Abstract：
:Susceptibility to systemic lupus erythematosus (SLE) is associated with genetic, hormonal, immunological, and environmental factors. Many genes have been related with the appearance of SLE, including several loci that code different complement components and their receptors. Some genetic deficiencies of complement molecules are strongly associated with SLE, probably because these deficiencies could cause decreased clearance of apoptotic cell material. As a consequence of the apoptotic material accumulation, high levels of autoantigens can be presented inappropriately to the immune system in an inflammatory context, resulting in an imbalance on the mechanisms of immunological tolerance, immune system activation, and autoantibody production. Recent studies proposed a role to the mannose-binding lectin (MBL) in the SLE physiopathogenesis. This protein activates the complement system, and the presence of several polymorphisms at the promoter and coding regions of the MBL-2 gene determines alterations at the plasma levels of MBL. Some of these polymorphisms have been associated with SLE susceptibility, as well as with clinical and laboratory typical features of this disease, cardiovascular events, and infections. Besides, it has been described that the presence of anti-MBL autoantibodies in sera of SLE patients can influence MBL plasma levels and its functional activity.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Monticielo OA,Mucenic T,Xavier RM,Brenol JC,Chies JAdoi
10.1007/s10067-008-0838-8subject
Has Abstractpub_date
2008-04-01 00:00:00pages
413-9issue
4eissn
0770-3198issn
1434-9949journal_volume
27pub_type
杂志文章,评审abstract：:The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differenti...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2111-4
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION/OBJECTIVES:Primary Sjögren syndrome (pSS) is usually encountered between the fourth and sixth decades. It is known that the age of onset in autoimmune diseases may affect the clinical features. In this study, we aimed to investigate the clinical and laboratory characteristics of early onset pSS patients. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05017-3
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:This study was designed to compare outcomes of dose reduction, withdrawal, and continuation of tofacitinib in patients with rheumatoid arthritis (RA) and to examine effectiveness of rescue with an original treatment regimen for disease flare. METHODS:We prospectively enrolled 100 patients who had high or mod...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04721-z
更新日期：2019-12-01 00:00:00
abstract：:Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3647-0
更新日期：2017-08-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-04975-y
更新日期：2020-07-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04789-7
更新日期：2020-02-01 00:00:00
abstract：:The authors of the published version of this article incorrectly presented the affiliation of Li-Chin Sung. The revised affiliation is now presented correctly in this article. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10067-019-04531-3
更新日期：2019-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0698-1
更新日期：2003-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3928-7
更新日期：2018-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-017-3976-z
更新日期：2018-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-012-2062-9
更新日期：2012-12-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-3117-5
更新日期：2016-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3831-2
更新日期：2018-02-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-014-2642-y
更新日期：2015-03-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1222-z
更新日期：2009-10-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02204466
更新日期：1988-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02283118
更新日期：1992-12-01 00:00:00
abstract：:Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites. In recent years, with the continuous research on gout animal models and patient clinical investigations, the mechanism of i...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05090-8
更新日期：2020-10-01 00:00:00
abstract：:Psoriatic arthritis (PsA) patients are often treated by dermatology and rheumatology specialities and may receive different treatments. To evaluate the impact of dermatology/rheumatology specialist settings on diagnosis and therapeutic approach in PsA patients. This cross-sectional multicounty study in Italy involved ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05482-w
更新日期：2020-11-06 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3563-3
更新日期：2017-04-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2603-5
更新日期：2014-09-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-019-04638-7
更新日期：2019-10-01 00:00:00
abstract：:In a great majority of patients with systemic lupus erythematosus (SLE) lymphocytotoxic antibodies (LCA) are detected. The reported prevalence depends on the methods of detection and definition of test-positivity. The pathogenetic role of LCA remains unclear. Different reports show that LCA can have an influence on mo...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02229861
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVE:To investigate the clinical characteristics, laboratory features, and treatment outcomes of Thai patients compared between those with necrotizing autoimmune myopathy (NAM) and those with other idiopathic inflammatory myopathies (IIMs) or non-NAM. METHODS:This multicenter case-control study included patients ...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-019-04756-2
更新日期：2019-12-01 00:00:00
abstract：:To determine serum interleukin-33 (IL-33) levels and their associations with clinical parameters in patients with systemic sclerosis (SSc). Serum IL-33 levels were examined by enzyme-linked immunosorbent assay in 69 patients with SSc and 30 healthy individuals. In a retrospective longitudinal study, sera from 14 patie...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-011-1686-5
更新日期：2011-06-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system and that measures of hearing may be related to indices of RA disease activity. The aims of this study were to determine whether hearing loss in young subjects with rheumatoid ar...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0802-z
更新日期：2008-05-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670170112
更新日期：2001-01-01 00:00:00
abstract：:We described a 21-year-old woman with a diagnosis of Sjögren syndrome that came for consultation with a localized mass over her left arm of fast growth. Lab results were normal; a Doppler ultrasound showed the presence of partial thrombosis in the left axillary vein; a magnetic resonance imaging showed edema on the bi...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-015-3133-5
更新日期：2016-04-01 00:00:00
abstract：:A number of laboratory variables, including Hb., ESR and several phase proteins, fluctuated in concord with the clinical signs of synovitis activity in patients with rheumatoid arthritis during a controlled study of 3 disease-modifying anti-rheumatic drugs (DMARD). The correlation between laboratory variables and clin...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02201028
更新日期：1987-06-01 00:00:00
