Mucosal damage during intestinal anaphylaxis in the rat. Effect of betamethasone and disodium cromoglycate.


:In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epithelial damage with shorter villi, decreased activity of digestive enzymes, decreased levels of mucosal histamine, a mast cell mediator, and increased blood uptake of [51Cr]EDTA from the lumen. Low-dose betamethasone, 24 and 48 hr before antigen, was not effective in preventing the effects: villus damage and increased [51Cr]EDTA uptake were seen, although mucosal mast cell numbers were significantly reduced by the drug. High-dose betamethasone completely prevented intestinal anaphylaxis: villus height, digestive function, and [51Cr]EDTA recovery in antigen-challenged animals were not significantly different from controls. Mucosal histamine levels and mast cells were significantly reduced in the high dose betamethasone group. Oral disodium cromoglycate did not prevent the abnormalities but provided a slight beneficial effect.


Dig Dis Sci


D'Incà R,Hunt RH,Perdue MH




Has Abstract


1992-11-01 00:00:00












  • Effects of somatostatin analog SMS 201-995 on enterotoxigenic diarrhea.

    abstract::Somatostatin analog SMS 201-995 causes a dose-related suppression of the release and/or action of several gastrointestinal hormones and impairs several anterior pituitary functions. Some patients with illness involving abnormal hormonal activity have responded to treatment with SMS 201-995, including resolution of sev...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Greenberg RN

    更新日期:1991-12-01 00:00:00

  • Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea: a population-based study.

    abstract::Various reports on the prevalence of gastroesophageal reflux disease (GERD) and uninvestigated dyspepsia have been conducted in Western countries. We sought to determine the frequency of GERD symptoms and uninvestigated dyspepsia in Korea. Telephone interviews were conducted with 1,044 individuals. Of all subjects, 7....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yang SY,Lee OY,Bak YT,Jun DW,Lee SP,Lee SH,Park GT,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH

    更新日期:2008-01-01 00:00:00

  • Small bowel cancers diagnosed by device-assisted enteroscopy at a U.S. referral center: a five-year experience.

    abstract:BACKGROUND:Primary malignant neoplasms of the small bowel comprise only 1-3% of all gastrointestinal malignancies. Small bowel cancers pose a significant diagnostic challenge. The recent development of video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE) have greatly facilitated evaluation of the small b...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Partridge BJ,Tokar JL,Haluszka O,Heller SJ

    更新日期:2011-09-01 00:00:00

  • Cryptosporidiosis and inflammatory bowel disease. Experience from the Milwaukee outbreak.

    abstract::The 1993 Milwaukee Cryptosporidium outbreak posed several questions regarding appropriate management and prognosis of inflammatory bowel disease patients acutely infected with this organism. We prospectively identified and monitored 12 patients with stable ulcerative colitis or Crohn's disease who suffered abrupt clin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Manthey MW,Ross AB,Soergel KH

    更新日期:1997-08-01 00:00:00

  • Reevaluation of manometric criteria for vigorous achalasia. Is this a distinct clinical disorder?

    abstract::Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Todorczuk JR,Aliperti G,Staiano A,Clouse RE

    更新日期:1991-03-01 00:00:00

  • Microendoscopic nasointestinal feeding tube placement in mechanically ventilated patients with gastroparesis.

    abstract::Gastroparesis often precludes gastric enteral nutrition (EN) in critically ill patients. Our aim was to determine the feasibility of bedside microendoscopic placement of nasointestinal feeding tubes to facilitate enteral nutrition in critically ill patients with poor gastric emptying. Nine mechanically ventilated pati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Taylor SJ,Przemioslo R,Manara AR

    更新日期:2003-04-01 00:00:00

  • Intravenous versus high-dose oral proton pump inhibitor therapy after endoscopic hemostasis of high-risk lesions in patients with acute nonvariceal upper gastrointestinal bleeding.

    abstract::Intravenous proton pump inhibitors (IV PPIs) decrease rebleeding following endoscopic hemostasis of bleeding peptic ulcers. Oral PPIs may be equally efficacious and may significantly reduce health care costs. This study aimed to compare outcomes in patients receiving oral versus IV PPI therapy following endoscopic hem...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Murthy S,Keyvani L,Leeson S,Targownik LE

    更新日期:2007-07-01 00:00:00

  • Bleeding duodenal ulcer. Role of gastric acid hypersecretion.

    abstract::Basal gastric acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of gastric acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulce...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Collen MJ,Kalloo AN,Sheridan MJ

    更新日期:1993-02-01 00:00:00

  • Effect of Long-Term Mesalamine Therapy on Cancer-Associated Gene Expression in Colonic Mucosa of Patients with Ulcerative Colitis.

    abstract:BACKGROUND:The role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was reported, but the effect on molecular targets in UC colon mucosa is unknown. AIM:This observational study evaluates gene expression levels of 5-ASA targets using serial colo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bajpai M,Seril DN,Van Gurp J,Geng X,Alvarez J,Minacapelli CD,Gorin S,Das KK,Poplin E,Cheng J,Amenta PS,Das KM

    更新日期:2019-03-01 00:00:00

  • Acute type A hepatitis in three patients with chronic HBV infection.

    abstract::We have studied three patients with chronic HBV infection who had a superimposed bout of type A hepatitis. The patients recovered uneventfully without observing a change in their clinical course afterwards. In one patient we observed transient disappearance of DNA polymerase during type A hepatitis; we have postulated...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Conteas C,Kao H,Rakela J,Weliky B

    更新日期:1983-08-01 00:00:00

  • Nutritional implications of chronic dyspepsia in childhood.

    abstract::Chronic dyspepsia is common in children. However, the association of individual predominant symptoms with gastric emptying and their impact on nutritional status are poorly defined. We therefore studied 31 children (mean age 11 years, 14 boys) with chronic dyspepsia and classified their predominant symptoms (PS) by th...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Papadopoulou A,Vazeou A,Siafakas C,Papadimitriou A,Bartsocas C

    更新日期:2002-01-01 00:00:00

  • Gastric functions in portal hypertension. Role of endothelin.

    abstract::This study investigated the effects of portal hypertension on gastric motor and secretory functions and the role of endothelin in rats. Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Günal O,Yeğen C,Aktan AO,Yalin R,Yeğen BC

    更新日期:1996-03-01 00:00:00

  • Celiac disease and autoimmune endocrinologic disorders.

    abstract::Patients with insulin-dependent diabetes mellitus, autoimmune thyroid disease, Addison's disease, and alopecia areata are at increased risk of celiac disease. We investigated whether patients with more than one autoimmune endocrinologic disorder are even more susceptible to celiac disease or have celiac-type mucosal i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Kaukinen K,Collin P,Mykkänen AH,Partanen J,Mäki M,Salmi J

    更新日期:1999-07-01 00:00:00

  • Aspirin may prevent cholangiocarcinoma: a case-control study from the United kingdom.

    abstract:BACKGROUND:The proliferation of cholangiocarcinoma cells is suppressed in cell culture by nonsteroidal antiinflammatory drugs (NSAIDs) through the inhibition of cyclo-oxygenase-2 enzyme and also by statins which decrease the production of mediators of the cell cycle. AIMS:To investigate whether there is an inverse ass...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Burr NE,Talboys RJ,Savva S,Clark A,Phillips M,Metcalfe M,Dennison A,Robinson R,Lewis MP,Rhodes M,Rushbrook S,Hart AR

    更新日期:2014-07-01 00:00:00

  • Lymphocytic gastritis in nonulcer dyspepsia.

    abstract::The prevalence of lymphocytic gastritis, a specific form of chronic gastritis characterized by infiltration of gastric superficial epithelium with T lymphocytes, has been established in nonulcer dyspepsia. Among a population sample of 586 patients at risk for gastric carcinoma, 0.83% of patients with nonulcer dyspepsi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jaskiewicz K,Price SK,Zak J,Louwrens HD

    更新日期:1991-08-01 00:00:00

  • Natural antibiotic expression in celiac disease--correlation with villous atrophy and response to a gluten-free diet.

    abstract::As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 mo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Taha AS,Faccenda E,Angerson WJ,Balsitis M,Kelly RW

    更新日期:2005-04-01 00:00:00

  • Weight loss induced by gastric implant in rats. Effects of capsaicin sensory denervation.

    abstract::To study the efficacy and mechanism of action of the intragastric bubble, 1- to 5-ml silicone bubbles were surgically implanted into the stomachs of 10- to 12-week-old female rats. To test the hypothesis that the satiety effects of the implant are mediated by visceral sensory nerves, a subgroup was treated as neonates...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Northway MG,Geisinger KR,Gilliam JH,MacLean DB

    更新日期:1992-07-01 00:00:00

  • Association between swallow perception and esophageal bolus clearance in patients with globus sensation.

    abstract:BACKGROUND:Globus sensation is common, but its pathogenesis is not yet clear. AIMS:Our purpose was to investigate subjective perception of swallowing and esophageal motility by combined multichannel intraluminal impedance and manometry (MII-EM) for patients with globus sensation. METHODS:Combined MII-EM was performed...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Chen CL,Yi CH,Liu TT

    更新日期:2013-04-01 00:00:00

  • Production of ectopic gastric intrinsic factor in gastric mucosa of humans with chronic gastritis.

    abstract:BACKGROUND:Ectopic expression of gastric intrinsic factor (IF) has been described in rodent models of chronic gastritis. AIMS:The current study undertook to determine if ectopic IF was also present in chronic gastritis in humans and might identify the process of ectopic protein expression as part of the response to ch...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shao JS,Carmel R,Alpers DH

    更新日期:2011-11-01 00:00:00

  • Perioperative allogenic blood transfusion and serum levels of immunosuppressive acidic protein in patients undergoing resection of colorectal carcinoma.

    abstract::Serum levels of immunosuppressive acidic protein (IAP) were determined in 68 patients undergoing resection of colorectal cancer and 21 healthy subjects. Eighteen patients had perioperative transfusion of allogeneic blood (transfused patients) and 50 patients had no blood transfusion (nontransfused patients). Transfuse...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Iwanaga T,Suzuki H

    更新日期:1999-08-01 00:00:00

  • Sulfamethoxazole-induced hepatic injury.

    abstract::A patient with several episodes of jaundice associated with sulfamethoxazole therapy is described. In contrast to the histologic picture of hepatocellular necrosis with or without cholestasis that is generally associated with sulfonamide hepatotoxicity, in the present case a relatively pure cholestatic pattern was fou...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Steinbrecher UP,Mishkin S

    更新日期:1981-08-01 00:00:00

  • Omentum and basic fibroblast growth factor in healing of chronic gastric ulcerations in rats.

    abstract::Omentum was shown to exhibit angiogenic activity, but its role in healing of chronic gastric ulcers is unknown. This study was designed to compare the effects of omentum and basic fibroblast growth factor (bFGF), a potent angiogenic factor, on healing of chronic gastric ulcers in rats. Several series of rats with gast...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Konturek SJ,Brzozowski T,Majka I,Pawlik W,Stachura J

    更新日期:1994-05-01 00:00:00

  • Hyperplastic polyps of the gastric antrum in patients with gastrointestinal blood loss.

    abstract::The significance of hyperplastic polyps of the gastric antrum in anemic patients with suspected gastrointestinal bleeding has not been determined. The aim of this study is to evaluate the prevalence and prognosis of such polyps in this patient group. Clinical records of patients referred to our endoscopy lab from Nove...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Al-Haddad M,Ward EM,Bouras EP,Raimondo M

    更新日期:2007-01-01 00:00:00

  • Role of hepatitis delta virus infection in hepatocellular carcinoma.

    abstract::Hepatitis B virus (HBV) DNA integrates into the host DNA and shows a series of potentially oncogenetic properties, but HBV is not an acutely transforming virus, because HCC develops decades after infection. Other factors, namely cirrhosis, inflammation, alcohol intake, and viral superinfections, could promote the onco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Verme G,Brunetto MR,Oliveri F,Baldi M,Forzani B,Piantino P,Ponzetto A,Bonino F

    更新日期:1991-08-01 00:00:00

  • Increased susceptibility of rat gastric mucosa to ulcerogenic stimulation with aging. Role of capsaicin-sensitive sensory neurons.

    abstract::We examined the influences of aging on gastric damage and gastric mucosal blood flow (GMBF) responses induced by acid back-diffusion, following the barrier disruption, and investigated the relation of capsaicin-sensitive sensory nerves to these changes. Male Fischer rats 3, 13, and 24 months old were used. Under ureth...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Miyake H,Inaba N,Kato S,Takeuchi K

    更新日期:1996-02-01 00:00:00

  • Leptin in the field of hepatic fibrosis: a pivotal or an incidental player?

    abstract::Leptin is a 16-kDa nonglycosylated protein primarily secreted from the adipocytes of white fat; minor levels of regulated leptin expression also occurs at other sites such as placenta, skeletal muscle, the stomach fundus, and culture-activated hepatic stellate cells (HSCs). Leptin is primarily involved in the regulati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Bethanis SK,Theocharis SE

    更新日期:2006-10-01 00:00:00

  • Signet ring carcinoma of the pancreas, a rare variant with very high CEA values. Immunohistologic comparison with adenocarcinoma.

    abstract::Signet ring carcinoma of the pancreas is rare. We report a case which was remarkable for (1) diffuse, infiltrating growth which suggested chronic pancreatitis at laparotomy, and (2) an associated very high circulating carcinoembryonic antigen (CEA) level of 6400 ng/ml. The case report and autopsy are presented. Twelve...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Tracey KJ,O'Brien MJ,Williams LF,Klibaner M,George PK,Saravis CA,Zamcheck N

    更新日期:1984-06-01 00:00:00

  • Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study.

    abstract::Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Froehlich F,Hartmann D,Guezelhan C,Gonvers JJ,Jansen JB,Fried M

    更新日期:1996-12-01 00:00:00

  • Hepatitis A, hepatitis B, and combination hepatitis vaccines for immunoprophylaxis: an update.

    abstract::Since the publication of the last extensive review of hepatitis vaccines, use of inactivated hepatitis A vaccines has been extended to high-risk regions of the United States and specific patient groups, such as those with chronic liver disease, and use of the recombinant hepatitis B vaccines has been recommended for o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Koff RS

    更新日期:2002-06-01 00:00:00

  • Comparison of Small Versus Large Volume Split Dose Preparation for Colonoscopy: A Study of Colonoscopy Outcomes.

    abstract:BACKGROUND:Split dose bowel preparations (SDP) have superior outcomes for colonoscopy as compared to evening before regimens. However, the association of the actual volume of the SDP to colonoscopy outcome measures has not been well studied. AIMS:Compare adenoma detection rate (ADR), sessile serrated polyp detection r...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Siddiki H,Ravi S,Al-Qaisi MT,Fath AR,Ramirez F,Crowell MD,Pannala R,Faigel DO,Gurudu SR

    更新日期:2018-09-01 00:00:00