Abstract:
:The involvement of brain-derived neurotrophic factor (BDNF) in rheumatoid arthritis (RA) is largely unknown. The distribution of BDNF and its associated receptors, TrkB and p75, in the synovial tissue of patients with RA was examined and contrasted with that in patients with osteoarthritis (OA). Additionally, levels of BDNF in both synovial tissue and synovial fluid were measured. Furthermore, the effects of anti-tumour necrosis factor (anti-TNF; infliximab) treatment on BDNF levels in the plasma of RA patients were analysed. Cells in the synovium showed immunoreactivity for BDNF and BDNF-, p75- and TrkB-receptor immunoreactions were seen in nerve fibres of nerve fascicles and in association with sensory corpuscles. The levels of BDNF in synovial tissue were not correlated with the number of inflammatory cells observed microscopically or with levels of TNFalpha. Nor did the BDNF levels in synovial fluid correlate with erythrocyte sedimentation rate (ESR) or white blood cell counts. Anti-TNF treatment lead to a decrease in plasma levels of BDNF 14 weeks after the initiation of anti-TNF therapy, i.e., 8 weeks after the last infusion. Higher levels of BDNF were observed in RA patients at baseline compared with those for healthy individuals. However, the levels of BDNF in plasma of patients treated with anti-TNF did not correlate with the changes in ESR or a disease activity score. The clinical significance of this study is that anti-TNF treatment influences plasma levels of BDNF although there was no evidence that BDNF levels correlate with inflammatory parameters in either infliximab-treated or non-infliximab-treated patients with RA. Instead it is likely that sources other than inflammatory cells, including nerve structures, are important sources of BDNF and that the effects of anti-TNF treatment on BDNF levels may be related to effects on circulating and various local cells and/or BDNF-containing neurons.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Grimsholm O,Rantapää-Dahlqvist S,Dalén T,Forsgren Sdoi
10.1007/s10067-008-0910-4subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1289-97issue
10eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章abstract::Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization and treatment of sex hormone-dependent cancers due to their ability to bring about 'chemical castration'. Recently it has been showed that it also plays an important role in the m...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1426-2
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:There are no pharmacovigilance studies on adverse event (AE) data for tumour necrosis factor alpha (TNFα) inhibitors in South Korea. We analysed AEs induced by adalimumab, infliximab, and etanercept METHODS: We used data from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Events Reporti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04802-z
更新日期:2020-02-01 00:00:00
abstract::In addition to juxtaarticular osteoporosis, which appears to reflect predominantly local disease mechanisms, more generalized bone loss can occur in rheumatoid arthritis (RA). The aim of this study was to compare bone mineral density (BMD) of the lumbar spine and proximal femur in RA patients versus controls and evalu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207677
更新日期:1995-07-01 00:00:00
abstract::Infection is a major cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). To describe the pattern of serious infections in patients with SLE and to identify the predictors of infection-related mortality among SLE patients with serious infections, we prospectively studied all SLE pat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4102-6
更新日期:2018-08-01 00:00:00
abstract::Leptin is known to play an important role in the pathophysiology of osteoarthritis (OA). This study investigated whether synovial fluid (SF) leptin level is related to the radiographic severity of OA and its role as a quantitative marker for the detection of OA. SF was obtained from 42 OA patients who underwent knee s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1242-8
更新日期:2009-12-01 00:00:00
abstract::Forty-four patients with typical palindromic rheumatism were typed for HLA-A,B,C and DR antigens. The mean duration of follow-up of our patients was 4.0 yrs. (range 1-12 yrs.). During this time 27% of patients showed a seropositivity; 22% of patients developed polyarthritis, 1 patient revealed a Sjögren syndrome and 3...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02284051
更新日期:1988-03-01 00:00:00
abstract::In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematolo...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231787
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. MATERIALS AND METHODS:We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10067-006-0227-0
更新日期:2007-06-01 00:00:00
abstract::The aim of this study was to identify and evaluate laboratory parameters associated with normal bone mineral density (BMD) and to test if -308 tumour necrosis factor (TNF) alpha gene promoter polymorphisms could influence BMD. We performed a comparative cross-sectional study of four main groups: young healthy individu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0706-y
更新日期:2008-03-01 00:00:00
abstract::A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0037-9
更新日期:2006-07-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs/systems with variable activities. We performed a retrospective study to investigate the relationship of clinical characteristics and complications with SLE activity in Chinese Han population. A cohort of 1,490 SLE inpatients w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1240-x
更新日期:2009-11-01 00:00:00
abstract::Innate immunity has been widely accepted as one of the major cause for the alteration of immune system and progression of autoimmune diseases. Natural killer (NK) cells and natural killer T (NKT) cells have not been explored in clinical studies for their cytolytic components in association with rheumatoid arthritis (R...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2641-z
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:Interstitial lung disease (ILD) is frequent and highly disabling in systemic sclerosis (SSc). Magnetic resonance imaging (MRI) is not routinely used to evaluate the lung, due to poorer spatial resolution compared to high-resolution computed tomography (HRCT). We aimed to compare lung MRI signal ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05491-9
更新日期:2020-11-07 00:00:00
abstract::We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with ster...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670050131
更新日期:1999-01-01 00:00:00
abstract::Intercellular adhesion molecule-1 (ICAM-1) is a membrane bound molecule that plays an important role in the pathogenic inflammatory responses observed in vasculitis. The aim of this study was to determine whether levels of soluble ICAM-1 sICAM-1) shedding into the circulation reflect the vascular injury found in nailf...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02230359
更新日期:1996-07-01 00:00:00
abstract::The objective is to investigate the accrual rate and risk factors of chronic kidney disease (CKD) in an inception cohort of patients with systemic lupus erythematosus (SLE) followed at a single tertiary center. A prospectively collected database of 256 consecutive patients with SLE followed over a 25-year period was s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2527-0
更新日期:2014-05-01 00:00:00
abstract::Socio-economic gradients in occurrence of diseases have been reported for many chronic conditions. However, whether the magnitude of socio-economic gradients differs across diseases and the extent to which lifestyle mediates such relationships are not known. Cross-sectional data from The National Monitor on Musculoske...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4158-3
更新日期:2018-12-01 00:00:00
abstract::Circulating intercellular adhesion molecule-1 (ICAM-1) and 3 types of autoantibodies were measured in 30 patients with angiographical or pathological proved vasculitis. There were 18 patients with systemic vasculitis and 12 patients with cutaneous vasculitis. The measured antibodies included anti-endothelial cell anti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02231583
更新日期:1993-09-01 00:00:00
abstract::In the last 5 years, several hundred articles have been published concerning the link between primary immunodeficiency disease (PID) and rheumatologic diseases. Although rheumatologic complications were originally thought to be at the opposite ends of the spectrum of immunopathologic manifestations, they are now all b...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-016-3229-6
更新日期:2016-04-01 00:00:00
abstract::The presence of nail changes was investigated in 102 patients with nodal osteoarthritis of the hand. Nail lesions were seen in 14/102 patients (13.7%), a prevalence higher than that observed in 96 controls (4/96, 4.2%; chi square 4.37, p = 0.036). An increased risk of nail changes was associated with osteoarthritis of...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02249013
更新日期:1994-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-007-0815-7
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:This study examined whether phase angle (PhA) is associated with hip osteoarthritis (HOA) severity and quadriceps strength in patients with HOA. METHOD:A series of 549 patients with HOA, obtained from the Screening for People Suffering Sarcopenia in the Orthopedic cohort of Kobe study, were ana...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05419-3
更新日期:2020-09-29 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-015-3045-4
更新日期:2015-11-01 00:00:00
abstract::To describe clinical and epidemiological data of Behçet's disease (BD) in Brazil, we retrospectively reviewed records of all patients seen between 2006 and 2007 at the BD outpatient clinic of University of Sao Paulo. One hundred and six patients fulfilled the International Study Group for Behçet's Disease diagnostic c...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1081-z
更新日期:2009-05-01 00:00:00
abstract::Clinical guidelines regarding anti-viral prophylaxis for HBV surface antigen (HBsAg) carriers starting anti-TNFα agents are not yet fully established, even in endemic regions of HBV infection. We retrospectively collected the clinical data of 52 HBsAg carriers with rheumatoid arthritis (RA) or ankylosing spondylitis (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1960-1
更新日期:2012-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030760
更新日期:1984-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1397-3
更新日期:2010-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04756-2
更新日期:2019-12-01 00:00:00
abstract::In patients with fibromyalgia (FM) syndrome, stress and pain may chronically enhance sympathetic activity, altering cardiovascular response and inducing endothelial dysfunction. We investigated endothelial function in FM patients using echocardiography and analyzed whether endothelial function was affected by the clin...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1599-8
更新日期:2011-05-01 00:00:00