Abstract：
:The objective of the study was to study the functioning and health-related quality of life (HRQoL) in patients with systemic sclerosis (SSc) and its associated factors. Consecutive SSc patients and an equal number of age- and gender-matched healthy controls were recruited for the assessment of functioning and HRQoL by the Health assessment questionnaire disability index (HAQ-DI) and Medical Outcomes Study Short Form 36 (SF-36), respectively. The extent of skin involvement of SSc was assessed by the modified Rodnan skin score (mRSS), and disease severity was assessed by the Medsger severity index. Factors associated with functioning and HRQoL in SSc patients were studied by linear regression. Seventy-eight Chinese SSc patients were studied (87 % women; age 50.2 ± 12.1 years; disease duration 7.8 ± 6.5 years; 81 % limited cutaneous subtype). The median mRSS of the patients was 8 (IQR 0-10). Patients with SSc had significantly higher HAQ-DI (0.69 ± 0.69 vs 0.04 ± 0.18; p < 0.001) but lower SF36 scores (p < 0.05 in all domains) than matched controls. Linear regression revealed that the mRSS was inversely associated with the physical component (beta = -0.39; p = 0.001) and mental component scores (beta = -0.27; p = 0.031) of the SF36 but positively correlated with the HAQ-DI score (beta = 0.51; p < 0.001) adjusted for age, sex, and disease duration. The SF36 and HAQ-DI scores also correlated significantly with the Medsger SSc severity index in the general, peripheral vascular, skin, tendon/joint, and heart domains. SSc patients had impaired physical and social functioning and poorer HRQoL than healthy individuals. The extent of skin involvement, tendon/joint contracture, damage in the heart, and peripheral vascular system were associated with poorer functioning and HRQoL.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Chan PT,Mok CC,Chan KL,Ho LYdoi
10.1007/s10067-014-2525-2subject
Has Abstractpub_date
2014-05-01 00:00:00pages
659-66issue
5eissn
0770-3198issn
1434-9949journal_volume
33pub_type
杂志文章abstract：:As part of a larger body of work to develop a rheumatology priority referral score, a literature review was conducted. The objective of the literature review was to identify preexisting priority-setting, triage, and referral tools/scales developed to guide referrals from primary care to specialist care/consultation us...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0938-5
更新日期：2008-11-01 00:00:00
abstract：:Systemic sclerosis (SS) alters smooth muscle function throughout the gastrointestinal tract, the oesophagus being the segment most often involved. Involvement of the colon, though less common, may lead to life-threatening complications. We studied 23 unselected patients with SS and 20 age-matched healthy controls usin...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1581-5
更新日期：2011-01-01 00:00:00
abstract：:Acute gouty arthritis (AGA) is an auto-inflammatory disease characterized by resolving spontaneously, which suggests that negative feedback loops control inflammatory and immunological responses to monosodium urate (MSU) crystals. By now, the molecular mechanism for spontaneous resolution of acute GA remains unclear; ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3109-5
更新日期：2016-09-01 00:00:00
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doi：10.1007/s10067-019-04843-4
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0919-8
更新日期：2008-11-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：1992-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-008-0970-5
更新日期：2008-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-05-01 00:00:00
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更新日期：2012-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-016-3376-9
更新日期：2016-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-019-04693-0
更新日期：2019-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-019-04508-2
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1985-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10067-018-4158-3
更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章
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journal_title：Clinical rheumatology
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Clinical rheumatology
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doi：10.1007/BF02229707
更新日期：1996-05-01 00:00:00
