Abstract:
:The aim of this study was to ascertain whether fibromyalgia patients with positive ANA develop other features of connective tissue disease over 2-4 years' follow-up. Patients attending our clinic with a diagnosis of fibromyalgia were identified. All ANA-positive patients (n = 12) were recruited and matched for age and sex with 12 ANA-negative FMS patients. As further control groups, patients with a diagnosis of osteoarthritis (OA) were included. A screening questionnaire for possible features of connective tissue disease was sent to all participants. Patients who had three or more positive criteria were invited for further assessment. The ANA-positive rate was 12/137 (8.8%) in FMS and 20/225 (8.9%) in OA patients. All ANA positivity was at a low titre. Fourteen out of 20 (70%) FMS patients and 17/30 (56.7%) OA patients had three or more criteria (P = 0.34). No significant differences in the number of the positive criteria were found between those who were ANA positive or negative in both groups. On full assessment we found one patient who fulfilled the criteria for SLE from the ANA-positive FMS group and one in the ANA-negative group who fulfilled the criteria for primary Sjögren's syndrome. Of the patients with OA, one who was ANA positive was diagnosed as having rheumatoid arthritis. The results from our study show that ANA (at least in low titre) is not a good predictor of the future development of connective tissue.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Al-Allaf AW,Ottewell L,Pullar Tdoi
10.1007/s100670200118subject
Has Abstractpub_date
2002-11-01 00:00:00pages
472-7issue
6eissn
0770-3198issn
1434-9949journal_volume
21pub_type
杂志文章abstract::This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-yea...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-014-2630-2
更新日期:2015-02-01 00:00:00
abstract::Four patients with rheumatoid nodulosis are here described, together with a review of cases reported to date in the literature. This particular variant of rheumatoid arthritis (RA) is characterized by the presence of subcutaneous rheumatoid nodules, scanty or absent systemic manifestations and a clinically benign cour...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02207201
更新日期:1992-09-01 00:00:00
abstract::The objective of this study was to determine tendon involvements and enthesal abnormalities in patients with rheumatoid arthritis (RA) using high-resolution ultrasonographic images and to compare the findings with those seen in patients with ankylosing spondylitis (AS) and healthy controls. A total of 24 patients with...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0997-1
更新日期:2005-06-01 00:00:00
abstract::The authors wish to acknowledge that whilst this study and that published in Hammad et al [1] explore different areas - blood cell ratios and serum endocan, respectively - the reader may identify some similarities between the papers owing to the same patient cohort being analysed in both studies. ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10067-019-04583-5
更新日期:2019-07-01 00:00:00
abstract::The lactogenic hormone prolactin is produced in part by cells of the immune system and serves as an upregulator of immune function. Hyperprolactinemia is common in patients with systemic lupus erythematosus (SLE), raising the possibility that the hormone contributes to the excessive immune response in the disease. The...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0117-x
更新日期:2006-07-01 00:00:00
abstract::A 61-year-old female with a history of vaginal dryness, Raynaud's phenomenon, xerostomia and xerophthalmia presented with exertional dyspnoea and weakness. Laboratory and instrumental examinations enabled us to make the diagnosis of primary Sjögren's syndrome, while cardiologic and imaging investigations evidenced iso...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-004-1071-8
更新日期:2005-08-01 00:00:00
abstract::The aim of this study was to determine the emotional and sociodemographic characteristics of patients with ankylosing spondylitis (AS) and to investigate the impact of the disease on their social life and quality of life (QOL). This study included 101 patients with the diagnosis of AS. All patients filled in a questio...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-1150-5
更新日期:2006-03-01 00:00:00
abstract::Monovariate and multivariate analyses including logistic regression were performed to determine associations among predicting variables [age, gender, immunofluorescence pattern, and anti-nuclear antibody (ANA) titer] and anti-extractable nuclear antigen (ENA) and -dsDNA antibodies (Abs) in 1089 patients with positive ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-004-0937-0
更新日期:2004-12-01 00:00:00
abstract::In juvenile chronic arthritis (JCA) the indices of disease activity, such as joint swelling, pain, tenderness, and limitation of motion, may poorly correlate with the degree of functional impairment. Since the improvement of functional capacity is one of the main objectives of treatment, we evaluated the effect of met...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02208347
更新日期:1995-05-01 00:00:00
abstract::The relationship between ankylosing spondylitis and the recently proposed entity called axial spondyloarthritis with its radiographic and non-radiographic forms that have been defined by the Assessment of Spondyloarthritis International Society (ASAS) criteria for axial spondyloarthritis (axSpA), is currently being de...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-016-3261-6
更新日期:2016-06-01 00:00:00
abstract::Amyloid arthropathy is said to be distinguished roentgenographically from rheumatoid arthritis by the absence of joint space narrowing and the absence of articular erosions. We present a patient with multiple myeloma with swelling, stiffness and firm synovial thickening of the wrists, metacarpophalangeal joints and pr...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02032296
更新日期:1985-06-01 00:00:00
abstract::Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-on...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04470-z
更新日期:2019-05-01 00:00:00
abstract::We report a case of a 56-year-old woman with an alleged diagnosis of an acute coronary syndrome that was later correctly identified in our Cardiology Unit as antisynthetase syndrome (AS) with inflammatory cardiac involvement. In this case report, we focus on clinical features of this rare autoimmune disease aiming to ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-019-04527-z
更新日期:2019-08-01 00:00:00
abstract::We report a patient with idiopathic portal hypertension (IPH) associated with systemic sclerosis (SSc) and Sjögren's syndrome. A 72-year-old Japanese woman was admitted to our hospital because of Raynaud's phenomenon, sclerodactyly, and dyspnea. The patient had splenomegaly, esophageal varices in the absence of extrah...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-1084-y
更新日期:2005-09-01 00:00:00
abstract::The objective of this study is to identify baseline factors associated with rheumatoid arthritis (RA) diagnosis at the end of 1-year follow-up in a cohort of patients with very recent onset arthritis. Incident cases with self-reported arthritis ( journal_title:Clinical rheumatology pub_type: 杂志文章 doi:10.1007/s10067-009-1206-z 更新日期:2009-10-01 00:00:00
abstract::In this scoping review, we sought to summarize the types of outcomes collected in pregnant patients with ankylosing spondylitis (AS), and to identify some methodological limitations related to pregnancy research in these patients. A comprehensive search was done to identify relevant articles in MEDLINE and Embase. We ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-021-05588-9
更新日期:2021-01-19 00:00:00
abstract::There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...
journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10067-013-2342-z
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To compare the efficacy and safety of tocilizumab with those of abatacept in patients with active rheumatoid arthritis not responding to anti-tumor necrosis factor therapy. METHODS:A prospective, open-label study was carried out on adult females with moderate-to-severe rheumatoid arthritis. Patients were ra...
journal_title:Clinical rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10067-019-04508-2
更新日期:2019-08-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there w...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-010-1395-5
更新日期:2010-07-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that affects various organs and systems. Increased apoptosis, together with defects in the uptake of apoptotic bodies, are thought to have a pathogenic role in SLE. By detection of chromatin condensation, 30% of apoptosis was detected in peripheral bl...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-005-0162-5
更新日期:2006-09-01 00:00:00
abstract::Atherosclerosis has been shown to be increased in chronic inflammatory diseases including ankylosing spondylitis (AS). Impaired endothelial function, the first step in atherosclerosis, may be reflected by changes in various endothelial biomarkers of hemostasis and the release of several cellular adhesion molecules or ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1760-z
更新日期:2012-01-01 00:00:00
abstract::It has recently been claimed that some of the symptoms in patients with Behçet's disease (BD) can be activated after the patient has stopped smoking. In this study we investigated the effect of smoking on the symptoms of Behçet's disease. Fifty asymptomatic current smokers (CS) who promised to stop smoking (group 1) a...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670070020
更新日期:2000-01-01 00:00:00
abstract::Two major complications in scleroderma patients that cause substantial morbidity and mortality are ischemic digital lesions (DL) and pulmonary hypertension (PH). The clinician's ability to predict which patients will develop these complications is imperfect. We conducted a prospective observational cohort study of 300...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-018-4148-5
更新日期:2018-09-01 00:00:00
abstract::In a Sidonian sarcophagus, from the Late Antique/early Christian period, skeletal remains of two persons were found. One of them, male, 30-50 years old, was found almost completely ankylosed, with highly osteoporotic bones and prominent erosion of joint surfaces. We diagnosed rheumatoid arthritis based on the eroded o...
journal_title:Clinical rheumatology
pub_type: 历史文章,杂志文章
doi:10.1007/s10067-016-3493-5
更新日期:2017-01-01 00:00:00
abstract::Anaerobic bacteria are uncommon pathogens in septic arthritis. We report a case of pyarthrosis of the right hip caused by Fusobacterium nucleatum, following a transient synovitis in an otherwise healthy boy. There are only a few cases involving this species described in the literature. This report illustrates the diff...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170072
更新日期:2001-01-01 00:00:00
abstract::This study quantified the association between recreational physical activity and daily function in women with fibromyalgia, and determined if this association is mediated by symptoms of pain, depression, or body mass. Twenty-three women diagnosed with fibromyalgia participated in an observational survey study. Recreat...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-013-2386-0
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-020-04975-y
更新日期:2020-07-01 00:00:00
abstract::Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-012-2127-9
更新日期:2013-03-01 00:00:00
abstract::This study aimed to compare the intraobserver and interobserver reliability of three-dimensional (3D) and two-dimensional (2D) power Doppler ultrasonography (PDUS) and to assess the relationship between 3D PDUS and clinical parameters in patients with rheumatoid arthritis (RA). Bilateral second/third metacarpophalange...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-011-1811-5
更新日期:2012-02-01 00:00:00
abstract::Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, showing a high incidence of lung involvements. The aim of this study is to identify risk factors, other than melanoma differentiation-associated protein (MDA)-5, for developing rapidly progressive-interstitial lung disease (RP-ILD) in ...
journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-015-3139-z
更新日期:2016-01-01 00:00:00