Abstract:
:The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differentiate SpA from non-SpA. Finally, we investigated the reliability of US compared to clinical examination of Achilles tendinopathy, using MRI as gold standard reference. Twelve SpA patients and 15 non-SpA patients with pain and tenderness at at least one Achilles tendon and/or enthesis due to sports-related causes and 10 CTRLs were examined at the Achilles tendons and entheses with US, MRI and clinical assessment. Intratendinous changes, entheseal changes, bursitis and peritendonitis were assessed. An US interobserver substudy was performed in nine persons. US findings showed high agreement between observers (median 89 %, κ = 0.64) and with MRI (median 89 %, κ = 0.74). All inflammatory intratendinous changes were less frequent in SpA than non-SpA patients (p < 0.05). Entheseal changes and bursitis were found equally frequent in both patient groups except for enthesophytes, which were most common in the SpA group (p < 0.01). No findings were exclusively found in SpA. When MRI was considered gold standard, US showed higher sensitivity for intratendinous and entheseal changes than clinical examination (median sensitivity 0.83 versus 0.66). Especially, entheseal changes had higher sensitivity than clinical examination without loss of specificity. In conclusion, US performed by a trained operator can be a useful adjunct to clinical examination for improved assessment of Achilles tendons and entheses.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Wiell C,Szkudlarek M,Hasselquist M,Møller JM,Nørregaard J,Terslev L,Ostergaard Mdoi
10.1007/s10067-012-2111-4subject
Has Abstractpub_date
2013-03-01 00:00:00pages
301-8issue
3eissn
0770-3198issn
1434-9949journal_volume
32pub_type
杂志文章abstract:INTRODUCTION:Interleukin-1 receptor-associated kinases (IRAKs) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways. They play a key role in inflammation and innate immunity. IRAKs have been previously incriminated in autoimmune diseases such as systemic lupus erythematosus (...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04781-1
更新日期:2020-02-01 00:00:00
abstract::Antibodies to beta(2)-glycoprotein I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). We investigated the sensitivity and specificity of ELISA for anti-beta(2)-GPI in Thai systemic lupus...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0566-5
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0890-y
更新日期:2004-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF01451298
更新日期:1998-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1305-x
更新日期:2010-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0058-4
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02238958
更新日期:1997-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0726-1
更新日期:2003-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
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更新日期:1984-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3690-x
更新日期:2017-10-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-002-0639-4
更新日期:2003-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-013-2277-4
更新日期:2013-08-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2410-4
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Sarcoidosis is a chronic inflammatory disease characterized by non-caseating granuloma which etiology is unknown yet. Adipokines are different proteins synthesized by adipose tissue that have an influence on angiogenesis, hemostasis, lipid metabolism, and immune system regulation. Adipokines may play a role ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04980-1
更新日期:2020-07-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05370-3
更新日期:2020-08-27 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05132-1
更新日期:2020-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207928
更新日期:1995-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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更新日期:2015-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206850
更新日期:1987-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2525-2
更新日期:2014-05-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170112
更新日期:2001-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0117-x
更新日期:2006-07-01 00:00:00
abstract::Ankylosing spondylitis (AS) is the prototype for spondyloarthritis primarily affecting young men. Geographic and ethnic variations exist in the prevalence and severity of AS and relate to the wide disparity in the frequency of human leukocyte antigen (HLA)-B27, a major genetic risk factor. The strength of the disease ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2058-5
更新日期:2012-11-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章,多中心研究
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更新日期:2019-07-01 00:00:00
abstract::Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathway were found, and the turnove...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02030760
更新日期:1984-06-01 00:00:00