Abstract:
:In a double-blind, randomized crossover study, the hypotheses were tested that more powerful inhibition of gastric acid secretion by adjuvant omeprazole further improves the efficacy of pancreatic enzyme replacement therapy compared to adjuvant cimetidine and that excluding the influence of pH-related factors, by virtually complete inhibition of gastric acid secretion with 60 mg omeprazole daily, does not lead to total elimination of steatorrhea. During both adjuvant cimetidine and omeprazole treatment, fecal fat excretion was significantly lower compared to pancreatin monotherapy (P < 0.01). Omeprazole showed a trend towards a more favorable decrease of fecal fat excretion compared to cimetidine but no statistically significant difference. Steatorrhea was almost never abolished, even during 60 mg omeprazole daily. Generally, pH-related factors are considered to explain an inadequate therapeutic response during pancreatic enzyme replacement therapy. However, this study indicates that in vivo other factors also play a significant role.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Bruno MJ,Rauws EA,Hoek FJ,Tytgat GNdoi
10.1007/BF02087549subject
Has Abstractpub_date
1994-05-01 00:00:00pages
988-92issue
5eissn
0163-2116issn
1573-2568journal_volume
39pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
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abstract::A model for gastric mucosal injury is proposed in which a key pathogenetic event is the disruption in the normal relationships among several circadian rhythms of gastric function. In the rat a circadian rhythm in acid secretion was found to be out of phase with a circadian rhythm in gastric pepsin secretion, another a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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journal_title:Digestive diseases and sciences
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pub_type: 已发布勘误
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00