Assay of erythrocyte glucose-6-phosphate dehydrogenase on the GEMSAEC analyser.

abstract：:Immunoturbidimetric assays for specific proteins are available on "open system" clinical chemistry analyzers. The analytical performance of nine immunoturbidimetric specific protein assays (C3, C4, CRP, Haptoglobin, IgA, IgG, IgM, RF, and Transferrin) was compared to immunonephelometry. Testing was performed on the Ab...

journal_title：Clinical biochemistry

authors： Mali B,Armbruster D,Serediak E,Ottenbreit T

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Vitamin B(12), or B(12), is an essential nutrient for humans, and its deficiency is a public health problem, especially in elderly population. Around 30% of circulating total B(12) levels are attached to transcobalamin II (TCN2), being referred as holotranscobalamin (holo-TC), and representing the biological...

journal_title：Clinical biochemistry

authors： Castro R,Barroso M,Rocha M,Esse R,Ramos R,Ravasco P,Rivera I,de Almeida IT

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Automatic photometric determination of the hemolysis index (HI) on serum and plasma samples is central to detect potential interferences of in vitro hemolysis on laboratory tests. When HI is above an established cut-off for interference, results may suffer from a significant bias and undermine clinical relia...

journal_title：Clinical biochemistry

authors： Aloisio E,Carnevale A,Pasqualetti S,Birindelli S,Dolci A,Panteghini M

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Sweat chloride test is the gold standard test for cystic fibrosis (CF) diagnosis. In 2014 the Istituto Superiore di Sanità established the Italian pilot external quality assessment program for CF sweat test (IEQA-ST). DESIGN AND METHODS:Ten laboratories, included among the 33 Italian CF Referral Centers, we...

journal_title：Clinical biochemistry

authors： Salvatore M,Floridia G,Amato A,Censi F,Carta C,de Stefano MC,Ferrari G,Tosto F,Capoluongo E,Caruso U,Castaldo G,Cirilli N,Corbetta C,Padoan R,Raia V,Taruscio D

更新日期：2016-05-01 00:00:00

abstract：:We evaluated two chemical methods for quantifying mannitol in serum, based on the oxidation of mannitol by periodate, and measurement of the formaldehyde formed with chromotropic acid (colorimetry) or acetylacetone (fluorometry). We found interference in these methods by serum glycerol. Additionally, a high-performanc...

journal_title：Clinical biochemistry

authors： Diamandis EP,Grass CL,Uldall R,Mendelssohn D,Maini D

更新日期：1992-12-01 00:00:00

abstract：:An understanding of the production, transport, hepatic uptake, biotransformation and excretion of bile pigments is necessary for the rational investigation of a patient presenting with jaundice. These aspects are reviewed, and at each step of bilirubin metabolism the clinical abnormalities giving rise to jaundice are ...

journal_title：Clinical biochemistry

authors： Badley BW

更新日期：1976-06-01 00:00:00

abstract：OBJECTIVES:This study investigates how some of human physiological parameters, in particular sex and daytime, can contribute to the normal variation in blood gene expression. DESIGN AND METHODS:The expressions of two genes: SOD1 (Cu/Zn) and SOD2 (Mn) in white blood cells of 19 healthy individuals (10 men and 9 women) ...

journal_title：Clinical biochemistry

authors： Khymenets O,Covas MI,Farré M,Langohr K,Fitó M,de la Torre R

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:We investigated the relationships of biomarkers of various pathophysiologic pathways including high-sensitivity C-reactive protein (hs-CRP), lipocalin-2 (LCN2), myeloperoxidase (MPO) and matrix metalloproteinases 9 (MMP9) with mortality in stroke patients. DESIGN AND METHODS:hs-CRP, LCN2 and MPO concentrati...

journal_title：Clinical biochemistry

authors： Chan CP,Jiang HL,Leung LY,Wan WM,Cheng NM,Ip WS,Cheung KY,Chan RW,Wong LK,Graham CA,Renneberg R,Rainer TH

更新日期：2012-11-01 00:00:00

abstract：:Congestive heart failure usually features a mild to moderate increase in aspartate aminotransferase (AST) activity. A marked increase in AST may occur rarely and is usually preceded by prolonged shock or hypotensive episodes and is accompanied by hyperbilirubinemia. I report two patients with congestive heart failure ...

journal_title：Clinical biochemistry

authors： Nanji AA

更新日期：1983-04-01 00:00:00

abstract：:This review focusses on research performed by the author and coworkers. The absorption, turnover and excretion of cobalamin and the pathogenesis of cobalamin deficiency states are described and the laboratory tests used to diagnose these states are discussed. Topics dealt with in detail include: overall turnover, dail...

journal_title：Clinical biochemistry

authors： Gräsbeck R

更新日期：1984-04-01 00:00:00

abstract：:An immunosuppressive substance was isolated from ascitic fluids of patients with advanced colon cancer by means of ammonium sulphate precipitation and preparative isoelectric focusing. This was a glycoprotein with an isoelectric point of pH 2.7-3.3, a molecular weight of about 52,000, and a sedimentation coefficient o...

journal_title：Clinical biochemistry

authors： Fujii M,Takahashi N,Hayashi H,Matsunaga K,Yoshikumi C

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To review screening for cancer in high risk families. METHODS AND RESULTS:Screening for hereditary cancer involves three steps: it is first necessary to identify families at high risk by examining the number and sites of cancer in a family. Special attention is given to cancers appearing at an early age, to ...

journal_title：Clinical biochemistry

authors： Narod SA

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:Elevated advanced glycation endproducts (AGEs) are implicated in diabetic complications. Methylglyoxal-derived hydroimidazolone (MG-H) is one of the most abundant AGEs in vivo. Our objective was to develop a time-saving, specific method to measure free MG-H in plasma and determine its levels in complication-...

journal_title：Clinical biochemistry

authors： Han Y,Randell E,Vasdev S,Gill V,Curran M,Newhook LA,Grant M,Hagerty D,Schneider C

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:To develop a Rapid Flow-through assay for distinguishing replicating Tiantan vaccine-generated serological response from true HIV infection. DESIGN AND METHOD:A Rapid Flow-through Test including gp41, gp36, sk1, sk2 and sk3 antigens was established and the performance of the assay was evaluated in clinical s...

journal_title：Clinical biochemistry

authors： Yuan Z,Chen W,Zhang J,Zhang J,Xiang T,Hu J,Wu Z,Du X,Huang A,Zheng J

更新日期：2012-10-01 00:00:00

abstract：:Several clinical entities are associated with disorders of fatty acid oxidation or transfer across the inner mitochondrial membrane. Over 40 cases of the primary carnitine deficiency syndrome have been reported to date and various subtypes have been characterized. This represents a large clinical spectrum. The deficie...

journal_title：Clinical biochemistry

authors： Angelini C,Trevisan C,Isaya G,Pegolo G,Vergani L

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVES:Newly presented solid-phase extraction methods (Solid Phase Disc Extraction, SPEC-Plus, Multi-Modal, and Solid Phase Micro Extraction, SPME have been checked with respect to their applicability to clinical toxicological analysis. In comparison with conventional liquid/liquid-extraction and a common mixed-pha...

journal_title：Clinical biochemistry

authors： Degel F

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:Recently it has been suggested that serum beta-N-acetylhexosaminidase (Hex) could be a joint destruction marker in rheumatoid arthritis (RA) patients. However, a large amount of serum Hex activity has its source from platelets, and the blood platelet-count is often increased in RA, which may have masked the ...

journal_title：Clinical biochemistry

authors： Casal JA,Mera A,Pérez LF,Tutor JC

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs), some ubiquitous environmental contaminants are capable to cause oxidative stress, during its metabolism. It is believed that many diseases that have a common origin in oxidative stress begin in childhood. Considering oxidative stress evolved during PAHs metabolism as ...

journal_title：Clinical biochemistry

authors： Singh VK,Patel DK,Jyoti,Ram S,Mathur N,Siddiqui MK

更新日期：2008-02-01 00:00:00

abstract：CONTEXT:Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements. OBJECTIVES:We have examined the use of urinary neopt...

journal_title：Clinical biochemistry

authors： Baxter-Parker G,Roffe L,Cross S,Frampton C,Hooper GJ,Gieseg SP

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:This study explored the relationship between oxidative stress biomarkers and stability of carotid plaque. We decided to analyze the broad range of parameters describing oxidative stress in patients with carotid stenosis. DESIGN AND METHODS:124 consecutive patients undergoing carotid endarterectomy were enro...

journal_title：Clinical biochemistry

authors： Rozalski R,Migdalski A,Gackowski D,Guz J,Siomek A,Foksinski M,Szpila A,Zarakowska E,Majer M,Jawien A,Olinski R

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To evaluate a novel surface plasmon resonance (SPR) system for the direct measurement of tumor marker carbohydrate antigen 15-3 (CA15-3) in human saliva. DESIGN AND METHODS:We measured the presence of the tumor marker carbohydrate antigen 15-3 (CA15-3) in human saliva using 2 different surface plasmon resona...

journal_title：Clinical biochemistry

authors： Liang YH,Chang CC,Chen CC,Chu-Su Y,Lin CW

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVES:To compare the accuracy of procalcitonin (PCT) in early-onset neonatal sepsis (EOS) using standard cut-off values and a multilevel probabilistic approach. DESIGN AND METHODS:A retrospective study of PCT was performed in 149 newborns at risk of EOS, including preterm or prolonged rupture of membranes, chorio...

journal_title：Clinical biochemistry

authors： Santuz P,Soffiati M,Dorizzi RM,Benedetti M,Zaglia F,Biban P

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Coenzyme Q(10) (CoQ(10)) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ(10) levels, mitochondr...

journal_title：Clinical biochemistry

authors： Cordero MD,Moreno-Fernández AM,Carmona-López MI,Sánchez-Alcázar JA,Rodríguez AF,Navas P,de Miguel M

更新日期：2010-09-01 00:00:00

abstract：:Technological developments and economic drivers have led to major changes in clinical laboratories worldwide, principally represented by an increase in testing productivity and efficiency. Currently, major expectations are entrusted on the introduction of diagnostically more effective tests as well as on translating t...

journal_title：Clinical biochemistry

authors： Plebani M,Lippi G

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. This study was undertaken to specifically evaluate the transient elevations in these markers that are observed during systemic treatment for metastatic disease. This phenomenon has been termed "spiking." DESIGN AND MAT...

journal_title：Clinical biochemistry

authors： Yasasever V,Dinçer M,Camlica H,Karaloğlu D,Dalay N

更新日期：1997-02-01 00:00:00

abstract：:An early diagnosis is crucial for effective triage and management of patients with suspected acute myocardial infarction (AMI). Although troponin testing is the cornerstone of diagnosis, the sensitivity of this biomarker is still suboptimal at patient admission. The heart-type fatty acid binding protein (H-FABP) is an...

journal_title：Clinical biochemistry

authors： Lippi G,Mattiuzzi C,Cervellin G

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Δ(9)-Tetrahydrocannabinol (THC) can be measured in exhaled breath by using an aerosol particle collection device. The sampling procedure is simple, non-invasive and takes only 2-3min. In the present study we measured the amount of THC in exhaled breath of cannabis users at specific time intervals up to 3h af...

journal_title：Clinical biochemistry

authors： Coucke L,Massarini E,Ostijn Z,Beck O,Verstraete AG

更新日期：2016-09-01 00:00:00

abstract：:The purpose of this report is to evaluate whether a new, simple, non-invasive method for chymotrypsin measurement in stools is useful for the diagnosis of exocrine pancreatic insufficiency in cystic fibrosis (CF). A hundred children aged from 2 months to 12 years were tested: 50 children had been admitted for chronic ...

journal_title：Clinical biochemistry

authors： Scotta MS,Marzani MD,Maggiore G,De Giacomo C,Melzi D'Eril GV,Moratti R

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVES:Carbohydrate-deficient transferrin CDT has originally been defined as the sum of isotransferrins exhibiting isoelectric point values > or = 5.7 asialo, monosialo, and disialo transferrin but may also include at least in part trisialo transferrin when measured by modern commercial immunoassays. To examine the...

journal_title：Clinical biochemistry

authors： Lipkowski M,Dibbelt L,Seyfarth M

更新日期：2000-11-01 00:00:00

abstract：:Creatine kinase (CK) isoenzymes were determined on 15 patients undergoing open heart surgery with bypass. The study was performed to examine the relationship between the hypothermia under which the surgery is conducted and the appearance of CK isoenzymes in the serum both during and after surgery. All patients showed ...

journal_title：Clinical biochemistry

authors： Devine JE,Spatz LA

更新日期：1982-12-01 00:00:00