Abstract:
:Different isolates of human immunodeficiency virus type 1 (HIV-1) vary in the cell tropisms they display, i.e., the range of cell types in which they are able to establish a productive infection. Here, we report on the phenotypes of recombinants between two molecularly cloned strains of HIV-1. Our results prove that the envelope glycoprotein gp120 is solely responsible for the difference in cell tropism between the two parental isolates and that no other genes or sequences are involved in determining the cell tropism of these strains. The region of the envelope involved in the determination of cell tropism includes sequences which encode the V3 loop of gp120. Control of cell tropism by this region of the virus env gene is a general phenomenon which applies to many different HIV-1 isolates.
journal_name
J Viroljournal_title
Journal of virologyauthors
Cann AJ,Churcher MJ,Boyd M,O'Brien W,Zhao JQ,Zack J,Chen ISdoi
10.1128/JVI.66.1.305-309.1992subject
Has Abstractpub_date
1992-01-01 00:00:00pages
305-9issue
1eissn
0022-538Xissn
1098-5514journal_volume
66pub_type
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