Illusory self-motion and motion sickness: a model for brain-gut interactions and nausea.

Abstract:

:Motion sickness provides a unique setting for the study of nausea. Studies of illusory self-motion have linked nausea and objective measures of gastric dysrhythmias and the stress hormones vasopressin and epinephrine. Electrogastrographic methods utilize Ag-AgCl electrodes placed on the abdominal surface in the epigastric region to record electrogastrograms (EGGs), a noninvasive measure of gastric myoelectrical activity. The EGG frequencies of interest are the normal range (2.4-3.6 cpm), tachygastrias (3.6-9.9 cpm), and bradygastrias (1.0-2.4 cpm), and duodenal respiratory frequencies (10.0-15.0 cpm). Illusory self-motion or vection is produced with a rotating drum. Minutes before vection-induced nausea is reported, the baseline EGG signal shifts into tachygastrias or mixed tachygastrias and bradygastrias. Quantitative analyses show that the percentage of power in the tachygastria range correlates with the intensity of nausea. Plasma vasopressin levels correlate positively with intensity of nausea. Asian subjects have higher intensity nausea and higher vasopressin levels compared with Caucasian subjects, indicating a potential genetic susceptibility to vection-induced motion sickness and nausea. Vection-induced motion sickness represents an experimental model of acute-onset nausea with accompanying symptoms such as headache, drowsiness, cold sweating, and fatigue. Illusory self-motion is a purely central nervous system (visual-vestibular) stimulation that evokes dramatic shifts in gastric electrical activity and significant release of the posterior pituitary hormone vasopressin. Central nervous systems pathways that evoke gastric dysrhythmias and release vasopressin may also have a pathophysiologic role in the cyclic vomiting syndrome.

journal_name

Dig Dis Sci

authors

Koch KL

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

53S-57S

issue

8 Suppl

eissn

0163-2116

issn

1573-2568

journal_volume

44

pub_type

杂志文章,评审
  • Widespread changes in neurotransmitter expression and number of enteric neurons and interstitial cells of Cajal in lethal spotted mice: an explanation for persisting dysmotility after operation for Hirschsprung's disease?

    abstract::Gastrointestinal motor dysfunction persists in a large number of children subjected to surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining intestine. The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitia...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1015085923245

    authors: Sandgren K,Larsson LT,Ekblad E

    更新日期:2002-05-01 00:00:00

  • Hepatic morphology in obesity.

    abstract::Changes in hepatic morphology were evaluated in 242 consecutive liver biopsy specimens obtained from nonalcoholic obese subjects. Steatosis occurred in 59.7% of the subjects but was moderate to severe in 28.7%. An alcoholic hepatitis-like picture was present in 8.7% and cirrhosis in 2.7%. Fibrosis of mild and moderate...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308373

    authors: Nasrallah SM,Wills CE Jr,Galambos JT

    更新日期:1981-04-01 00:00:00

  • Infliximab delays but does not avoid the need for surgery in treatment-resistant pediatric Crohn' disease.

    abstract::The aim of this study was to review the impact of infliximab therapy on children with treatment-resistant Crohn's disease. Treatment resistance was defined as clinically active disease despite >4 months of immunosuppressive therapy. The outcome variables were time to first remission, duration of remission and the need...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-8102-1

    authors: Afzal NA,Ozzard A,Keady S,Thomson M,Murch S,Heuschkel R

    更新日期:2007-12-01 00:00:00

  • Functional Gastrointestinal Symptoms Are Associated with Higher Serum Total IgE Levels, but Less Atopic Sensitization.

    abstract:BACKGROUND:The relation of gastrointestinal (GI) complaints to IgE-mediated allergy is not well understood. Increased numbers of "IgE-armed" mast cells have been observed in duodenal mucosa of patients with functional GI complaints. AIMS:To explore whether total IgE and atopic sensitization were associated with functi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-015-3835-1

    authors: Vara EJ,Svanes C,Skorge TD,Berstad A,Florvaag E,Jarvis D,Omenaas E,Waatevik M,Johannessen A,Lied GA

    更新日期:2016-01-01 00:00:00

  • Hepatolithiasis in East Asia. Retrospective study.

    abstract::Hepatolithiasis is a major disease in Asia but differences in operative incidence between countries have not been examined. A retrospective study was conducted in Taiwan, Hong Kong, and Singapore, and the results were compared with those in Japan with the aim of defining factors involved in the etiology of the conditi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01347905

    authors: Nakayama F,Soloway RD,Nakama T,Miyazaki K,Ichimiya H,Sheen PC,Ker CG,Ong GB,Choi TK,Boey J

    更新日期:1986-01-01 00:00:00

  • Domperidone to Treat Symptoms of Gastroparesis: Benefits and Side Effects from a Large Single-Center Cohort.

    abstract:BACKGROUND:There is increased awareness about risks and benefits of using domperidone to treat gastroparesis. AIM:To describe the outcome of treating patients with refractory gastroparesis symptoms with domperidone. METHODS:Domperidone 10 mg QID or TID was prescribed to patients with refractory gastroparesis symptoms...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4272-5

    authors: Schey R,Saadi M,Midani D,Roberts AC,Parupalli R,Parkman HP

    更新日期:2016-12-01 00:00:00

  • Does empiric esophageal dilation benefit dysphagia when endoscopy is normal?

    abstract::Some patients referred for esophagogastroduodenoscopy (EGD) to evaluate symptoms of dysphagia have normal endoscopies. How best to manage these patients is unclear. We reviewed our experience with empiric esophageal dilation in this setting. Over a five-year period, 40 consecutive patients with esophageal dysphagia an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088225

    authors: Marshall JB,Chowdhury TA

    更新日期:1996-06-01 00:00:00

  • Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy.

    abstract::In a double-blind, randomized crossover study, the hypotheses were tested that more powerful inhibition of gastric acid secretion by adjuvant omeprazole further improves the efficacy of pancreatic enzyme replacement therapy compared to adjuvant cimetidine and that excluding the influence of pH-related factors, by virt...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02087549

    authors: Bruno MJ,Rauws EA,Hoek FJ,Tytgat GN

    更新日期:1994-05-01 00:00:00

  • Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs.

    abstract::The mechanisms of pentagastrin-induced gastric mucosal blood flow (GMBF) response were investigated in anesthetized rats. A rat stomach was mounted on an ex vivo chamber, perfused with saline, and GMBF was measured by a laser Doppler flowmetry simultaneously with acid secretion. Pentagastrin infused intravenously prod...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02282323

    authors: Kato S,Okabe S,Takeuchi K

    更新日期:1996-03-01 00:00:00

  • Ultra-short Celiac Disease Is a Distinct and Milder Phenotype of the Disease in Children.

    abstract:BACKGROUND AND AIMS:Approximately 10% of children with celiac disease (CD) have ultra-short celiac disease (USCD), where histological abnormalities are limited to the duodenal bulb. The aim of our retrospective study was to identify clinical and serological characteristics at baseline and at follow-up of children with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5323-x

    authors: Doyev R,Cohen S,Ben-Tov A,Weintraub Y,Amir A,Galai T,Moran-Lev H,Yerushalmy-Feler A

    更新日期:2019-01-01 00:00:00

  • Non-invasive testing for Helicobacter pylori in patients hospitalized with peptic ulcer hemorrhage: a cost-effectiveness analysis.

    abstract:PURPOSE:Guidelines recommend routine invasive screening for Helicobacter pylori in patients with peptic ulcer hemorrhage (PUH). However, compliance with screening remains suboptimal. The aim of this study was to determine if a simplified approach based on noninvasive screening is cost effective in PUH. RESULTS:In the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0865-6

    authors: Atreja A,Fu AZ,Sanaka MR,Vargo JJ

    更新日期:2010-05-01 00:00:00

  • Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects.

    abstract::There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296008

    authors: Grisham MB,Ware K,Marshall S,Yamada T,Sandhu IS

    更新日期:1992-09-01 00:00:00

  • Antiulcer drugs and gastric cancer.

    abstract::Inhibitors of gastric acid secretion are efficient drugs in the treatment of acid-related diseases. However, by reducing gastric acidity, hypergastrinemia develops. Gastrin regulates its target cell, the enterochromaffin (ECL) cell, both functionally and tropicaly. Long-term hypergastrinemia in whatever species studie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-005-2805-4

    authors: Waldum HL,Gustafsson B,Fossmark R,Qvigstad G

    更新日期:2005-10-01 00:00:00

  • Correction to: Antenatal Management for Women with Inflammatory Bowel Disease: Experience from Our 'IBD MOM' Clinic.

    abstract::The original version of the article unfortunately contained tagging error in first and family name of authors Ariella Bar-Gil Shitrit and Ami Ben Ya'acov. This has been corrected with this erratum. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10620-018-5084-6

    authors: Bar-Gil Shitrit A,Cohen Y,Hassin O,Ben Ya'acov A,Farkash R,Koslowsky B,Milgrom Y,Livovsky DM,Samueloff A,Goldin E,Grisaru-Granovsky S

    更新日期:2018-09-01 00:00:00

  • Interdigestive canine pancreatic juice composition and pancreatic reflux and pancreatic sphincter anatomy.

    abstract::Canine and human exocrine pancreatic secretion into the duodenum during fasting is cyclical and related to intestinal motility. To characterize the composition of pure pancreatic juice during the cyclically recurring sequence of propagated motor events (interdigestive motor complex) and to establish whether pancreatic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01367667

    authors: Keane FB,Dozois RR,Go VL,Dimagno EP

    更新日期:1981-07-01 00:00:00

  • Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats.

    abstract::In addition to regulating blood pressure and body fluid homeostasis, the renin-angiotensin system (RAS) is also involved in hepatic fibrogenesis. We aimed to investigate the effect of losartan, an angiotensin II (Ang II) antagonist, on CCl4-induced hepatic fibrosis in rats. Hepatic fibrosis was induced by a subcutaneo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000043369.88701.5b

    authors: Wei YH,Jun L,Qiang CJ

    更新日期:2004-10-01 00:00:00

  • Administration of bacterial lipopolysaccharide to rats induces heme oxygenase-1 and formation of antioxidant bilirubin in the intestinal mucosa.

    abstract::Heme oxygenase (HO)-1, the rate-limiting enzyme in heme degradation, is induced by oxidative stress and its major end product, bilirubin, is a potent physiological antioxidant. We studied the induction of HO-1 and bilirubin production in intestinal mucosa using a rat model of sepsis. E. coli lipopolysaccharide was adm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005626622203

    authors: Otani K,Shimizu S,Chijiiwa K,Morisaki T,Yamaguchi T,Yamaguchi K,Kuroki S,Tanaka M

    更新日期:2000-12-01 00:00:00

  • Racial differences in epidemiology of irritable bowel syndrome alone, un-investigated dyspepsia alone, and "overlap syndrome" among african americans compared to Caucasians: a population-based study.

    abstract::There is A paucity of data on racial differences in epidemiology of irritable bowel syndrome (IBS) alone and un-investigated dyspepsia (UD) alone compared to "overlap syndrome" (OS). We conducted a random survey (n = 990). Subjects completed a questionnaire which included Rome II criteria for IBS and functional dyspep...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3112-4

    authors: Minocha A,Chad W,Do W,Johnson WD

    更新日期:2006-01-01 00:00:00

  • Validation of the 7th edition TNM staging system for hepatocellular carcinoma: an analysis of 8,828 patients in a single medical center.

    abstract:BACKGROUND:Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2716-8

    authors: Kee KM,Wang JH,Lin CY,Wang CC,Cheng YF,Lu SN

    更新日期:2013-09-01 00:00:00

  • A procedure for measuring gastric bleeding caused by drugs.

    abstract::Seven subjects were given one day's treatment with full doses of either aspirin, ibuprofen, or placebo, and then their stomachs were washed out three times at intervals of 10 min, for five successive days. The blood in the recoveries was estimated chemically. After compensating for gastric emptying, the rate of bleedi...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01489320

    authors: Hunt JN

    更新日期:1979-07-01 00:00:00

  • Community-based health preferences for proctocolectomy: a race comparison.

    abstract::Our objective was to determine whether there are dominating racial differences in patient preferences for surgery that may explain the disparities in proctocolectomy utilization between African Americans (AA) and whites. We used the time trade-off technique to measure health preferences for undergoing ileal pouch anal...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9915-0

    authors: Nguyen GC,Tuskey A,Bayless TM,LaVeist TA,Brant SR

    更新日期:2008-03-01 00:00:00

  • Transjugular liver biopsy in 52 patients with an automated Trucut-type needle.

    abstract::A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the s...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1026678806368

    authors: De Hoyos A,Loredo ML,Martínez-Ríos MA,Gil MR,Kuri J,Cárdenas M

    更新日期:1999-01-01 00:00:00

  • Food-Induced Acute Pancreatitis.

    abstract::Food allergy, a commonly increasing problem worldwide, defined as an adverse immune response to food. A variety of immune-related effector cells such as mast cells, eosinophils, neutrophils, and T cells are involved in food-related allergic responses categorized as IgE mediated, non-IgE mediated, and mixed (IgE and no...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-017-4817-2

    authors: Manohar M,Verma AK,Upparahalli Venkateshaiah S,Goyal H,Mishra A

    更新日期:2017-12-01 00:00:00

  • [*C]octanoic acid breath test to measure gastric emptying rate of solids.

    abstract::We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid. In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02300385

    authors: Maes BD,Ghoos YF,Rutgeerts PJ,Hiele MI,Geypens B,Vantrappen G

    更新日期:1994-12-01 00:00:00

  • Morphological disruption of colonic mucosa by free or cholestyramine-bound bile acids.

    abstract::In order to assess the effects of free or resin-bound bile acids on colonic topography, adult rats were surgically provided with an indwelling infusion catheter in the proximal cecum, which exited at the neck behind the head. Conscious, unrestrained rats were allowed chow ad libitum and were administered 1 ml of an in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296219

    authors: Vahouny GV,Satchithanandam S,Lightfoot F,Grau L,Haas-Smith S,Kritchevsky D,Cassidy MM

    更新日期:1984-05-01 00:00:00

  • Gastritic glandularis et cystica profunda: a report of three cases with discussion of etiology and pathogenesis.

    abstract::Three cases of gastritis glandularis et cystica profunda are presented, two associated with severe chronic gastritis and the other with invasive gastric carcinoma and chronic gastritis. This poorly known entity consists of benign downgrowths of deep gastric glands through the muscularis mucosae into the submucosa. The...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297238

    authors: Honoré LH,Lewis AS,O'Hara KE

    更新日期:1979-01-01 00:00:00

  • Falls and fall-related injury are common in older people with chronic liver disease.

    abstract:BACKGROUND:Improved survival with chronic liver disease (CLD) and increased incidence in the older has led to a rapidly expanding population which faces similar "geriatric syndromes" as the general population. With risk factors such as autonomic dysfunction, cognitive impairment, and muscle abnormalities in CLD it is e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2193-5

    authors: Frith J,Kerr S,Robinson L,Elliott CS,Wilton K,Jones DE,Day CP,Newton JL

    更新日期:2012-10-01 00:00:00

  • Helicobacter pylori infection, oxidative DNA damage, gastric carcinogenesis, and reversibility by rebamipide.

    abstract::Several epidemiological studies have demonstrated a close association between Helicobacter pylori infection and carcinoma of the mid- or distal stomach. If this can be shown to be a causal association, eradication of the organism may prevent later development of cancer. Several mechanisms have been proposed by which H...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Hahm KB,Lee KJ,Kim JH,Cho SW,Chung MH

    更新日期:1998-09-01 00:00:00

  • Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese.

    abstract::Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) has been shown to inhibit the proliferation of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. We investigated the influence of PPARgamm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9944-8

    authors: Tahara T,Arisawa T,Shibata T,Nakamura M,Wang F,Maruyama N,Kamiya Y,Nakamura M,Fujita H,Nagasaka M,Iwata M,Takahama K,Watanabe M,Hirata I,Nakano H

    更新日期:2008-03-01 00:00:00

  • Triolein breath test of fat absorption in patients with chronic liver disease.

    abstract::We have compared the [14C]triolein breath test for fat malabsorption with fecal fat excretion corrected for marker pellet recovery in 23 subjects with chronic liver disease. The breath test identified 15 of the 17 subjects with abnormal fecal fat excretion (sensitivity 88%). However, four of the six subjects with norm...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01798358

    authors: Absalom SR,Saverymuttu SH,Maxwell JD,Levin GE

    更新日期:1988-05-01 00:00:00