Abstract:
:Based on unbeatable genetic accessibility and relative simplicity, the Drosophila larval neuromuscular junction has become a widely used model system for studying functional and structural aspects of excitatory glutamatergic synapses. Membrane-associated guanylate kinase-like proteins (MAGUKs) are first-order scaffolding molecules enriched at many cellular junctions, including synapses, where they coordinate multiple binding partners, including cell adhesion molecules and ion channels. The enrichment of the prototypic MAGUK Discs-Large at larval NMJs apparently parallels the high abundance of its homologs at excitatory synapses in the mammalian central nervous system. Here, the authors review selected aspects of the long-standing work on Dlg at fly neuromuscular junctions, thereby scrutinizing its subcellular localization, function, and regulation with regard to corresponding aspects of MAGUKs in vertebrate neurons.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Thomas U,Kobler O,Gundelfinger EDdoi
10.3109/01677063.2010.493589subject
Has Abstractpub_date
2010-09-01 00:00:00pages
109-19issue
3eissn
0167-7063issn
1563-5260journal_volume
24pub_type
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