Catastrophic thromboses and severe thrombocytopenia during heparin therapy in a patient with anti-phospholipid syndrome.

Abstract:

:Catastrophic anti-phospholipid syndrome (CAPS) is a medical emergency characterized by thromboses of multiple small vessels of internal organs and the brain. Herein we present a patient with primary anti-phospholipid syndrome who developed CAPS manifested by hepatic, renal and splenic artery thromboses, as well as cerebral venous thrombosis. The course was further complicated by severe thrombocytopenia and haemolytic anemia. Two episodes of catastrophic thrombosis developed within 24-36 h after the initiation of heparin therapy, suggesting a role of heparin in triggering thromboses. The patient had no anti-platelet-factor-4 antibodies in repeated measurements, making clinical diagnosis of heparin-induced thrombocytopenia unlikely. The possible role of heparin in induction of thromboses and its therapeutic implication are detailed.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Zeller L,Almog Y,Tomer A,Sukenik S,Abu-Shakra M

doi

10.1007/s10067-005-0017-0

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

426-9

issue

3

eissn

0770-3198

issn

1434-9949

journal_volume

25

pub_type

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