abstract：:To date, less than 10 pedigrees have been reported with ZNF335 mutations since it was discovered in 2012 and little is known about ZNF335-related clinical spectrum. We describe a 12 years old male patient who is only child of nonconsanguineous Turkish parents. Trio whole genome sequencing identified previously unrepor...

journal_title：Journal of neurogenetics

authors： Caglayan AO,Yaghouti K,Kockaya T,Kemer D,Cankaya T,Ameziane N,Cogulu O,Coker M,Yalcinkaya C

更新日期：2020-11-20 00:00:00

abstract：:A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have gues...

journal_title：Journal of neurogenetics

authors： Chalfie M

更新日期：2020-09-01 00:00:00

abstract：:Caenorhabditis elegans has a simple nervous system of 302 neurons. It however senses environmental cues incredibly precisely and produces various behaviors by processing information in the neural circuit. In addition to classical genetic analysis, fluorescent proteins and calcium indicators enable in vivo monitoring o...

journal_title：Journal of neurogenetics

authors： Takeishi A,Takagaki N,Kuhara A

更新日期：2020-09-01 00:00:00

abstract：:From Sydney Brenner's backyard to hundreds of labs across the globe, inspiring six Nobel Prize winners along the way, Caenorhabditis elegans research has come far in the past half century. The journey is not over. The virtues of C. elegans research are numerous and have been recounted extensively. Here, we focus on th...

journal_title：Journal of neurogenetics

authors： Iliff AJ,Xu XZS

更新日期：2020-09-01 00:00:00

abstract：:Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neuro...

journal_title：Journal of neurogenetics

authors： Wei JY,Chung PC,Chu SY,Yu HH

更新日期：2019-03-01 00:00:00

abstract：:The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a...

journal_title：Journal of neurogenetics

authors： Martins de Carvalho L,Lauar Gonçalves J,Sondertoft Braga Pedersen A,Damasceno S,Elias Moreira Júnior R,Uceli Maioli T,Faria AMC,Brunialti Godard AL

更新日期：2019-03-01 00:00:00

abstract：:Signaling from the postsynaptic compartment regulates multiple aspects of synaptic development and function. Syntaxin 4 (Syx4) is a plasma membrane t-SNARE that promotes the growth and plasticity of Drosophila neuromuscular junctions (NMJs) by regulating the localization of key synaptic proteins in the postsynaptic co...

journal_title：Journal of neurogenetics

authors： Harris KP,Littleton JT,Stewart BA

更新日期：2018-09-01 00:00:00

abstract：:Altered synaptic strength underlies information storage in neural circuits. Neuromodulatory transmitters such as norepinephrine (NE) facilitate long-lasting synaptic plasticity by recruiting and modifying multiple molecular elements of synaptic signaling, including specific transmitter receptors, intracellular protein...

journal_title：Journal of neurogenetics

authors： Nguyen PV,Gelinas JN

更新日期：2018-09-01 00:00:00

abstract：:Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2...

journal_title：Journal of neurogenetics

authors： Tse A,Lee AK,Takahashi N,Gong A,Kasai H,Tse FW

更新日期：2018-09-01 00:00:00

abstract：:When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of...

journal_title：Journal of neurogenetics

authors： Qiu X,Martin GB,Blache D

更新日期：2017-01-01 00:00:00

abstract：:Sarcoglycanopathies (SGPs) constitute a subgroup of autosomal recessive limb girdle muscular dystrophies (LGMDs) which are caused by mutations in sarcoglycan (SGs) genes. SG proteins form a core complex consisting of α, β, γ and δ sarcoglycans which are encoded by SGCA, SGCB, SGCG and SGCD genes, respectively. Genetic...

journal_title：Journal of neurogenetics

authors： Mojbafan M,Nilipour Y,Tonekaboni SH,Bagheri SD,Bagherian H,Sharifi Z,Zeinali Z,Tavakkoly-Bazzaz J,Zeinali S

更新日期：2016-03-01 00:00:00

abstract：:Animals make decisions on behavioral choice by evaluating internal and external signals. Individuals often make decisions in different ways, but the underlying neural mechanisms are not well understood. Here, we describe a system for observing the behavior of individual Drosophila melanogaster larvae simultaneously pr...

journal_title：Journal of neurogenetics

authors： Koseki N,Mori S,Suzuki S,Tonooka Y,Kosugi S,Miyakawa H,Morimoto T

更新日期：2016-01-01 00:00:00

abstract：:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...

journal_title：Journal of neurogenetics

authors： Zeuner KE,Acewicz A,Knutzen A,Dressler D,Lohmann K,Witt K

更新日期：2016-01-01 00:00:00

abstract：:Kinase-mediated signaling cascades regulate a number of different molecular mechanisms involved in cellular homeostasis, and are viewed as one of the most common intracellular processes that are robustly dysregulated in the pathophysiology of mood disorders such as depression. Newly emerged, rapid acting antidepressan...

journal_title：Journal of neurogenetics

authors： Yuan LL,Wauson E,Duric V

更新日期：2016-01-01 00:00:00

abstract：:The slo gene encodes the BK-type Ca(2+)-activated K(+) channels. In Drosophila, expression of slo is induced by organic solvent sedation (benzyl alcohol and ethanol), and this increase in neural slo expression contributes to the production of functional behavioral tolerance (inducible resistance) to these drugs. Withi...

journal_title：Journal of neurogenetics

authors： Li X,Ghezzi A,Krishnan HR,Pohl JB,Bohm AY,Atkinson NS

更新日期：2015-01-01 00:00:00

abstract：:Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...

journal_title：Journal of neurogenetics

authors： Nicita F,Garone G,Papetti L,Consoli F,Magliozzi M,De Luca A,Spalice A

更新日期：2015-01-01 00:00:00

abstract：:The horizontal system and vertical system cells of the dipteran optic lobes are well understood regarding their physiology and role in visually guided behavior. Little is known, however, about their development. Drosophila optomotor-blind (omb) is required for the development of the HS/VS cells which are lacking in th...

journal_title：Journal of neurogenetics

authors： Sen A,Grimm S,Hofmeyer K,Pflugfelder GO

更新日期：2014-09-01 00:00:00

abstract：:Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...

journal_title：Journal of neurogenetics

authors： Agi E,Langen M,Altschuler SJ,Wu LF,Zimmermann T,Hiesinger PR

更新日期：2014-09-01 00:00:00

abstract：:Each neuropil module, or cartridge, in the fly's lamina has a fixed complement of cells. Of five types of monopolar cell interneurons, only L4 has collaterals that invade neighboring cartridges. In the proximal lamina, these collaterals form reciprocal synapses with both the L2 of their own cartridge and the L4 collat...

journal_title：Journal of neurogenetics

authors： Lüthy K,Ahrens B,Rawal S,Lu Z,Tarnogorska D,Meinertzhagen IA,Fischbach KF

更新日期：2014-09-01 00:00:00

abstract：:Predictions from the theory of transfection, Karl-Friedrich Fischbach's first paper, were confirmed 20 years later. Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functio...

journal_title：Journal of neurogenetics

authors： Spatz HC

更新日期：2014-09-01 00:00:00

abstract：:Membrane fusion is essential for the communication of membrane-defined compartments, development of multicellular organisms and tissue homeostasis. Although membrane fusion has been studied extensively, still little is known about the molecular mechanisms. Especially the intercellular fusion of cells during developmen...

journal_title：Journal of neurogenetics

authors： Önel SF,Rust MB,Jacob R,Renkawitz-Pohl R

更新日期：2014-09-01 00:00:00

abstract：:One of the most fascinating questions in evolutionary biology is how traits unique to humans, such as their high cognitive abilities, erect bipedalism, and hairless skin, are encoded in the genome. Recent advances in genomics have begun to reveal differences between the genomes of the great apes. It has become evident...

journal_title：Journal of neurogenetics

authors： Sassa T

更新日期：2013-09-01 00:00:00

abstract：:Disturbances in sleep are encountered in the majority of patients with depressive disorder. To elucidate the molecular mechanisms behind this relationship, we examined gene expression changes in a rodent model for disturbed sleep and depression. The animals were treated with daily injections of clomipramine to affect ...

journal_title：Journal of neurogenetics

authors： Lagus M,Gass N,Saharinen J,Savelyev S,Porkka-Heiskanen T,Paunio T

更新日期：2012-09-01 00:00:00

abstract：:Some of the very first chemosensory mutants in Drosophila were generated in screens done in the 1970s at Obaid Siddiqi's lab in Tata Institute of Fundamental Research (TIFR), Mumbai. This is a personal account of some of the early work with these mutants, which led to their physiological and molecular characterization...

journal_title：Journal of neurogenetics

authors： Hasan G

更新日期：2012-09-01 00:00:00

abstract：:Abstract: This essay is dedicated to Obaid on the occasion of his 80th birthday. We both worked on the behavior of Drosophila and on what underlies behavior in the fly brain. Is that the fly's mind? The essay is about some limitations of brain science. It is just a little piece of writing. It is meant to honor Obaid f...

journal_title：Journal of neurogenetics

authors： Heisenberg M

更新日期：2012-09-01 00:00:00

abstract：:Cacna1f gene mutation could lead to incomplete congenital stationary night blindness (iCSNB) disease. The CSNB-like phenotype rat is a spontaneous rat model caused by Cacna1f gene mutation. The present study explored the phenotypic properties of behavior performance in CSNB rats further. The vision-related behaviors o...

journal_title：Journal of neurogenetics

authors： An J,Wang L,Guo Q,Li L,Xia F,Zhang Z

更新日期：2012-09-01 00:00:00

abstract：:This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...

journal_title：Journal of neurogenetics

authors： Leung HT,Shino S,Kim E

更新日期：2012-06-01 00:00:00

abstract：:A telomere is a repetitive DNA structure at chromosomal ends that stabilizes the chromosome structure and prevents harmful end-to-end recombinations. The telomere length of somatic cells becomes shorter with aging because of the "end replication problem." This telomere shortening is accelerated by pathophysiological c...

journal_title：Journal of neurogenetics

authors： Maeda T,Guan JZ,Koyanagi M,Higuchi Y,Makino N

更新日期：2012-06-01 00:00:00

abstract：:Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...

journal_title：Journal of neurogenetics

authors： Masuyama K,Zhang Y,Rao Y,Wang JW

更新日期：2012-03-01 00:00:00

abstract：:The aim of this review is to summarize the history of Dr. Yoshiki Hotta and his collaborators' contributions to the research field of Drosophila phototransduction. The electroretinogram-defective mutants reported in 1970 by Dr. Hotta and Dr. Seymour Benzer in the article entitled "Genetic dissection of the Drosophila ...

journal_title：Journal of neurogenetics

authors： Suzuki E,Masai I,Inoue H

更新日期：2012-03-01 00:00:00

abstract：:Glioblastoma multiform (GBM; World Health Organization (WHO) grade IV) and anaplastic astrocytomas (AA; WHO grade III) are highly aggressive and lethal astrocytic brain tumors. To detect cancer-specific somatic mutations in two hot-spot regions of PIK3CA gene, the helical and kinase domains (encoded by exons 9 and 20,...

journal_title：Journal of neurogenetics

authors： Derakhshandeh-Peykar P,Alivi J,Hossein-nezhad A,Rautenstrauss B,Vesal RE,Doriani A

更新日期：2011-12-01 00:00:00

abstract：:The serotonin transporter is an important regulator of serotonergic signaling. In order to analyze where the Drosophila melanogaster ortholog of the mammalian serotonin transporter (dSERT) is expressed in the nervous system, a dSERT antibody serum was used. Ectopic expression studies and loss of function analysis reve...

journal_title：Journal of neurogenetics

authors： Giang T,Ritze Y,Rauchfuss S,Ogueta M,Scholz H

更新日期：2011-03-01 00:00:00

abstract：:Based on unbeatable genetic accessibility and relative simplicity, the Drosophila larval neuromuscular junction has become a widely used model system for studying functional and structural aspects of excitatory glutamatergic synapses. Membrane-associated guanylate kinase-like proteins (MAGUKs) are first-order scaffold...

journal_title：Journal of neurogenetics

authors： Thomas U,Kobler O,Gundelfinger ED

更新日期：2010-09-01 00:00:00

abstract：:Learnt predictive behavior faces a dilemma: predictive stimuli will never 'replay' exactly as during the learning event, requiring generalization. In turn, minute differences can become meaningful, prompting discrimination. To provide a study case for an adaptive adjustment of this generalization-discrimination balanc...

journal_title：Journal of neurogenetics

authors： Mishra D,Louis M,Gerber B

更新日期：2010-09-01 00:00:00

abstract：:The shape of a neuron, its morphological signature, dictates the neuron's function by establishing its synaptic partnerships. Here, we review various anatomical methods used to reveal neuron shape and the contributions these have made to our current understanding of neural function in the Drosophila brain, especially ...

journal_title：Journal of neurogenetics

authors： Meinertzhagen IA,Takemura SY,Lu Z,Huang S,Gao S,Ting CY,Lee CH

更新日期：2009-01-01 00:00:00

abstract：:The cell-surface-signaling protein Notch, is required for numerous developmental processes and typically specifies which of two adjacent cells will adopt a non-neuronal developmental fate. It has recently been implicated in long-term memory formation in mammals and Drosophila. Here, we investigated whether activity-de...

journal_title：Journal of neurogenetics

authors： de Bivort BL,Guo HF,Zhong Y

更新日期：2009-01-01 00:00:00

abstract：:Single-gene mutants of Drosophila have not only increased our understanding of the biochemical processes underlying learning and memory processes, but also established structure-function relationships. The first relevant mutants were identified by Martin Heisenberg nearly 30 years ago in a screen for altered adult bra...

journal_title：Journal of neurogenetics

authors： Hovhanyan A,Raabe T

更新日期：2009-01-01 00:00:00

abstract：:We have identified helmsman (hlm), which is expressed in the fruit fly photoreceptor cells during neural network development. Hlm is also expressed in the elongating cells of the embryonic trachea. Both photoreceptor neurons and embryonic trachea cells elongate in precise, targeted growth for cell-to-cell specific rec...

journal_title：Journal of neurogenetics

authors： McKay JP,Nightingale B,Pollock JA

更新日期：2008-01-01 00:00:00

abstract：:This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward lo...

journal_title：Journal of neurogenetics

authors： Ardiel EL,Rankin CH

更新日期：2008-01-01 00:00:00

abstract：:Autosomal recessive cerebellar ataxias are a group of clinically and genetically heterogeneous neurodegenerative disorders. Growing data have shown that there is difficulty with genetic counseling in a deeply consanguineous population because of the presence of genetic heterogeneity in patients sharing similar phenoty...

journal_title：Journal of neurogenetics

authors： Bouhlal Y,Zouari M,Kefi M,Ben Hamida C,Hentati F,Amouri R

更新日期：2008-01-01 00:00:00