Abstract：
:Abnormalities in colonic glycoprotein synthesis have been implicated in the pathogenesis of ulcerative colitis and Crohn's disease. Glucosamine synthetase is the rate-limiting step in the biosynthesis of gastrointestinal glycoprotein and has been measured in control subjects (N = 23) and patients with ulcerative colitis (N = 26) or Crohn's disease of the colon (N = 20) classified according to the macroscopic status of the rectum. Glucosamine synthetase activity was relatively constant around the normal colon but lower levels were found in the terminal ileum. In ulcerative colitis, glucosamine synthetase activity was similar to controls (24.0 +/- 1.9) mmol/g wet (wt/hr) irrespective of disease activity (quiescent: N = 13, = 27.3 +/- 1.9; active N = 16, = 26.2 +/- 2.3). Rectal glucosamine synthetase activity was normal in the presence of active Crohn's proctocolitis (29.4 +/- 3.1) but raised in patients with Crohn's colitis and rectal sparing (37.2 +/- 4.9 P < 0.02). Glucosamine synthetase activity was strongly influence by the degree of epithelial preservation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Winslet MC,Poxon V,Allan A,Keighley MRdoi
10.1007/BF02088339subject
Has Abstractpub_date
1994-03-01 00:00:00pages
540-4issue
3eissn
0163-2116issn
1573-2568journal_volume
39pub_type
杂志文章abstract：:A discrepancy exists on the effects of somatostatin on the absorption of nutrients: in humans, absorption was found to be reduced, whereas in rats no effects were observed. However, intestinal absorption might be influenced by the transit rate of contents. This was not considered in previous studies. Therefore, we inv...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02091528
更新日期：1996-05-01 00:00:00
abstract：:The macroscopic appearance of the liver after primary portal vein thrombosis often mimics cirrhosis, despite the absence of bridging fibrosis at histology. The purpose of this study was to describe unique morphologic changes of the liver after portal venous thrombosis. A retrospective review was performed to find pati...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0201-6
更新日期：2008-10-01 00:00:00
abstract：:Rectally administered suspensions of 5-aminosalicylic acid (5-ASA) are topically effective in treating left-sided ulcerative colitis. The extent to which the contents of these enemas are distributed to inflamed mucosal linings has not previously been determined. This study was undertaken to validate a technique for la...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540060
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Acid reflux has been associated with poor outcomes following lung transplantation. Unlike surgical fundoplication, the role of noninvasive, pharmacologic acid suppression remains uncertain. AIMS:To assess the relationship between post-transplant acid suppression with proton pump inhibitors (PPI) or histamin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-017-4827-0
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND AND AIMS:Researchers have not clearly described the clinical and pathogenetic features of hypoganglionosis and adult-onset Hirschsprung's disease, which cause pseudo-obstruction or intractable constipation. We conducted this study to explore these features of hypoganglionosis and adult-onset Hirschsprung's d...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1522-9
更新日期：2011-06-01 00:00:00
abstract：:Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigra...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02090199
更新日期：1994-02-01 00:00:00
abstract：:Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297052
更新日期：1987-03-01 00:00:00
abstract：:This study was undertaken to determine whether the synthetic prostaglandin E2 analog enprostil is able to inhibit basal and postprandial hypergastrinemia induced by omeprazole. We also studied the effect of omeprazole, enprostil, and the combination of both drugs on serum pepsinogen A and C levels. Eight normal subjec...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02088350
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Eosinophilic esophagitis is among the causes of refractory reflux disease. Biopsy of esophagus is the gold standard for diagnosis. In this study we determined the frequency of eosinophilic esophagitis (EE) in refractory reflux cases referred to Motility Department of Shahid Beheshti Research Center of Gastro...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0706-z
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:MELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy of estimates of survival. AIMS:To assess and compare the prognostic ability ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5360-5
更新日期：2019-02-01 00:00:00
abstract：:A patient who had a cecostomy because of a complicated appendicitis at the age of 17 functioned with an excluded colon for 47 years. He was then hospitalized for diverticulitis and left pericolic abscess. After treatment of the abscess by left segmental colectomy and reanastomosis, the cecostomy was closed. Two years ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01312240
更新日期：1981-02-01 00:00:00
abstract：:The purpose of this study was to use simultaneous anal manometry and high-frequency endoluminal ultrasonography (EUS) to determine the relationship between resting anal pressure and cross-sectional area of the internal and external anal sphincters. Eleven normal subjects underwent simultaneous anal EUS and manometry u...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026605409557
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Percutaneous gastrostomy (PEG) is a common inpatient procedure. Prior data from National Inpatient Sample (NIS) in 2006 reported a mortality rate of 10.8% and recommended more careful selection of PEG candidates. This study assessed for improvement in the last 10 years in mortality rate and complica...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06396-y
更新日期：2020-06-19 00:00:00
abstract：:Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01307557
更新日期：1993-02-01 00:00:00
abstract：:We describe the first reported case of mantle zone lymphoma of the colon presenting as diffuse ileocolitis simulating severe inflammatory bowel disease. This case serves to illustrate the importance of immunohistochemistry in establishing the diagnosis of lymphoma in extranodal sites. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300394
更新日期：1992-06-01 00:00:00
abstract：:Altered peripheral neutrophil function is a feature of IBD that may contribute to the chronicity and extragastrointestinal manifestations of this disease, but clinical evidence for such alterations is confounded by variations in patient characteristics, disease onset, and use of therapeutics that can influence neutrop...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02063966
更新日期：1995-01-01 00:00:00
abstract：:The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537267
更新日期：1989-08-01 00:00:00
abstract：:To examine the relationship between peptic ulcer and gastric cancer, we investigated 2529 patients with peptic ulcer diagnosed from 1963 to 1975. During the follow-up period of 9-23 years, we found 38 in whom gastric cancer developed or who died of gastric cancer. Included were nine in whom gastric cancer was detected...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01540181
更新日期：1990-06-01 00:00:00
abstract：:The susceptibility to sepsis in obstructive jaundice may be related to bacterial translocation (BT) from the gastrointestinal tract. We evaluated BT to visceral organs and morphological changes of the intestinal mucosa in a rat model of obstructive jaundice. Animals were randomly divided into two groups: in group A th...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1014733226337
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:Histological remission represents a target distinct from endoscopic healing in ulcerative colitis (UC) and seems a better predictor of clinical outcomes. AIMS:The aim of this study was to assess the ability of adalimumab to achieve histological remission in UC patients. METHODS:Single-center, retrospective...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-4935-5
更新日期：2018-03-01 00:00:00
abstract：:Accurate and cost-effective diagnosis of Helicobacter pylori gastritis has taken on major importance. Several serologic tests for the diagnosis of H. pylori infection are commercially available. We compared the performance of the FlexSure HP rapid IgG antibody test with the conventional HM-CAP ELISA to evaluate whethe...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018832306135
更新日期：1998-01-01 00:00:00
abstract：:The efficacy of comaruman CP, a pectin of marsh cinquefoil Comarum palustre L., was investigated using a model of acetic acid-induced colitis in mice. Mice were administered comaruman CP orally 2 days prior to rectal injection of 5% acetic acid and examined for colonic damage 24 hr later. Colonic inflammation was char...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-9034-8
更新日期：2006-09-01 00:00:00
abstract：:Not much is known about the relationship between portal hemodynamics and the grades of cirrhosis. Using pulsed Doppler ultrasonography, we studied portal vein diameter, portal flow velocity, and portal blood flow rate in 37 patients with liver cirrhosis (11 Child's A, 13 Child's B, and 13 Child's C) and 10 healthy con...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018814624307
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is universal and tends to be more aggressive. Data on post-transplant HCV genotype 4 treatment is scarce. The aim of this study is to assess the safety and efficacy of pegylated interferon alpha-2a (PEG-IFN) in combination with ribavirin in ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1526-5
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Concerns over the hypothetical adverse effects of water absorption and the disturbance of serum sodium and potassium levels prompted a quality assurance evaluation of water exchange (WE) colonoscopy. AIM:The purpose of this study was to evaluate the balance of water infused and suctioned in WE colonoscopy, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-013-2934-0
更新日期：2014-03-01 00:00:00
abstract：:Microvesicular steatosis is a potentially severe manifestation of valproic acid hepatotoxicity due to an acquired impairment of mitochondrial function. Tests currently used to investigate mitochondrial fonction are cumbersome and cannot be used routinely. We report on a noninvasive breath test using [13C]methionine fo...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1012791832730
更新日期：2001-12-01 00:00:00
abstract：:Achalasia has been described following fundoplication and is attributed to vagal nerve damage during surgery. Similarly, other traumatic events to the distal esophagus may be linked to the development of achalasia. Operative and nonoperative trauma as a possible factor in the development of achalasia was studied. A re...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-004-9577-0
更新日期：2004-11-01 00:00:00
abstract：:Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318195
更新日期：1991-03-01 00:00:00
abstract：:Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypers...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01308088
更新日期：1992-12-01 00:00:00
abstract：:Significant species differences have been demonstrated in gastric physiology, a factor that limits extrapolation of animal data to man. Primate physiology is thought to be similar to that of man; however, gastric function has not been adequately documented in the primate. In the present study six baboons (body weight ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295997
更新日期：1992-09-01 00:00:00
