Abstract：
:The evaluation of suspected esophageal chest pain is frustrating because of difficulty in clearly implicating the esophagus. Balloon distention was considered as a new provocative test in the esophagus because it has been shown to safely produce pain in other hollow gastrointestinal organs. Studies were performed in 50 chest pain patients (mean age 50 years) with negative coronary arteriograms and 30 healthy volunteers (mean age 41 years). A polyvinyl balloon (length 30 mm; maximum diameter after 10 cc distention 25 mm) was positioned 10 cm above the lower esophageal sphincter and inflated with 1-cc increments of air to a total volume of 10 cc. Using a placebo-controlled design, pain response was recorded along with associated balloon volumes. Pain occurred in 28/50 (56%) patients and 6/30 (20%) volunteers (P less than 0.005). Symptoms were unassociated with ECG changes, and resolved immediately with decompression of the balloon. Most patients (24/28) experienced their typical chest pain at less than or equal to 8 cc distention, while all volunteers with pain noted it at greater than or equal to 9 cc distention. For this reason, 8 cc was considered a diagnostic cutoff. Chest pain patients were also studied with two other commonly used provocative tests: intraesophageal acid perfusion and intravenous edrophonium (80 micrograms/kg). These tests reproduced pain in only 12 (24%) patients. Positive balloon studies occurred in 11 of these patients and identified an additional 13 patients, thus increasing the diagnostic yield from 24% to 48%. Only one of 22 (4%) balloon-negative patients had a positive acid-perfusion or edrophonium test.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Barish CF,Castell DO,Richter JEdoi
10.1007/BF01299805subject
Has Abstractpub_date
1986-12-01 00:00:00pages
1292-8issue
12eissn
0163-2116issn
1573-2568journal_volume
31pub_type
临床试验,杂志文章abstract：:Anorexia nervosa is considered one type of eating disorder that may result in severe malnutrition. Patients with this disorder commonly complain of postprandial nausea, abdominal pain, and distension. We describe the radiologic and motility abnormalities associated with anorexia nervosa in a 21-year-old female. Barium...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02090220
更新日期：1994-02-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-3002-1
更新日期：2005-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087779
更新日期：1994-08-01 00:00:00
abstract：:The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1024799303676
更新日期：2003-08-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02220459
更新日期：1995-12-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01311944
更新日期：1979-12-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10620-007-9965-3
更新日期：2008-04-01 00:00:00
abstract：:In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epith...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01299863
更新日期：1992-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297024
更新日期：1991-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-01 00:00:00
abstract：:Prostaglandins (PGs) are products of polyunsaturated acid metabolism, particularly arachidonic acid (AA) released from membrane phospholipids by the action of phospholipase A2 in response to a variety of physical, chemical, and neurohormonal factors. AA is rapidly metabolized to oxygenated products by two distinct enz...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01309317
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyli...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05600-y
更新日期：2019-09-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9346-3
更新日期：2006-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1021090113274
更新日期：2002-12-01 00:00:00
abstract：:The effect of psyllium hydrophilic mucilloid (PHM) when used as a laxative and/or stool softener on serum cholesterol concentrations was examined in 176 ambulatory elderly participants attending a health screening program. The change in one-year serum cholesterol concentration in subjects using PHM was compared with t...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01318205
更新日期：1991-03-01 00:00:00
abstract：:Gastroesophageal reflux disease (GERD) is caused by a mechanically defective lower esophageal sphincter (LES) and may be worsened by impaired esophageal peristalsis. The aim of this study was to evaluate the efficacy of medical treatment depending on the function of the LES and esophageal peristalsis. We studied 128 G...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1025434726161
更新日期：2003-09-01 00:00:00
abstract：:Clostridium difficile (CD) is one of the most common causes of diarrhea in solid organ transplantation (SOT). Between 1996 and 2005, a total of 2474 solid organ transplants were performed at our institution, of which 43 patients developed CD-associated diarrhea. There were 3 lung, 3 heart, 20 liver, 8 kidney-pancreas,...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9770-z
更新日期：2007-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005501930808
更新日期：2000-05-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088339
更新日期：1994-03-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01535788
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...
journal_title：Digestive diseases and sciences
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doi：10.1007/s10620-012-2232-2
更新日期：2012-08-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02208599
更新日期：1996-01-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296375
更新日期：1987-11-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318698
更新日期：1986-06-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,随机对照试验
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更新日期：2009-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10620-017-4750-4
更新日期：2017-11-01 00:00:00
abstract：:Microvesicular steatosis is a potentially severe manifestation of valproic acid hepatotoxicity due to an acquired impairment of mitochondrial function. Tests currently used to investigate mitochondrial fonction are cumbersome and cannot be used routinely. We report on a noninvasive breath test using [13C]methionine fo...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1012791832730
更新日期：2001-12-01 00:00:00
