Abstract:
:Catastrophic anti-phospholipid syndrome (CAPS) is a medical emergency characterized by thromboses of multiple small vessels of internal organs and the brain. Herein we present a patient with primary anti-phospholipid syndrome who developed CAPS manifested by hepatic, renal and splenic artery thromboses, as well as cerebral venous thrombosis. The course was further complicated by severe thrombocytopenia and haemolytic anemia. Two episodes of catastrophic thrombosis developed within 24-36 h after the initiation of heparin therapy, suggesting a role of heparin in triggering thromboses. The patient had no anti-platelet-factor-4 antibodies in repeated measurements, making clinical diagnosis of heparin-induced thrombocytopenia unlikely. The possible role of heparin in induction of thromboses and its therapeutic implication are detailed.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Zeller L,Almog Y,Tomer A,Sukenik S,Abu-Shakra Mdoi
10.1007/s10067-005-0017-0subject
Has Abstractpub_date
2006-05-01 00:00:00pages
426-9issue
3eissn
0770-3198issn
1434-9949journal_volume
25pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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