Abstract：
:Pulse therapy is one of the most well-known methods used in the treatment of juvenile rheumatoid arthritis. This study assessed the outcome of methylprednisolone pulse therapy, its rate of efficacy, and its associated complications in patients with juvenile rheumatoid arthritis (JRA). This cross-sectional study was performed on 120 children with JRA who attended the Pediatric Ward of Imam Khomeini Hospital from 1994 to 2004 and who had undergone around 500 cycles of methylprednisolone pulse therapies. Clinical signs, including signs of improvement, complications, or recurrence of disease, were noted. SPSS version 11.5 and paired t test were used to compare the variables prior to and after treatment. Clinical signs observed included: feeling of weakness (100%), malaise (98.3%), loss of appetite (93.3%), fever (88.3%), skin rash (28%), lymphadenopathy (18.3%), serositis (4.2%), splenomegaly (3.3%), and hepatomegaly (1.7%); however, none of these findings were present after pulse therapy. The number of swollen and tender joints, duration of morning stiffness, erythrocyte sedimentation rate, C-reactive protein, and hemoglobin levels showed significant improvement after pulse therapy. Complications of pulse therapy included tachycardia (n = 16, 13.3%), hypertension (n = 10, 8.3%), headache (n = 2, 1.7%), and flashing (n = 2, 1.7%). The mean duration of remission was 3.3 +/- 0.7 months.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Aghighi Y,Attarod L,Javanmard Mdoi
10.1007/s10067-008-0919-8subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1371-5issue
11eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章abstract：:The aim of this study was to describe a single-center experience in the treatment and follow-up of cystoid macular edema patients. Clinical records of all patients with cystoid macular edema followed up in the Rheumatologic and Ophthalmological Unit of our center between 1993 and 2013 were retrospectively evaluated. T...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2694-z
更新日期：2015-04-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIg) is currently used with much enthusiasm for the treatment of many autoimmune diseases, including systemic lupus erythematosus (SLE). Among its various indications, IVIg has also been found to be beneficial in myocarditis, whether or not it is associated with an autoimmune disease (e.g....
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050091
更新日期：1999-01-01 00:00:00
abstract：:If rheumatoid arthritis (RA) patients with a mild disease course could be identified early in the phase of the disease, therapy with less aggressive and probably less toxic antirheumatic drugs seems to be rational. The aim of this study was to investigate which factors at baseline could predict a clinical response (Am...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s100670050121
更新日期：1999-01-01 00:00:00
abstract：:The study aimed to determine the serum level of glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) in patients with rheumatoid arthritis (RA) and investigate its clinical significance. GITRL levels were measured by enzyme-linked immunosorbent assay (ELISA) in 88 RA patients, 20...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3280-3
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:This study was designed to compare outcomes of dose reduction, withdrawal, and continuation of tofacitinib in patients with rheumatoid arthritis (RA) and to examine effectiveness of rescue with an original treatment regimen for disease flare. METHODS:We prospectively enrolled 100 patients who had high or mod...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04721-z
更新日期：2019-12-01 00:00:00
abstract：:The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a p...
journal_title：Clinical rheumatology
pub_type： 杂志文章,meta分析
doi：10.1007/s10067-017-3595-8
更新日期：2017-07-01 00:00:00
abstract：:With the aim of evaluating the role of 1,25 dihydroxyvitamin D in the pathogenesis of osteoporosis, this hormone was studied in 90 subjects. They were divided into three groups: the first group consisted of 30 normal female subjects (aged 30 to 45); the second group comprised 30 elderly female subjects (aged 67 to 90)...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02031970
更新日期：1990-06-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the production of autoantibodies and the involvement of multiple organ systems. Systemic sclerosis (SSc) is another autoimmune disease that causes fibrosis. We will aim to analyse the role of killer cell immunoglobulin-like receptor (KIR) gen...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3222-0
更新日期：2016-04-01 00:00:00
abstract：:The aim of the study was to determine the main demographic, epidemiological, clinical characteristics, and outcome in patients with various types of brucellar monoarticular involvement. Retrospectively, we analyzed medical histories of 331 patients with brucellar monoarticular involvement who were treated at the infec...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3207-z
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To identify factors associated with active tuberculosis (TB) in patients with systemic lupus erythematosus (SLE). METHODS:We performed a retrospective case-control study in two tertiary care teaching hospitals in Medellín, Colombia. From January 2007 to December 2017, a total of 268 patients with SLE were in...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05225-x
更新日期：2021-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207968
更新日期：1992-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-016-3229-6
更新日期：2016-04-01 00:00:00
abstract：UNLABELLED:It has been suggested that in some patients non-traumatic aseptic osteonecrosis of the hip (AOH) could be the result of the intra-osseous thrombosis. Antiphospholipid antibodies (APL) have been associated with venous and arterial occlusive events and the association between AOH and APL syndrome has been repo...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02242453
更新日期：1997-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3241-x
更新日期：2016-07-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670050116
更新日期：1999-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0744-5
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:This study aims to analyze factors related to pregnancy outcomes in women with positive antiphospholipid antibodies and previous adverse pregnancy outcomes (APOs) prospectively. METHODS:Patients' characteristics were described. Factors associated with obstetric complications were analyzed using logistic regr...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05203-3
更新日期：2021-01-01 00:00:00
abstract：:Brucellosis is a chronic infectious disease with articular involvement. Discrimination between brucellosis and rheumatologic disorders is difficult in regions endemic for brucellosis. There are few studies about the rate of positive autoantibodies as rheumatologic biomarkers in brucellosis, and the prevalence is varia...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-016-3171-7
更新日期：2016-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2441-x
更新日期：2014-04-01 00:00:00
abstract：:Fragile X mental retardation 1 (FMR1) premutation carriers, who are at risk of having children with fragile X Syndrome, were initially considered as clinically unaffected. However, recent clinical and molecular studies have shifted this point of view. The incidence of premutation in the general population is substanti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2052-y
更新日期：2012-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-016-3261-6
更新日期：2016-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2569-3
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of steroid injection (local treatment, LT) into the digital flexor tendon sheath of dactylitis in psoriatic arthritis (PsA) patients as compared with systemic treatment (ST). METHODS:Forty-six PsA patients with a total of 73 dactylitic fingers were assessed in an observational, mu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05142-z
更新日期：2020-11-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) patients had an increased susceptibility to tuberculosis (TB). The aim of this study was to investigate the prevalence and clinical characteristics of TB in SLE patients, with focus on the differences between pulmonary and extra-pulmonary TB. This is a retrospective study that review...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0741-8
更新日期：2008-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-012-2026-0
更新日期：2012-10-01 00:00:00
abstract：:Osteonecrosis (ON) is a clinical entity characterized by death of bone marrow and trabecular bone as a result of disruption of blood supply to the bone. The antiphospholipid (APL) syndrome is characterized by arterial and/or venous thrombosis and pregnancy morbidity in association with APL antibodies. The involvement ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0716-9
更新日期：2008-02-01 00:00:00
abstract：:The clinical response to traditional disease-modifying anti-rheumatic drugs (DMARDs) in indigent South Africans with early rheumatoid arthritis was investigated. A cohort of patients with early (≤2 years) RA who were DMARD-naïve at inception were prospectively assessed for response to DMARDs using the Simplified Disea...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1900-5
更新日期：2012-04-01 00:00:00
abstract：:Renal involvement in systemic lupus erythematosus (SLE) is common and has been associated with an increased risk of mortality [1]. Early diagnosis is imperative to control proteinuria and prevent the progression to end-stage renal disease. Standard induction therapies include cyclophosphamide (CYC) and mycophenolate m...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-016-3511-7
更新日期：2017-03-01 00:00:00
abstract：:Polymyositis may occur along with other manifestations of chronic graft vs host disease after allogeneic bone marrow transplantation (BMT). Donor lymphocyte infusion (DLI) could produce durable remissions in relapsed patients with chronic myelogenous leukemia (CML) but it may contribute to the development of polymyosi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-006-0346-7
更新日期：2007-07-01 00:00:00
abstract：:Heterogenous population of cells, including macrophages, synoviocytes and lymphocytes play important roles in the immunopathogenesis of rheumatoid arthritis (RA). T cells, however, seem to be a common thread throughout the disease process. In inhibiting T lymphocytes, cyclosporin A presents a more selective form of th...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02215854
更新日期：1995-09-01 00:00:00
