Abstract:
:The aim of this study is to describe the clinical features of Lebanese patients with Behçet's disease (BD) followed up at a tertiary care center in Lebanon. A retrospective review of medical records of 90 patients who fulfilled the International Study Group (ISG) criteria for diagnosis was performed. The clinical characteristics and severity score were compared with those reported from other populations of Arab and of Turkish origin using the same diagnostic criteria, and a comparison over two decades for the Lebanese population was made. The male-to-female ratio was 2.9:1, the mean age at onset, 25.4 years, and mean age at diagnosis, 29.2 years. One hundred percent of the patients had mouth ulceration; 72.2%, genital ulceration; 59.1%, arthritis; 55.7%, papulopustular skin lesion; 53.9%, ocular disease; 36.8%, vascular disease; 29.5%, erythema nodosum; and 23.0%, neurologic disease. The characteristics of our patient population are similar to that reported from other countries in the region. However, we found a higher prevalence of vascular and neurologic disease.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Hamdan A,Mansour W,Uthman I,Masri AF,Nasr F,Arayssi Tdoi
10.1007/s10067-005-0058-4subject
Has Abstractpub_date
2006-05-01 00:00:00pages
364-7issue
3eissn
0770-3198issn
1434-9949journal_volume
25pub_type
杂志文章abstract::Anti-tumour necrosis factor alpha therapy has led to significant advancement in the treatment of rheumatological disease. Rarely, anti-TNFalpha antagonists have been associated with vasculitis, predominantly cutaneous leukocytoclastic vasculitis. We present the first case of angiographically-confirmed digital vasculit...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-1015-9
更新日期:2008-12-01 00:00:00
abstract::The aim of this study was to ascertain whether fibromyalgia patients with positive ANA develop other features of connective tissue disease over 2-4 years' follow-up. Patients attending our clinic with a diagnosis of fibromyalgia were identified. All ANA-positive patients (n = 12) were recruited and matched for age and...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670200118
更新日期:2002-11-01 00:00:00
abstract::Giant cell arteritis (GCA) is a granulomatous vasculitis involving large- and middle-sized arteries, with a predilection for cranial arteries. In this paper, we aim to describe a case of a biopsy- and ultrasound-proven GCA, presenting with anterior ischemic optic neuropathy (AION) and normal CRP and ESR at diagnosis a...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05116-1
更新日期:2020-10-01 00:00:00
abstract::Clinical characteristics of antitumor necrosis factor (TNF) agents-related tuberculosis (TB) in ankylosing spondylitis (AS) are not well described. The aim was to compare the incidences and the characteristics of TB in AS and rheumatoid arthritis (RA) during TNF inhibitor treatment. AS (n = 1,322) and RA (n = 3,154) p...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2387-z
更新日期:2014-09-01 00:00:00
abstract::Anti-nucleosome antibodies, which recognise conformational epitopes consisting of histone and DNA in chromatin, have been described in autoimmune diseases. In this study, an attempt was made to isolate anti-nucleosome antibodies from the anti-DNA-depleted plasma IgG of two lupus patients either with or without nephrit...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01451045
更新日期:1998-01-01 00:00:00
abstract::In the midst of the COVID-19 pandemic, further understanding of its complications points towards dysregulated immune response as a major component. Systemic lupus erythematosus (SLE) is also a disease of immune dysregulation leading to multisystem compromise. We present a case of new-onset SLE concomitantly with COVID...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-020-05310-1
更新日期:2020-09-01 00:00:00
abstract::A 62-year-old man who suffered from severe deforming arthritis, secondary to chronic tophaceous gout with multilobular, solid, tender, enlarged subcutaneous nodules, and draining tophi in right second finger, was treated by free flap and finally got the more functional and aesthetic result. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-009-1321-x
更新日期:2010-03-01 00:00:00
abstract::Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4010-9
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:To test the psychometric properties of the United Kingdom's Commissioning for Quality in Rheumatoid Arthritis Patient-Reported Experience Measure (CQRA-PREM) in patients with spondyloarthritis (SpA) and rheumatoid arthritis (RA) and to implement this questionnaire in daily practice in the Netherlands. METHO...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05076-6
更新日期:2020-10-01 00:00:00
abstract::A 12-week double-blind randomized drug trial followed by an open extension period of 36 weeks was carried out in 38 male patients with ankylosing spondylitis (AS) to compare the efficacy and safety of diflunisal (500 mg twice daily) and phenylbutazone (200 mg twice daily). Both drugs proved to be effective in improvin...
journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02032359
更新日期:1986-06-01 00:00:00
abstract::The involvement of brain-derived neurotrophic factor (BDNF) in rheumatoid arthritis (RA) is largely unknown. The distribution of BDNF and its associated receptors, TrkB and p75, in the synovial tissue of patients with RA was examined and contrasted with that in patients with osteoarthritis (OA). Additionally, levels o...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-008-0910-4
更新日期:2008-10-01 00:00:00
abstract::This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventu...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3794-3
更新日期:2017-10-01 00:00:00
abstract::Sustained cough is a frequent complaint in methotrexate (MTX) treatment for rheumatoid arthritis and can be a symptom of incipient MTX-induced pneumonitis. This study was performed to characterize MTX-associated cough clinically and to clarify by which means this condition can be distinguished from incipient MTX pneum...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02229707
更新日期:1996-05-01 00:00:00
abstract::The aim of this study was to analyse microvascular damage and compensatory angiogenesis in skin from patients with systemic sclerosis (SSc) compared with systemic lupus erythematosus (SLE), Raynaud's phenomenon (RP) and healthy controls. Immunohistochemistry was used for skin biopsies (9 SSc, 10 SLE, 9 RP and 12 healt...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-003-0698-1
更新日期:2003-09-01 00:00:00
abstract::Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and e...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-017-3563-3
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04975-y
更新日期:2020-07-01 00:00:00
abstract::A patient presenting with interstitial lung disease was predicted to have underlying polymyositis when found to be anti-Jo-1 antibody positive. When myopathy developed later with elevated serum creatine phosphokinase and myoglobin levels, the electromyogram was nonmyopathic, and polymyositis was confirmed by muscle bi...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02201038
更新日期:1987-06-01 00:00:00
abstract:INTRODUCTION/OBJECTIVES:We hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) would mobilize occult extractable fluid and improve arthrocentesis success. METHODS:Sixty-seven consecutive knees with RA and 186 knees with OA and were included. Conventional arthrocentesis was performed and s...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04524-2
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:The association between pyoderma gangrenosum (PG) and rheumatoid arthritis (RA) was not investigated in the setting of controlled studies. The risk of PG among patients with RA is not established. OBJECTIVE:The study aims to evaluate the magnitude of the association between RA and the subsequent development...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-05253-7
更新日期:2021-02-01 00:00:00
abstract::Psoriatic arthritis (PsA) is a chronic T cell-mediated inflammatory spondyloarthropathy affecting 10-40 % of psoriasis (PSO) patients (0.3-1.0 % of the general population). Recent epidemiological studies have shown an increased prevalence of cardiovascular (CV) risk factors and/or morbidity among PSO or PsA patients a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2743-7
更新日期:2014-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of manifestations and potential to affect several organ systems. Complications arise from both disease and medications especially glucocorticoids, significantly contributing to overall morbidity and mortality. SLE predominantly affect...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-019-04795-9
更新日期:2020-03-01 00:00:00
abstract::We report a 54 year old female whose successful treatment of cerebral lupus with rituximab was complicated by the development of streptococcus intermedius, on valves damaged by Libman-Sacks endocarditis more than 20 years previously. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0031-2
更新日期:2006-07-01 00:00:00
abstract::The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CEN...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-2981-3
更新日期:2015-11-01 00:00:00
abstract::The tendency of patients with DISH towards obesity or an adult onset of diabetes has been reflected in marked hyperinsulinaemia following glucose challenge. It is hypothesized that insulin at prolonged and high physiologic levels promotes new bone growth, particularly in the entheseal regions. These areas are also sub...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031611
更新日期:1985-09-01 00:00:00
abstract::Cardiovascular disease is a major health care problem and the most common cause of death among individuals from developed nations. Our understanding of atherosclerosis has evolved from a passive process resulting in narrowing of the lumen and consequent myocardial ischemia to a dynamic process that involves inflammati...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-007-0548-7
更新日期:2007-08-01 00:00:00
abstract::Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microso...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02238968
更新日期:1997-05-01 00:00:00
abstract::We encountered an adult patient with acute parvovirus B19 infection who presented with transient lupus-like symptoms (i.e., polyarthritis, fever, myalgia, pancytopenia, hypocomplementemia, and nephritis). Our case is characterized by the demonstration of acute nephritis as a complication of this infection, making it d...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0691-1
更新日期:2008-01-01 00:00:00
abstract::Fragile X mental retardation 1 (FMR1) premutation carriers, who are at risk of having children with fragile X Syndrome, were initially considered as clinically unaffected. However, recent clinical and molecular studies have shifted this point of view. The incidence of premutation in the general population is substanti...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2052-y
更新日期:2012-11-01 00:00:00
abstract::Hepatitis B virus (HBV) reactivation is a common complication of immunosuppressive treatment in high prevalence countries. Biological disease-modifying antirheumatic drugs (bDMARDs) cause this adverse event more often than conventional immunosuppressants. The incidence of HBV reactivation during treatment for rheumati...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4295-8
更新日期:2018-11-01 00:00:00
abstract::The antigens of HLA-DR locus were determined in 127 patients with rheumatoid arthritis and in 175 healthy persons. The frequency of HLA-DR1 antigen was discovered in 45% of the patients and in 22.3% of the examinees from the control group (p less than 0.001). The relative risk is 2.84. 69% of the patients were seropos...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/BF02030241
更新日期:1990-03-01 00:00:00