Abstract:
:Anorexia nervosa is considered one type of eating disorder that may result in severe malnutrition. Patients with this disorder commonly complain of postprandial nausea, abdominal pain, and distension. We describe the radiologic and motility abnormalities associated with anorexia nervosa in a 21-year-old female. Barium gastrointestinal series demonstrated marked dilation of the duodenum, with prolongation of intestinal transit. A 4-hr fasting gastroduodenal motility study showed no propagating migrating motor complexes (MMC). Prolonged, but nonpropagating, bursts of high-amplitude phasic and tonic contractions were seen in the duodenum. In contrast, antral contractions were of low amplitude and esophageal motor function was normal. Metoclopramide and edrophonium caused an increase in gastroduodenal motor activity, but increased contractions were not associated with symptoms. Following a renutrition program that raised the patient's weight from 64 to 80% of her ideal body weight, the radiographic abnormalities and gastrointestinal dysmotility resolved completely. These observations suggest that anorexia-associated gastrointestinal motor dysfunctions are a consequence, not the cause of the generalized protein-calorie malnutrition associated with anorexia nervosa. The facts that motility in different parts of the gut is affected to different degrees and that gastric and duodenal muscle responds normally to exogenous stimulation argue against a generalized myogenic dysfunction and, rather, point to a reversible dysfunction of neural regulation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Buchman AL,Ament ME,Weiner M,Kodner A,Mayer EAdoi
10.1007/BF02090220subject
Has Abstractpub_date
1994-02-01 00:00:00pages
433-40issue
2eissn
0163-2116issn
1573-2568journal_volume
39pub_type
杂志文章abstract:BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06711-7
更新日期:2020-11-18 00:00:00
abstract:INTRODUCTION:Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06348-6
更新日期:2020-05-23 00:00:00
abstract::Ethanol is a common cause of both acute and chronic pancreatitis. Studies in other organs suggest that polymorphonuclear neutrophils activated by ethanol may cause tissue injury in a variety of conditions. The aim of this study was to investigate the effects of ethanol on neutrophil extravasation in the feline pancrea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026634807335
更新日期:1998-12-01 00:00:00
abstract::Intestinal bacterial overgrowth (IBO) has been suggested to play a pathogenic role in patients with nonalcoholic fatty liver disease (NAFLD). Delayed intestinal transit may contribute to IBO development. Ten nondiabetic patients with NAFLD and abnormal liver enzymes were recruited. Ten healthy individuals, matched by ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2720-8
更新日期:2005-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018834609306
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Esophageal epithelial microRNAs may be used to diagnose Barrett's esophagus (BE) and possibly monitor its progression to esophageal adenocarcinoma (EAC). AIMS:We reviewed studies that have investigated this to identify microRNAs with high biomarker potential for screening and disease monitoring in BE. METH...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3959-3
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Patients with irritable bowel syndrome (IBS) frequently have meal-related symptoms and can recognize specific trigger foods. Lactose intolerance is a well-established carbohydrate malabsorption syndrome that causes symptoms similar to IBS such as bloating, abdominal pain, and diarrhea. However, the prevalenc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05780-7
更新日期:2020-02-01 00:00:00
abstract::Cytomegalovirus (CMV) inclusions were found at colonic perforation sites in three patients with clinical settings suggesting a compromised immunologic status. This could be interpreted as: (1) CMV was an etiologic agent in these perforations; or (2) CMV was an opportunistic superinfection in areas of preexisting infla...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297124
更新日期:1979-05-01 00:00:00
abstract::We studied the prevalence as well as the sociodemographic characteristics and QOL of older adults (> 50 years) with irritable bowel syndrome (IBS) among the population at large and compared it to their younger counterparts'. We hypothesized that IBS is less prevalent among older persons and they suffer poorer QOL comp...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-3153-8
更新日期:2006-03-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01309495
更新日期:1981-10-01 00:00:00
abstract::Many studies have indicated changes in neuropeptides in inflammatory bowel disease (IBD), but with contradictory results. Nerve growth factor also has a potential role in the maintenance of enteric nerves and may be associated with IBD. A quantitative immunohistochemical method was used to measure area density of immu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1017943430627
更新日期:2002-03-01 00:00:00
abstract::An intussusception of the small intestine in association with a long tube usually occurs in the vicinity of the mercury-filled bag and can be visualized radiographically by instilling barium directly into the tube. On rare occasions, an intussusception develops in the proximal jejunum and is difficult to recognize. We...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318698
更新日期:1986-06-01 00:00:00
abstract::To evaluate pancreatic exocrine function in uremia, 25 patients undergoing regular hemodialysis without clinical evidence of pancreatic disease and 25 healthy control subjects were studied by fecal elastase 1 and chymotrypsin. Abdominal ultrasonography and measurement of serum lipase, calcium, phosphate, and parathorm...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026487807555
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires manual quantification of tissue eosinophils. Eosinophil peroxidase (EPX) is an eosinophil-specific, cytoplasmic granule protein released during degranulation. AIMS:The objective of this study was to evaluate image analysis of EPX immunohistochemistry as a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06230-5
更新日期:2020-04-04 00:00:00
abstract:BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0770-z
更新日期:2010-03-01 00:00:00
abstract::In a previous study we demonstrated that patients with recently diagnosed non-insulin-dependent diabetes mellitus (NIDDM) had significantly increased gastric emptying rates of glucose solutions compared with those of nondiabetic sex- and age-matched controls. This finding of rapid gastric emptying contrasts with the d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296773
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subg...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3246-8
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Obesity, gastroesophageal reflux, and Barrett's esophagus have all been linked to esophageal adenocarcinoma. In addition, the decline in Helicobacter pylori (H. pylori) infection in affluent societies has also been suggested to be a major factor in the recent rise in the incidence of esophageal adenocarcinom...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1473-1
更新日期:2011-05-01 00:00:00
abstract::To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1 beta, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and interleu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087671
更新日期:1994-11-01 00:00:00
abstract::Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenoty...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018869617076
更新日期:1997-08-01 00:00:00
abstract::Management of pancreatic cystic lesions relies on patients' clinical presentation, imaging, and endoscopic ultrasound. Current research in basic science, radiology, and endoscopy is evolving and making progress in this condition which is relatively common in the general population. This review focuses on the recent en...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-017-4544-8
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Eosinophilic esophagitis (EoE) is defined by a minimum of 15 eosinophils (eos) per high-powered field (HPF) on esophageal biopsy, along with esophageal symptoms and the exclusion of gastroesophageal reflux (GERD). The clinical significance of fewer eosinophils is unknown. METHODS:Fifty-nine adult patients w...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1594-1
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Proton pump inhibitors (PPIs) may reduce the risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. PPIs are prescribed for virtually all patients with Barrett's esophagus, irrespective of the presence of reflux symptoms, and represent a de facto chemopreventive agent in this populatio...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3186-3
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Evidence of humanistic detriments of Clostridium difficile infection (CDI) remains limited. AIMS:To assess humanistic burden associated with CDI. METHODS:Self-reported National Health and Wellness Survey data between 2013 and 2016 were analyzed for the USA, five European countries, China, and Brazil. Outco...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-018-5222-1
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Hypoxia is an important factor in malignant tumors, and glycolysis is a major metabolic contributor in their development. Glycolytic enzymes have gained increasing attention as potential therapeutic targets because they are associated with cancer-specific metabolism. Fructose-bisphosphate aldolase A (ALDOA),...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05642-2
更新日期:2019-11-01 00:00:00
abstract::Because of the technical difficulty during subsequent surgical intervention, adhesion remains the most important predictor of outcome in the staged procedures following emergent colorectal surgery. The aim of this study was to assess the long-term effects of hyaluronan (HA)-based adhesion barriers 3 months following t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000034571.30602.36
更新日期:2004-06-01 00:00:00
abstract::Our purpose is to focus attention on the cancer family history, coupled with an understanding of the natural history and extracolonic tumor spectrum of familial adenomatous polyposis (FAP), through a family study. This family report provides an example of how colorectal cancer (CRC) can be prevented by knowledgeable g...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012330626600
更新日期:2001-11-01 00:00:00
abstract::Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) has been shown to inhibit the proliferation of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer. We investigated the influence of PPARgamm...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9944-8
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Suppressive activity of recurrence by interferon-free direct-acting antivirals (DAA) is not elucidated after curative treatment of hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 177 patients received DAA after curative manners of HCC: 89 patients underwent DAA therapy after initial HCC trea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4739-z
更新日期:2017-10-01 00:00:00
abstract::Lactose malabsorption was studied, by hydrogen breath test, in 72 adults suffering from irritable bowel syndrome, in 20 ulcerative colitis patients, and in 69 healthy subjects. The minimum dose of lactose required to cause a positive breath test was determined, and the symptoms caused and the resulting hydrogen elimin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01317083
更新日期:1984-12-01 00:00:00