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Utility of CA 15-3 and CEA in monitoring breast cancer patients with bone metastases: special emphasis on "spiking" phenomena.

Abstract：

OBJECTIVES:CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. This study was undertaken to specifically evaluate the transient elevations in these markers that are observed during systemic treatment for metastatic disease. This phenomenon has been termed "spiking." DESIGN AND MATERIALS:Serum tumor marker levels were investigated by enzyme immunoassay in 20 breast cancer patients without metastases and in 20 patients with bone metastases receiving systemic treatment. RESULTS:Both CEA and CA 15-3 levels were significantly elevated in the patients with bone metastases. Serum CEA and CA 15-3 levels in patients with metastases displayed a transient, but significant, elevation days 15 and 30, respectively, after commencing systemic treatment, which returned to pretreatment levels on the 60th day. CONCLUSIONS:The spiking effect observed in the tumor marker levels should be carefully evaluated, and not be misdiagnosed as disease progression.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Yasasever V,Dinçer M,Camlica H,Karaloğlu D,Dalay N

doi

10.1016/s0009-9120(96)00133-6

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

53-6

issue

1

eissn

0009-9120

issn

1873-2933

pii

S0009912096001336

journal_volume

30

pub_type

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