Abstract:
:With the aim of evaluating the role of 1,25 dihydroxyvitamin D in the pathogenesis of osteoporosis, this hormone was studied in 90 subjects. They were divided into three groups: the first group consisted of 30 normal female subjects (aged 30 to 45); the second group comprised 30 elderly female subjects (aged 67 to 90) the third group consisted of female patients (aged 65 to 87) with clinical and radiological evidence of osteoporosis. Variations of serum 1,25 dihydroxyvitamin D, after stimulation with oral P04 (1,000 mg/day for 10 days) and stimulation with oral Ca (1,000 mg/day for 10 days), were studied in 16 osteoporotic females (10 of them received P04) and six Ca (Controls). This second study was performed to evaluate the renal 1-alpha-hydroxylation. No significant variation between serum 1,25 dihydroxyvitamin D of elderly and osteoporotic females was observed when compared with normal young healthy subjects. Moreover, a significant increase in serum 1,25(OH)2D after oral P04 was found in accordance with a significant increase in serum parathormone. These data demonstrate that changes in serum 1,25(OH)2D levels did not seem to play a significant part in the pathogenesis of osteoporosis in our population neither could a deficit of renal 1-alpha-hydroxylation be demonstrated.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Cantatore FP,Carrozzo Mdoi
10.1007/BF02031970subject
Has Abstractpub_date
1990-06-01 00:00:00pages
210-3issue
2eissn
0770-3198issn
1434-9949journal_volume
9pub_type
杂志文章abstract:INTRODUCTION:The prevalence of herpes zoster (HZ) is high in patients with rheumatologic diseases. The incidence in patients with rheumatoid arthritis (RA) is at least twice as high as in healthy people. Nevertheless, little is known about humoral immunity against varicella zoster virus (VZV), in particular in patients...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04563-9
更新日期:2019-09-01 00:00:00
abstract::The authors studied the incidence of atlanto-axial joint involvement by conventional radiography and CT in 183 patients with classical or definite rheumatoid arthritis (RA). In determining lesions the significance of factors such as age, sex, duration and severity of the disease was evaluated. Atlanto-axial subluxatio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02242943
更新日期:1994-09-01 00:00:00
abstract::Adult onset Still's disease (AOSD) is an inflammatory disease of unknown etiology, characterized by spiking fever, evanescent salmon pink maculopapular rash, arthritis, and leukocytosis with neutrophilia. Malignant lymphoma is one of the most important differential diagnoses of AOSD. AOSD has been reported as one of p...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1305-x
更新日期:2010-02-01 00:00:00
abstract::Treatment with methotrexate (MTX) is well established in rheumatoid arthritis (RA), but dosing remains arbitrary as studies on the effect of different dosing schedules are lacking. In a randomised crossover design of 20 patients with RA, the effect of low (2.5mg) oral daily doses of MTX (15 mg weekly) was compared to ...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02231528
更新日期:1993-06-01 00:00:00
abstract::The presentation of the Table 1 of the original version of this article was incorrectly published. The Table is now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4098-y
更新日期:2018-09-01 00:00:00
abstract::This study aimed to compare the diagnostic value of ultrasonography to conventional radiography in detecting osteophytes and erosions in the midfoot joints in patients suffering from inflammatory and non-inflammatory joint disease. Patients with current foot radiographs were included and stratified in two cohorts: inf...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3658-x
更新日期:2017-09-01 00:00:00
abstract::The role of opioid therapy in chronic musculoskeletal disease continues to be controversial. However, recent years have seen a gradual shift towards the use of opioid therapy in chronic non-malignant pain (CNMP) following recognition that at least a subpopulation of such patients appears to benefit from long-term opio...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s100670200029
更新日期:2002-02-01 00:00:00
abstract::Interstitial lung disease (ILD) is a severe rheumatoid arthritis (RA) manifestation. The worst survival has been associated with usual interstitial pneumonia (UIP) definitive pattern in high-resolution chest tomography (HRCT) scans. Moreover, the use of methotrexate in RA-ILD is controversial. Our aim was to evaluate ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3707-5
更新日期:2017-07-01 00:00:00
abstract::The aims of our study are to observe the pregnancy outcome of anti-Sjögren's syndrome-related antigen A (SSA)/Ro-positive women and to predict the risk factors for adverse pregnancy outcome and neonatal lupus erythematosus (NLE). Clinical data of 126 anti-SSA/Ro-positive patients with 140 pregnancies were evaluated re...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3050-7
更新日期:2015-10-01 00:00:00
abstract::Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-on...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04470-z
更新日期:2019-05-01 00:00:00
abstract::Subcutaneous nodules are the most common conspicuous extra-articular manifestation of rheumatoid arthritis (RA). Cardiovascular disease (CVD) is the leading cause of death in patients with RA. The objective of this study is to examine the possibility of a relationship between subcutaneous nodules and "first ever" card...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3032-9
更新日期:2015-10-01 00:00:00
abstract::To characterize the distinctive chest high-resolution computerized tomography (HRCT) features and clinical manifestations of primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD). The demographic data, clinical manifestations, and laboratory and radiological findings of 527 pSS patients were retrospec...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4289-6
更新日期:2018-11-01 00:00:00
abstract::Ochronosis involves primarily the large cartilaginous joint surfaces, ribs, intervertebral discs, ear cartilage etc. We report on a 53-year-old woman with typical alkaptonuric ochronosis with dark urine, blue-black pigmentation of the auriculae and hands, focal brown hyperpigmentation of the sclera, spondylarthropathy...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-8277-4
更新日期:2002-05-01 00:00:00
abstract::Neurological involvement is uncommon in systemic sclerosis. Most of the reported cases concern trigeminal neuropathy or peripheral nerve entrapment. We report a third case of brachial plexopathy, presumably related to vasculitis, in a patient with systemic sclerosis, which improved after cyclophosphamide therapy. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200106
更新日期:2002-09-01 00:00:00
abstract::The aim of this study was to evaluate clinical remission and MDA in PsA patients who started TNF-inhibitors (TNFi) treatment with a 2-year follow-up. Concomitant therapies as well as comorbidities were assessed. Level of concordance of clinimetric indices and the potential predictive factors of remission/MDA were also...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3769-4
更新日期:2017-10-01 00:00:00
abstract::Patients with osteoporosis often have chronic kidney disease (CKD). CKD is associated with bone and mineral disturbances, renal osteodystrophy, which like osteoporosis leads to a higher risk of fractures. Bisphosphonates are first-line therapy for osteoporosis; however, these are contra-indicated in patients with a GF...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-2883-4
更新日期:2015-08-01 00:00:00
abstract::Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0838-8
更新日期:2008-04-01 00:00:00
abstract::The aim of this blinded, randomised, multicentre study was to compare the tolerability of aspirin, paracetamol and ibuprofen in common pain resulting from musculoskeletal conditions (MSC) in general practice with patients with other non-MSC pain conditions. Patients took aspirin, paracetamol (both up to 3g daily) or i...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s100670200007
更新日期:2002-02-01 00:00:00
abstract::We report a case of a 53-year-old woman diagnosed of systemic sclerosis. She underwent an episode of pulmonary haemorrhage, characterized by haemoptysis, sudden anaemization, and bilateral alveolar infiltration during her hospitalization, which was resolved with steroid treatment. Subsequently, she developed a focal n...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02207098
更新日期:1992-03-01 00:00:00
abstract::Primary knee osteoarthritis (OA) contributes to disability among middle-aged and elderly people. Dickkopf-1 (Dkk-1) and sclerostin are inhibitors of Wnt/β-catenin signaling pathway implicated in regulation of cartilage homeostasis and bone formation, respectively. We aim to investigate the association between the seru...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3640-7
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:We investigated whether rheumatoid arthritis (RA)-related autoantibodies were associated with abnormalities on pulmonary function tests (PFTs). METHODS:We studied RA serostatus and PFT abnormalities within a RA registry. RA serostatus was assessed by research assays for cyclic citrullinated peptide (CCP) ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04733-9
更新日期:2019-12-01 00:00:00
abstract::Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032322
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To compare effectiveness of ultrasound-guided local insulin injection, local steroid injection, and local steroid followed by insulin injections in treating mild to moderate carpal tunnel syndrome (CTS) in type 2 diabetes mellitus (DM). METHOD:Study included 60 patients with electrophysiologic evidence of mi...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-019-04638-7
更新日期:2019-10-01 00:00:00
abstract::We report three cases of tricho-rhino-phalangeal syndrome (TRPS) type I in a Belgian family. They presented typical characteristics such as a pear-shaped nose, and short, deformed fingers with cone-shaped epiphyses of some middle phalanges of the hands. Hair growth was practically normal in our patients, except for so...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02201022
更新日期:1987-06-01 00:00:00
abstract::In this study we aimed to investigate the findings in patients with adult-onset Still's disease (AOSD) admitted with fever of unknown origin (FUO) during the last 18 years in our unit, in order to discover the ratio of such patients to all patients with FUO during the same period, and to determine the clinical feature...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-0680-3
更新日期:2003-05-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04856-z
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The purpose of this study was to develop an understanding of treatment preferences in patients with inflammatory arthritis (IA) [rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA)] focussing on treatment attributes that patients' value, their relative importan...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04843-4
更新日期:2020-04-01 00:00:00
abstract::We report a case of hypokalaemic, flaccid quadriparesis with sudden respiratory arrest in a 27-year-old Japanese woman in whom the discovery of distal renal tubular acidosis led to the diagnosis of primary Sjögren's syndrome (SS). Hypokalaemic periodic paralysis as the initial manifestation of primary SS is rare, but ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170028
更新日期:2001-01-01 00:00:00
abstract::Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02229707
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:To compare the efficacy and safety of tocilizumab with those of abatacept in patients with active rheumatoid arthritis not responding to anti-tumor necrosis factor therapy. METHODS:A prospective, open-label study was carried out on adult females with moderate-to-severe rheumatoid arthritis. Patients were ra...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-019-04508-2
更新日期:2019-08-01 00:00:00