当前位置： SCI文献检索 > CLINICAL RHEUMATOLOGY期刊下所有文献 > Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity.

Higher activation of the interferon-gamma signaling pathway in systemic lupus erythematosus patients with a high type I IFN score: relation to disease activity.

Abstract：

:Increased IFN-γ levels have been associated with systemic lupus erythematosus (SLE). However, the relationships among IFN-γ, type I interferons (IFNs) and clinical features have not been extensively studied. Peripheral blood samples from 44 SLE patients and 36 healthy donors (HDs) were collected. Quantitative real-time PCR was used to assess the mRNA expression of IFNG, type II IFN-inducible genes (IRF1, GBP1, CXCL9, CXCL10, and SERPING1, which are used for the type II IFN score), type I IFN-inducible genes (IRF7, MX1, ISG15, and ISG20, which are used for the type I IFN score), TBX21, and EOMES in peripheral blood mononuclear cells. Flow cytometry was used to measure the IFN-γ levels in lymphocytes. The mRNA levels of type II IFN-inducible genes, IFNG, TBX21, and EOMES were significantly higher in SLE patients than those in HDs. Similarly, the percentages of IFN-γ-producing cells in lymphocytes and their subsets in SLE patients were significantly increased. Linear regression indicated that IFNG expression levels and type II IFN scores were positively correlated with anti-double-stranded DNA autoantibody levels and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Compared with patients with low type I IFN scores, patients with high type I IFN scores showed increased type II IFN scores and SLEDAI scores. Type II IFN scores were positively associated with type I IFN scores. The IFN-γ signaling pathway is activated in SLE patients and may be considered an index of disease activity. IFN-γ, together with type I IFNs, promotes the pathogenesis of SLE.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Liu M,Liu J,Hao S,Wu P,Zhang X,Xiao Y,Jiang G,Huang X

doi

10.1007/s10067-018-4138-7

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

2675-2684

issue

10

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-018-4138-7

journal_volume

37

pub_type

杂志文章

相关文献

CLINICAL RHEUMATOLOGY文献大全
  • Echocardiographic features in patients with ANCA-associated vasculitis within 3 months before and after diagnosis.

    abstract：:We investigated the all-inclusive echocardiographic features in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) within 3 months before and after diagnosis. We reviewed the medical records of 89 AAV patients taking echocardiography and 35 age- and gender-matched controls. We collect...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-017-3868-2

    authors： Ahn SS,Park ES,Jung SM,Song JJ,Park YB,Lee SW

    更新日期：2017-12-01 00:00:00

  • Effect of delayed diagnosis on disease course and management of Churg-Strauss syndrome: a retrospective study.

    abstract：:Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-012-2127-9

    authors： Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

    更新日期：2013-03-01 00:00:00

  • Correction to: Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines.

    abstract：:In the original version of this article the first name of the co-author was incorrectly spelled as "Khaled A. Alnaqbi". The correct spelling should have been "Khalid A. Alnaqbi". This is now presented correctly in this article. ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s10067-018-4282-0

    authors： Arayssi T,Harfouche M,Darzi A,Al Emadi S,Alnaqbi KA,Badsha H,Al Balushi F,Dib C,Elzorkany B,Halabi H,Hammoudeh M,Hazer W,Masri B,Merashli M,Omair M,Salloum N,Uthman I,Zahirovic S,Ziade N,Bannuru RR,McAlindon T,N

    更新日期：2018-11-01 00:00:00

  • Appearance concern and depression in adolescent girls with systemic lupus erythematous.

    abstract：:To examine the relationship between physical appearance concern and psychological distress in female adolescent patients with systemic lupus erythematosus (SLE) was the aim of this study. A total of 84 adolescent SLE female patients and 80 age-matching healthy adolescents were evaluated for levels of appearance concer...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-012-2071-8

    authors： Ji L,Lili S,Jing W,Yanyan H,Min W,Juan X,Hongmei S

    更新日期：2012-12-01 00:00:00

  • A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis.

    abstract：:Adult-onset Still's disease (AOSD) has often been regarded as the adult spectrum of systemic juvenile idiopathic arthritis (sJIA). The present study aims to compare the clinical and laboratory features, the disease course and the response to treatment in patients having AOSD with those having sJIA. Retrospective revie...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10067-005-0138-5

    authors： Pay S,Türkçapar N,Kalyoncu M,Simşek I,Beyan E,Ertenli I,Oztürk MA,Düzgün N,Erdem H,Ozbalkan Z,Kiraz S,Kinikli G,Besbas N,Dinç A,Ateş A,Olmez U,Calgüneri M,Aydintuğ OT,Bakkaloğlu A,Turan M,Turgay M,Karaaslan Y,

    更新日期：2006-09-01 00:00:00

  • Outcomes for patients undergoing one or more total hip and knee arthroplasties.

    abstract：:Either total hip arthroplasty (THA), total knee arthroplasty (TKA) or both were performed in 105 patients from 1981 to 1994. These patients were experiencing severe joint destruction in the lower extremities due to rheumatoid arthritis (RA). These patients were followed for more than 2 years after their last operation...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF01452259

    authors： Kageyama Y,Miyamoto S,Ozeki T,Hiyoshi M,Kushida K,Inoue T

    更新日期：1998-01-01 00:00:00

  • Takayasu's arteritis: clinical features and outcomes of 125 patients in China.

    abstract：:Takayasu's arteritis (TA) is a chronic inflammation that frequently involves the aorta and its major branches. The clinical features of TA vary in different ethnic populations. The objective of this study is to characterize the clinical features, angiographic findings, and response to treatment of patients with TA in ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-010-1496-1

    authors： Cong XL,Dai SM,Feng X,Wang ZW,Lu QS,Yuan LX,Zhao XX,Zhao DB,Jing ZP

    更新日期：2010-09-01 00:00:00

  • Correction to: Microstructure of osteophytes in medial knee osteoarthritis.

    abstract：:The above article originally published with an error present in Table 2 and is now presented correctly in this article. ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s10067-018-4280-2

    authors： Kizaki K,Uchida S,Yamashita F,Tsukamoto M,Azuma K

    更新日期：2018-10-01 00:00:00

  • Severe infections in systemic lupus erythematosus: disease pattern and predictors of infection-related mortality.

    abstract：:Infection is a major cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). To describe the pattern of serious infections in patients with SLE and to identify the predictors of infection-related mortality among SLE patients with serious infections, we prospectively studied all SLE pat...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-018-4102-6

    authors： Teh CL,Wan SA,Ling GR

    更新日期：2018-08-01 00:00:00

  • Effect of spa therapy in Tiberias on patients with ankylosing spondylitis.

    abstract：:Fourteen patients with ankylosing spondylitis (AS) were treated in a pilot study for two weeks at a Tiberias spa with a combination of hot mineral water baths and mud packs. A significant improvement was noticed in morning stiffness, finger to floor distance and the overall well-being assessment both by the patient an...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF02208080

    authors： Tishler M,Brostovski Y,Yaron M

    更新日期：1995-01-01 00:00:00

  • Secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis.

    abstract：:The goals of this study were to determine if secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis (RA) compared to control subjects and to examine the relationships of S-SMase activity with functional status, quality of life, and RA disease activity measurements. We collected...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-017-3824-1

    authors： Hanaoka BY,Ormseth MJ,Michael Stein C,Banerjee D,Nikolova-Karakashian M,Crofford LJ

    更新日期：2018-05-01 00:00:00

  • Infliximab therapy for familial Mediterranean fever-related amyloidosis: case series with long term follow-up.

    abstract：:Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent self-limited attacks of fever and polyserositis. Reactive amyloid A amyloidosis is the most devastating complication of FMF, and amyloidosis continues to occur in the colchicine era in untreated and noncompliant patients. U...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/s10067-012-2009-1

    authors： Özçakar ZB,Yüksel S,Ekim M,Yalçınkaya F

    更新日期：2012-08-01 00:00:00

  • Psychological variables associated with foot function and foot pain in patients with plantar heel pain.

    abstract：:It is widely accepted that psychological variables are associated with self-reported pain and self-reported physical function in patients with musculoskeletal pain. However, the relationship between psychological variables and foot pain and foot function has not been evaluated in people with plantar heel pain. Eighty-...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-014-2565-7

    authors： Cotchett MP,Whittaker G,Erbas B

    更新日期：2015-05-01 00:00:00

  • Antioxidant enzyme activities, lipid peroxidation, and total antioxidant status in children with Henoch-Schönlein purpura.

    abstract：:The aim of this study was to assess the role of oxidative stress in the pathogenesis of Henoch-Schönlein purpura (HSP) vasculitis. The activities of catalase (CAT), arylesterase (ARYL), and paraoxonase (PON) as antioxidant enzymes and serum malondialdehyde (MDA) level as an indicator of lipid peroxidation, together wi...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-007-0671-5

    authors： Ece A,Kelekçi S,Kocamaz H,Hekimoğlu A,Balik H,Yolbaş I,Erel O

    更新日期：2008-02-01 00:00:00

  • Increased IL-6 expression on THP-1 by IL-34 stimulation up-regulated rheumatoid arthritis Th17 cells.

    abstract：:IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-017-3746-y

    authors： Wang B,Tang Y,Sun X,Ouyang X,Li H,Wei J,Zhang Y,Li X

    更新日期：2018-01-01 00:00:00

  • Accelerated hypertension and nephroangiosclerosis associated with antiphospholipid syndrome. Report of two cases and review of the literature.

    abstract：:We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertensio...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02243009

    authors： Durand JM,Lefevre P,Kaplanski G,Casanova P,Soubeyrand J

    更新日期：1994-12-01 00:00:00

  • The risk of leukemia in patients with rheumatoid arthritis: a systematic review and meta-analysis.

    abstract：OBJECTIVES:The relationship between rheumatoid arthritis (RA) and the risk of leukemia was still controversial. This study aimed to assess the risk of leukemia in patients with rheumatoid arthritis by systematic review and meta-analysis. METHODS:Relevant studies were identified by searching PubMed, Embase, Cochrane Li...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-020-05396-7

    authors： Luo X,He Y,Xu W,Liu M,Zhao Z,Peng L,He C,Chen J

    更新日期：2020-09-17 00:00:00

  • Evaluation of tool-like receptor-2 and 4 and interleukin-6 gene expressions in Turkish rheumatoid arthritis patients.

    abstract：:Rheumatoid arthritis (RA) is a progressive inflammatory disease. Although the etiology and pathogenesis of RA are not known well, genetic and environmental factors are proposed to initiate an autoimmune process. We aimed to investigate mRNA expression levels of Toll-like receptor-2 (TLR-2), TLR-4, and interleukin-6 (I...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-016-3282-1

    authors： Eser B,Sahin N

    更新日期：2016-11-01 00:00:00

  • Depressed fibromyalgia patients are equipped with an emphatic competence dependent self-esteem.

    abstract：:Employing a recently developed questionnaire we studied the self-esteem structure of 61 female fibromyalgia (FM) patients by comparing them with i) 40 healthy psychology students and ii) 37 patients suffering from rheumatoid arthritis. Depressed FM patients (n=36) had a high need to gain self-esteem through competence...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF02247798

    authors： Johnson M,Paananen ML,Rahinantti P,Hannonen P

    更新日期：1997-11-01 00:00:00

  • Treatment of therapy-resistant sarcoidosis with adalimumab.

    abstract：:A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-005-0037-9

    authors： Callejas-Rubio JL,Ortego-Centeno N,Lopez-Perez L,Benticuaga MN

    更新日期：2006-07-01 00:00:00

  • Modifiable cardiovascular risk factors in patients with ankylosing spondylitis.

    abstract：:The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the general population. Ei...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-013-2410-4

    authors： Sundström B,Johansson G,Johansson I,Wållberg-Jonsson S

    更新日期：2014-01-01 00:00:00

  • Treatment of osteoporosis in renal insufficiency.

    abstract：:Patients with osteoporosis often have chronic kidney disease (CKD). CKD is associated with bone and mineral disturbances, renal osteodystrophy, which like osteoporosis leads to a higher risk of fractures. Bisphosphonates are first-line therapy for osteoporosis; however, these are contra-indicated in patients with a GF...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/s10067-015-2883-4

    authors： Schipper LG,Fleuren HW,van den Bergh JP,Meinardi JR,Veldman BA,Kramers C

    更新日期：2015-08-01 00:00:00

  • Spondyloarthritis in women: differences in disease onset, clinical presentation, and Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI) between men and women with spondyloarthritides.

    abstract：:The aim of this study is to assess the gender differences in spondyloarthritides (SpAs) in terms of disease onset, clinical presentation, and the Bath Ankylosing Spondylitis Disease Activity and Functional indices (BASDAI and BASFI). We analysed data from a predominantly female cohort. Five hundred and 16 patients (ma...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-010-1581-5

    authors： Roussou E,Sultana S

    更新日期：2011-01-01 00:00:00

  • Clinical study of Thai patients with ankylosing spondylitis.

    abstract：:Sixty-one Thai patients with ankylosing spondylitis (AS), diagnosed in accordance with Rome and New York criteria for AS, were studied. The cases includes idiopathic AS (46 cases), Reiter's syndrome AS (8 cases) and psoriatic spondylitis (7 cases). The vast majority of patients were male (Male:Female = 11.2:1), and in...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF02032322

    authors： Deesomchok U,Tumrasvin T

    更新日期：1985-03-01 00:00:00

  • Cardiovascular events prediction by left ventricular longitudinal strain and serum high-sensitivity troponin I in patients with axial spondyloarthritis.

    abstract：OBJECTIVE:Patients with axial spondyloarthritis (SpA) are subjected to elevated cardiovascular risks, but assessment of early myocardial damage and clinical risk stratification remained obscure. The aim of this study was to evaluate the prognostic value of speckle-tracking strain analysis and serum high-sensitivity tro...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-020-05112-5

    authors： Chen Y,Chan YH,Chung HY,Wu MZ,Yu YJ,Pi KL,Lau CS,Tse HF,Yiu KH

    更新日期：2020-11-01 00:00:00

  • Serum microRNAs as Potential Biomarkers of Juvenile Idiopathic Arthritis.

    abstract：:MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression of targeted mRNAs, which are important in the pathogenesis of autoimmune diseases. MiRNAs may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile ...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-015-2922-1

    authors： Kamiya Y,Kawada J,Kawano Y,Torii Y,Kawabe S,Iwata N,Ito Y

    更新日期：2015-10-01 00:00:00

  • Anxiety and depression in adult-onset Still's disease patients and associations with health-related quality of life.

    abstract：OBJECTIVE:Adult-onset Still's disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients. METHODS:In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Dem...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-020-05094-4

    authors： Chi H,Jin H,Wang Z,Feng T,Zeng T,Shi H,Wu X,Wan L,Teng J,Sun Y,Liu H,Cheng X,Ye J,Hu Q,Zhou Z,Gu J,Jia J,Liu T,Qiao X,Yang C,Su Y

    更新日期：2020-12-01 00:00:00

  • Microwave thermography as a noninvasive assessment of disease activity in inflammatory arthritis.

    abstract：:Microwave thermography is the technique of measuring natural thermal radiation from body tissues of clinical interest. It is safe, requires no control of environmental conditions and exposes the patient to no ionising radiation. In this study, we found that microwave thermography of the knee joints showed weak correla...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/BF02242999

    authors： MacDonald AG,Land DV,Sturrock RD

    更新日期：1994-12-01 00:00:00

  • Factors associated with regional rheumatic pain disorders in a population of Puerto Ricans with diabetes mellitus.

    abstract：:The aim of the study was to determine the prevalence and factors associated with bursitis/tendonitis disorders in Puerto Ricans with diabetes mellitus (DM). A cross-sectional study was performed in 202 adult Puerto Ricans (100 DM patients and 102 non-diabetic subjects). For each participant, a complete medical history...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章

    doi：10.1007/s10067-013-2474-1

    authors： Font YM,Castro-Santana LE,Nieves-Plaza M,Maldonado M,Mayor AM,Vilá LM

    更新日期：2014-07-01 00:00:00

  • From molecular mimicry to cross-reactivity or pathogen expansion? A hypothesis.

    abstract：:Very recently, several studies have convincingly demonstrated the role of infection in the development of the antiphospholipid syndrome. Cross antibody-mediated reactivity due to molecular mimicry between endothelial glycoproteins and microbial products was considered as an important pathogenic mechanism. However, ano...

    journal_title：Clinical rheumatology

    pub_type： 杂志文章,评审

    doi：10.1007/s10067-006-0352-9

    authors： Rozin AP

    更新日期：2007-03-01 00:00:00