Abstract:
:In patients with fibromyalgia (FM) syndrome, stress and pain may chronically enhance sympathetic activity, altering cardiovascular response and inducing endothelial dysfunction. We investigated endothelial function in FM patients using echocardiography and analyzed whether endothelial function was affected by the clinical parameters of FM. Fifty-five postmenopausal women with FM and 35 healthy controls were included. Endothelial function was examined by brachial artery flow-mediated dilatation (FMD, endothelium dependent) and response to 40 μg of sublingual nitroglycerine (NTG-induced dilatation, endothelium independent). FM patients underwent manual tender point survey and completed visual analogue scale (VAS) of pain and fibromyalgia impact questionnaire (FIQ). The study participants were subdivided into two groups based on the sum of the FIQ score (group A, FIQ ≥ 50, group B, <50). The FMD value (5.7 ± 3.9% vs. 7.0 ± 1.4%, P = 0.008) and NTG-induced dilatation (12.5 ± 5.1% vs. 14.7 ± 2.5%, P = 0.006) were significantly lower in FM group than healthy control. There were no significant differences in FMD between groups A and B (5.4 ± 3.3% vs. 6.6 ± 3.5%, P = 0.19). However, significant decreases were noted in NTG-induced dilatation values of group A compared with those of group B (11.0 ± 4.4% vs. 14.3 ± 3.8%, P = 0.004). FMD and NTG-induced dilatation showed a significant inverse association with pain VAS and FIQ. Pain exerts a negative effect on endothelial function in FM patients, and that effect was significantly different according to the FIQ score.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Cho KI,Lee JH,Kim SM,Lee HG,Kim TIdoi
10.1007/s10067-010-1599-8subject
Has Abstractpub_date
2011-05-01 00:00:00pages
647-54issue
5eissn
0770-3198issn
1434-9949journal_volume
30pub_type
杂志文章abstract::Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3647-0
更新日期:2017-08-01 00:00:00
abstract::Atherosclerosis plays a key role in cardiovascular disease in patients with rheumatoid arthritis (RA). Although therapy with TNF-alpha antagonists has resulted in dramatic improvement in the prognosis of RA, its effects on circulatory lipids are unclear. We conducted a systematic review of the literature to summarize ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1405-7
更新日期:2010-09-01 00:00:00
abstract::The objectives of the study were to assess sleep disturbances in systemic lupus erythematosus (SLE) and to compare these with a working sample and a treatment-seeking sample reporting insomnia. The primary sample was 172 people with SLE. This sample represented 32% of all members of two lupus support association. Two ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0884-2
更新日期:2008-09-01 00:00:00
abstract::The authors describe an atypical case of a patient having giant cell arteritis presenting only with fever, diagnosed by positron emission tomography and subsequently confirmed by temporal artery biopsy. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0831-7
更新日期:2008-06-01 00:00:00
abstract::Objectives of this study were to examine work disability (WD) and its leading causes in incident SLE patients. Data were derived from the Finnish nationwide registries to identify all non-retired, 18 to 64-year-old incident SLE patients between 2000 and 2007. Sick benefits and WD pensions and the causes for them were ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4066-6
更新日期:2018-05-01 00:00:00
abstract::Eighty patients with Reiter's syndrome (RS) were studied retrospectively. A comparison was made between patients with the complete syndrome and patients with the incomplete syndrome. A comparison was also made between patients with and without HLA-B27. There were no major differences in severity and duration of the ar...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030971
更新日期:1986-01-01 00:00:00
abstract::Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032322
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To determine the serum levels of Dickkopf-1 (DKK-1) and sclerostin, as well as their correlations with the structural damage assessed by modified stoke ankylosing spondylitis spine score (mSASSS) and the disease activity evaluated by ankylosing spondylitis disease activity score (ASDAS) in patients with ankyl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4356-z
更新日期:2019-04-01 00:00:00
abstract::Adult onset Still's disease (AOSD) is an inflammatory disease of unknown etiology, characterized by spiking fever, evanescent salmon pink maculopapular rash, arthritis, and leukocytosis with neutrophilia. Malignant lymphoma is one of the most important differential diagnoses of AOSD. AOSD has been reported as one of p...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1305-x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:Action potential simulation (APS) is becoming a popular method of pain reduction. Nevertheless, little is known about the efficacy of this relatively new treatment. The aim of this study was to investigate whether APS helps to reduce pain, improves patients' perception of daily functioning and social partici...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-006-0297-z
更新日期:2007-03-01 00:00:00
abstract::Joint hypermobility syndrome (JHS) is common in patients presenting to rheumatologists and can cause a range of symptoms leading to physical and psychological distress. Chronic musculoskeletal pain in patients with JHS often responds poorly to analgesics, and a pain management approach may be helpful. Since patients w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2539-9
更新日期:2014-11-01 00:00:00
abstract::To compare IgG anti-cyclic citrullinated peptide (CCP) enzyme-linked immunosorbent assays (ELISAs) of second (anti-CCP2) and third generations (anti-CCP3) for the diagnosis of rheumatoid arthritis (RA), an IgA CCP3 ELISA was also evaluated. Combinations of the use of the three tests were evaluated. Anti-CCP2 IgG, anti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0999-5
更新日期:2009-02-01 00:00:00
abstract::The relationship of TNF-alpha promoter polymorphisms and ankylosing spondylitis (AS) has been reported with conflicting results. We perform this meta-analysis to collect all the relevant studies up to date to further clarify the association of TNF-alpha promoter polymorphisms with AS. A review was conducted of studies...
journal_title:Clinical rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10067-010-1499-y
更新日期:2010-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1395-5
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:Cardiovascular risk management of patients with systemic lupus erythematosus (SLE) is medically relevant. The objectives were to estimate the cardiovascular risk by different strategies in patients with SLE, analyzing which proportion of patients would be candidates to receive statin therapy, an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04856-z
更新日期:2020-02-01 00:00:00
abstract::The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in Finland was clinically followed-up by rheumatologists with visits a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2247-x
更新日期:2013-08-01 00:00:00
abstract::The original version of this article contained error. Table 1 was shown in the wrong version, thus corrected table is shown in this article. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04480-x
更新日期:2019-06-01 00:00:00
abstract::This study aimed to investigate the effects of colchicine on growth parameters in familial Mediterranean fever (FMF) patients. Fifty-one (29 girls, 22 boys) FMF patients were enrolled in the study. All of the patients were in the prepubertal stage and had not received colchicine treatment before the study. Anthropomet...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3077-9
更新日期:2016-06-01 00:00:00
abstract::The patient, a 44-year old woman with systemic lupus erythematosus, (SLE), developed infarction of the bowel and spleen after occlusion of the inferior mesenteric and splenic arteries, necessitating colectomy and splenectomy. She had had previous cerebral thromboses and a lower limb deep vein thrombosis. Histological ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030977
更新日期:1986-01-01 00:00:00
abstract::Sternoclavicular septic arthritis is a rare complication of subclavian venous catheterization. We estimate that septic involvement of this joint may be as common as one in 500 catheterizations. We report two patients with insidious onset of shoulder pain, chest discomfort, low-grade fever and slight but painful swelli...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02242953
更新日期:1994-09-01 00:00:00
abstract::Over the last few years, several studies in patients with systemic lupus erythematosus (SLE) have demonstrated an association between valvulopathy, including Libman-Sacks endocarditis (LS) and the presence of antiphospholipid antibodies (aPL), suggesting a role of these antibodies in the pathogenesis of the lesions. O...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-010-1662-5
更新日期:2011-02-01 00:00:00
abstract::In sera of patients with systemic lupus erythematosus (SLE) a wide variety of antibodies against nuclear antigens can be found, including antibodies to nucleic acids, histones and non-histone nuclear proteins. Among these, antibodies to double stranded DNA (dsDNA) appear to be mainly restricted to SLE. Yet, in daily p...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02200721
更新日期:1987-06-01 00:00:00
abstract::Susceptibility to ankylosing spondylitis is highly genetic, with a heritability greater than 90 %. Presence of the HLA-B27 MHC class I allele remains the greatest genetic risk factor identified to date. Beyond its nominal role in antigen presentation, HLA-B27 displays interesting and possibly unique biochemical charac...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-015-3117-5
更新日期:2016-06-01 00:00:00
abstract::Fifty-two patients with psoriatic arthritis (PA), treated with auranofin (AF), were entered into a one year prospective, open study. The total group showed a significant increase in frequency of HLA antigens A1 and B38, and a reduction of B5 when compared to healthy controls. There was a remission or an important impr...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031069
更新日期:1989-03-01 00:00:00
abstract::A number of laboratory variables, including Hb., ESR and several phase proteins, fluctuated in concord with the clinical signs of synovitis activity in patients with rheumatoid arthritis during a controlled study of 3 disease-modifying anti-rheumatic drugs (DMARD). The correlation between laboratory variables and clin...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02201028
更新日期:1987-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs/systems with variable activities. We performed a retrospective study to investigate the relationship of clinical characteristics and complications with SLE activity in Chinese Han population. A cohort of 1,490 SLE inpatients w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1240-x
更新日期:2009-11-01 00:00:00
abstract::Current Canadian osteoporosis guidelines recommend routine bone density screening of men at age 65. The purpose of this study is to determine the prevalence of osteoporosis in men aged 65-75 in after application of screening guidelines. All males aged 65-75 years who attended a large primary care clinic were advised o...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-014-2642-y
更新日期:2015-03-01 00:00:00
abstract::Chronic whiplash-associated disorders (WAD) remains a challenging condition for clinicians. There is substantial evidence for the presence of various cervical dysfunctions (e.g., increased cervical muscle tone and impaired cervical movement control), but their contribution to the complex clinical picture of subjects w...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-008-1083-x
更新日期:2009-03-01 00:00:00
abstract::Catastrophic anti-phospholipid syndrome (CAPS) is a medical emergency characterized by thromboses of multiple small vessels of internal organs and the brain. Herein we present a patient with primary anti-phospholipid syndrome who developed CAPS manifested by hepatic, renal and splenic artery thromboses, as well as cer...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0017-0
更新日期:2006-05-01 00:00:00
abstract::This study aims to investigate pre-clinical esophageal involvement in systemic sclerosis (SSc) by high-resolution impedance manometry (HRiM), its associations with disease features including lung involvement, and its predictivity of esophageal symptoms overtime. Charts of 45 asymptomatic (no heartburn/regurgitation/dy...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4026-1
更新日期:2018-05-01 00:00:00