Abstract:
:To characterize the distinctive chest high-resolution computerized tomography (HRCT) features and clinical manifestations of primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD). The demographic data, clinical manifestations, and laboratory and radiological findings of 527 pSS patients were retrospectively analyzed. ILD was defined based on the presences of pulmonary signs in HRCT. Two hundred six of 527 patients were diagnosed as pSS-ILD, and the prevalence was 39.1%. The three most frequent abnormalities in HRCT were reticular pattern (92.7%), ground-glass attenuation (87.4%), and bronchovascular bundle thickening (82%). One hundred twenty-four cases (60.2%) of the pSS-ILD patients had only a single HRCT pattern, which involved 86 non-specific interstitial pneumonitis (NSIP) cases (41.7%), 22 usual interstitial pneumonia (UIP) cases (10.68%), 8 organizing pneumonia (OP) cases (3.9%), and 8 lymphocytic interstitial pneumonia (LIP) cases (3.9%), respectively. Besides, the more important observation was that 82 cases had no less than two HRCT patterns, and NSIP admixed with OP (43.9%), NSIP admixed with UIP (35.4%), and NSIP admixed with LIP (19.5%) were the most frequent. HRCT of pSS-ILD patients demonstrated bilateral infiltrates (99%), with abnormalities predominantly in the lower lobes (89.3%) and subpleural areas (81.1%), and a few lesions were characterized by hilum distributed (8.7%). Pulmonary function tests (PFTs) revealed impaired diffusion capacity for carbon monoxide and total lung capacity, and the rate of small airway lesions in the pSS-ILD patients was 3.5 times higher in patients of pSS. Logistic regression analysis showed that dry cough (OR 59.05), clubbing (OR 6.26), elevated lactate dehydrogenase (OR 21.38) and positive anti-Ro (OR 7.86) were relevant factors of pSS-ILD. ILD is the common pulmonary involvement of pSS and the prevalence of pSS-ILD is 39.1%. The single pattern of NSIP and UIP in HRCT are the commonest, and about 40% of the pSS-ILD patients possess multiple patterns in HRCT. The classification of idiopathic pulmonary fibrosis cannot completely include the pulmonary imaging features of pSS-ILD.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Dong X,Zhou J,Guo X,Li Y,Xu Y,Fu Q,Lu Y,Zheng Ydoi
10.1007/s10067-018-4289-6subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2981-2988issue
11eissn
0770-3198issn
1434-9949pii
10.1007/s10067-018-4289-6journal_volume
37pub_type
杂志文章abstract::Churg-Strauss syndrome (CSS) is a rare, systemic, necrotizing, small- and middle-sized vessel vasculitis which is accompanied by blood eosinophilia, eosinophil infiltration of various tissues, and bronchial asthma. The lungs are the organs most often involved in CSS. The aim of this study was a retrospective evaluatio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1530-3
更新日期:2010-10-01 00:00:00
abstract::The relations between parameters obtained by clinical absorptiometric techniques, such as SPA, DPA, DXA and QCT, and geometrical and material parameters of bone structures are investigated. Two types of bone are considered: the diaphysis of a long bone, modelled as a hollow cylindrical structure consisting of compact ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::The aim of this study was to investigate the association between the polymorphism of transporters associated with antigen processing ( TAP1/TAP2) genes and rheumatoid arthritis in Chinese patients. A total of 100 RA patients and 99 healthy control subjects were enrolled. Analyses with polymerase chain reaction (PCR) b...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0769-3
更新日期:2004-02-01 00:00:00
abstract::Giant cell (temporal) arteritis presenting with syncope due to carotid sinus hypersensitivity is described. Although the association of giant cell (temporal) arteritis and carotid sinus hypersensitivity is known, there are no previous reports of syncope as the presenting feature of giant cell (temporal) arteritis. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030761
更新日期:1984-06-01 00:00:00
abstract::Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement mol...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-0838-8
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare small to medium-size vessel systemic diseases. As their clinical picture, organ involvement, and factors influencing outcome may differ between countries and geographical areas, we decided to describe a large cohort of Polish AA...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04538-w
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:The association between hyperuricemia and insulin resistance (IR) has been demonstrated by many studies, but the traditional IR indexes are too impractical to be used in clinical practice for the recognition of the IR state in individuals with hyperuricemia. Therefore, we aimed to further investigate the asso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04671-6
更新日期:2019-11-01 00:00:00
abstract::Extensive subcutaneous and muscular calcification developed in a patient having adult-onset dermatopolymyositis (DM-PM) with an 'overlap' connective tissue disease. We wish to emphasize the rarity of calcification in adult onset DM-PM, which is contrary to the generally held impression. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::Patients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3676-8
更新日期:2018-01-01 00:00:00
abstract::Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal B...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05181-6
更新日期:2020-10-01 00:00:00
abstract::Back problems and back pain are amongst the most prevalent conditions afflicting Australians and carry high direct and indirect costs for the health care systems of all developed countries. A major gap in the research literature on this topic is the longitudinal analysis of health seeking behaviour for people with bac...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1299-4
更新日期:2010-01-01 00:00:00
abstract::2'5'-Oligoadenylate synthetase (OAS) was shown to be related to systemic lupus erythematosus (SLE) 20 years ago, and was rediscovered to be involved in type I interferon pathway in SLE by several microarray gene expression studies recently. The goal of this study was to investigate OAS isoform expressions in lupus pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0260-z
更新日期:2007-02-01 00:00:00
abstract::Adropin, a secreted protein, is encoded by the energy homeostasis associated (ENHO) gene. It has been implicated in the several physiological and pathological processes such as angiogenesis and apoptosis. Therefore, the aim of present study was to investigate serum adropin levels and ENHO gene expressions in systemic ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3266-1
更新日期:2016-06-01 00:00:00
abstract::A case of pseudo-pseudohypoparathyroidism (PPH) with shortening of the left femur and tibia and coalition of the base of the fourth metacarpals with capitatum and hamatum in bilateral wrist joints was presented. Involvement of the fourth digits both in hands and feet were more prominent on the left side, with shorteni...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0279-1
更新日期:2007-07-01 00:00:00
abstract::This study aims to evaluate the impact of arthritis on the physical function of people living in a Maya-Yucateco rural community and to assess the association of known modifiable risk factors with the prevalence of overall arthritis and its main types (osteoarthritis and rheumatoid arthritis). Using a cross-sectional,...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3084-x
更新日期:2016-07-01 00:00:00
abstract::Erythema nodosum is an unusual manifestation of Hodgkin's lymphoma. One patient with long remission of Hodgkin's disease manifested persistent erythema nodosum beginning one and three months before relapse was clinically evident. So, the diagnosis of Hodgkin's disease should be considered in patients with unexplained ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02114402
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVES:The invalidation or social pain is an important but neglected issue in polysymptomatology of fibromyalgia (FM). This study sought whether tracing-perceived invalidation could be effective to discriminate between the presence and absence of FM in chronic pain patients with respect to five different sources, i...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05515-4
更新日期:2021-01-07 00:00:00
abstract::Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with r...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3699-1
更新日期:2017-07-01 00:00:00
abstract::Over the last few years, several studies in patients with systemic lupus erythematosus (SLE) have demonstrated an association between valvulopathy, including Libman-Sacks endocarditis (LS) and the presence of antiphospholipid antibodies (aPL), suggesting a role of these antibodies in the pathogenesis of the lesions. O...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1662-5
更新日期:2011-02-01 00:00:00
abstract::The effects of vitamin C on 1,25(OH)2D3 synthesis in humans were evaluated; the study included 20 females. They were divided into 2 groups. The first of the 10 subjects (age range 55-71) received ascorbic acid at a dose of 150 mg/die i.v. for 10 days; the second 10 subjects (age range 55-69) received a placebo i.v. fo...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02207657
更新日期:1991-06-01 00:00:00
abstract::Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephrit...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01451045
更新日期:1998-01-01 00:00:00
abstract::Children with juvenile idiopathic arthritis (JIA) may infrequently present with localized anterior knee pain or swelling, in addition to generalize knee pain induced by JIA. We report five cases of deep infrapatellar bursitis in children with JIA. The clinical features, radiological findings, management, and outcome o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1620-2
更新日期:2011-02-01 00:00:00
abstract::The aim of this study was to assess the diagnostic value of the Psoriatic Arthritis Screening Evaluation (PASE) and Early Psoriatic Arthritis Screening Questionnaire (EARP) questionnaires in the ultrasonographic detection of enthesitis, synovitis, and tenosynovitis. A cross-sectional study was done in a total of 96 co...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-016-3392-9
更新日期:2016-10-01 00:00:00
abstract::We encountered only three patients of carpal tunnel syndrome (CTS) due to tophaceous gout during 25 years of practice in a 'hand clinic' situated in a large metropolis in West India. In two patients, the CTS was bilateral, a rare occurrence in gout. There was an unwarranted delay (up to 9 years) in the diagnosis of bo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0672-4
更新日期:2007-12-01 00:00:00
abstract::Musculoskeletal disorders represent a large and growing clinical challenge to primary care clinicians. Unfortunately, there appears to be a gap in current training and continuing education to meet this challenge. We used script concordance within a continuing medical education program entitled "Joint Adventures" to as...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0446-4
更新日期:2007-07-01 00:00:00
abstract::A 67-year-old woman, suffering from continuous hemoptysis, was admitted to our hospital where she was managed with mechanical ventilation. Computed tomography of the chest demonstrated bilateral massive alveolar hemorrhage without evidence of infectious disease. She was diagnosed with anti-myeloperoxidase antineutroph...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-006-0355-6
更新日期:2007-07-01 00:00:00
abstract::B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0665-3
更新日期:2007-10-01 00:00:00
abstract::Ankylosing spondylitis (AS) is the prototype for spondyloarthritis primarily affecting young men. Geographic and ethnic variations exist in the prevalence and severity of AS and relate to the wide disparity in the frequency of human leukocyte antigen (HLA)-B27, a major genetic risk factor. The strength of the disease ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2058-5
更新日期:2012-11-01 00:00:00
abstract::Intussusception is characterized by one segment of the gastrointestinal tract telescoping into the lumen of the adjacent segment; it is rarely reported in systemic lupus erythematosus (SLE), and the condition can be threatening. Only four cases of intussusception with SLE have been reported in literature. Here, we des...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-017-3879-z
更新日期:2018-01-01 00:00:00
abstract::The above article originally published with an error present in Table 2 and is now presented correctly in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-018-4280-2
更新日期:2018-10-01 00:00:00