Abstract:
:Abstract: This essay is dedicated to Obaid on the occasion of his 80th birthday. We both worked on the behavior of Drosophila and on what underlies behavior in the fly brain. Is that the fly's mind? The essay is about some limitations of brain science. It is just a little piece of writing. It is meant to honor Obaid for his contributions to Drosophila neurogenetics in 40 years and to science in India. I hope he takes it instead of a bowl of flowers-adding to the praise.
journal_name
J Neurogenetjournal_title
Journal of neurogeneticsauthors
Heisenberg Mdoi
10.3109/01677063.2012.687796subject
Has Abstractpub_date
2012-09-01 00:00:00pages
267-70issue
3-4eissn
0167-7063issn
1563-5260journal_volume
26pub_type
历史文章,杂志文章abstract::To date, less than 10 pedigrees have been reported with ZNF335 mutations since it was discovered in 2012 and little is known about ZNF335-related clinical spectrum. We describe a 12 years old male patient who is only child of nonconsanguineous Turkish parents. Trio whole genome sequencing identified previously unrepor...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2020.1833006
更新日期:2020-11-20 00:00:00
abstract::Some of the very first chemosensory mutants in Drosophila were generated in screens done in the 1970s at Obaid Siddiqi's lab in Tata Institute of Fundamental Research (TIFR), Mumbai. This is a personal account of some of the early work with these mutants, which led to their physiological and molecular characterization...
journal_title:Journal of neurogenetics
pub_type: 历史文章,杂志文章
doi:10.3109/01677063.2012.677880
更新日期:2012-09-01 00:00:00
abstract::Neural tube defects (NTD) are a common birth defect, with both genetic and environmental contributions to their etiology. In mouse, null mutations in Noggin result in fully-penetrant NTDs. We investigated Noggin for mutations that may predispose to human NTDs in 202 NTD cases. One variant allele was identified in a ma...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::From Sydney Brenner's backyard to hundreds of labs across the globe, inspiring six Nobel Prize winners along the way, Caenorhabditis elegans research has come far in the past half century. The journey is not over. The virtues of C. elegans research are numerous and have been recounted extensively. Here, we focus on th...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2020.1823386
更新日期:2020-09-01 00:00:00
abstract::We have identified helmsman (hlm), which is expressed in the fruit fly photoreceptor cells during neural network development. Hlm is also expressed in the elongating cells of the embryonic trachea. Both photoreceptor neurons and embryonic trachea cells elongate in precise, targeted growth for cell-to-cell specific rec...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677060801893276
更新日期:2008-01-01 00:00:00
abstract::Newly eclosed Drosophila melanogaster flies were systemically depleted of dopamine by feeding an inhibitor of the biosynthetic enzyme, tyrosine hydroxylase, and analyzed for abnormalities in courtship behavior. Dopamine-depleted females were significantly less receptive to males than were control females, although mal...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069809167259
更新日期:1998-03-01 00:00:00
abstract::The shape of a neuron, its morphological signature, dictates the neuron's function by establishing its synaptic partnerships. Here, we review various anatomical methods used to reveal neuron shape and the contributions these have made to our current understanding of neural function in the Drosophila brain, especially ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.1080/01677060802610604
更新日期:2009-01-01 00:00:00
abstract::Kinase-mediated signaling cascades regulate a number of different molecular mechanisms involved in cellular homeostasis, and are viewed as one of the most common intracellular processes that are robustly dysregulated in the pathophysiology of mood disorders such as depression. Newly emerged, rapid acting antidepressan...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.1080/01677063.2016.1245303
更新日期:2016-01-01 00:00:00
abstract::Abstract: Nuclear factor of activated T cells (NFAT) is a calcium-responsive transcription factor. We describe here an NFAT-based neural tracing method-CaLexA (calcium-dependent nuclear import of LexA)-for labeling active neurons in behaving animals. In this system, sustained neural activity induces nuclear import of ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2011.642910
更新日期:2012-03-01 00:00:00
abstract::Intrahippocampal microinjections with anti-Met-enkephalin antiserum enhanced novelty-induced vertically oriented exploratory acts and horizontal locomotor activity in inbred mouse strain DBA/2 and reduced these behaviors in C57BL/6 so that strain differences originally present between the normal serum controls were el...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106848
更新日期:1986-05-01 00:00:00
abstract::Trembler-J, TrJ, is a peripheral hypomyelinating murine mutant. In intercrosses (TrJ/ + X TrJ/ +) there are severely affected (behaviorally and pathologically), mildly affected, and normal offspring, while backcrosses (TrJ/ + X + / +) produce only mildly affected and normal offspring. We used the closely linked marker...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068309107071
更新日期:1983-09-01 00:00:00
abstract::A search for the defective gene causing torsion dystonia has been carried out in a family manifesting an autosomal dominant mode of inheritance of this movement disorder. Complete neurologic examination and establishment of lymphoblast lines have been carried out for over 50 members. Linkage analysis, using cloned DNA...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106846
更新日期:1986-05-01 00:00:00
abstract::One of the most fascinating questions in evolutionary biology is how traits unique to humans, such as their high cognitive abilities, erect bipedalism, and hairless skin, are encoded in the genome. Recent advances in genomics have begun to reveal differences between the genomes of the great apes. It has become evident...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2013.789512
更新日期:2013-09-01 00:00:00
abstract::Myoclonic status in nonprogressive encephalopathy (MSNE) is an early-onset, drug-resistant epileptic syndrome characterized by occurrence of continuous diffuse epileptiform abnormalities, associated with positive and/or negative phenomena and accompanied by transient and recurring motor, cognitive, and behavioral impa...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2015.1091452
更新日期:2015-01-01 00:00:00
abstract::Some cases of Alzheimer's disease are inherited as a dominant trait in humans. To date, mutations in three genes account for some of them: the amyloid precursor protein (APP) and presenilins 1 and 2 (PS-1 and PS-2, respectively). The function of the presenilins is still unclear, although they belong to a transmembrane...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069809108554
更新日期:1998-01-01 00:00:00
abstract::Glioblastoma multiform (GBM; World Health Organization (WHO) grade IV) and anaplastic astrocytomas (AA; WHO grade III) are highly aggressive and lethal astrocytic brain tumors. To detect cancer-specific somatic mutations in two hot-spot regions of PIK3CA gene, the helical and kinase domains (encoded by exons 9 and 20,...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2011.623202
更新日期:2011-12-01 00:00:00
abstract::Writers' cramp is a movement disorder with dystonic co-contraction of fingers and hand during writing and is part of the clinical spectrum of focal dystonias. Previous studies showed reduced striatal dopamine receptor D2 (DRD2) availability in dystonia. The expression of D2 receptors is modulated by a DRD2/ANKK1-Taq1A...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2016.1238916
更新日期:2016-01-01 00:00:00
abstract::The horizontal system and vertical system cells of the dipteran optic lobes are well understood regarding their physiology and role in visually guided behavior. Little is known, however, about their development. Drosophila optomotor-blind (omb) is required for the development of the HS/VS cells which are lacking in th...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2014.917645
更新日期:2014-09-01 00:00:00
abstract::Each neuropil module, or cartridge, in the fly's lamina has a fixed complement of cells. Of five types of monopolar cell interneurons, only L4 has collaterals that invade neighboring cartridges. In the proximal lamina, these collaterals form reciprocal synapses with both the L2 of their own cartridge and the L4 collat...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2014.883390
更新日期:2014-09-01 00:00:00
abstract::This review outlines research into the cellular and molecular mechanisms underlying a simple behavior in the soil-dwelling nematode, C. elegans. A tap administered to the side of a petri plate acts as a nonlocalized mechanical stimulus to the worms within. Most adult worms respond to this tap stimulus with backward lo...
journal_title:Journal of neurogenetics
pub_type: 杂志文章,评审
doi:10.1080/01677060802298509
更新日期:2008-01-01 00:00:00
abstract::Chemosensory glomus cells of the carotid bodies release transmitters, including ATP and dopamine mainly via the exocytosis of small dense core granules (SDCGs, vesicular diameter of ∼100 nm). Using carbon-fiber amperometry, we showed previously that with a modest uniform elevation in cytosolic Ca2+ concentration ([Ca2...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2018.1497629
更新日期:2018-09-01 00:00:00
abstract::Autosomal recessive cerebellar ataxias are a group of clinically and genetically heterogeneous neurodegenerative disorders. Growing data have shown that there is difficulty with genetic counseling in a deeply consanguineous population because of the presence of genetic heterogeneity in patients sharing similar phenoty...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677060802025233
更新日期:2008-01-01 00:00:00
abstract::In the homozygous staggerer (sg/sg) mutant mouse, most of the Purkinje cells (the primary targets for olivocerebellar climbing fibers) are missing or ectopic. In this study, the organization and cell number of the inferior olivary complex in sg/sg were determined and compared to the inferior olive of the wildtype (+/+...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068509100143
更新日期:1985-02-01 00:00:00
abstract::Based on the staining of Drosophila embryos with neuron-specific monoclonal antibodies we describe the differentiation of the earliest neurons in the central nervous system. The metameric array undergoes a number of changes during development that distinguish several morphological units: metameres, neuromeres and gang...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677068609106856
更新日期:1986-09-01 00:00:00
abstract::Learnt predictive behavior faces a dilemma: predictive stimuli will never 'replay' exactly as during the learning event, requiring generalization. In turn, minute differences can become meaningful, prompting discrimination. To provide a study case for an adaptive adjustment of this generalization-discrimination balanc...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2010.498066
更新日期:2010-09-01 00:00:00
abstract::otal (ota=olfactory trap abnormal), an X-linked mutation of Drosophila isolated by virtue of abnormal olfactory behavior, is shown to be an allele of rdgB (retinal degeneration B), a gene required for normal visual system physiology. rdgB function is shown to be necessary for olfactory response of both adult files and...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677060701695441
更新日期:2007-10-01 00:00:00
abstract::Predictions from the theory of transfection, Karl-Friedrich Fischbach's first paper, were confirmed 20 years later. Also a model, proposed already in 1977 by Karl-Friedrich and colleagues, to explain the nonmonotonous dependence on light intensity of phototaxis in Drosophila, finds support in recent studies of functio...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677063.2013.873430
更新日期:2014-09-01 00:00:00
abstract::Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neuro...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2018.1556651
更新日期:2019-03-01 00:00:00
abstract::Messenger RNA editing of transcripts encoding voltage-sensitive ion channels has not been extensively analyzed--least of all in Drosophila, for which several channel-encoding genes are known. Previous sequence studies of D. melanogaster's cacophony gene, which encodes an alpha 1 calcium-channel subunit called Dmca1A, ...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.3109/01677069809108560
更新日期:1998-11-01 00:00:00
abstract::Caenorhabditis elegans has a simple nervous system of 302 neurons. It however senses environmental cues incredibly precisely and produces various behaviors by processing information in the neural circuit. In addition to classical genetic analysis, fluorescent proteins and calcium indicators enable in vivo monitoring o...
journal_title:Journal of neurogenetics
pub_type: 杂志文章
doi:10.1080/01677063.2020.1734001
更新日期:2020-09-01 00:00:00