Abstract：
:Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites. In recent years, with the continuous research on gout animal models and patient clinical investigations, the mechanism of inflammation activation of gout has been further discovered. Studies have shown that pro-inflammatory factors such as interleukin (IL)-1β, IL-8 and IL-17, NLRP3 inflammasome, and tumor necrosis factor alpha (TNF-α), anti-inflammatory factors such as IL-10, IL-37 are all involved in the MSU-induced gout inflammatory process. And the immune cells in gout, including neutrophils, monocytes/macrophages, and lymphocytes, all play important roles in the pathogenesis of gout. In this review, we mainly emphasize the understanding of various cytokines, inflammasome, and immune cells involved in the onset of gout, in order to provide a systematic and theoretical basis for the novel exploration of inflammatory therapeutic targets for gout.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Wu M,Tian Y,Wang Q,Guo Cdoi
10.1007/s10067-020-05090-8subject
Has Abstractpub_date
2020-10-01 00:00:00pages
2849-2859issue
10eissn
0770-3198issn
1434-9949pii
10.1007/s10067-020-05090-8journal_volume
39pub_type
杂志文章,评审abstract：:In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of met...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02208347
更新日期：1995-05-01 00:00:00
abstract：:Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-2127-9
更新日期：2013-03-01 00:00:00
abstract：:Kidney involvement in immuno-mediated diseases is a life threatening complication to be early detected. Glomerulo-tubular functional indices, kidney-released enzymes and metabolic profiles were assessed in 21 patients with systemic lupus erythematosus, progressive systemic sclerosis and mixed cryoglobulinaemia, withou...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02231679
更新日期：1996-01-01 00:00:00
abstract：:The Revised Fibromyalgia Impact Questionnaire (FIQR) attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Turkish version of the FIQR available, we aimed to investigate the validity and reliability of a Turkish translation of the FIQR in Turkish female fibromyalgia (FM) pa...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1546-8
更新日期：2011-03-01 00:00:00
abstract：:The aim of this study was to evaluate whether corticosteroid use is the etiological agent in acute pancreatitis in patients with systemic lupus erythematosus, or whether it is related to the underlying connective tissue disorder. Hospital admissions at Thomas Jefferson University Hospital between 1982 and 2002 that ca...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0793-3
更新日期：2004-04-01 00:00:00
abstract：:We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3902-4
更新日期：2018-10-01 00:00:00
abstract：:To characterize the distinctive chest high-resolution computerized tomography (HRCT) features and clinical manifestations of primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD). The demographic data, clinical manifestations, and laboratory and radiological findings of 527 pSS patients were retrospec...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4289-6
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of steroid injection (local treatment, LT) into the digital flexor tendon sheath of dactylitis in psoriatic arthritis (PsA) patients as compared with systemic treatment (ST). METHODS:Forty-six PsA patients with a total of 73 dactylitic fingers were assessed in an observational, mu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05142-z
更新日期：2020-11-01 00:00:00
abstract：:Oxidative stress was related with carpal tunnel syndrome (CTS). We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. One hundred-forty patients with CTS and 97 healthy controls were enrolled in this study. Tinel and Phalen signs were noted as ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2855-0
更新日期：2016-05-01 00:00:00
abstract：:The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 pa...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3967-0
更新日期：2018-05-01 00:00:00
abstract：:Takayasu arteritis (TA) is a chronic inflammatory disease. Interleukin (IL)-6 and IL-10 are important cytokines involved in the immune response of TA in some ethnicities. We investigated whether the single-nucleotide polymorphism (SNP) of IL-6 and IL-10 genes and their expressions were associated with TA in a Chinese ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4260-6
更新日期：2019-01-01 00:00:00
abstract：:Dego's disease is an uncommon thrombo-occlusive vasculopathy that presented with skin rash and thrombotic complications affecting internal organs that may simulate rheumatic diseases and may be brought to the attention of rheumatologists. We present here a case of a middle-aged woman who presented with acute bowel inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1164-5
更新日期：2009-07-01 00:00:00
abstract：:The objective of this study is to identify the clinical differences between infectious meningitis and neuropsychiatric systemic lupus erythematosus (NPSLE) in patients with SLE. Clinical manifestations, laboratory test results, and prognoses of 14 SLE patients complicated with various infectious meningitis, hospitaliz...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2726-8
更新日期：2015-02-01 00:00:00
abstract：:To compare the efficacy and safety of aceclofenac (AC) and tenoxicam (TX) in the treatment of rheumatoid arthritis (RA), a multicentric parallel, randomized, double-blind trial of three months duration was performed in 292 patients: 145 were randomized to the AC treatment group and 147 to the TX treatment group. The t...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02229644
更新日期：1996-09-01 00:00:00
abstract：:Juvenile idiopathic arthritis (JIA) has rarely been reported among Black Africans. This retrospective case study was part of an audit of cases presenting to a private practice rheumatology clinic in Lagos, Nigeria. The objective of this study was to determine the clinical, laboratory, and radiographic features of pati...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1401-y
更新日期：2010-07-01 00:00:00
abstract：:A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to t...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670070047
更新日期：2000-01-01 00:00:00
abstract：:The aim of this study is to assess the gender differences in spondyloarthritides (SpAs) in terms of disease onset, clinical presentation, and the Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI). We analysed data from a predominantly female cohort. Five hundred and 16 patients (ma...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1581-5
更新日期：2011-01-01 00:00:00
abstract：:Joint hypermobility syndrome (JHS) is common in patients presenting to rheumatologists and can cause a range of symptoms leading to physical and psychological distress. Chronic musculoskeletal pain in patients with JHS often responds poorly to analgesics, and a pain management approach may be helpful. Since patients w...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-014-2539-9
更新日期：2014-11-01 00:00:00
abstract：:The aim of this study was to evaluate if pulsed electromagnetic field therapy (PEMF) has additional effect on the classical physical treatment of knee osteoarthritis (OA) composed of hot pack, therapeutic ultrasound, and terminal isometric exercises. Forty patients (29 women and 11 men), ages 44 to 78 (mean age was 61...
journal_title：Clinical rheumatology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10067-010-1453-z
更新日期：2010-08-01 00:00:00
abstract：:We report the case of a 45-year-old Caucasian woman suffering from ankylosing spondylitis and undifferentiated connective tissue disease in whom the prevailing clinical features were retinal vasculitis and inflammatory low back pain. HLA typing revealed the concomitant presence of B27 and DR2 antigens. We hypothesise ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF01451055
更新日期：1998-01-01 00:00:00
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journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02715692
更新日期：1984-03-01 00:00:00
abstract：:Reactive arthritis (ReA) due to Gram-negative intestinal bacteria or Chlamydia, is associated by an unknown mechanism with HLA-B27. Like other MHC class I molecules, HLA-B27 presents antigenic peptides derived from intracellular proteins to CD8+ cytotoxic T cells (CTL). In humans however, CTL specific for ReA associat...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF03342653
更新日期：1996-01-01 00:00:00
abstract：:The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). Levels of human PAD4 and anti-PAD4 Abs in s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-3082-z
更新日期：2016-05-01 00:00:00
abstract：:The effect of the immunostimulant C. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. Male Swiss albino mice were injected intra-venously with M. arthritidis culture and intraperitoneally with C. parvum. It was shown that mice immunostimulated with C. parvum were significantly p...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02032174
更新日期：1983-06-01 00:00:00
abstract：:In the past decade, lung ultrasound (LUS) B-lines and serum Krebs von den Lungen-6 (KL-6) antigen have been recognized as biomarkers of the connective tissue disease-associated interstitial lung diseases (CTD-ILDs). Robust data have demonstrated that B-lines total numbers and KL-6 levels are correlated with high-resol...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04462-z
更新日期：2019-05-01 00:00:00
abstract：:A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0037-9
更新日期：2006-07-01 00:00:00
abstract：:The outbreak of SARS-CoV-2 has changed the habits and lives of people worldwide. Patients affected by systemic sclerosis (SSc) experienced constant fear because of their immunocompromised status. The aim of this study was to investigate the prevalence of SARS-CoV-2 infection and to analyze the lifestyle changes in a s...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05504-7
更新日期：2020-11-14 00:00:00
abstract：:A 73-year-old woman was admitted to our hospital because of persistent high fever and cough, generalized myalgia, and renal dysfunction. Laboratory examination revealed severe inflammatory signs, pulmonary fibrosis, progression of renal impairment with active nephritic urinary sediments, and a high titer of myeloperox...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0142-9
更新日期：2007-03-01 00:00:00
abstract：:Anaerobic bacteria are uncommon pathogens in septic arthritis. We report a case of pyarthrosis of the right hip caused by Fusobacterium nucleatum, following a transient synovitis in an otherwise healthy boy. There are only a few cases involving this species described in the literature. This report illustrates the diff...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670170072
更新日期：2001-01-01 00:00:00
abstract：:The aim of this study was to analyse microvascular damage and compensatory angiogenesis in skin from patients with systemic sclerosis (SSc) compared with systemic lupus erythematosus (SLE), Raynaud's phenomenon (RP) and healthy controls. Immunohistochemistry was used for skin biopsies (9 SSc, 10 SLE, 9 RP and 12 healt...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-003-0698-1
更新日期：2003-09-01 00:00:00
