Abstract：
BACKGROUND:Exercise-triggered asthma (ETA) develops when physical activity triggers asthma symptoms during or directly after exercise. In patients prone to symptoms of supra-esophageal reflux, exercise may trigger gastroesophageal reflux (GER), resulting in such symptoms. AIMS:To determine the prevalence of abnormal pH in patients with ETA and to determine whether acid suppression improves symptoms in ETA patients. METHODS:We performed a randomized double-blind trial of rabeprazole versus placebo in the treatment of patients with ETA. Patients underwent treadmill protocol to determine their VO(2 max). Next, pH testing was initiated while undergoing a 30-min treadmill program exercising them at 65% of their VO(2 max). They were subsequently randomized to rabeprazole or placebo for 10 weeks. At the end of 10 weeks, exercise testing was repeated. RESULTS:A total of 31 patients completed the study (20 asthmatics, 11 non-asthmatics). Twenty-two out of 30 (73%) subjects had abnormal pH studies. For all subjects, rabeprazole improved symptoms more than placebo (P = 0.03). The association was stronger in the pH-positive group (P = 0.009). CONCLUSION:Acid reflux is common in ETA patients. Many patients with exercise-related respiratory symptoms are misdiagnosed as chronic asthmatics. Exercise-related symptoms improve with the use of acid suppression. This study suggests that ETA patients may benefit from acid suppression.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Peterson KA,Samuelson WM,Ryujin DT,Young DC,Thomas KL,Hilden K,Fang JCdoi
10.1007/s10620-008-0396-6subject
Has Abstractpub_date
2009-03-01 00:00:00pages
564-71issue
3eissn
0163-2116issn
1573-2568journal_volume
54pub_type
杂志文章,随机对照试验abstract：:Leptin is a 16-kDa nonglycosylated protein primarily secreted from the adipocytes of white fat; minor levels of regulated leptin expression also occurs at other sites such as placenta, skeletal muscle, the stomach fundus, and culture-activated hepatic stellate cells (HSCs). Leptin is primarily involved in the regulati...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-006-9126-0
更新日期：2006-10-01 00:00:00
abstract：:To examine the differentiating parameters between cholesterol and pigment gallstones, we compared the nucleation times, concentrations of biliary lipid and protein, and the distribution of vesicular cholesterol in gallbladder bile of 16 patients with cholesterol, eight patients with black pigment gallstones, and nine ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296790
更新日期：1993-01-01 00:00:00
abstract：:The original version of the article unfortunately contained an error in article title. The corrected title is 'Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose'. ...
journal_title：Digestive diseases and sciences
pub_type： 已发布勘误
doi：10.1007/s10620-019-05527-4
更新日期：2019-07-01 00:00:00
abstract：:We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a c...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0531-4
更新日期：2009-01-01 00:00:00
abstract：:The effect of 5-hydroxytryptamine (5HT) was studied in circular and longitudinal muscle from the proximal and distal colon of New Zealand white rabbits. 5HT stimulated a dose-dependent isometric contraction of distal and proximal circular muscle that was greater than in distal longitudinal muscle (P less than 0.01). 5...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300751
更新日期：1991-02-01 00:00:00
abstract：:Possible differences in the abilities of esophageal body and lower esophageal sphincter muscles to utilize substrates to support agonist-induced contractions were studied. Strips of longitudinal, circular, and lower esophageal sphincter muscle from the opossum esophagus were first contracted to approximately 70% of th...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297447
更新日期：1991-08-01 00:00:00
abstract：INTRODUCTION:Crohn's disease (CD) follows a relapsing and remitting course incurring cumulative bowel damage over time. The question of whether or not the timing of the initiating biologic therapy affects long-term disease progression remains unanswered. Herein, we calculated rates of change in the Lémann index-which q...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5434-4
更新日期：2019-11-01 00:00:00
abstract：:Ornithine decarboxylase (ODC) activity has been associated with mucosal growth and injury, yet, little information is available on ODC activity during gastric ulcer healing. We measured ODC activity in the ulcer base submucosa and the surrounding mucosa at 1 cm and 2 cm and assessed ulcer surface healing and a histolo...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300280
更新日期：1992-07-01 00:00:00
abstract：:The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308176
更新日期：1992-02-01 00:00:00
abstract：:Over a one-year period, 95 children and adolescents presenting with epigastric pain and/or vomiting, and without associated risk factors for development of peptide disease, underwent endoscopic antral biopsies for pathologic diagnosis and to detect presence of Campylobacter ss. pylori (C. pylori). Additional biopsies ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537100
更新日期：1989-10-01 00:00:00
abstract：:Campylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum, four from antrum, and four from body and fundus, were taken before and after four weeks of cimetidine trea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296375
更新日期：1987-11-01 00:00:00
abstract：BACKGROUND AND AIM:Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. METHODS:Hematoxylin- and eosin-stai...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3121-7
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Dextran sodium sulphate (DSS) is commonly used to induce intestinal inflammation in rodents. Despite its continuing importance as a model system for examining IBD pathogenesis, the mucosal and systemic immune responses have not been comprehensively documented. AIMS:The purpose of this study was to dissect f...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1240-3
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1007/s10620-014-3488-5
更新日期：2015-05-01 00:00:00
abstract：:Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297056
更新日期：1987-03-01 00:00:00
abstract：:A sustained increase in cytosolic Ca2+ can damage gastric mucosal cells. The present study has examined the role of Ca2+ in thromboxane B2 (TXB2)-mediated damage of rabbit isolated gastric mucosal cells. Cells were isolated from rabbit oxyntic mucosa by collagenase-EDTA digestion. Cell metabolic activity and cell dama...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02208674
更新日期：1995-09-01 00:00:00
abstract：:Opioids, both endogenous and exogenous, have been shown to exert a modulating influence on many gastrointestinal functions. Animal studies suggest an inhibitory role for opioids in the control of pancreatic secretion, which may be exerted through their inhibitory effect on acetylcholine release from intramural neurons...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01798363
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:It is unclear whether the quality of bowel preparation affects colonoscopic detection of non-polypoid colorectal neoplasms (NP-CRNs). AIM:To evaluate the impact of bowel-cleansing quality on detection of NP-CRNs. METHODS:We performed a retrospective analysis of asymptomatic screening colonoscopy cases afte...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3628-6
更新日期：2015-08-01 00:00:00
abstract：:There is, currently, no consensus with regard to the role of endoscopy in the etiologic investigation of asymptomatic pemenopausal women suffering from iron deficiency anemia (IDA). We conducted a retrospective case-control study to evaluate the contribution of esophagogastroduodenoscopy (EGD) and colonoscopy to the e...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-9069-x
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Antibiotic prophylaxis can reduce the incidence of the first episode and recurrent episodes of spontaneous bacterial peritonitis (SBP) in high-risk cirrhotic patients. However, recent data suggest that SBP prophylaxis may be underused. It is unclear how many cases of cirrhosis that develop SBP might actually...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1647-5
更新日期：2011-09-01 00:00:00
abstract：:In cases of difficult biliary cannulation, transpancreatic sphincterotomy (TPS) can be an alternative approach of biliary access. However, its success and safety profile have not been studied in detail. A systematic review and meta-analysis were performed to study the overall cannulation success and adverse events of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析
doi：10.1007/s10620-019-05640-4
更新日期：2019-09-01 00:00:00
abstract：:We retrospectively evaluated clinical factors affecting long-term survival after treatment for hepatocellular carcinoma (HCC) to predict the reliability of the prognosis of patients with HCC. We analyzed 157 patients who received treatment for HCC. The prognostic index (PI) was evaluated using the Cox regression model...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9137-x
更新日期：2007-09-01 00:00:00
abstract：:Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536682
更新日期：1988-10-01 00:00:00
abstract：:Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid messengers with cell-cycle regulating effects. The enzyme is significantly decreased in ulcerative colitis and colon cancer. Based on this information, we wanted to investiga...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0509-2
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM:To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS:W...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4432-7
更新日期：2017-08-01 00:00:00
abstract：:Detecting plasma protein loss from the stomach is quite difficult by measuring fecal alpha1-AT clearance because alpha1-AT is rapidly destroyed in the gastric juice at values below pH 3. We examined protein loss from the stomach using fecal alpha1-AT clearance with lansoprazole, a proton pump inhibitor. A 38-year-old ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026625308572
更新日期：1999-11-01 00:00:00
abstract：:There is a lack of information about the effect of omeprazole or other antisecretory drugs on intraduodenal pH. Aim of the study was to document the variation over time of intraduodenal pH during a 24-hr period and to simultaneously study the effect of omeprazole 40 mg once daily on intragastric and intraduodenal pH i...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1018827003641
更新日期：1997-11-01 00:00:00
abstract：:Signet ring carcinoma of the pancreas is rare. We report a case which was remarkable for (1) diffuse, infiltrating growth which suggested chronic pancreatitis at laparotomy, and (2) an associated very high circulating carcinoembryonic antigen (CEA) level of 6400 ng/ml. The case report and autopsy are presented. Twelve...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296277
更新日期：1984-06-01 00:00:00
abstract：:Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular co...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02212712
更新日期：1995-08-01 00:00:00
abstract：:Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We explored Msi-1 expression and its potential implications in the human stomach. Reverse transcription-PCR revea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9858-5
更新日期：2008-02-01 00:00:00
