in CSNB rats further. The vision-related behaviors o...

journal_title：Journal of neurogenetics

authors： An J,Wang L,Guo Q,Li L,Xia F,Zhang Z

更新日期：2012-09-01 00:00:00

abstract：:The serotonin transporter is an important regulator of serotonergic signaling. In order to analyze where the Drosophila melanogaster ortholog of the mammalian serotonin transporter (dSERT) is expressed in the nervous system, a dSERT antibody serum was used. Ectopic expression studies and loss of function analysis reve...

journal_title：Journal of neurogenetics

authors： Giang T,Ritze Y,Rauchfuss S,Ogueta M,Scholz H

更新日期：2011-03-01 00:00:00

abstract：:The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a...

journal_title：Journal of neurogenetics

authors： Martins de Carvalho L,Lauar Gonçalves J,Sondertoft Braga Pedersen A,Damasceno S,Elias Moreira Júnior R,Uceli Maioli T,Faria AMC,Brunialti Godard AL

更新日期：2019-03-01 00:00:00

abstract：:We have cloned the cDNA encoding human liver glycogen phosphorylase (glycogenosis type VI) from a fetal brain cDNA library. Liver(L) and muscle(M) phosphorylase cDNA probes were used to determine the relative abundance of mRNA encoding the L- and M-isozymes of phosphorylase in human fetal and adult tissues. The transc...

journal_title：Journal of neurogenetics

authors： Gorin FA,Mullinax RL,Ignacio PC,Neve RL,Kurnit DM

更新日期：1987-12-01 00:00:00

abstract：:The horizontal system and vertical system cells of the dipteran optic lobes are well understood regarding their physiology and role in visually guided behavior. Little is known, however, about their development. Drosophila optomotor-blind (omb) is required for the development of the HS/VS cells which are lacking in th...

journal_title：Journal of neurogenetics

authors： Sen A,Grimm S,Hofmeyer K,Pflugfelder GO

更新日期：2014-09-01 00:00:00

abstract：:Some cases of Alzheimer's disease are inherited as a dominant trait in humans. To date, mutations in three genes account for some of them: the amyloid precursor protein (APP) and presenilins 1 and 2 (PS-1 and PS-2, respectively). The function of the presenilins is still unclear, although they belong to a transmembrane...

journal_title：Journal of neurogenetics

authors： Marfany G,Del-Favero J,Valero R,De Jonghe C,Woodrow S,Hendriks L,Van Broeckhoven C,Gonzàlez-Duarte R

更新日期：1998-01-01 00:00:00

abstract：:We used the hippocampal slice to examine extracellular electrophysiological responses to nicotine and the difference in sensitivity to nicotine-induced electrophysiological effects between the DBA and C3H mouse strains. Nicotine enhanced CA1 population spikes (PS) evoked by Schaffer collateral stimulation in a concent...

journal_title：Journal of neurogenetics

authors： Freund RK,Wehner JM

更新日期：1987-04-01 00:00:00

abstract：:Immature D. melanogaster males, like virgin females, often elicit vigorous courtship from mature males. Since males perform the same behaviors in response to attractive males and females, the question arises as to whether the foci--cells in the courting male's nervous system that must be haplo-X for the fly to perform...

journal_title：Journal of neurogenetics

authors： Napolitano LM,Tompkins L

更新日期：1989-11-01 00:00:00