Abstract:
:This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward locomotion, an action known as the tap-withdrawal response. This behavior has been thoroughly characterized and the neural circuit mediating it has been determined. The response habituates following repeated stimulation, and current work is aimed at elucidating the mechanism behind this simple form of nonassociative learning. Changes in cell excitability and the strength of glutamatergic synapses play key roles in mediating this plasticity.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Ardiel EL,Rankin CHdoi
10.1080/01677060802298509subject
Has Abstractpub_date
2008-01-01 00:00:00pages
239-55issue
3eissn
0167-7063issn
1563-5260pii
905566269journal_volume
22pub_type
杂志文章,评审abstract::Newly eclosed Drosophila melanogaster flies were systemically depleted of dopamine by feeding an inhibitor of the biosynthetic enzyme, tyrosine hydroxylase, and analyzed for abnormalities in courtship behavior. Dopamine-depleted females were significantly less receptive to males than were control females, although mal...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069809167259
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journal_title:Journal of neurogenetics
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::Signaling from the postsynaptic compartment regulates multiple aspects of synaptic development and function. Syntaxin 4 (Syx4) is a plasma membrane t-SNARE that promotes the growth and plasticity of Drosophila neuromuscular junctions (NMJs) by regulating the localization of key synaptic proteins in the postsynaptic co...
journal_title:Journal of neurogenetics
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abstract::The molecular analysis of the Notch locus of Drosophila melanogaster demonstrated that it codes for a protein which shows homology to the epidermal growth factor as well as to the products of certain yeast genes involved in the control of the cell cycle (Wharton et al., 1985a; Breeden and Nasmyth, 1987). The structure...
journal_title:Journal of neurogenetics
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doi:10.3109/01677068909107097
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journal_title:Journal of neurogenetics
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doi:10.3109/01677063.2014.917645
更新日期:2014-09-01 00:00:00
abstract::The development of the olfactory sense organs on the antenna of the fruit fly Drosophila utilises mechanisms distinct from those used in the rest of the adult peripheral nervous system. Lozenge (lz) is the only locus hither-to identified as required for the development of antennal sense organs. In addition to effects ...
journal_title:Journal of neurogenetics
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doi:10.3109/01677069509083460
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abstract::Trembler-J, TrJ, is a peripheral hypomyelinating murine mutant. In intercrosses (TrJ/ + X TrJ/ +) there are severely affected (behaviorally and pathologically), mildly affected, and normal offspring, while backcrosses (TrJ/ + X + / +) produce only mildly affected and normal offspring. We used the closely linked marker...
journal_title:Journal of neurogenetics
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abstract::Courtship suppression is an associative conditioning procedure in Drosophila melanogaster that is ethologically based and capable of being tested on individual flies. We have expanded the range of the courtship conditioning by developing an excitatory procedure in which male flies learn to associate a novel odor with ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Some cases of Alzheimer's disease are inherited as a dominant trait in humans. To date, mutations in three genes account for some of them: the amyloid precursor protein (APP) and presenilins 1 and 2 (PS-1 and PS-2, respectively). The function of the presenilins is still unclear, although they belong to a transmembrane...
journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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更新日期:1987-12-01 00:00:00
abstract::The Drosophila receptor oscillation A (rosA) mutations, which cause electroretinogram (ERG) defects, including oscillations, were localized to the 24F4-25A2 region of chromosome 2L. Genomic fragments from this region, isolated from bacteriophage P1 clones, included those that detect transcriptional defects in rosA mut...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
abstract::A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode Caenorhabditis elegans. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have gues...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
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journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106846
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journal_title:Journal of neurogenetics
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abstract::Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...
journal_title:Journal of neurogenetics
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更新日期:2012-03-01 00:00:00
abstract::This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.3109/01677063.2011.650253
更新日期:2012-06-01 00:00:00
abstract::Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neuro...
journal_title:Journal of neurogenetics
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更新日期:2019-03-01 00:00:00
abstract::We used the hippocampal slice to examine extracellular electrophysiological responses to nicotine and the difference in sensitivity to nicotine-induced electrophysiological effects between the DBA and C3H mouse strains. Nicotine enhanced CA1 population spikes (PS) evoked by Schaffer collateral stimulation in a concent...
journal_title:Journal of neurogenetics
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abstract::Immature D. melanogaster males, like virgin females, often elicit vigorous courtship from mature males. Since males perform the same behaviors in response to attractive males and females, the question arises as to whether the foci--cells in the courting male's nervous system that must be haplo-X for the fly to perform...
journal_title:Journal of neurogenetics
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journal_title:Journal of neurogenetics
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pub_type: 历史文章,杂志文章
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abstract::The shape of a neuron, its morphological signature, dictates the neuron's function by establishing its synaptic partnerships. Here, we review various anatomical methods used to reveal neuron shape and the contributions these have made to our current understanding of neural function in the Drosophila brain, especially ...
journal_title:Journal of neurogenetics
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abstract::Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.1080/01677063.2017.1324857
更新日期:2017-01-01 00:00:00
abstract::Sarcoglycanopathies (SGPs) constitute a subgroup of autosomal recessive limb girdle muscular dystrophies (LGMDs) which are caused by mutations in sarcoglycan (SGs) genes. SG proteins form a core complex consisting of α, β, γ and δ sarcoglycans which are encoded by SGCA, SGCB, SGCG and SGCD genes, respectively. Genetic...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2016.1141208
更新日期:2016-03-01 00:00:00
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journal_title:Journal of neurogenetics
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更新日期:2014-09-01 00:00:00
abstract::Many declared aims of the genome projects have been achieved. The total genomic sequences of several relatively noncomplex/complex organisms (such as E. coli, yeast, Caenorhabditis, Drosophila) are being determined, and the nucleotide sequencing of the entire human genome will be complete in the near future. However, ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
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journal_title:Journal of neurogenetics
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更新日期:2011-03-01 00:00:00
abstract::C. elegans animals mutant for the unc-119 gene exhibit movement, sensory and behavioral abnormalities. Consistent with a nervous system role, unc-119 reporter genes are expressed throughout the C. elegans nervous system. The UNC-119 protein has strong sequence similarity to the predicted protein from a human gene, HRG...
journal_title:Journal of neurogenetics
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更新日期:2000-01-01 00:00:00