Abstract：
:Messenger RNA editing of transcripts encoding voltage-sensitive ion channels has not been extensively analyzed--least of all in Drosophila, for which several channel-encoding genes are known. Previous sequence studies of D. melanogaster's cacophony gene, which encodes an alpha 1 calcium-channel subunit called Dmca1A, suggested that several nucleotides within the ORF of the primary transcript are edited such that "A-to-G" substitutions occur (these two nucleotides being the adenine that is found at the relevant sites in the sense strand of genomic DNA or the primary transcript, compared to the substitution of guanine that is detected at the level of cDNA analysis). Such A-to-G changes are the same kind of post-transcriptional variations originally discovered--in a neurobiological context--for a ligand-sensitive channel in vertebrates. Here, we extracted RNA from adult flies and revealed, by RT-PCR and restriction-enzyme analyses, that transcript heterogeneity exists in vivo for three distinct edited sites within the cac-encoded RNA. Each such nucleotide would lead to channel variability at the level of the Dmca1A polypeptide. Owing to cacophony being originally identified as a "behavioral gene," the possible significance of Dmca1A RNA editing for influencing the relevant neuro-functional phenotypes is discussed.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Smith LA,Peixoto AA,Hall JCdoi
10.3109/01677069809108560subject
Has Abstractpub_date
1998-11-01 00:00:00pages
227-40issue
4eissn
0167-7063issn
1563-5260journal_volume
12pub_type
杂志文章abstract：:C. elegans animals mutant for the unc-119 gene exhibit movement, sensory and behavioral abnormalities. Consistent with a nervous system role, unc-119 reporter genes are expressed throughout the C. elegans nervous system. The UNC-119 protein has strong sequence similarity to the predicted protein from a human gene, HRG...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677060009084494
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abstract：:Learnt predictive behavior faces a dilemma: predictive stimuli will never 'replay' exactly as during the learning event, requiring generalization. In turn, minute differences can become meaningful, prompting discrimination. To provide a study case for an adaptive adjustment of this generalization-discrimination balanc...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2010.498066
更新日期：2010-09-01 00:00:00
abstract：:Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2015.1091452
更新日期：2015-01-01 00:00:00
abstract：:Visual systems have a rich history as model systems for the discovery and understanding of basic principles underlying neuronal connectivity. The compound eyes of insects consist of up to thousands of small unit eyes that are connected by photoreceptor axons to set up a visual map in the brain. The photoreceptor axon ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2014.922557
更新日期：2014-09-01 00:00:00
abstract：:When individuals are exposed to stressful environmental challenges, the response varies widely in one or more of three components: psychology, behavior and physiology. This variability among individuals can be defined as temperament. In recent years, an increasing large body of evidence suggests that the dimensions of...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677063.2017.1324857
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abstract：:Courtship suppression is an associative conditioning procedure in Drosophila melanogaster that is ethologically based and capable of being tested on individual flies. We have expanded the range of the courtship conditioning by developing an excitatory procedure in which male flies learn to associate a novel odor with ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The molecular analysis of the Notch locus of Drosophila melanogaster demonstrated that it codes for a protein which shows homology to the epidermal growth factor as well as to the products of certain yeast genes involved in the control of the cell cycle (Wharton et al., 1985a; Breeden and Nasmyth, 1987). The structure...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068909107097
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journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068509100143
更新日期：1985-02-01 00:00:00
abstract：:We used the hippocampal slice to examine extracellular electrophysiological responses to nicotine and the difference in sensitivity to nicotine-induced electrophysiological effects between the DBA and C3H mouse strains. Nicotine enhanced CA1 population spikes (PS) evoked by Schaffer collateral stimulation in a concent...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:Some of the very first chemosensory mutants in Drosophila were generated in screens done in the 1970s at Obaid Siddiqi's lab in Tata Institute of Fundamental Research (TIFR), Mumbai. This is a personal account of some of the early work with these mutants, which led to their physiological and molecular characterization...
journal_title：Journal of neurogenetics
pub_type： 历史文章,杂志文章
doi：10.3109/01677063.2012.677880
更新日期：2012-09-01 00:00:00
abstract：:The Drosophila receptor oscillation A (rosA) mutations, which cause electroretinogram (ERG) defects, including oscillations, were localized to the 24F4-25A2 region of chromosome 2L. Genomic fragments from this region, isolated from bacteriophage P1 clones, included those that detect transcriptional defects in rosA mut...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677069609107063
更新日期：1996-12-01 00:00:00
abstract：:Disturbances in sleep are encountered in the majority of patients with depressive disorder. To elucidate the molecular mechanisms behind this relationship, we examined gene expression changes in a rodent model for disturbed sleep and depression. The animals were treated with daily injections of clomipramine to affect ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2012.694932
更新日期：2012-09-01 00:00:00
abstract：:The shape of a neuron, its morphological signature, dictates the neuron's function by establishing its synaptic partnerships. Here, we review various anatomical methods used to reveal neuron shape and the contributions these have made to our current understanding of neural function in the Drosophila brain, especially ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677060802610604
更新日期：2009-01-01 00:00:00
abstract：:This is the first of two reviews that include some of the studies that we, members of the Pak lab and collaborators, carried out from 1998 to 2010 on the functional and physical interactions among several Drosophila phototransduction components. The report includes our studies on the regulations and/or the functions o...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2011.650253
更新日期：2012-06-01 00:00:00
abstract：:Membrane fusion is essential for the communication of membrane-defined compartments, development of multicellular organisms and tissue homeostasis. Although membrane fusion has been studied extensively, still little is known about the molecular mechanisms. Especially the intercellular fusion of cells during developmen...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2014.936014
更新日期：2014-09-01 00:00:00
abstract：:Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2016.1238916
更新日期：2016-01-01 00:00:00
abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, T...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677060590949692
更新日期：2005-01-01 00:00:00
abstract：:Each neuropil module, or cartridge, in the fly's lamina has a fixed complement of cells. Of five types of monopolar cell interneurons, only L4 has collaterals that invade neighboring cartridges. In the proximal lamina, these collaterals form reciprocal synapses with both the L2 of their own cartridge and the L4 collat...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2014.883390
更新日期：2014-09-01 00:00:00
abstract：:This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward lo...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677060802298509
更新日期：2008-01-01 00:00:00
abstract：:Single-gene mutants of Drosophila have not only increased our understanding of the biochemical processes underlying learning and memory processes, but also established structure-function relationships. The first relevant mutants were identified by Martin Heisenberg nearly 30 years ago in a screen for altered adult bra...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.1080/01677060802471700
更新日期：2009-01-01 00:00:00
abstract：:Trembler-J, TrJ, is a peripheral hypomyelinating murine mutant. In intercrosses (TrJ/ + X TrJ/ +) there are severely affected (behaviorally and pathologically), mildly affected, and normal offspring, while backcrosses (TrJ/ + X + / +) produce only mildly affected and normal offspring. We used the closely linked marker...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677068309107071
更新日期：1983-09-01 00:00:00
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journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677069809167259
更新日期：1998-03-01 00:00:00
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journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.651665
更新日期：2012-06-01 00:00:00
abstract：:Mutations at two fragile sites, FRAXA and FRAXE, loci are caused by an expansion of a CGG/GCC trinucleotide repeat and are characterized by mental retardation. Here we report molecular screening survey of 97 unrelated individuals diagnosed with non-specific mental retardation (MR), which produced positive test for FRA...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/neg.17.2-3.223.230
更新日期：2003-04-01 00:00:00
abstract：:Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.642910
更新日期：2012-03-01 00:00:00
abstract：:Neural tube defects (NTD) are a common birth defect, with both genetic and environmental contributions to their etiology. In mouse, null mutations in Noggin result in fully-penetrant NTDs. We investigated Noggin for mutations that may predispose to human NTDs in 202 NTD cases. One variant allele was identified in a ma...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.1080/01677063.2018.1497629
更新日期：2018-09-01 00:00:00
abstract：:The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
abstract：:Based on unbeatable genetic accessibility and relative simplicity, the Drosophila larval neuromuscular junction has become a widely used model system for studying functional and structural aspects of excitatory glutamatergic synapses. Membrane-associated guanylate kinase-like proteins (MAGUKs) are first-order scaffold...
journal_title：Journal of neurogenetics
pub_type： 杂志文章,评审
doi：10.3109/01677063.2010.493589
更新日期：2010-09-01 00:00:00
abstract：:Glioblastoma multiform (GBM; World Health Organization (WHO) grade IV) and anaplastic astrocytomas (AA; WHO grade III) are highly aggressive and lethal astrocytic brain tumors. To detect cancer-specific somatic mutations in two hot-spot regions of PIK3CA gene, the helical and kinase domains (encoded by exons 9 and 20,...
journal_title：Journal of neurogenetics
pub_type： 杂志文章
doi：10.3109/01677063.2011.623202
更新日期：2011-12-01 00:00:00
