The role of N-acetyltransferase 2 polymorphism in the etiopathogenesis of inflammatory bowel disease.


BACKGROUND AND PURPOSE:Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD), which are complex genetic disorders resulting from the interplay between several genetic and environmental risk factors. The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs. Acetylation catalyzed by NAT2 is an important process in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. The aim of our study was to determine whether there is any association between the susceptibility to inflammatory bowel disease among the variations of NAT2 genotypes. METHODS:This study was carried out in 80 patients with IBD. The control group consisted of 100 healthy volunteers. The most common mutations found in the Caucasian population are at the positions 481T, 803G, 590A and 857A on the NAT2 gene. This was determined using the polymerase chain reaction-restriction fragment length polymorphism method with DNA extracted from peripheral blood. RESULTS:Risk of IBD development was 3.86 for the carriers of the NAT2*5/NAT2*7 genotype and 2.53 for the carriers with NAT2*6/NAT2*7, but it was not statistically significant. A statistically significant correlation between the NAT2*7 allele prevalence and the risk for developing IBD was found (OR = 5.8; P = 0.005). CONCLUSIONS:Higher prevalence of the NAT2*7 allele in patients with IBD and the obtained OR values could suggest that this mutation has the effect of increasing IBD development. Future studies are needed to confirm our assumptions on larger group of patients.


Dig Dis Sci


Baranska M,Trzcinski R,Dziki A,Rychlik-Sych M,Dudarewicz M,Skretkowicz J




Has Abstract


2011-07-01 00:00:00












  • Selection of patients with gastroesophageal reflux disease for antireflux surgery based on esophageal manometry.

    abstract::Gastroesophageal reflux disease (GERD) is caused by a mechanically defective lower esophageal sphincter (LES) and may be worsened by impaired esophageal peristalsis. The aim of this study was to evaluate the efficacy of medical treatment depending on the function of the LES and esophageal peristalsis. We studied 128 G...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Klaus A,Gadenstaetter M,Mühlmann G,Kirchmayr W,Profanter C,Achem SR,Wetscher GJ

    更新日期:2003-09-01 00:00:00

  • Effects of beta-adrenoceptor stimulation on rectosigmoid motility in man.

    abstract::Effects of selective beta-adrenoceptor agonists on rectosigmoid motility during prolonged rectal distension were studied in 12 healthy volunteers in a double-blind, randomized fashion. Continuous distension was performed with a balloon in the proximal part of the rectum. Pressure was recorded by this balloon and by a ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lyrenäs E,Abrahamsson H,Dotevall G

    更新日期:1985-06-01 00:00:00

  • Heat stress increases protein antigen transport across the intestinal epithelium via a mechanism of impairing proteolytic enzymatic activity.

    abstract::It has not been fully understood how intact protein antigens escape digestion in the course of absorption. The present study was designed to investigate the mechanism that heat stress induced an increase in intact protein antigen absorption. Human colonic cell line Caco-2 cells were treated with high temperature (37 t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yang PC,Wang CS

    更新日期:2006-05-01 00:00:00

  • Reevaluation of manometric criteria for vigorous achalasia. Is this a distinct clinical disorder?

    abstract::Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Todorczuk JR,Aliperti G,Staiano A,Clouse RE

    更新日期:1991-03-01 00:00:00

  • Apamin attenuated cerulein-induced acute pancreatitis by inhibition of JNK pathway in mice.

    abstract:BACKGROUND/AIM:We have previously reported that bee venom (BV) has a protective role against acute pancreatitis (AP). However, the effects of apamin, the major compound of BV, on AP have not been determined. The aim of this study was to evaluate the effects of apamin on cerulein-induced AP. METHODS:AP was induced via ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bae GS,Heo KH,Park KC,Choi SB,Jo IJ,Seo SH,Kim DG,Shin JY,Kang DG,Lee HS,Song HJ,Shin BC,Park SJ

    更新日期:2013-10-01 00:00:00

  • Oncogenic transformation of normal enterocytes by overexpression of cyclin D1.

    abstract::Cyclin D1 plays an important role in the multi-step process of gastrointestinal tumorigenesis. We hypothesize that normal enterocytes over-expressing cyclin D1 will demonstrate a transformed phenotype. The nontumorigenic intestinal epithelial cell line, IEC-18, was transfected with the vector pMV7-CCND1, encoding cycl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kazanov D,Shapira I,Pick M,Kolker O,Liberman E,Deutsch V,Strier L,Dvory-Sobol H,Kunik T,Arber N

    更新日期:2003-07-01 00:00:00

  • Cortical evoked responses following esophageal balloon distension and electrical stimulation in healthy volunteers.

    abstract::Recording of evoked potential responses represents an objective and quantifiable method to study visceral afferent sensory pathways in humans. We examined the evoked responses to mechanical distension (balloon) and electrical stimulation of the proximal and distal esophagus. A standard manometric catheter with a latex...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Hollerbach S,Hudoba P,Fitzpatrick D,Hunt R,Upton AR,Tougas G

    更新日期:1998-11-01 00:00:00

  • Overexpression of protein phosphatase non-receptor type 11 (PTPN11) in gastric carcinomas.

    abstract:BACKGROUND:Tyrosine phosphorylation and dephosphorylation by protein tyrosine kinases and phosphatases (PTPs), respectively, play crucial roles in cellular signal transduction. Protein phosphatase non-receptor type 11 (PTPN11) is a positive signaling PTP that activates RAS and ERK signaling. Also, the PTPN11 binds with...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kim JS,Shin OR,Kim HK,Cho YS,An CH,Lim KW,Kim SS

    更新日期:2010-06-01 00:00:00

  • Different mechanism of magnesium and calcium transport across rat duodenum.

    abstract::Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Karbach U,Schmitt A,Saner FH

    更新日期:1991-11-01 00:00:00

  • Impaired alveolar gas exchange in acute pancreatitis.

    abstract::We evaluated the alveolar-arterial oxygen difference (deltaA-a) and the ratio between PaO2 and the fractional concentration of inspired oxygen (P/F) in acute pancreatitis. Eleven patients had mild uncomplicated disease, six showed acute abdominal fluid collections, six had acute abdominal collections and asymptomatic ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Salomone T,Tosi P,Di Battista N,Binetti N,Raiti C,Tomassetti P,Migliori M,Gullo L

    更新日期:2002-09-01 00:00:00

  • Effect of casein-derived peptides on D-xylose absorption assessed by H2 breath test in normal volunteers.

    abstract::Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Defilippi C,Madrid AM,Salas K,Michea L,Lagos N

    更新日期:2000-04-01 00:00:00

  • New clinical method for distinguishing D-IBS from other gastrointestinal conditions causing diarrhea: the LA/IBS diagnostic strategy.

    abstract::Modern methods of diagnosing diarrhea-predominant irritable bowel syndrome (D-IBS) require a "diagnosis of exclusion" approach. In this study we aim to test the diagnostic ability of using the fluctuation of frequency and consistency of bowel patterns in IBS to discriminate it from other causes of diarrhea. Eligible s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pimentel M,Hwang L,Melmed GY,Low K,Vasiliauskas E,Ippoliti A,Yang J,Lezcano S,Conklin JL,Sahakian A

    更新日期:2010-01-01 00:00:00

  • Effect of S-adenosyl-L-methionine on ethanol cholestasis and hepatotoxicity in isolated perfused rat liver.

    abstract::We investigated whether S-adenosyl-L-methionine (SAMe) influences the inhibitory effect of ethanol on bile secretion and ethanol hepatotoxicity in the isolated perfused rat liver. SAMe (25 mg/kg intramuscularly three times a day) was administered for three days consecutively. Liver was then isolated and perfused with ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Alvaro D,Gigliozzi A,Piat C,Carli L,Bini A,La Rosa T,Furfaro S,Capocaccia L

    更新日期:1995-07-01 00:00:00

  • Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury.

    abstract:BACKGROUND:Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1 (SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury is unclear. AIMS:To explore the function of SIRT1 and IRF9 in hyperlipidemia acute p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Liu Y,Sun Y,Xue BH,Wang XD,Yu WL

    更新日期:2020-05-28 00:00:00

  • Factors affecting the success of endoscopic bougia dilatation of radiation-induced esophageal stricture.

    abstract:AIMS:The purpose of this retrospective study was to assess clinical outcomes of endoscopic bougie dilation of esophageal strictures after radiation therapy for head and neck cancer, and to assess the risk factors which affect the treatment success. METHODS:Thirty-one patients with esophageal stricture due to radiation...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tuna Y,Koçak E,Dinçer D,Köklü S

    更新日期:2012-02-01 00:00:00

  • Incidence of esophageal carcinoma among Malays in North-Eastern Peninsular Malaysia: an area with an exceptionally low prevalence of Helicobacter pylori infection.

    abstract:BACKGROUND:Obesity, gastroesophageal reflux, and Barrett's esophagus have all been linked to esophageal adenocarcinoma. In addition, the decline in Helicobacter pylori (H. pylori) infection in affluent societies has also been suggested to be a major factor in the recent rise in the incidence of esophageal adenocarcinom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lee YY,Raj SM,Sharif SE,Salleh R,Ayub MC,Graham DY

    更新日期:2011-05-01 00:00:00

  • Prostaglandins and sulfhydryls may mediate gastric protection induced by verapamil in rats.

    abstract::Verapamil, a type-1 calcium-channel blocker, given intraperitoneally, macroscopically protected the gastric mucosa of rats from 96% ethanol-induced lesions in a dose-dependent fashion. This effect was significant when verapamil at 10 or 20 mg/kg was given 1 hr before ethanol. Histopathologically, verapamil prevented t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gutiérrez-Cabano CA

    更新日期:1993-11-01 00:00:00

  • Association between small intestinal bacterial overgrowth and peripheral bacterial DNA in cirrhotic patients.

    abstract:BACKGROUND:Small intestinal bacterial overgrowth (SIBO) is regarded as the major risk factor of bacterial translocation. Few studies have investigated the direct relation between SIBO and translocation in cirrhotic patients. The purpose of this study is to examine the correlation between SIBO and bacterial DNA in the p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jun DW,Kim KT,Lee OY,Chae JD,Son BK,Kim SH,Jo YJ,Park YS

    更新日期:2010-05-01 00:00:00

  • Women's health training in gastroenterology fellowship: a national survey of fellows and program directors.

    abstract:BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

    更新日期:2011-03-01 00:00:00

  • Predicting short-term mortality and long-term survival for hospitalized US patients with alcoholic hepatitis.

    abstract:BACKGROUND:No study has evaluated current scoring systems for their accuracy in predicting short and long-term outcome of alcoholic hepatitis in a US population. METHODS:We reviewed electronic records for patients with alcoholic liver disease (ALD) admitted to Parkland Memorial Hospital between January 2002 and August...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cuthbert JA,Arslanlar S,Yepuri J,Montrose M,Ahn CW,Shah JP

    更新日期:2014-07-01 00:00:00

  • Electrogastrography in patients with gastroparesis and effect of long-term cisapride.

    abstract::Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rothstein RD,Alavi A,Reynolds JC

    更新日期:1993-08-01 00:00:00

  • Granular cell tumor of the esophagus: natural history, diagnosis, and therapy.

    abstract::Five cases of granular cell tumor of the esophagus are reported. In four cases, the tumor was an asymptomatic, incidental finding. In one case, a larger granular cell tumor presented with dysphagia and required local surgical excision. Long-term follow-up in three cases revealed no evidence of tumor progression. Esoph...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Brady PG,Nord HJ,Connar RG

    更新日期:1988-10-01 00:00:00

  • Diverticulitis in a patient with a 47-year defunctionalized colon.

    abstract::A patient who had a cecostomy because of a complicated appendicitis at the age of 17 functioned with an excluded colon for 47 years. He was then hospitalized for diverticulitis and left pericolic abscess. After treatment of the abscess by left segmental colectomy and reanastomosis, the cecostomy was closed. Two years ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Desechalliers JP,Galmiche JP,Denis P,Teniere P,Testart J,Colin R

    更新日期:1981-02-01 00:00:00

  • Gas within the wall of the stomach report of a case and review of the literature.

    abstract::Gas within the stomach wall is a rare occurrence. A case of intramural gas is presented. When air or gas is seen within the gastric wall on x-ray, gastric emphysema, emphysematous gastritis, or pneumatosis intestinalis is diagnosed. These classifications have become vague and contradictory. Gas in the gastric wall can...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kussin SZ,Henry C,Navarro C,Stenson W,Clain DJ

    更新日期:1982-10-01 00:00:00

  • Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection.

    abstract:BACKGROUND AND AIM:The purpose of this study was to examine the association between celiac disease (CD) and prior respiratory syncytial virus (RSV) infection or any viral bronchiolitis. METHODS:This was a retrospective case-control study. During 2006-2008 small intestinal biopsy data were collected from Sweden's 28 pa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tjernberg AR,Ludvigsson JF

    更新日期:2014-07-01 00:00:00

  • CARD15/NOD2 in a Tunisian population with Crohn's disease.

    abstract::Crohn's disease (CD) is a heterogeneous disorder. A genetic linkage to chromosome 16 (IBD1) has been previously observed and replicated in unrelated populations. Recently, in this region, NOD2/CARD15 has been identified as a susceptibility gene. The aim of this report is to determine whether this gene is implicated in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Zouiten-Mekki L,Zaouali H,Boubaker J,Karoui S,Fekih M,Matri S,Hamzaoui S,Filali A,Chaabouni H,Hugot JP

    更新日期:2005-01-01 00:00:00

  • Efficacy of T2 in active Crohn's disease: a prospective study report.

    abstract::To date few therapies have been shown to reliably prevent the evolution of Crohn's disease (CD). The traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), has both immunomodulatory and anti-inflammatory activities. Our aim was to investigate the potential efficacy of T2, the major constituent of extracts...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ren J,Tao Q,Wang X,Wang Z,Li J

    更新日期:2007-08-01 00:00:00

  • Prognostic Factors for Acute Transjugular Intrahepatic Portosystemic Shunt Occlusion Using Expanded Polytetrafluoroethylene-Covered Stent.

    abstract:BACKGROUND:The expanded polytetrafluoroethylene (ePTFE)-covered stent has been widely used in the transjugular intrahepatic portosystemic shunt (TIPS) procedure. However, the epidemiologic data of acute TIPS occlusion (ATO) and the underlying mechanisms are scarce. AIMS:The purpose of this study was to evaluate the in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wang X,Luo X,Zhao M,Song J,Li X,Yang L

    更新日期:2020-10-01 00:00:00

  • Failure of inhibitor assay to determine isoamylase distribution.

    abstract::Isoamylase distribution in the urine of normal individuals and patients admitted to the hospital with hyperamylasemia was determined by a wheat inhibitor mmethod and compared to results obtained by cellulose-acetate electrophoresis. We report two cases where the inhibitor ethod failed to give accurate results in urine...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gersten M,Bank S,Lendvai S

    更新日期:1983-11-01 00:00:00

  • Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome.

    abstract:BACKGROUND:This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. METHODS:A total of 163 patients were randomized into two groups: Group A to consume...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Bahrudin MF,Abdul Rani R,Tamil AM,Mokhtar NM,Raja Ali RA

    更新日期:2020-02-01 00:00:00