The role of N-acetyltransferase 2 polymorphism in the etiopathogenesis of inflammatory bowel disease.


BACKGROUND AND PURPOSE:Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD), which are complex genetic disorders resulting from the interplay between several genetic and environmental risk factors. The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs. Acetylation catalyzed by NAT2 is an important process in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. The aim of our study was to determine whether there is any association between the susceptibility to inflammatory bowel disease among the variations of NAT2 genotypes. METHODS:This study was carried out in 80 patients with IBD. The control group consisted of 100 healthy volunteers. The most common mutations found in the Caucasian population are at the positions 481T, 803G, 590A and 857A on the NAT2 gene. This was determined using the polymerase chain reaction-restriction fragment length polymorphism method with DNA extracted from peripheral blood. RESULTS:Risk of IBD development was 3.86 for the carriers of the NAT2*5/NAT2*7 genotype and 2.53 for the carriers with NAT2*6/NAT2*7, but it was not statistically significant. A statistically significant correlation between the NAT2*7 allele prevalence and the risk for developing IBD was found (OR = 5.8; P = 0.005). CONCLUSIONS:Higher prevalence of the NAT2*7 allele in patients with IBD and the obtained OR values could suggest that this mutation has the effect of increasing IBD development. Future studies are needed to confirm our assumptions on larger group of patients.


Dig Dis Sci


Baranska M,Trzcinski R,Dziki A,Rychlik-Sych M,Dudarewicz M,Skretkowicz J




Has Abstract


2011-07-01 00:00:00












  • Gallbladder dynamics in chronic pancreatitis. Relationship to exocrine pancreatic function, CCK, and PP release.

    abstract::Gallbladder dynamics, cholecystokinin (CCK), and pancreatic polypeptide (PP) release were studied in 14 patients with chronic pancreatitis (CP) (2 females, 12 males; age range 24-56 years) and 12 control subjects (4 females, 8 males, 21-50 years). On day 1, gallbladder contractility was investigated after ceruletide i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Glasbrenner B,Malfertheiner P,Pieramico O,Klatt S,Riepl R,Friess H,Ditschuneit H

    更新日期:1993-03-01 00:00:00

  • Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.

    abstract::Cyclic GMP plays an important role in maintaining homeostasis in the gastric mucosa. NSAIDs damage the mucosa by mechanisms that may be mediated by alterations in the intragastric concentration of cyclic GMP. To test this hypothesis we studied the effects of the oral administration of acetylsalicylic acid (100, 300, a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Herrerías JM,Esteban JM,Caballero-Plasencia AM,Valenzuela-Barranco M,Motilva V,Alarcón C,Martín J,Herrerías JM Jr,Esteban P

    更新日期:2003-05-01 00:00:00

  • Management of Less Than 10-mm-Sized Pedunculated (Ip) Polyps with Thin Stalk: Hot Snare Polypectomy Versus Cold Snare Polypectomy.

    abstract:BACKGROUND:Although the use of cold snare polypectomy (CSP) has spread rapidly, its safety for pedunculated (Ip) polyps remains controversial. In particular, the outcomes of hot snare polypectomy (HSP) and CSP for Ip polyps have not been previously compared. AIMS:This study evaluated whether the rate of delayed postpo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Arimoto J,Chiba H,Ashikari K,Fukui R,Tachikawa J,Okada N,Suto T,Kawano N,Niikura T,Kuwabara H,Nakaoka M,Ida T,Goto T,Nakajima A

    更新日期:2020-07-04 00:00:00

  • Effect of growth factors and prostaglandin E2 on restitution and proliferation of rabbit esophageal epithelial cells.

    abstract::Factors and mechanisms involved in esophageal mucosal injury and repair are not well known. The aim of this study was to assess the effects of growth factors and prostaglandins on esophageal mucosal cell repair activities. Rabbit esophageal cells were isolated, cultured, and exposed to different growth factors and pro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jimenez P,Lanas A,Piazuelo E,Esteva F

    更新日期:1998-10-01 00:00:00

  • The effect of hyaluronan-based agents on adhesion formation in an intraabdominal sepsis model.

    abstract::Because of the technical difficulty during subsequent surgical intervention, adhesion remains the most important predictor of outcome in the staged procedures following emergent colorectal surgery. The aim of this study was to assess the long-term effects of hyaluronan (HA)-based adhesion barriers 3 months following t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tüzüner A,Kuzu MA,Akin B,Karaca S,Hazinedaroglu S

    更新日期:2004-06-01 00:00:00

  • Endoscopic evaluation of the effect of sucralfate therapy and other clinical parameters on the recurrence rate of gastric ulcers.

    abstract::A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miyake T,Ariyoshi J,Suzaki T,Oishi M,Sakai M,Ueda S

    更新日期:1980-01-01 00:00:00

  • Accurate Identification of Fatty Liver Disease in Data Warehouse Utilizing Natural Language Processing.

    abstract:INTRODUCTION:Natural language processing is a powerful technique of machine learning capable of maximizing data extraction from complex electronic medical records. METHODS:We utilized this technique to develop algorithms capable of "reading" full-text radiology reports to accurately identify the presence of fatty live...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Redman JS,Natarajan Y,Hou JK,Wang J,Hanif M,Feng H,Kramer JR,Desiderio R,Xu H,El-Serag HB,Kanwal F

    更新日期:2017-10-01 00:00:00

  • Reevaluation of manometric criteria for vigorous achalasia. Is this a distinct clinical disorder?

    abstract::Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    更新日期:1991-03-01 00:00:00

  • Development of an improved multi-pressure-sensor probe for recording muscle contraction in human intestine.

    abstract::We have developed an improved semiconductor recording probe for monitoring motility of the upper small intestine in humans. The probe consists of six ultraminiature silicon pressure sensors spaced 10 cm apart and encased in a flexible polyurethane sheath. The probe is small [2.67 mm (8F) diameter], is easily passed tr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Mathias JR,Sninsky CA,Millar HD,Clench MH,Davis RH

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  • Probability-based interpretation of liver stiffness measurement in untreated chronic hepatitis B patients.

    abstract:BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


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    更新日期:2015-05-01 00:00:00

  • The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.

    abstract::This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNM...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ding WJ,Fang JY,Chen XY,Peng YS

    更新日期:2008-08-01 00:00:00

  • Impaired interdigestive pancreatic polypeptide release. Early hormonal disorder in chronic pancreatitis?

    abstract::The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). We investigated nine patients with mild-moderate CP (MCP), eight patients with severe CP and steathorrea (SCP), and 17 he...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


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    更新日期:1994-01-01 00:00:00

  • Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiography. Report of a case without biliary tract disease.

    abstract::We report a case of Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiopancreatography (ERCP) in a patient without evidence of biliary tract disease and of any known cause of hepatic infection. Computer tomography (CT) scan was the best method of diagnosis, allowing, through guided percuta...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Davion T,Braillon A,Delamarre J,Delcenserie R,Joly JP,Capron JP

    更新日期:1987-09-01 00:00:00

  • Measurement of postprandial changes in urine acid output to detect changes of gastric acid secretion after proton pump inhibitors in children.

    abstract::Acid inhibition after proton pump inhibitors in children is variable, and to measure it by a noninvasive method may help to tailor treatment. To study gastric acid inhibition after a single dose of PPI, by measuring urinary acid output (UAO), which decreases as parietal cells release acid into the stomach during a mea...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Oderda G,Rapa A,Chiorboli E,Ronchi B,Zavallone A,Strigini L

    更新日期:2002-08-01 00:00:00

  • Estrogen-induced proliferation in cultured hepatocytes involves cyclin D1, p21(Cip1) and p27(Kip1).

    abstract::The purpose of this study was to establish if estrogen-induced hepatocyte proliferation in vitro involves the cell cycle regulators cyclin D1, p21(Cip1), and p27(Kip1). Male rat hepatocytes were cultured in presence of 17-beta-estradiol (E2) +/- ICI-182780, a pure estrogen antagonist, and [3H]-thymidine, as required. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Barone M,Ladisa R,Di Leo A,Spano D,Francioso D,Aglio V,Amoruso A,Francavilla A,Iolascon A

    更新日期:2006-03-01 00:00:00

  • Consensus statement: octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel.

    abstract::Octreotide is an effective therapeutic option in controlling secretory diarrhea of varied etiology. However, marked patient-to-patient differences in the antidiarrheal effects necessitate titration of octreotide dose in individual patients to achieve optimal symptom control. A consensus development panel established g...

    journal_title:Digestive diseases and sciences

    pub_type: 共识发展会议,杂志文章,评审


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    更新日期:1995-07-01 00:00:00

  • Intravenous cyclosporine in attacks of ulcerative colitis: short-term and long-term responses.

    abstract::The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one po...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Carbonnel F,Boruchowicz A,Duclos B,Soulé JC,Lerebours E,Lémann M,Belaïche J,Colombel JF,Cosnes J,Gendre JP

    更新日期:1996-12-01 00:00:00

  • Gastrointestinal endoscopic terminology coding (GET-C): a WHO-approved extension of the ICD-10.

    abstract::Technological developments have greatly promoted interest in the use of computer systems for recording findings and images at endoscopy and creating databases. The aim of this study was to develop a comprehensive WHO-approved code system for gastrointestinal endoscopic terminology. The International Classification of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Groenen MJ,Hirs W,Becker H,Kuipers EJ,Van Berge Henegouwen GP,Fockens P,Ouwendijk RJ

    更新日期:2007-04-01 00:00:00

  • Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease.

    abstract:BACKGROUND:Eosinophilic esophagitis is among the causes of refractory reflux disease. Biopsy of esophagus is the gold standard for diagnosis. In this study we determined the frequency of eosinophilic esophagitis (EE) in refractory reflux cases referred to Motility Department of Shahid Beheshti Research Center of Gastro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Foroutan M,Norouzi A,Molaei M,Mirbagheri SA,Irvani S,Sadeghi A,Derakhshan F,Tavassoli S,Besharat S,Zali M

    更新日期:2010-01-01 00:00:00

  • Mechanical characteristics of distension-evoked peristaltic contractions in the esophagus of systemic sclerosis patients.

    abstract:BACKGROUND:Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. AIMS:To apply, for the first time in gastrointestinal (GI) patien...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gregersen H,Villadsen GE,Liao D

    更新日期:2011-12-01 00:00:00

  • Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis.

    abstract:BACKGROUND:Diagnosis of pediatric inflammatory bowel diseases (IBD) remains challenging. We aimed at the value of immunohistochemical assessment of CD30+ lymphocytes in the intestinal mucosa in differential diagnosis between pediatric Crohn's disease (CD) and ulcerative colitis (UC) and its utility as a predictor of fu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fabian O,Hradsky O,Drskova T,Mikus F,Zamecnik J,Bronsky J

    更新日期:2018-07-01 00:00:00

  • Topical prostaglandin E2 protects isolated gastric mucosa against acidified taurocholate-, but not ethanol- or aspirin-induced injury.

    abstract::This study investigates whether topical prostaglandins protect isolated gastric mucosa against injury provoked by acidified "barrier-breaking" agents. Intracellular pH (pHi), apical cell membrane potential (Vcm) and intraepithelial resistances in isolated Necturus antral mucosa were measured using double-barreled liqu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ranta-Knuuttila T,Mustonen H,Kivilaakso E

    更新日期:2000-01-01 00:00:00

  • Altered bile acid metabolism in primary biliary cirrhosis.

    abstract::Selected aspects of bile acid metabolism were assessed in six women with primary biliary cirrhosis and varying degrees of cholestasis. Urinary bile acid excretion was markedly increased and correlated highly with serum levels. In three patients in whom urinary bile acids were separated by chromatography, the majority ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Raedsch R,Lauterburg BH,Hofmann AF

    更新日期:1981-05-01 00:00:00

  • Association between gastrointestinal tract carriage of Candida, blood group O, and nonsecretion of blood group antigens in patients with peptic ulcer.

    abstract::Of 112 patients with peptic ulcer disease examined for oral carriage of Candida, 66 (59%) were carriers. Candida carriage was associated with blood group O (P < 0.05) and, independently, with nonsecretion of blood group antigens (P < 0.01). For each subject, the presence or absence of yeasts was found to be a constant...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Burford-Mason AP,Willoughby JM,Weber JC

    更新日期:1993-08-01 00:00:00

  • Diagnosis of malignant ascites. Comparison of ascitic fibronectin, cholesterol, and serum-ascites albumin difference.

    abstract::The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Prieto M,Gómez-Lechón MJ,Hoyos M,Castell JV,Carrasco D,Berenguer J

    更新日期:1988-07-01 00:00:00

  • Efficacy of daily induction dosing vs standard thrice weekly dosing of interferon-alpha2B for initial treatment of chronic hepatitis C.

    abstract::The aim of this study was to compare the effect on HCV RNA levels of using induction dosing with 5 MU interferon-alpha2b (IFN) given daily for four weeks followed by 5 MU IFN given three times a week (TIW) for 44 weeks vs standard noninduction TIW dosing of 5 MU IFN for 48 weeks. We randomly assigned 135 patients with...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gonzalez HJ,Ho SB,Gross JB,Peine C,McKee D,Smith T,Midwest Hepatitis Study Group.

    更新日期:2002-04-01 00:00:00

  • Indium scanning in assessment of acute Crohn's disease. A prospective study of sensitivity and correlation with severity of mucosal damage.

    abstract::The aim of this study was to determine whether the sensitivity of indium-111 (111In) scanning in the assessment of the activity and extent of Crohn's disease correlates with the severity of intestinal lesions as measured by the newly validated Crohn's disease endoscopic index of severity (CDEIS). Nineteen patients wit...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Heresbach D,Bretagne JF,Raoul JL,Moisan A,Siproudhis L,Devillers A,Gosselin M

    更新日期:1993-09-01 00:00:00

  • Predictors and noninvasive identification of severe liver fibrosis in patients with chronic hepatitis C.

    abstract::Diagnosis of severe fibrosis (stages III and IV) in hepatitis C has clinical implications. Our objective was to distinguish independent predictors of severe fibrosis and use them to identify patients with severe fibrosis without a liver biopsy. One hundred ninety-nine hepatitis C patients were included in the initial ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Metwally MA,Zein CO,Zein NN

    更新日期:2007-02-01 00:00:00

  • Sigmoid afferent mechanisms in patients with irritable bowel syndrome.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lembo T,Munakata J,Naliboff B,Fullerton S,Mayer EA

    更新日期:1997-06-01 00:00:00

  • In vitro tests overestimate in vivo neutralizing capacity of antacids in presence of food.

    abstract::The neutralizing capacity of two antacids (Alucol = A, Syntrogel = S), differing both in their composition and theoretical neutralizing capacity, was evaluated in vitro and in vivo. In vitro at pH 3.5, 1 ml of A or S neutralizes 3.9 and 1.6 meq of acid, respectively, in an aqueous solution. When tested in vivo in the ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Berchtold P,Reinhart WH,Niederhäuser U,Koller U,Halter F

    更新日期:1985-06-01 00:00:00