Abstract：
:Two major complications in scleroderma patients that cause substantial morbidity and mortality are ischemic digital lesions (DL) and pulmonary hypertension (PH). The clinician's ability to predict which patients will develop these complications is imperfect. We conducted a prospective observational cohort study of 300 patients with scleroderma who were followed for at least a 5-year period. At baseline, patients lacked evidence of PH and were without a current DL. At each 6-month visit, the patient was examined for signs/symptoms of PH and/or a DL. The primary outcomes were (1) PH defined as a mean pulmonary artery pressure ≥ 25 mmHg by right heart catheterization and (2) ≥ 1 DL defined as new onset of severe vascular compromise. Thirty patients (10%) developed PH (11 group 1/PAH, 4 group II, 15 group III) and 69 developed DL. The average time from enrollment until diagnosis of PH was 3.2 ± 2 years. In multivariable analyses, patients who developed PH were more likely to have diffuse disease (HR 3.2, p = 0.004), a forced vital capacity (FVC)/diffusing capacity of the lungs for carbon monoxide (DLCO) ratio > 1.6 (HR 1.7, p = 0.008), and elevated RVSP (HR = 1.07, p = 0.007). Patients who developed PAH were more likely to have a FVC/DLCO ratio > 1.6 (HR = 5.8, p = 0.014), and patients who developed group III PH were less likely to have an elevated FVC (HR = 0.92, p = 0.001). Patients were more likely to develop a DL if they had a history of prior DL (HR = 7.0, p < 0.001), or were men (HR = 2.3, p = 0.007). In a prevalent cohort of scleroderma patients, individuals who develop PH or DL have simple to measure clinical features that can predict these complications years before they occur.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Mecoli CA,Shah AA,Boin F,Wigley FM,Hummers LKdoi
10.1007/s10067-018-4148-5subject
Has Abstractpub_date
2018-09-01 00:00:00pages
2429-2437issue
9eissn
0770-3198issn
1434-9949pii
10.1007/s10067-018-4148-5journal_volume
37pub_type
杂志文章abstract：:Severe exacerbation of symptoms following physical activity is characteristic for chronic-fatigue syndrome (CFS) and fibromyalgia (FM). These exacerbations make it understandable for people with CFS and FM to develop fear of performing body movement or physical activity and consequently avoidance behaviour toward phys...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-013-2277-4
更新日期：2013-08-01 00:00:00
abstract：:The objective of this study was to compare total ankle arthroplasty (TAA) utilization and outcomes by patient residence. We used the Nationwide Inpatient Sample (NIS) from 2003 to 2011 to compare utilization and outcomes (post-arthroplasty discharge disposition, length of hospitalization, and mortality) by rural vs. u...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-015-2908-z
更新日期：2016-02-01 00:00:00
abstract：:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is characterized by recurrent episodes of inflammation with fever, abdominal pain, chest pain, rash, myalgia, arthralgia, conjunctivitis, and periorbital edema. This condition is a rare autosomal dominant disease that is strongly associated with heter...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-018-4023-4
更新日期：2018-05-01 00:00:00
abstract：:Since diffuse idiopathic skeletal hyperostosis (DISH) is frequently difficult to differentiate radiologically from the axial involvement of ankylosing spondylitis and osteoarthrosis, some features of these 3 different diseases were compared. The predominantly horizontal nature of the enthesiophyte in DISH and its righ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02283118
更新日期：1992-12-01 00:00:00
abstract：:Despite improved quality of care for rheumatoid arthritis (RA) patients, many still experience treatment failure with a biologic agent and eventually switch to another biologic agent. We investigated patterns of biologic treatment and reasons for switching biologics in patients with RA. Patients with RA who had starte...
journal_title：Clinical rheumatology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10067-017-3584-y
更新日期：2017-05-01 00:00:00
abstract：:Antibodies to beta(2)-glycoprotein I (anti-beta(2)-GPI) have been reported to have stronger association with clinical antiphospholipid syndrome (APS) than anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). We investigated the sensitivity and specificity of ELISA for anti-beta(2)-GPI in Thai systemic lupus...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-007-0566-5
更新日期：2007-10-01 00:00:00
abstract：:We reviewed three cases of systemic lupus erythematosus (SLE) in children with mesenteric vasculitis (LMV) as initial presentation and analysed their clinical characteristics to improve the understanding of this disease. Three patients with SLE were admitted to our hospital and initially presented with gastrointestina...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-017-3841-0
更新日期：2018-01-01 00:00:00
abstract：:We and others have previously shown that IL-17 is elevated in the synovial fluid of patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA) having acute synovitis. Major source for IL-17 is Th17 cells, which differentiate from Th0 cells under the influence of TGF-β and IL-6, IL1-β and are ma...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1646-5
更新日期：2011-06-01 00:00:00
abstract：:Recurrences of COVID-19 were observed in a patient with long-term usage of hydroxychloroquine, leflunomide, and glucocorticoids due to her 30-year history of rheumatoid arthritis (RA). Tocilizumab was applied and intended to target both COVID-19 and RA. However, disease of this patient aggravated after usage of tocili...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/s10067-020-05234-w
更新日期：2020-09-01 00:00:00
abstract：:The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in Finland was clinically followed-up by rheumatologists with visits a...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2247-x
更新日期：2013-08-01 00:00:00
abstract：:Adult onset Still's disease (AOSD) is an inflammatory disease of unknown etiology, characterized by spiking fever, evanescent salmon pink maculopapular rash, arthritis, and leukocytosis with neutrophilia. Malignant lymphoma is one of the most important differential diagnoses of AOSD. AOSD has been reported as one of p...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-009-1305-x
更新日期：2010-02-01 00:00:00
abstract：:Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-tim...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-018-4138-7
更新日期：2018-10-01 00:00:00
abstract：:Idiopathic paroxysmal rhabdomyolysis indicating a classical triad of symptoms consisting of muscle pain, weakness, and discolored urine is known as "Meyer-Betz syndrome". It may result in acute renal failure due to precipitation of the myoglobin casts in the tubuli or to the direct toxic effects of myoglobin to the tu...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-005-0091-3
更新日期：2006-11-01 00:00:00
abstract：:We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertensio...
journal_title：Clinical rheumatology
pub_type： 杂志文章,评审
doi：10.1007/BF02243009
更新日期：1994-12-01 00:00:00
abstract：:Heart rate variability (HRV) gives information about sympathetic parasympathetic autonomic balance. Our purpose was to determine whether HRV is abnormal in patients with Sjögren's syndrome. In 16 patients with Sjögren's syndrome and 30 matched controls, a short time analysis of HRV was performed for both the frequency...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/pl00011180
更新日期：2000-01-01 00:00:00
abstract：:Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02283113
更新日期：1992-12-01 00:00:00
abstract：:This study aims to explore patient's concerns when discussing sexual problems caused by chronic low back pain with their healthcare provider. It also aims to identify factors influencing and limiting such communication. A cross-sectional analysis of 100 consenting chronic low back pain sexually active patients was car...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-013-2299-y
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibrom...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-019-04447-y
更新日期：2019-05-01 00:00:00
abstract：:Bacteroides fragilis is a rare cause of septic arthritis. Most patients with B. fragilis septic arthritis have a chronic joint disease, particularly rheumatoid arthritis, and sources of infection are lesions of the gastrointestinal tract and the skin. We report a 69-year-old male, who developed B. fragilis septic arth...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02247808
更新日期：1997-11-01 00:00:00
abstract：:This study aimed to compare the diagnostic value of ultrasonography to conventional radiography in detecting osteophytes and erosions in the midfoot joints in patients suffering from inflammatory and non-inflammatory joint disease. Patients with current foot radiographs were included and stratified in two cohorts: inf...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-017-3658-x
更新日期：2017-09-01 00:00:00
abstract：:The objectives of the study were to investigate short and long-term changes and relations to treatment response of plasma interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), YKL-40, matrix metalloproteinase-3 (MMP-3), and total aggrecan in patients with spondyloarthritis (SpA) treated with tumor necrosis ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-010-1528-x
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, m...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-05573-8
更新日期：2021-01-02 00:00:00
abstract：:We report a case of hypokalaemic, flaccid quadriparesis with sudden respiratory arrest in a 27-year-old Japanese woman in whom the discovery of distal renal tubular acidosis led to the diagnosis of primary Sjögren's syndrome (SS). Hypokalaemic periodic paralysis as the initial manifestation of primary SS is rare, but ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670170028
更新日期：2001-01-01 00:00:00
abstract：:Giant cell (temporal) arteritis presenting with syncope due to carotid sinus hypersensitivity is described. Although the association of giant cell (temporal) arteritis and carotid sinus hypersensitivity is known, there are no previous reports of syncope as the presenting feature of giant cell (temporal) arteritis. ...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02030761
更新日期：1984-06-01 00:00:00
abstract：INTRODUCTION:Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory benign breast disease. Although the etiology of this disease is unknown, it has been suggested that hormonal disorders, autoimmunity, smoking, and α1-antitrypsin deficiency may play a role in the etiopathogenesis. The aim is to investi...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-020-04925-8
更新日期：2020-05-01 00:00:00
abstract：:The effect of long-term (18-70 months) chloroquine treatment 250 mg daily, in rheumatoid arthritis (RA) was studied in 20 patients. Sedimentation rates were significantly reduced, as compared to a reference group of 10 RA patients on no treatment of disease modifying anti-rheumatic drugs. Radiographical progression of...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02041561
更新日期：1983-12-01 00:00:00
abstract：:Treatment with methotrexate (MTX) is well established in rheumatoid arthritis (RA), but dosing remains arbitrary as studies on the effect of different dosing schedules are lacking. In a randomised crossover design of 20 patients with RA, the effect of low (2.5mg) oral daily doses of MTX (15 mg weekly) was compared to ...
journal_title：Clinical rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02231528
更新日期：1993-06-01 00:00:00
abstract：:Behçet's disease is a multisystem disorder affecting the skin, mucous membranes, eye, joints, central nervous system, and blood vessels. One of the known vascular complications of Behçet's disease is venous thrombosis or aneurysm formation. We report, herewith, a patient with Behçet's disease who developed radial arte...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/BF02229654
更新日期：1996-09-01 00:00:00
abstract：:A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to t...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s100670070047
更新日期：2000-01-01 00:00:00
abstract：:Clinical guidelines regarding anti-viral prophylaxis for HBV surface antigen (HBsAg) carriers starting anti-TNFα agents are not yet fully established, even in endemic regions of HBV infection. We retrospectively collected the clinical data of 52 HBsAg carriers with rheumatoid arthritis (RA) or ankylosing spondylitis (...
journal_title：Clinical rheumatology
pub_type： 杂志文章
doi：10.1007/s10067-012-1960-1
更新日期：2012-06-01 00:00:00
