Abstract:
OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, miRNAs improve cardiovascular risk estimation beyond traditional risk factors. Our objective was to develop a miRNA panel that predicts coronary atherosclerosis in RA patients. METHODS:Plasma small RNA next-generation sequencing (NGS) was performed on 161 RA patients whose Agatston scores for coronary artery calcium were previously measured. Random forest analysis of plasma NGS miRNA expression was used to determine which miRNAs best differentiated between those patients with and without coronary artery calcium. Top predictive miRNAs were assayed by quantitative PCR (qPCR). Elastic net regression was used to develop the most parsimonious models with qPCR-measured miRNA concentrations and clinical variables (age, sex, ACC/AHA 10-year risk score, DAS28 score, and diabetes) separately to predict the presence of coronary artery calcium and high coronary artery calcium. C-statistics were used to assess performance model performance. RESULTS:The top miRNAs which differentiated those with and without coronary atherosclerosis based on random forest analysis included let-7c-5p, miR-30e-5p, miR-30c-5p, miR-4446-3p, miR-126-5p, miR-3168, miR-425-5p, miR-126-3p, miR-30a-5p, and miR-125a-5p. For coronary artery calcium prediction, addition of all miRNAs except miR-126-3p to clinical factors improved the c-statistic modestly from 0.86 to 0.87. For high coronary artery calcium prediction, addition of all miRNAs except miR-30c-5p to clinical factors improved the c-statistic from 0.75 to 0.80. CONCLUSION:A plasma miRNA panel improved the prediction of high coronary artery calcium beyond traditional risk factors and RA disease activity. Further evaluation of the miRNA panel for prediction of coronary events in RA is necessary. Key Point • A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR-126-3p, miR-126-5p, miR-425-5p, miR-3168, and miR-4446-3p improved the prediction of high coronary artery calcium beyond clinical factors in patients with rheumatoid arthritis.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Ormseth MJ,Solus JF,Sheng Q,Chen SC,Ye F,Wu Q,Oeser AM,Allen R,Raggi P,Vickers KC,Stein CMdoi
10.1007/s10067-020-05573-8subject
Has Abstractpub_date
2021-01-02 00:00:00eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-05573-8pub_type
杂志文章abstract:OBJECTIVE:To investigate the clinical characteristics, laboratory features, and treatment outcomes of Thai patients compared between those with necrotizing autoimmune myopathy (NAM) and those with other idiopathic inflammatory myopathies (IIMs) or non-NAM. METHODS:This multicenter case-control study included patients ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10067-019-04756-2
更新日期:2019-12-01 00:00:00
abstract::Although a number of reports have now described an association between polymorphism of the LMP2 gene and disease phenotype in HLA-B27 positive individuals with ankylosing spondylitis (AS), some describe associations with acute anterior uveitis, others with juvenile onset disease, and one report provides no association...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
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journal_title:Clinical rheumatology
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pub_type: 杂志文章
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abstract::In the midst of the COVID-19 pandemic, further understanding of its complications points towards dysregulated immune response as a major component. Systemic lupus erythematosus (SLE) is also a disease of immune dysregulation leading to multisystem compromise. We present a case of new-onset SLE concomitantly with COVID...
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/pl00011211
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1007/s10067-012-2040-2
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200096
更新日期:2002-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1186-z
更新日期:2010-01-01 00:00:00
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doi:10.1007/s10067-015-2922-1
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-007-0716-9
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To explore the trends in diagnosis of Kawasaki disease (KD) and determine the characteristics for patients outside the usual age range of 6 months to 4 years. METHOD:A retrospective review of patients with KD identified in four epidemiological surveys spanning 20 years (1998-2017) in Shanghai was performed. ...
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pub_type: 杂志文章
doi:10.1007/s10067-020-05361-4
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pub_type: 杂志文章
doi:10.1007/s10067-007-0572-7
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/s10067-005-0117-x
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pub_type: 杂志文章
doi:10.1007/s100670070034
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,meta分析
doi:10.1007/s10067-015-3045-4
更新日期:2015-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4202-3
更新日期:2018-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-1987-3
更新日期:2012-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030760
更新日期:1984-06-01 00:00:00
abstract::To evaluate the influence of TNF-α inhibitor on lipid profile and atherogenic index of plasma (AIP) in axial spondyloarthritis (axSpA) patients with long-term use of stable dose TNF-α inhibitor. AxSpA patients were enrolled in the Catholic Axial Spondyloarthritis COhort (CASCO). We collected their data annually and an...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04767-z
更新日期:2020-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02207098
更新日期:1992-03-01 00:00:00