Abstract：
:B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of patients with RA. Thirty-two RA patients and 16 controls were enrolled in this study, and CD22 expressions on B cells were analyzed by flow cytometry. In patients with RA, CD22(+) B cells significantly decreased in comparison to the controls (ratio: P < 0.05). However, there was no correlation between this decrease and the clinical data. Interestingly, CD5(+) CD22(-) B cells significantly increased in RA patients. The decrease in CD22(+) B cells and increased in CD5(+)CD22(-) B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Nakiri Y,Minowa K,Suzuki J,Mitsuo A,Amano H,Morimoto S,Tokano Y,Takasaki Ydoi
10.1007/s10067-007-0665-3subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1721-3issue
10eissn
0770-3198issn
1434-9949journal_volume
26pub_type
杂志文章abstract：:The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differenti...
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journal_title：Clinical rheumatology
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pub_type： 杂志文章,已发布勘误
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更新日期：2018-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02207968
更新日期：1992-06-01 00:00:00
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journal_title：Clinical rheumatology
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更新日期：2011-01-01 00:00:00
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更新日期：2007-12-01 00:00:00
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doi：10.1007/s10067-013-2474-1
更新日期：2014-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF03342660
更新日期：2001-11-01 00:00:00
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Clinical rheumatology
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更新日期：1991-12-01 00:00:00
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更新日期：1997-11-01 00:00:00
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更新日期：2017-05-01 00:00:00
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更新日期：2015-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670170072
更新日期：2001-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：1985-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
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journal_title：Clinical rheumatology
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doi：10.1007/s10067-007-0749-0
更新日期：2008-05-01 00:00:00
